US2878264A
(en)
|
|
1959-03-17 |
|
Substituted amino alcohols |
CH372667A
(de)
|
1957-09-26 |
1963-10-31 |
Robins Co Inc A H |
Verfahren zur Herstellung von 3-Aryl-3-pyrrolidinolen
|
US3135766A
(en)
|
1961-10-03 |
1964-06-02 |
Mead Johnson & Co |
3-substituted-3-pyrrolidinols
|
US3484473A
(en)
|
1967-05-12 |
1969-12-16 |
Buckman Labor Inc |
Methylene bisesters of thiolsulfonic acids
|
DE1934150A1
(de)
|
1968-07-10 |
1970-01-15 |
Pennwalt Corp |
Neue 1-Alkanoyloxy-1,2,4,5-tetrahydro-3H,3-benzazepine
|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
US3745162A
(en)
|
1970-08-31 |
1973-07-10 |
Robins Co Inc A H |
1,2,3,4-tetrahydroisoquinoline-2-(thio)-carboxamides
|
GB1448437A
(en)
|
1973-02-24 |
1976-09-08 |
Beecham Group Ltd |
Diphenylpropylamines
|
US4022791A
(en)
|
1975-06-03 |
1977-05-10 |
Pfizer Inc. |
2-Aminomethyl-3,4-dihydronaphthalenes
|
GB1504424A
(en)
|
1975-08-09 |
1978-03-22 |
Beecham Group Ltd |
Isoquinoline-derived aminoethers
|
BR7807288A
(pt)
|
1977-11-08 |
1979-06-12 |
Genentech Inc |
Processo para sintese de polinucleotidos
|
DD133885B1
(de)
|
1978-01-04 |
1981-02-25 |
Hans Lehmann |
Mittel zur bekaempfung von phytopathogenen bakterien und pilzen
|
US4458066A
(en)
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US5132418A
(en)
|
1980-02-29 |
1992-07-21 |
University Patents, Inc. |
Process for preparing polynucleotides
|
US4500707A
(en)
|
1980-02-29 |
1985-02-19 |
University Patents, Inc. |
Nucleosides useful in the preparation of polynucleotides
|
US4668777A
(en)
|
1981-03-27 |
1987-05-26 |
University Patents, Inc. |
Phosphoramidite nucleoside compounds
|
US4973679A
(en)
|
1981-03-27 |
1990-11-27 |
University Patents, Inc. |
Process for oligonucleo tide synthesis using phosphormidite intermediates
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
US4542142A
(en)
|
1982-11-22 |
1985-09-17 |
Roussel Uclaf |
Insecticidal cyclopropane carboxylic acid derivatives with 3-unsaturated-side chain
|
DE3329892A1
(de)
|
1983-08-18 |
1985-03-07 |
Köster, Hubert, Prof. Dr., 2000 Hamburg |
Verfahren zur herstellung von oligonucleotiden
|
US5118800A
(en)
|
1983-12-20 |
1992-06-02 |
California Institute Of Technology |
Oligonucleotides possessing a primary amino group in the terminal nucleotide
|
US5643889A
(en)
|
1984-07-11 |
1997-07-01 |
Temple University-Of The Commonwealth System Of Pennsylvania |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
|
FR2567892B1
(fr)
|
1984-07-19 |
1989-02-17 |
Centre Nat Rech Scient |
Nouveaux oligonucleotides, leur procede de preparation et leurs applications comme mediateurs dans le developpement des effets des interferons
|
US5367066A
(en)
|
1984-10-16 |
1994-11-22 |
Chiron Corporation |
Oligonucleotides with selectably cleavable and/or abasic sites
|
FR2575751B1
(fr)
|
1985-01-08 |
1987-04-03 |
Pasteur Institut |
Nouveaux nucleosides de derives de l'adenosine, leur preparation et leurs applications biologiques
|
FR2576898B1
(fr)
|
1985-02-01 |
1988-01-08 |
Lafon Labor |
Derives de 3-phenyl-tetrahydropyridine, procede de preparation et utilisation en therapeutique
|
JPH0658512B2
(ja)
|
1985-04-12 |
1994-08-03 |
富士写真フイルム株式会社 |
ハロゲン化銀写真感光材料
|
US4659774A
(en)
|
1985-11-01 |
1987-04-21 |
American Hoechst Corporation |
Support for solid-phase oligonucleotide synthesis
|
US4735949A
(en)
|
1986-02-18 |
1988-04-05 |
Warner-Lambert Company |
Disubstituted-7-pyrrolidinonaphthyridine antibacterial agents
|
US4840956A
(en)
|
1986-02-18 |
1989-06-20 |
Warner-Lambert Company |
Novel disubstituted-7-pyrrolidinoquinoline antibacterial agents
|
IL83663A0
(en)
|
1986-10-27 |
1988-01-31 |
Robins Co Inc A H |
Preparation of 3-pyrrolidinols
|
JP2828642B2
(ja)
|
1987-06-24 |
1998-11-25 |
ハワード フローレイ インスティテュト オブ イクスペリメンタル フィジオロジー アンド メディシン |
ヌクレオシド誘導体
|
ES2045028T3
(es)
|
1987-07-30 |
1994-01-16 |
Univ Bar Ilan |
Esteres de acidos carboxilicos biologicamente activos.
