MX370828B - Métodos de purificación de polipéptidos. - Google Patents
Métodos de purificación de polipéptidos.Info
- Publication number
- MX370828B MX370828B MX2016016228A MX2016016228A MX370828B MX 370828 B MX370828 B MX 370828B MX 2016016228 A MX2016016228 A MX 2016016228A MX 2016016228 A MX2016016228 A MX 2016016228A MX 370828 B MX370828 B MX 370828B
- Authority
- MX
- Mexico
- Prior art keywords
- methods
- polypeptide
- purifying
- purifying polypeptides
- polypeptides
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 4
- 229920001184 polypeptide Polymers 0.000 title abstract 4
- 102000004196 processed proteins & peptides Human genes 0.000 title abstract 4
- 108090000765 processed proteins & peptides Proteins 0.000 title abstract 4
- 239000000463 material Substances 0.000 abstract 2
- 239000000203 mixture Substances 0.000 abstract 2
- 238000005341 cation exchange Methods 0.000 abstract 1
- 239000000356 contaminant Substances 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/18—Ion-exchange chromatography
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/36—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving ionic interaction, e.g. ion-exchange, ion-pair, ion-suppression or ion-exclusion
- B01D15/361—Ion-exchange
- B01D15/362—Cation-exchange
-
- B—PERFORMING OPERATIONS; TRANSPORTING
- B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
- B01D—SEPARATION
- B01D15/00—Separating processes involving the treatment of liquids with solid sorbents; Apparatus therefor
- B01D15/08—Selective adsorption, e.g. chromatography
- B01D15/26—Selective adsorption, e.g. chromatography characterised by the separation mechanism
- B01D15/38—Selective adsorption, e.g. chromatography characterised by the separation mechanism involving specific interaction not covered by one or more of groups B01D15/265 and B01D15/30 - B01D15/36, e.g. affinity, ligand exchange or chiral chromatography
- B01D15/3847—Multimodal interactions
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/165—Extraction; Separation; Purification by chromatography mixed-mode chromatography
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/14—Extraction; Separation; Purification
- C07K1/16—Extraction; Separation; Purification by chromatography
- C07K1/22—Affinity chromatography or related techniques based upon selective absorption processes
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
- G01N30/02—Column chromatography
- G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
- G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
- G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
- G01N2030/8831—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving peptides or proteins
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Analytical Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un método para purificar un anticuerpo o una inmunoadhesina de una composición que comprende el anticuerpo o la inmunoadhesina y al menos un contaminante de proteína de ovario de hámster chico a un pH de 4.5 a 6.5.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US34814310P | 2010-05-25 | 2010-05-25 | |
PCT/US2011/037977 WO2011150110A1 (en) | 2010-05-25 | 2011-05-25 | Methods of purifying polypeptides |
Publications (1)
Publication Number | Publication Date |
---|---|
MX370828B true MX370828B (es) | 2020-01-08 |
Family
ID=45004368
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013575A MX344248B (es) | 2010-05-25 | 2011-05-25 | Metodos de purificacion de polipeptidos. |
