MX369999B - Uso de masitinib en combinación con gemcitabina para el tratamiento de cáncer pancreatico en subpoblaciones de pacientes identificados en base al factor predictor de la intensidad de dolor. - Google Patents
Uso de masitinib en combinación con gemcitabina para el tratamiento de cáncer pancreatico en subpoblaciones de pacientes identificados en base al factor predictor de la intensidad de dolor.Info
- Publication number
- MX369999B MX369999B MX2015004264A MX2015004264A MX369999B MX 369999 B MX369999 B MX 369999B MX 2015004264 A MX2015004264 A MX 2015004264A MX 2015004264 A MX2015004264 A MX 2015004264A MX 369999 B MX369999 B MX 369999B
- Authority
- MX
- Mexico
- Prior art keywords
- inhibitor
- masitinib
- tyrosine kinase
- mast cell
- treatment
- Prior art date
Links
- 239000002139 L01XE22 - Masitinib Substances 0.000 title abstract 4
- WJEOLQLKVOPQFV-UHFFFAOYSA-N masitinib Chemical compound C1CN(C)CCN1CC1=CC=C(C(=O)NC=2C=C(NC=3SC=C(N=3)C=3C=NC=CC=3)C(C)=CC=2)C=C1 WJEOLQLKVOPQFV-UHFFFAOYSA-N 0.000 title abstract 4
- 229960004655 masitinib Drugs 0.000 title abstract 4
- 206010028980 Neoplasm Diseases 0.000 title abstract 2
- 201000011510 cancer Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 abstract 5
- 229940124204 C-kit inhibitor Drugs 0.000 abstract 4
- 210000003630 histaminocyte Anatomy 0.000 abstract 4
- 239000003112 inhibitor Substances 0.000 abstract 4
- 229940121358 tyrosine kinase inhibitor Drugs 0.000 abstract 4
- 239000005483 tyrosine kinase inhibitor Substances 0.000 abstract 4
- 150000004917 tyrosine kinase inhibitor derivatives Chemical class 0.000 abstract 4
- 229940034982 antineoplastic agent Drugs 0.000 abstract 3
- 239000002246 antineoplastic agent Substances 0.000 abstract 3
- 230000014509 gene expression Effects 0.000 abstract 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 abstract 1
- 239000000090 biomarker Substances 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- SDUQYLNIPVEERB-QPPQHZFASA-N gemcitabine Chemical compound O=C1N=C(N)C=CN1[C@H]1C(F)(F)[C@H](O)[C@@H](CO)O1 SDUQYLNIPVEERB-QPPQHZFASA-N 0.000 abstract 1
- 229960005277 gemcitabine Drugs 0.000 abstract 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 abstract 1
- 239000003550 marker Substances 0.000 abstract 1
- 201000002528 pancreatic cancer Diseases 0.000 abstract 1
- 208000008443 pancreatic carcinoma Diseases 0.000 abstract 1
- 210000004976 peripheral blood cell Anatomy 0.000 abstract 1
- 239000000092 prognostic biomarker Substances 0.000 abstract 1
- 230000004797 therapeutic response Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
- A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
- A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
- A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- Pathology (AREA)
- Genetics & Genomics (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Oncology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Abstract
La presente invención se refiere a un método para el tratamiento de pacientes afectados con cáncer, en el que dichos pacientes son tratados con un inhibidor de la tirosina quinasa, inhibidor de mastocitos o inhibidor de c-Kit, en particular masitinib, opcionalmente en combinación con al menos un agente antineoplásico. El inhibidor de la tirosina quinasa, inhibidor de mastocitos o inhibidor de c-Kit, y el opcional al menos un agente antineoplásico, se administra en un régimen de dosificación que comprende una cantidad terapéuticamente eficaz. La presente invención también se refiere a métodos para predecir la respuesta terapéutica a dicho tratamiento en un paciente dado y por lo tanto la identificación de subpoblaciones de pacientes aplicables basados en estos factores de predicción; a veces referido como biomarcadores. Un método se basa en el marcador clínico de la intensidad del dolor. El segundo método se basa en biomarcadores predictivos de expresión génica identídicados