|
US4923901A
(en)
|
1987-09-04 |
1990-05-08 |
Millipore Corporation |
Membranes with bound oligonucleotides and peptides
|
US5175273A
(en)
|
1988-07-01 |
1992-12-29 |
Genentech, Inc. |
Nucleic acid intercalating agents
|
US4943629A
(en)
|
1988-08-12 |
1990-07-24 |
American Cyanamid Company |
Antidiabetic alpha-substituted phosphonates
|
US4945158A
(en)
|
1988-08-12 |
1990-07-31 |
American Cyanamid Company |
Antidiabetic phosphonates
|
US5262530A
(en)
|
1988-12-21 |
1993-11-16 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
US5047524A
(en)
|
1988-12-21 |
1991-09-10 |
Applied Biosystems, Inc. |
Automated system for polynucleotide synthesis and purification
|
JP2794461B2
(ja)
|
1989-08-17 |
1998-09-03 |
有機合成薬品工業株式会社 |
ホスホアミダイト化合物及びそれを用いたオリゴリボヌクレオチドの固相合成法
|
US5141813A
(en)
|
1989-08-28 |
1992-08-25 |
Clontech Laboratories, Inc. |
Multifunctional controlled pore glass reagent for solid phase oligonucleotide synthesis
|
US5134066A
(en)
|
1989-08-29 |
1992-07-28 |
Monsanto Company |
Improved probes using nucleosides containing 3-dezauracil analogs
|
CA2029273A1
(en)
|
1989-12-04 |
1991-06-05 |
Christine L. Brakel |
Modified nucleotide compounds
|
US5130302A
(en)
|
1989-12-20 |
1992-07-14 |
Boron Bilogicals, Inc. |
Boronated nucleoside, nucleotide and oligonucleotide compounds, compositions and methods for using same
|
EP0507863A4
(en)
|
1989-12-28 |
1993-07-07 |
Virginia Commonwealth University |
Sigma receptor ligands and the use thereof
|
US5587361A
(en)
|
1991-10-15 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
US5506212A
(en)
|
1990-01-11 |
1996-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides with substantially chirally pure phosphorothioate linkages
|
US6339066B1
(en)
|
1990-01-11 |
2002-01-15 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides which have phosphorothioate linkages of high chiral purity and which modulate βI, βII, γ, δ, Ε, ζ and η isoforms of human protein kinase C
|
US7101993B1
(en)
|
1990-01-11 |
2006-09-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides containing 2′-O-modified purines
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
US5587470A
(en)
|
1990-01-11 |
1996-12-24 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
US5852188A
(en)
|
1990-01-11 |
1998-12-22 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
WO1991010671A1
(en)
|
1990-01-11 |
1991-07-25 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for detecting and modulating rna activity and gene expression
|
US5620963A
(en)
|
1991-10-15 |
1997-04-15 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating protein kinase C having phosphorothioate linkages of high chiral purity
|
US5635488A
(en)
|
1991-10-15 |
1997-06-03 |
Isis Pharmaceuticals, Inc. |
Compounds having phosphorodithioate linkages of high chiral purity
|
US5457191A
(en)
|
1990-01-11 |
1995-10-10 |
Isis Pharmaceuticals, Inc. |
3-deazapurines
|
US5212295A
(en)
|
1990-01-11 |
1993-05-18 |
Isis Pharmaceuticals |
Monomers for preparation of oligonucleotides having chiral phosphorus linkages
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
US5292875A
(en)
|
1990-04-20 |
1994-03-08 |
Lynx Therapeutics, Inc. |
Method of synthesizing sulfurized oligonucleotide analogs
|
ES2139578T3
(es)
|
1990-05-23 |
2000-02-16 |
Isis Pharmaceuticals Inc |
Composiciones y procedimiento para modular la actividad del arn mediante la modificacion de la estructura protectora 5' del arn.
