MX9701183A - Procedimiento de preparacion del virus gripal, antigenos obtenidos y sus aplicaciones. - Google Patents
Procedimiento de preparacion del virus gripal, antigenos obtenidos y sus aplicaciones.Info
- Publication number
- MX9701183A MX9701183A MX9701183A MX9701183A MX9701183A MX 9701183 A MX9701183 A MX 9701183A MX 9701183 A MX9701183 A MX 9701183A MX 9701183 A MX9701183 A MX 9701183A MX 9701183 A MX9701183 A MX 9701183A
- Authority
- MX
- Mexico
- Prior art keywords
- steps
- preparing
- applications
- influenza virus
- influenzal
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 239000000427 antigen Substances 0.000 title abstract 2
- 102000036639 antigens Human genes 0.000 title abstract 2
- 108091007433 antigens Proteins 0.000 title abstract 2
- 241000712461 unidentified influenza virus Species 0.000 title 1
- 241000700605 Viruses Species 0.000 abstract 2
- 238000001914 filtration Methods 0.000 abstract 2
- 238000013467 fragmentation Methods 0.000 abstract 2
- 238000006062 fragmentation reaction Methods 0.000 abstract 2
- 238000000746 purification Methods 0.000 abstract 2
- 239000000470 constituent Substances 0.000 abstract 1
- 239000003599 detergent Substances 0.000 abstract 1
- 230000002779 inactivation Effects 0.000 abstract 1
- 239000007788 liquid Substances 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 230000003612 virological effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/145—Orthomyxoviridae, e.g. influenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5252—Virus inactivated (killed)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/16011—Orthomyxoviridae
- C12N2760/16111—Influenzavirus A, i.e. influenza A virus
- C12N2760/16161—Methods of inactivation or attenuation
- C12N2760/16163—Methods of inactivation or attenuation by chemical treatment
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Virology (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Genetics & Genomics (AREA)
- Mycology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
Procedimiento de preparacion de antígenos gripales purificados, a partir de un líquido que contiene el virus gripal, que comprende las etapas de concentracion de purificacion, de fragmentacion y eventualmente de inactivacion caracterizado porque: A. o bien la etapa de purificacion comprende varias etapas de ultracentrifugacion separadas por una etapa de filtracion, B. o bien la etapa de fragmentacion no ionico anfífilo seguido de una eliminacion de substancias indeseables por filtracion que retiene el conjunto de constituyentes virales, o bien se opera de acuerdo a estas dos etapas en cualquier orden.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
FR9410039A FR2723740B1 (fr) | 1994-08-16 | 1994-08-16 | Procede de preparation d'antigenes du virus grippal, antigenes obtenus et leurs applications |
PCT/FR1995/000727 WO1996005294A1 (fr) | 1994-08-16 | 1995-06-06 | Procede de preparation du virus grippal, antigens obtenus et leurs applications |
Publications (1)
Publication Number | Publication Date |
---|---|
MX9701183A true MX9701183A (es) | 1997-05-31 |
Family
ID=9466323
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX9701183A MX9701183A (es) | 1994-08-16 | 1995-06-06 | Procedimiento de preparacion del virus gripal, antigenos obtenidos y sus aplicaciones. |
Country Status (10)
Country | Link |
---|---|
US (1) | US6048537A (es) |
EP (1) | EP0776362A1 (es) |
JP (1) | JPH10504033A (es) |
AU (1) | AU701024B2 (es) |
CA (1) | CA2197683C (es) |
FR (1) | FR2723740B1 (es) |
MX (1) | MX9701183A (es) |
NZ (1) | NZ288254A (es) |
WO (1) | WO1996005294A1 (es) |
ZA (1) | ZA956797B (es) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE19938767C2 (de) * | 1999-08-16 | 2002-10-24 | Tad Pharma Gmbh | Spaltimpfstoffe |
GB9924351D0 (en) | 1999-10-14 | 1999-12-15 | Brennan Frank | Immunomodulation methods and compositions |
EP1103610A1 (en) * | 1999-11-26 | 2001-05-30 | Introgene B.V. | Production of vaccines from immortalised mammalian cell lines |
US6951752B2 (en) | 2001-12-10 | 2005-10-04 | Bexter Healthcare S.A. | Method for large scale production of virus antigen |
KR100473070B1 (ko) * | 2002-08-31 | 2005-03-10 | 박승국 | 시각적 유도장치를 이용한 외국어 학습 및 교습 시스템 |
US7270990B2 (en) * | 2003-06-20 | 2007-09-18 | Microbix Biosystems, Inc. | Virus production |
RU2006145303A (ru) * | 2004-05-20 | 2008-06-27 | АйДи БАЙОМЕДИКАЛ КОРПОРЕЙШН (CA) | Способ получения противогриппозной вакцины |
US7691368B2 (en) | 2005-04-15 | 2010-04-06 | Merial Limited | Vaccine formulations |
AR054822A1 (es) | 2005-07-07 | 2007-07-18 | Sanofi Pasteur | Emulsion inmuno adyuvante |
US20080241184A1 (en) | 2005-08-25 | 2008-10-02 | Jules Maarten Minke | Canine influenza vaccines |