a través de la expresión de ARN en muestras de células de sangre periférica recogidas antes del tratamiento con un compuesto de la invención (es decir, un inhibidor de la tirosina quinasa, inhibidor de mastocitos o inhibidor de c-Kit, especialmente masitinib) . Ventajosamente, la presente invención se refiere a un método para el tratamiento de pacientes afectados con cáncer de páncreas en el que dichos pacientes son tratados con un inhibidor de la tirosina quinasa, inhibidor de mastocitos o inhibidor de c-Kit o, y, en particular masitinib, opcionalmente en combinación con al menos un agente antineoplásico y, en particular gemcitabina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP12306214 | 2012-10-04 | ||
| PCT/EP2013/070741 WO2014053650A1 (en) | 2012-10-04 | 2013-10-04 | Use of masitinib for treatment of cancer in patient subpopulations identified using predictor factors |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2015004264A MX2015004264A (es) | 2015-10-12 |
| MX369999B true MX369999B (es) | 2019-11-28 |
Family
ID=47073382
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2015004264A MX369999B (es) | 2012-10-04 | 2013-10-04 | Uso de masitinib en combinación con gemcitabina para el tratamiento de cáncer pancreatico en subpoblaciones de pacientes identificados en base al factor predictor de la intensidad de dolor. |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US10238649B2 (es) |
| EP (1) | EP2903616B8 (es) |
| JP (1) | JP6234466B2 (es) |
| KR (1) | KR102149483B1 (es) |
| CN (1) | CN104968347A (es) |
| AR (1) | AR092899A1 (es) |
| AU (1) | AU2013326463B2 (es) |
| BR (1) | BR112015007144A2 (es) |
| CA (1) | CA2886979C (es) |
| DK (1) | DK2903616T3 (es) |
| EA (1) | EA037368B1 (es) |
| ES (1) | ES2656640T3 (es) |
| IL (1) | IL238107B (es) |
| MX (1) | MX369999B (es) |
| NZ (1) | NZ706420A (es) |
| SG (1) | SG11201502626PA (es) |
| SI (1) | SI2903616T1 (es) |
| TW (1) | TWI609686B (es) |
| WO (1) | WO2014053650A1 (es) |
| ZA (1) | ZA201503054B (es) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AR097909A1 (es) * | 2013-10-04 | 2016-04-20 | Ab Science | Método para determinar el pronóstico del cáncer de páncreas |
| MX2016014574A (es) * | 2014-05-08 | 2017-02-23 | Oncoethix Gmbh | El uso de compuestos de tienotriazolodiazepina para el tratamiento de cancer de mama triple-negativo. |
| TW201615224A (zh) * | 2014-10-24 | 2016-05-01 | 朗齊生物醫學股份有限公司 | 消化系統疾病用藥臨床新應用 |
| US10722527B2 (en) | 2015-04-10 | 2020-07-28 | Capsugel Belgium Nv | Abiraterone acetate lipid formulations |
| MY189113A (en) | 2016-03-02 | 2022-01-26 | Eisai R&D Man Co Ltd | Eribulin-based antibody-drug conjugates and methods of use |
| DK3240538T3 (da) * | 2016-03-25 | 2021-12-06 | Ab Science | Anvendelse af masitinib til behandling af en underpopulation af patienter med amyotrofisk lateralsklerose |
| CN107267454A (zh) * | 2016-04-07 | 2017-10-20 | 北京京蒙高科干细胞技术有限公司 | 一种脐血nk细胞的体外扩增方法及其试剂盒与应用 |
| EP3571200B8 (en) | 2017-01-17 | 2022-08-03 | HepaRegeniX GmbH | Protein kinase inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death |
| US11400086B2 (en) * | 2017-02-01 | 2022-08-02 | Beyondspring Pharmaceuticals, Inc. | Method of reducing chemotherapy-induced neutropenia |
| SG11202007287XA (en) * | 2018-01-31 | 2020-08-28 | Deciphera Pharmaceuticals Llc | Combination therapy for the treatment of mastocytosis |
| WO2020092240A1 (en) * | 2018-10-29 | 2020-05-07 | Northwestern University | Big data-driven personalized management of chronic pain |
| WO2020115108A1 (en) * | 2018-12-06 | 2020-06-11 | Sørlandet Sykehus Hf | Egfr inhibitors and their use in the treatment of neuroathic pain |
| WO2020115261A1 (en) * | 2018-12-07 | 2020-06-11 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Methods and compositions for treating melanoma |