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
WO1994022886A1
(en)
|
1993-03-30 |
1994-10-13 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5998603A
(en)
|
1994-09-29 |
1999-12-07 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analogs, and oligomers thereof
|
US5223618A
(en)
|
1990-08-13 |
1993-06-29 |
Isis Pharmaceuticals, Inc. |
4'-desmethyl nucleoside analog compounds
|
US5608046A
(en)
|
1990-07-27 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Conjugated 4'-desmethyl nucleoside analog compounds
|
US5610289A
(en)
|
1990-07-27 |
1997-03-11 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogues
|
US5792844A
(en)
|
1990-07-27 |
1998-08-11 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent nitrogen atoms
|
US5834607A
(en)
|
1990-07-27 |
1998-11-10 |
Isis Pharmaceuticals, Inc. |
Amines and methods of making and using the same
|
US5783682A
(en)
|
1990-07-27 |
1998-07-21 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide mimics having nitrogen-containing linkages
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
CA2088258C
(en)
|
1990-07-27 |
2004-09-14 |
Phillip Dan Cook |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
US6121433A
(en)
|
1990-07-27 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having nitrogen-containing linkages
|
US5618704A
(en)
|
1990-07-27 |
1997-04-08 |
Isis Pharmacueticals, Inc. |
Backbone-modified oligonucleotide analogs and preparation thereof through radical coupling
|
US5677437A
(en)
|
1990-07-27 |
1997-10-14 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5688941A
(en)
|
1990-07-27 |
1997-11-18 |
Isis Pharmaceuticals, Inc. |
Methods of making conjugated 4' desmethyl nucleoside analog compounds
|
US5138045A
(en)
|
1990-07-27 |
1992-08-11 |
Isis Pharmaceuticals |
Polyamine conjugated oligonucleotides
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
US5378825A
(en)
|
1990-07-27 |
1995-01-03 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs
|
US5541307A
(en)
|
1990-07-27 |
1996-07-30 |
Isis Pharmaceuticals, Inc. |
Backbone modified oligonucleotide analogs and solid phase synthesis thereof
|
US6087482A
(en)
|
1990-07-27 |
2000-07-11 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
JPH04348044A
(ja)
|
1991-02-21 |
1992-12-03 |
Matsushita Electron Corp |
半導体用樹脂封止装置
|
US5512668A
(en)
|
1991-03-06 |
1996-04-30 |
Polish Academy Of Sciences |
Solid phase oligonucleotide synthesis using phospholane intermediates
|
US7015315B1
(en)
|
1991-12-24 |
2006-03-21 |
Isis Pharmaceuticals, Inc. |
Gapped oligonucleotides
|
US20020183502A1
(en)
|
1991-05-21 |
2002-12-05 |
Mesmaeker Alain De |
Backbone-modified oligonucleotide analogs and methods for using same
|
JPH04348077A
(ja)
|
1991-05-24 |
1992-12-03 |
Nec Corp |
薄膜トランジスタ
|
US6414112B1
(en)
|
1991-05-24 |
2002-07-02 |
Ole Buchardt |
Peptide nucleic acids having 2,6-diaminopurine nucleobases
|
CA2111108A1
(en)
|
1991-06-10 |
1992-12-23 |
Joong Myung Cho |
Hepatitis c diagnostics and vaccines
|
US5359052A
(en)
|
1991-08-05 |
1994-10-25 |
Polish Academy Of Sciences |
Chalcophospholanes useful in the synthesis of oligonucleoside phosphorothioates, phosphorodithioates and related selenates
|
US5646267A
(en)
|
1991-08-05 |
1997-07-08 |
Polish Academy Of Sciences |
Method of making oligonucleotides and oligonucleotide analogs using phospholanes and enantiomerically resolved phospholane analogues
|
US7119184B2
(en)
|
1991-08-12 |
2006-10-10 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US6369209B1
(en)
|
1999-05-03 |
2002-04-09 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having A-DNA form and B-DNA form conformational geometry
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
US5599797A
(en)
|
1991-10-15 |
1997-02-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
US5607923A
(en)
|
1991-10-15 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
|
EP0655088B1
(en)
|
1991-10-15 |
2002-07-24 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having chiral phosphorus linkages
|
US5654284A
(en)
|
1991-10-15 |
1997-08-05 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating RAF kinase having phosphorothioate linkages of high chiral purity
|
US5576302A
(en)
|
1991-10-15 |
1996-11-19 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating hepatitis C virus having phosphorothioate linkages of high chiral purity
|
ES2103918T3
(es)
|
1991-10-17 |
1997-10-01 |
Ciba Geigy Ag |
Nucleosidos biciclicos, oligonucleotidos, procedimiento para su obtencion y productos intermedios.