MX2016016228A MX370828B (es) | 2010-05-25 | 2011-05-25 | Métodos de purificación de polipéptidos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2012013575A MX344248B (es) | 2010-05-25 | 2011-05-25 | Metodos de purificacion de polipeptidos. |
Country Status (20)
Country | Link |
---|---|
US (4) | US20130079272A1 (es) |
EP (2) | EP3299380B1 (es) |
JP (3) | JP5934190B2 (es) |
KR (1) | KR101976853B1 (es) |
CN (2) | CN102905718A (es) |
AU (1) | AU2011258254B2 (es) |
CA (2) | CA2799915C (es) |
ES (1) | ES2637613T5 (es) |
HK (1) | HK1246328A1 (es) |
HR (1) | HRP20171095T4 (es) |
IL (2) | IL223029A0 (es) |
MX (2) | MX344248B (es) |
MY (1) | MY161534A (es) |
NZ (1) | NZ603648A (es) |
PL (1) | PL2575847T5 (es) |
RU (1) | RU2594163C2 (es) |
SG (2) | SG10201710439UA (es) |
SI (1) | SI2575847T2 (es) |
WO (1) | WO2011150110A1 (es) |
ZA (1) | ZA201208673B (es) |
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AU2012351751B2 (en) * | 2011-10-19 | 2017-09-07 | Novimmune S.A. | Methods of purifying antibodies |
KR102067075B1 (ko) * | 2011-12-22 | 2020-01-17 | 제넨테크, 인크. | 이온 교환 막 크로마토그래피 |
CN102911250B (zh) * | 2012-09-29 | 2014-04-16 | 浙江海正药业股份有限公司 | 酸性重组蛋白药物的纯化方法 |
CN103880947B (zh) * | 2012-12-21 | 2016-01-13 | 武汉禾元生物科技股份有限公司 | 一种分离纯化高纯度重组人血清白蛋白的层析方法 |
WO2014118685A2 (en) * | 2013-01-29 | 2014-08-07 | Dr. Reddy's Laboratories Limited | Method of altering the acidic variant content of antibody |
EP2971087B1 (en) | 2013-03-14 | 2017-11-01 | Qiagen Sciences, LLC | Assessing dna quality using real-time pcr and ct values |
CN104236983A (zh) * | 2013-06-14 | 2014-12-24 | 中国科学院大连化学物理研究所 | 溶液样品中含长烷基链的离子液体的去除方法 |
US20150093800A1 (en) * | 2013-09-05 | 2015-04-02 | Genentech, Inc. | Method for chromatography reuse |
CA2920686C (en) | 2013-09-13 | 2022-12-06 | Genentech, Inc. | Compositions and methods for detecting and quantifying host cell protein in cell lines and recombinant polypeptide products |
MY176026A (en) | 2013-09-13 | 2020-07-22 | Genentech Inc | Methods and composions comprising purified recombinant polypeptides |
CA2926588C (en) | 2013-10-16 | 2020-07-21 | Oncobiologics, Inc. | Buffer formulations for enhanced antibody stability |
US8859252B1 (en) | 2014-01-02 | 2014-10-14 | Aerial Biopharma, Llc | Prostatic acid phosphatase, compositions comprising the same, and methods for producing and/or purifying the same |
US10214747B2 (en) | 2014-01-09 | 2019-02-26 | Kentucky Bioprocessing, Inc. | Method of purifying monoclonal antibodies |
LT3116891T (lt) | 2014-03-10 | 2020-03-25 | Richter Gedeon Nyrt. | Imunoglobulino gryninimas, naudojant išankstinio valymo pakopas |
WO2015177751A1 (en) * | 2014-05-23 | 2015-11-26 | Instituto Massone S.A. | A process for obtaining hmg-up (human menopausal gonadotropin with ultra-purity grade) and a composition free of contaminants |
WO2015198320A1 (en) * | 2014-06-24 | 2015-12-30 | Insight Biopharmaceuticals Ltd. | Methods of purifying antibodies |
GB201411802D0 (en) | 2014-07-02 | 2014-08-13 | Univ Bradford | Effervescent compositions |
WO2016118707A1 (en) * | 2015-01-21 | 2016-07-28 | Oncobiologics, Inc. | Modulation of charge variants in a monoclonal antibody composition |
CN109563161A (zh) | 2016-02-03 | 2019-04-02 | 安口生物公司 | 用于提高抗体稳定性的缓冲制剂 |
JP2019521986A (ja) | 2016-06-17 | 2019-08-08 | ジェネンテック, インコーポレイテッド | 多重特異性抗体の精製 |
SG11201901228QA (en) * | 2016-08-15 | 2019-03-28 | Genentech Inc | Chromatography method for quantifying a non-ionic surfactant in a composition comprising the non-ionic surfactant and a polypeptide |