| CN114214396A (zh) * | 2020-06-30 | 2022-03-22 | 宁波市康宁医院(宁波市精神疾病预防控制中心、宁波市微循环与莨菪类药研究所) | Gabrd甲基化作为抗海洛因复吸靶点的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8450302B2 (en) * | 2002-08-02 | 2013-05-28 | Ab Science | 2-(3-aminoaryl) amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| WO2004014903A1 (en) | 2002-08-02 | 2004-02-19 | Ab Science | 2-(3-aminoaryl)amino-4-aryl-thiazoles and their use as c-kit inhibitors |
| US20090298061A1 (en) | 2005-07-29 | 2009-12-03 | Siemens Healthcare Diagnostics Inc. | Diagnostic Methods for the Prediction of Therapeutic Success, Recurrence Free and Overall Survival in Cancer Therapy |
| WO2008115300A1 (en) | 2006-12-01 | 2008-09-25 | Apocell, Inc. | C-kit phosphorylation in cancer |
| US8227470B2 (en) | 2007-01-12 | 2012-07-24 | Ab Science | Combination treatment of solid cancers with antimetabolites and tyrosine kinase inhibitors |
| ES2369617T3 (es) | 2007-02-13 | 2011-12-02 | Ab Science | Procedimiento para la síntesis de compuestos de 2-aminotiazol como inhibidores de la quinasa. |
| WO2011056963A1 (en) | 2009-11-04 | 2011-05-12 | The University Of North Carolina At Chapel Hill | Methods and compositions for predicting survival in subjects with cancer |
| TW201130830A (en) * | 2010-02-01 | 2011-09-16 | Ab Science | Combined treatment of pancreatic cancer with gemcitabine and masitinib |
| WO2012170640A1 (en) * | 2011-06-07 | 2012-12-13 | The Trustees Of Columbia University In The City Of New York | Methods and compositions for trail-drug combination therapy |
-
2013
- 2013-10-04 MX MX2015004264A patent/MX369999B/es active IP Right Grant
- 2013-10-04 TW TW102136110A patent/TWI609686B/zh not_active IP Right Cessation
- 2013-10-04 SG SG11201502626PA patent/SG11201502626PA/en unknown
- 2013-10-04 NZ NZ706420A patent/NZ706420A/en not_active IP Right Cessation
- 2013-10-04 SI SI201330891T patent/SI2903616T1/en unknown
- 2013-10-04 CN CN201380063241.4A patent/CN104968347A/zh active Pending
- 2013-10-04 AR ARP130103596A patent/AR092899A1/es unknown
- 2013-10-04 KR KR1020157011764A patent/KR102149483B1/ko active IP Right Grant
- 2013-10-04 DK DK13773731.8T patent/DK2903616T3/da active
- 2013-10-04 ES ES13773731.8T patent/ES2656640T3/es active Active
- 2013-10-04 AU AU2013326463A patent/AU2013326463B2/en not_active Ceased
- 2013-10-04 JP JP2015535036A patent/JP6234466B2/ja active Active
- 2013-10-04 EA EA201500373A patent/EA037368B1/ru unknown
- 2013-10-04 US US14/433,198 patent/US10238649B2/en active Active
- 2013-10-04 EP EP13773731.8A patent/EP2903616B8/en active Active
- 2013-10-04 CA CA2886979A patent/CA2886979C/en active Active
- 2013-10-04 BR BR112015007144A patent/BR112015007144A2/pt not_active Application Discontinuation
- 2013-10-04 WO PCT/EP2013/070741 patent/WO2014053650A1/en active Application Filing
-
2015
- 2015-04-01 IL IL238107A patent/IL238107B/en active IP Right Grant
- 2015-04-08 ZA ZA2015/03054A patent/ZA201503054B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2013326463B2 (en) | 2018-01-18 |
| JP6234466B2 (ja) | 2017-11-22 |
| TWI609686B (zh) | 2018-01-01 |
| BR112015007144A2 (pt) | 2017-12-12 |
| ES2656640T3 (es) | 2018-02-27 |
| CA2886979A1 (en) | 2014-04-10 |
| NZ706420A (en) | 2018-08-31 |
| MX2015004264A (es) | 2015-10-12 |
| US20150272945A1 (en) | 2015-10-01 |
| KR102149483B1 (ko) | 2020-08-28 |
| CN104968347A (zh) | 2015-10-07 |
| EA201500373A1 (ru) | 2016-02-29 |
| SG11201502626PA (en) | 2015-05-28 |
| KR20150092739A (ko) | 2015-08-13 |
| SI2903616T1 (en) | 2018-02-28 |
| IL238107B (en) | 2018-03-29 |
| EP2903616B8 (en) | 2018-02-07 |
| ZA201503054B (en) | 2016-11-30 |
| AR092899A1 (es) | 2015-05-06 |
| EP2903616A1 (en) | 2015-08-12 |
| WO2014053650A1 (en) | 2014-04-10 |
| EA037368B1 (ru) | 2021-03-19 |
| JP2015532296A (ja) | 2015-11-09 |
| EP2903616B1 (en) | 2017-12-13 |
| AU2013326463A1 (en) | 2015-04-16 |
| CA2886979C (en) | 2021-01-05 |
| TW201414475A (zh) | 2014-04-16 |
| DK2903616T3 (da) | 2018-01-29 |
| US10238649B2 (en) | 2019-03-26 |
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