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
US5484908A
(en)
|
1991-11-26 |
1996-01-16 |
Gilead Sciences, Inc. |
Oligonucleotides containing 5-propynyl pyrimidines
|
US6235887B1
(en)
|
1991-11-26 |
2001-05-22 |
Isis Pharmaceuticals, Inc. |
Enhanced triple-helix and double-helix formation directed by oligonucleotides containing modified pyrimidines
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
DK0618925T4
(da)
|
1991-12-24 |
2012-07-09 |
Isis Pharmaceuticals Inc |
Antisense-oligonukleotider
|
GB9213601D0
(en)
|
1992-06-26 |
1992-08-12 |
Mastico Robert A |
Protein based delivery system
|
US7067497B2
(en)
|
1992-09-29 |
2006-06-27 |
Isis Pharmaceuticals, Inc. |
Modulation of telomere length by oligonucleotides having a G-core sequence
|
US6005107A
(en)
|
1992-12-23 |
1999-12-21 |
Biochem Pharma, Inc. |
Antiviral compounds
|
US6444656B1
(en)
|
1992-12-23 |
2002-09-03 |
Biochem Pharma, Inc. |
Antiviral phosphonate nucleotides
|
ATE138384T1
(de)
|
1993-01-25 |
1996-06-15 |
Hybridon Inc |
Olionukleotidalkylphosphonate und - phosphonothioate
|
CA2159632A1
(en)
|
1993-03-31 |
1994-10-13 |
Ashis Kumar Saha |
Novel 5'-substituted nucleosides and oligomers produced therefrom
|
AU6551094A
(en)
|
1993-03-31 |
1994-10-24 |
Sterling Winthrop Inc. |
Bifunctional nucleosides, oligomers thereof, and methods of making and using the same
|
US5955591A
(en)
*
|
1993-05-12 |
1999-09-21 |
Imbach; Jean-Louis |
Phosphotriester oligonucleotides, amidites and method of preparation
|
US6015886A
(en)
|
1993-05-24 |
2000-01-18 |
Chemgenes Corporation |
Oligonucleotide phosphate esters
|
DE69412704T2
(de)
|
1993-06-10 |
1999-02-04 |
Idemitsu Petrochemical Co., Ltd., Tokio/Tokyo |
Spritzgiessform
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
US5643989A
(en)
|
1993-10-29 |
1997-07-01 |
Azdel, Inc. |
Fiber reinforced functionalized polyolefin composites
|
WO1998003542A1
(en)
|
1996-07-24 |
1998-01-29 |
Buchardt, Dorte |
Peptide nucleic acids having enhanced binding affinity, sequence specificity and solubility
|
US5457187A
(en)
|
1993-12-08 |
1995-10-10 |
Board Of Regents University Of Nebraska |
Oligonucleotides containing 5-fluorouracil
|
DE4435728A1
(de)
|
1994-01-19 |
1995-07-20 |
Boehringer Mannheim Gmbh |
Biotinsilan-Verbindungen und diese Verbindungen enthaltende Bindematrix
|
US6117679A
(en)
|
1994-02-17 |
2000-09-12 |
Maxygen, Inc. |
Methods for generating polynucleotides having desired characteristics by iterative selection and recombination
|
CN1077598C
(zh)
|
1994-02-22 |
2002-01-09 |
诺沃奇梅兹有限公司 |
制备脂解酶变异体的方法
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
AU2445795A
(en)
|
1994-05-11 |
1995-12-05 |
Novo Nordisk A/S |
An enzyme with endo-1,3(4)-beta -glucanase activity
|
US5525711A
(en)
|
1994-05-18 |
1996-06-11 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Pteridine nucleotide analogs as fluorescent DNA probes
|
HRP950288A2
(en)
|
1994-05-31 |
1997-08-31 |
Bayer Ag |
Oxalylamino-benzofuran- and benzothienyl-derivatives
|
ATE175667T1
(de)
|
1994-05-31 |
1999-01-15 |
Bayer Ag |
Aminobenzofuryl- und -thienylderivate
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
JP3468773B2
(ja)
|
1994-07-15 |
2003-11-17 |
ザ ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
免疫調節オリゴヌクレオチド
|
JPH10505094A
(ja)
*
|
1994-09-07 |
1998-05-19 |
ハイブリドン・インコーポレイテッド |
オリゴヌクレオチドプロドラッグ
|
US5681940A
(en)
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
AU4514696A
(en)
|
1994-12-22 |
1996-07-10 |
Hybridon, Inc. |
Synthesis of stereospecific oligonucleotide phosphorothioates
|
GB9501465D0
(en)
|
1995-01-25 |
1995-03-15 |
King S College London |