DE06808434T1 (de) * | 2005-11-04 | 2009-12-17 | Novartis Vaccines And Diagnostics S.R.L. | Emulsionen mit freiem wässrigen phasen tensid als adjuvans für spalt-grippeimpfstoffe |
WO2007096418A1 (en) * | 2006-02-23 | 2007-08-30 | Ovagen International Limited | Improved methods of producing avian eggs and birds of specified germ-free status |
WO2009014782A2 (en) * | 2007-04-27 | 2009-01-29 | Dow Global Technologies Inc. | Improved production and in vivo assembly of soluble recombinant icosahedral virus-like particles |
WO2008135230A1 (en) * | 2007-05-04 | 2008-11-13 | Baxter International Inc. | Two-step temperature profile for the propagation of viruses |
ES2459166T3 (es) * | 2007-08-28 | 2014-05-08 | Baxter International Inc. | Procedimiento para la producción de vacunas víricas |
TW200936758A (en) * | 2007-11-02 | 2009-09-01 | Intervet Int Bv | Orthomyxoviridae propagation |
TWI444384B (zh) * | 2008-02-20 | 2014-07-11 | Gilead Sciences Inc | 核苷酸類似物及其在治療惡性腫瘤上的用途 |
ES2615390T3 (es) * | 2008-03-05 | 2017-06-06 | Sanofi Pasteur | Proceso para estabilizar una composición de vacuna que contiene adyuvante |
JP5518041B2 (ja) | 2008-03-18 | 2014-06-11 | ノバルティス アーゲー | インフルエンザウイルスワクチン抗原の調製における改良 |
JP5843615B2 (ja) | 2009-02-06 | 2016-01-13 | グラクソスミスクライン バイオロジカルズ ソシエテ アノニム | 密度勾配超遠心分離によるウイルスまたはウイルス抗原の精製 |
CN103764160A (zh) * | 2009-05-29 | 2014-04-30 | 诺华有限公司 | 流感病毒血凝素试验 |
CN107213461B (zh) | 2009-09-10 | 2022-03-15 | 勃林格殷格翰动物保健美国公司 | 包含含有皂苷的佐剂的新疫苗制剂 |
US9644187B2 (en) | 2010-04-14 | 2017-05-09 | Emd Millipore Corporation | Methods of producing high titer, high purity virus stocks and methods of use thereof |
WO2013025274A1 (en) | 2011-08-12 | 2013-02-21 | Merial Limited | Vacuum -assisted preservation of biological products, in particular of vaccines |
FR3025107B1 (fr) | 2014-08-29 | 2018-10-05 | Calixar | Procede de preparation d'un antigene vaccinal, antigene vaccinal obtenu et utilisations |
TWI745278B (zh) | 2014-10-10 | 2021-11-11 | 以色列商艾畢克生物實驗有限公司 | 發泡性降低之疫苗組合物 |
JP7018941B2 (ja) | 2016-06-17 | 2022-02-14 | ベーリンガー インゲルハイム アニマル ヘルス ユーエスエイ インコーポレイテッド | 直鎖または分枝ポリアクリル酸ポリマーアジュバントを含む新規な免疫原性処方物 |
Family Cites Families (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4064232A (en) * | 1974-01-14 | 1977-12-20 | Sandoz Ltd. | Process for isolating the immunogenic components of influenza viruses |
US4000257A (en) * | 1975-12-22 | 1976-12-28 | American Cyanamid Company | Process for the purification of influenza virus vaccine |
US4057626A (en) * | 1976-10-08 | 1977-11-08 | Richardson-Merrell Inc. | Process for detoxifying influenza B virus |
FR2475572A1 (fr) * | 1980-02-11 | 1981-08-14 | Pasteur Institut | Procede pour l'obtention de fragments de virus a enveloppe lipidique, en particulier d'antigenes utilisables comme vaccins, produits obtenus et applications |
DE3014189A1 (de) * | 1980-04-14 | 1981-10-15 | Europäisches Laboratorium für Molekularbiologie (EMBL), 6900 Heidelberg | Verfahren zur herstellung eines immunogenen membranproteinaggregats von influenza-, parainfluenza- und rhabdo-viren |
FR2483779A1 (fr) * | 1980-06-05 | 1981-12-11 | Synthelabo | Procede pour isoler des antigenes glycoproteiques viraux et son application a la preparation de vaccins |
US4327182A (en) * | 1981-01-22 | 1982-04-27 | Connaught Laboratories Incorporated | Purification of influenza sub-unit vaccine |
FR2671974A1 (fr) * | 1991-01-24 | 1992-07-31 | Pasteur Merieux Serums Vacc | Composition vaccinale contre la grippe, a effet synergique, contenant comme additif du core de virus grippal. |
-
1994
- 1994-08-16 FR FR9410039A patent/FR2723740B1/fr not_active Expired - Lifetime
-
1995
- 1995-06-06 CA CA002197683A patent/CA2197683C/en not_active Expired - Lifetime
- 1995-06-06 WO PCT/FR1995/000727 patent/WO1996005294A1/fr not_active Application Discontinuation
- 1995-06-06 MX MX9701183A patent/MX9701183A/es unknown
- 1995-06-06 US US08/793,373 patent/US6048537A/en not_active Expired - Lifetime
- 1995-06-06 AU AU27412/95A patent/AU701024B2/en not_active Expired
- 1995-06-06 EP EP95922563A patent/EP0776362A1/fr not_active Withdrawn
- 1995-06-06 NZ NZ288254A patent/NZ288254A/xx not_active IP Right Cessation
- 1995-06-06 JP JP8507053A patent/JPH10504033A/ja active Pending
- 1995-08-15 ZA ZA9506797A patent/ZA956797B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
FR2723740A1 (fr) | 1996-02-23 |
WO1996005294A1 (fr) | 1996-02-22 |
CA2197683A1 (en) | 1996-02-22 |
US6048537A (en) | 2000-04-11 |
AU2741295A (en) | 1996-03-07 |
FR2723740B1 (fr) | 1996-11-08 |
NZ288254A (en) | 1999-01-28 |
JPH10504033A (ja) | 1998-04-14 |
ZA956797B (en) | 1997-02-17 |
EP0776362A1 (fr) | 1997-06-04 |
CA2197683C (en) | 2008-12-30 |
AU701024B2 (en) | 1999-01-21 |
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