JP6564539B1 (ja) | 2018-09-14 | 2019-08-21 | 長瀬産業株式会社 | スルホン酸化合物によるペプチド精製方法 |
EP3898689A1 (en) * | 2018-12-20 | 2021-10-27 | Armagen, Inc. | Purification of iduronate-2-sulfatase immunoglobulin fusion protein |
CN109765307B (zh) * | 2018-12-24 | 2021-06-29 | 山东省科学院海洋仪器仪表研究所 | 一种水体中六氯环己烷的测量方法 |
CN111366547A (zh) * | 2018-12-26 | 2020-07-03 | 贵州中烟工业有限责任公司 | 一种用连续流动法测定烟草或烟草制品中α-氨基氮的检测方法 |
CN113302197A (zh) | 2019-01-23 | 2021-08-24 | 第一三共株式会社 | 包括使用活性炭材料的工序的纯化抗体的方法 |
AR119264A1 (es) * | 2019-06-05 | 2021-12-09 | Genentech Inc | Método para reutilización de cromatografía |
US20220396598A1 (en) * | 2019-10-14 | 2022-12-15 | Pierce Biotechnology, Inc. | Peptide purification formulations and methods |
US20230251269A1 (en) * | 2020-07-15 | 2023-08-10 | The Johns Hopkins University | Comprehensive analysis of anti-allergen antibodies using phage display |
CN112852876B (zh) * | 2021-03-04 | 2022-11-29 | 西南大学 | 一种表达人表皮生长因子的家蚕丝腺重组表达载体及其制备方法和应用 |
EP4314009A1 (en) | 2021-03-31 | 2024-02-07 | F. Hoffmann-La Roche AG | Purification of antibodies by mixed mode chromatography |
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-
2011
- 2011-05-25 MX MX2012013575A patent/MX344248B/es active IP Right Grant
- 2011-05-25 EP EP17167800.6A patent/EP3299380B1/en active Active
- 2011-05-25 CA CA2799915A patent/CA2799915C/en active Active
- 2011-05-25 EP EP11787363.8A patent/EP2575847B2/en active Active
- 2011-05-25 CA CA3209878A patent/CA3209878A1/en active Pending
- 2011-05-25 MY MYPI2012005025A patent/MY161534A/en unknown
- 2011-05-25 HR HRP20171095TT patent/HRP20171095T4/hr unknown
- 2011-05-25 SI SI201131267T patent/SI2575847T2/sl unknown
- 2011-05-25 SG SG10201710439UA patent/SG10201710439UA/en unknown
- 2011-05-25 CN CN2011800254040A patent/CN102905718A/zh active Pending
- 2011-05-25 AU AU2011258254A patent/AU2011258254B2/en active Active
- 2011-05-25 SG SG2012086419A patent/SG185737A1/en unknown
- 2011-05-25 RU RU2012156271/04A patent/RU2594163C2/ru active
- 2011-05-25 JP JP2013512218A patent/JP5934190B2/ja active Active
- 2011-05-25 NZ NZ603648A patent/NZ603648A/en unknown
- 2011-05-25 ES ES11787363T patent/ES2637613T5/es active Active
- 2011-05-25 WO PCT/US2011/037977 patent/WO2011150110A1/en active Application Filing
- 2011-05-25 MX MX2016016228A patent/MX370828B/es unknown
- 2011-05-25 PL PL11787363.8T patent/PL2575847T5/pl unknown
- 2011-05-25 CN CN201710269454.2A patent/CN107365346A/zh active Pending
- 2011-05-25 KR KR1020127033600A patent/KR101976853B1/ko active IP Right Grant
-
2012
- 2012-11-14 IL IL223029A patent/IL223029A0/en active IP Right Grant
- 2012-11-19 ZA ZA2012/08673A patent/ZA201208673B/en unknown
- 2012-11-20 US US13/682,620 patent/US20130079272A1/en not_active Abandoned
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2016
- 2016-05-06 JP JP2016093347A patent/JP6272941B2/ja active Active
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2018
- 2018-01-04 JP JP2018000140A patent/JP2018087192A/ja active Pending
- 2018-05-08 HK HK18105945.5A patent/HK1246328A1/zh unknown
- 2018-08-14 IL IL261147A patent/IL261147A/en unknown
- 2018-10-22 US US16/167,364 patent/US20190300566A1/en not_active Abandoned
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2020
- 2020-01-22 US US16/749,888 patent/US20200399307A1/en not_active Abandoned
-
2021
- 2021-07-07 US US17/369,765 patent/US20220064209A1/en active Pending
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