Nucleoside phosphorothioate derivatives,synthesis and use thereof
|
US6166197A
(en)
|
1995-03-06 |
2000-12-26 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds having pyrimidine nucleotide (S) with 2'and 5 substitutions
|
ATE327244T1
(de)
|
1995-03-06 |
2006-06-15 |
Isis Pharmaceuticals Inc |
Verfahren zur synthese von 2'-0-substituierten pyrimidinen und oligomere davon
|
DE69638104D1
(de)
|
1995-04-27 |
2010-02-11 |
Takara Bio Inc |
Für Lacto-N-biosidase kodierendes Gen
|
RU2205874C2
(ru)
|
1995-05-11 |
2003-06-10 |
Апплайд Резеч Системз Арс Холдинг Н.В. |
Нуклеотидная последовательность, способная ингибировать активность il-6, плазмидный вектор для трансфекции в клетки млекопитающих, нуклеотидная последовательность, используемая при терапии, фармацевтическая композиция (варианты)
|
WO1996036627A1
(en)
|
1995-05-19 |
1996-11-21 |
Glycomed Incorporated |
Collection of activated glycoside compounds and their biological use
|
DE69609511T2
(de)
|
1995-05-23 |
2001-03-29 |
Hybridon, Inc. |
Neue Synthons für die stereoselektive Oligonuklodsynthese
|
AU5871196A
(en)
|
1995-05-23 |
1996-12-24 |
Hybridon, Inc. |
Methods and compounds for the synthesis of oligonucleotides and the oligonucleotides thereby produced
|
JPH10510433A
(ja)
|
1995-06-06 |
1998-10-13 |
アイシス・ファーマシューティカルス・インコーポレーテッド |
高いキラル純度のホスホロチオエート結合を有するオリゴヌクレオチド
|
US5932450A
(en)
|
1995-06-07 |
1999-08-03 |
Gen-Probe Incorporated |
Enzymatic synthesis of oligonucleotides using digestible templates
|
DE69635849T2
(de)
|
1995-06-29 |
2006-10-19 |
Takara Bio Inc., Otsu |
Für Endoglycoceramidase kodierendes Gen
|
EP0759470B1
(en)
|
1995-06-29 |
2006-10-25 |
Takara Bio Inc. |
Gene encoding endoglycoceramidase activator
|
US6017700A
(en)
|
1995-08-04 |
2000-01-25 |
Bayer Corporation |
Cationic oligonucleotides, and related methods of synthesis and use
|
US5936080A
(en)
|
1996-05-24 |
1999-08-10 |
Genta Incorporated |
Compositions and methods for the synthesis of organophosphorus derivatives
|
WO1997009443A1
(en)
|
1995-09-05 |
1997-03-13 |
Michigan State University |
PROCESS FOR THE ISOLATION AND PURIFICATION OF TAXOL AND TAXANES FROM TAXUS spp
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
US6160109A
(en)
|
1995-10-20 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Preparation of phosphorothioate and boranophosphate oligomers
|
US6476216B1
(en)
|
1995-10-20 |
2002-11-05 |
Mcgill University |
Preparation of phosphorothioate oligomers
|
US7018793B1
(en)
|
1995-12-07 |
2006-03-28 |
Diversa Corporation |
Combinatorial screening of mixed populations of organisms
|
US6214805B1
(en)
|
1996-02-15 |
2001-04-10 |
The United States Of America As Represented By The Department Of Health And Human Services |
RNase L activators and antisense oligonucleotides effective to treat RSV infections
|
US5998602A
(en)
|
1996-02-15 |
1999-12-07 |
The Cleveland Clinic Fouindation And Government |
RNase L activators and antisense oligonucleotides effective to treat RSV infections
|
GB9604669D0
(en)
|
1996-03-05 |
1996-05-01 |
Ciba Geigy Ag |
Chemical compounds
|
US5824669A
(en)
|
1996-03-22 |
1998-10-20 |
Nitromed, Inc. |
Nitrosated and nitrosylated compounds and compositions and their use for treating respiratory disorders
|
WO1997043409A2
(en)
|
1996-05-10 |
1997-11-20 |
Novo Nordisk A/S |
Method of providing novel dna sequences
|
US5856465A
(en)
|
1996-05-24 |
1999-01-05 |
Polska Akademia Nauk Centrum Badan Molekularnych I Makromolekularnych |
Compositions and methods for the synthesis of chirally pure organophosphorus nucleoside derivatives
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
DE19622783A1
(de)
|
1996-06-07 |
1997-12-11 |
Hoechst Ag |
Isolierung der Biosynthesegene für Pseudo-Oligosaccharide aus Streptomyces glaucescens GLA.O und ihre Verwendung
|
DK0912767T3
(da)
|
1996-07-16 |
2006-10-30 |
Gen Probe Inc |
Fremgangsmåde til sporing og forstærkning af nukleinsyresekvenser ved anvendelse af modificerede oligonukleotider med foröget targetspecifikt TM
|
AU4156197A
(en)
*
|
1996-08-21 |
1998-03-06 |
Hybridon, Inc. |
Oligonucleotide prodrugs
|
US6056973A
(en)
|
1996-10-11 |
2000-05-02 |
Sequus Pharmaceuticals, Inc. |
Therapeutic liposome composition and method of preparation
|
GB9621522D0
(en)
|
1996-10-16 |
1996-12-04 |
Biocompatibles Ltd |
Synthesis of phosphorus compounds
|
US6172209B1
(en)
|
1997-02-14 |
2001-01-09 |
Isis Pharmaceuticals Inc. |
Aminooxy-modified oligonucleotides and methods for making same
|
US6639062B2
(en)
|
1997-02-14 |
2003-10-28 |
Isis Pharmaceuticals, Inc. |
Aminooxy-modified nucleosidic compounds and oligomeric compounds prepared therefrom
|
US6369237B1
(en)
|
1997-03-07 |
2002-04-09 |
President And Fellows Of Harvard College |
DNA glycosylase inhibitors, and uses related thereto
|
US6015887A
(en)
|
1997-04-11 |
2000-01-18 |
Isis Pharmaceuticals, Inc. |
Chiral peptide nucleic acids and methods for preparing same
|
US6468983B2
(en)
|
1997-04-21 |
2002-10-22 |
The Cleveland Clinic Foundation |
RNase L activators and antisense oligonucleotides effective to treat telomerase-expressing malignancies
|
PL184612B1
(pl)
|
1997-04-25 |
2002-11-29 |
Pan |
Sposób wytwarzania modyfikowanych P chiralnych analogów nukleotydów
|
JP2001501975A
(ja)
|
1997-05-28 |
2001-02-13 |
ペーター・エー・ニールセン |
亢進した細胞取り込みを有する結合ペプチド核酸
|
JP2002507212A
(ja)
|
1997-06-27 |
2002-03-05 |
ザ、プロクター、エンド、ギャンブル、カンパニー |
プロ芳香性環状アセタール
|
WO1999005160A2
(en)
|
1997-07-25 |
1999-02-04 |
Hybridon, Inc. |
Oligonuclotides having 3' terminal stereospecific phosphorothioates
|
US6767739B2
(en)
|
2001-07-30 |
2004-07-27 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microsomal triglyceride transfer protein expression
|
US6383808B1
(en)
|
2000-09-11 |
2002-05-07 |
Isis Pharmaceuticals, Inc. |
Antisense inhibition of clusterin expression
|
GB9717158D0
(en)
|
1997-08-13 |
1997-10-22 |
King S College London |
Solution synthesis of oligonucleotides and their phosphorothioate analogues
|
US6750344B1
(en)
|
1997-09-05 |
2004-06-15 |
Isis Pharmaceuticals, Inc. |
Amine compounds and combinatorial libraries comprising same
|
US6794499B2
(en)
|
1997-09-12 |
2004-09-21 |
Exiqon A/S |
Oligonucleotide analogues
|
DE19741715A1
(de)
|
1997-09-22 |
1999-03-25 |
Hoechst Ag |
Pentopyranosyl-Nucleosid, seine Herstellung und Verwendung
|
US6232463B1
(en)
|
1997-10-09 |
2001-05-15 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
US6528640B1
(en)
|
1997-11-05 |
2003-03-04 |
Ribozyme Pharmaceuticals, Incorporated |
Synthetic ribonucleic acids with RNAse activity
|
US6617438B1
(en)
|
1997-11-05 |
2003-09-09 |
Sirna Therapeutics, Inc. |
Oligoribonucleotides with enzymatic activity
|
US6080543A
(en)
|
1997-12-08 |
2000-06-27 |
E. & J. Gallo Winery |
Detection of fungal pathogens
|
US6582936B1
(en)
|
1997-12-12 |
2003-06-24 |
The Regents Of The University Of California |
Methods for making nucleic acids
|
US6248519B1
(en)
|
1998-03-11 |
2001-06-19 |
E & J Gallo Winery |
Detection of fermentation-related microorganisms
|
US7045610B2
(en)
|
1998-04-03 |
2006-05-16 |
Epoch Biosciences, Inc. |
Modified oligonucleotides for mismatch discrimination
|
JP2002513763A
(ja)
|
1998-05-06 |
2002-05-14 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
Cpgオリゴヌクレオチドを使用して寄生生物感染および関連する疾患を予防および処置するための方法
|
NZ508650A
(en)
|
1998-05-14 |
2003-05-30 |
Coley Pharm Gmbh |
Regulating hematopoiesis using unmethylated C and G CpG-oligonucleotides with a phosphorothioate modification
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
US6867294B1
(en)
|
1998-07-14 |
2005-03-15 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
JP2002521489A
(ja)
|
1998-07-27 |
2002-07-16 |
ユニバーシティ オブ アイオワ リサーチ ファウンデーション |
CpGオリゴヌクレオチドの立体異性体および関連する方法
|
ATE315405T1
(de)
|
1998-08-10 |
2006-02-15 |
Antigenics Inc |
Cpg-zusammensetzungen, saponin-adjuvantien und verfahren zu deren verwendung
|
WO2000023444A1
(en)
|
1998-10-21 |
2000-04-27 |
Abbott Laboratories |
5,7-disubstituted-4-aminopyrido[2,3-d]pyrimidine compounds
|
US6995259B1
(en)
|
1998-10-23 |
2006-02-07 |
Sirna Therapeutics, Inc. |
Method for the chemical synthesis of oligonucleotides
|
US6451524B1
(en)
|
1998-11-25 |
2002-09-17 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
WO2000031110A1
(en)
|
1998-11-25 |
2000-06-02 |
Isis Pharmaceuticals, Inc. |
Identification of disease predictive nucleic acids
|
DE69941223D1
(de)
|
1998-12-21 |
2009-09-17 |
Billig Fritz |
Chemisch modifizierte enzymen mit mehrfachgeladenen varianten
|
CA2359816C
(en)
|
1999-01-06 |
2010-08-03 |
Genenews Inc. |
Method for the detection of gene transcripts in blood and uses thereof
|
US6265172B1
(en)
|
1999-02-08 |
2001-07-24 |
University Of Kentucky |
Diagnostic test and therapy for manganese superoxide dismutate (mNsod) associated diseases
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
US6506594B1
(en)
|
1999-03-19 |
2003-01-14 |
Cornell Res Foundation Inc |
Detection of nucleic acid sequence differences using the ligase detection reaction with addressable arrays
|
GB9907245D0
(en)
|
1999-03-29 |
1999-05-26 |
Goldsborough Andrew |
Cleavage of nucleic acids from solid supports
|
JP3072345B1
(ja)
|
1999-03-31 |
2000-07-31 |
農林水産省家畜衛生試験場長 |
豚丹毒菌の組換えサブユニットワクチン
|
US5998148A
(en)
|
1999-04-08 |
1999-12-07 |
Isis Pharmaceuticals Inc. |
Antisense modulation of microtubule-associated protein 4 expression
|
US6977245B2
(en)
|
1999-04-12 |
2005-12-20 |
The United States Of America As Represented By The Department Of Health And Human Services |
Oligodeoxynucleotide and its use to induce an immune response
|
US6300069B1
(en)
|
1999-05-03 |
2001-10-09 |
Qiagen Gmbh |
Generation and amplification of nucleic acids from ribonucleic acids
|
US6656730B1
(en)
|
1999-06-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides conjugated to protein-binding drugs
|
US6271004B1
(en)
|
1999-06-25 |
2001-08-07 |
Display Systems Biotech A/S |
Method for improved reverse transcription at high temperatures
|
US6066500A
(en)
|
1999-06-25 |
2000-05-23 |
Isis Pharmaceuticals Inc. |
Antisense modulation of Beta catenin expression
|
US6414135B1
(en)
|
1999-07-07 |
2002-07-02 |
Isis Pharmaceuticals, Inc. |
C3′-methylene hydrogen phosphonate monomers and related compounds
|
US20030092647A1
(en)
|
2001-08-08 |
2003-05-15 |
Crooke Rosanne M. |
Antisense modulation of cholesteryl ester transfer protein expression
|
US6147200A
(en)
|
1999-08-19 |
2000-11-14 |
Isis Pharmaceuticals, Inc. |
2'-O-acetamido modified monomers and oligomers
|
US7264932B2
(en)
|
1999-09-24 |
2007-09-04 |
Applera Corporation |
Nuclease inhibitor cocktail
|
EP1700603A3
(en)
|
1999-09-25 |
2007-06-13 |
Coley Pharmaceutical GmbH |
Immunostimulatory nucleic acids
|
MXPA02003059A
(es)
|
1999-09-27 |
2002-09-30 |
Univ Iowa Res Found |
Metodos relacionados con interferon inducido por acido nucleico inmunoestabilizador.
|
US6949520B1
(en)
|
1999-09-27 |
2005-09-27 |
Coley Pharmaceutical Group, Inc. |
Methods related to immunostimulatory nucleic acid-induced interferon
|
US20020082227A1
(en)
|
1999-09-30 |
2002-06-27 |
Scott Henry |
Use of oligonucleotides for inhibition of complement activation
|
IL148922A0
(en)
|
1999-10-06 |
2002-09-12 |
Quark Biotech Inc |
Method for enrichment of natural antisense messenger rna
|
GB9924285D0
(en)
|
1999-10-14 |
1999-12-15 |
Avecia Ltd |
Process
|
US20010055761A1
(en)
|
1999-10-29 |
2001-12-27 |
Agilent Technologies |
Small scale dna synthesis using polymeric solid support with functionalized regions
|
FR2800750B1
(fr)
|
1999-11-05 |
2003-01-31 |
Centre Nat Rech Scient |
Proteines membranaires ctl (choline transporter like) impliquees dans le transport de la choline
|
AU1656601A
(en)
|
1999-11-12 |
2001-06-12 |
Isis Pharmaceuticals, Inc. |
Gapped oligomers having site specific chiral phosphorothioate internucleoside linkages
|
US6322985B1
(en)
|
1999-12-27 |
2001-11-27 |
Technion Research And Development Foundation Ltd. |
Abundant, well distributed and hyperpolymorphic simple sequence repeats in prokaryote genomes and use of same for prokaryote classification and typing
|
US7501091B2
(en)
|
1999-12-30 |
2009-03-10 |
Smiths Detection Inc. |
Sensors with improved properties
|
US7055094B2
(en)
|
1999-12-30 |
2006-05-30 |
Rutgers, The State University Of New Jersey |
Virtual tags and the process of virtual tagging utilizing user feedback in transformation rules
|
US6649750B1
(en)
|
2000-01-05 |
2003-11-18 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotide compounds
|
US6159697A
(en)
|
2000-01-19 |
2000-12-12 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of Smad7 expression
|
US7585847B2
(en)
|
2000-02-03 |
2009-09-08 |
Coley Pharmaceutical Group, Inc. |
Immunostimulatory nucleic acids for the treatment of asthma and allergy
|
US6495677B1
(en)
|
2000-02-15 |
2002-12-17 |
Kanda S. Ramasamy |
Nucleoside compounds
|
GB0004889D0
(en)
|
2000-03-01 |
2000-04-19 |
Avecia Ltd |
Synthesis of oligonucleotides
|
CA2335389A1
(en)
|
2000-03-01 |
2001-09-01 |
Message Pharmaceuticals, Inc. |
Novel bacterial rnase p proteins and their use in identifying antibacterial compounds
|
EP1265840A2
(en)
|
2000-03-17 |
2002-12-18 |
Corixa Corporation |
Novel amphipathic aldehydes and their use as adjuvants and immunoeffectors
|
WO2001081303A1
(en)
|
2000-04-20 |
2001-11-01 |
F. Hoffmann-La Roche Ag |
Pyrrolidine and piperidine derivatives and their use for the treament of neurodegenerative disorders
|
DE10019756A1
(de)
|
2000-04-20 |
2001-10-25 |
Bayer Ag |
Verfahren zur Herstellung von superabsorbierenden Polymeren aus Polyacrylnitrilen
|
US20020013287A1
(en)
|
2000-05-09 |
2002-01-31 |
Reliable Biopharmaceuticals, Inc. St Louis Missouri |
Polymeric compounds useful as prodrugs
|
US6492171B2
(en)
|
2000-05-16 |
2002-12-10 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of TERT expression
|
US6815542B2
(en)
|
2000-06-16 |
2004-11-09 |
Ribapharm, Inc. |
Nucleoside compounds and uses thereof
|
EP1307469B1
(en)
|
2000-08-03 |
2008-01-23 |
Boehringer Mannheim Gmbh |
Nucleic acid binding compounds containing pyrazolo¬3,4-d pyrimidine analogues of purin-2,6-diamine and their uses
|
US6725412B1
(en)
|
2000-08-15 |
2004-04-20 |
Dolby Laboratories Licensing Corporation |
Low latency data encoder
|
US6809195B1
(en)
|
2000-08-16 |
2004-10-26 |
Isis Pharmaceuticals, Inc. |
Process for the preparation of oligonucleotides
|
US6559279B1
(en)
|
2000-09-08 |
2003-05-06 |
Isis Pharmaceuticals, Inc. |
Process for preparing peptide derivatized oligomeric compounds
|
ATE510850T1
(de)
|
2000-09-15 |
2011-06-15 |
Coley Pharm Gmbh |
Verfahren zum hochdurchsatzscreening von auf cpg basierenden immunagonisten und -antagonisten
|
EP1191097A1
(en)
|
2000-09-21 |
2002-03-27 |
Leids Universitair Medisch Centrum |
Induction of exon skipping in eukaryotic cells
|
GB0024752D0
(en)
|
2000-10-10 |
2000-11-22 |
Univ Belfast |
Oxidative halogenation of aromatic compounds
|
EP1889630B1
(en)
|
2000-10-18 |
2011-11-23 |
GlaxoSmithKline Biologicals S.A. |
Vaccines comprising MAGE antigen linked to protein D fragment
|
US6372492B1
(en)
|
2000-10-30 |
2002-04-16 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of talin expression
|
US6682889B1
(en)
|
2000-11-08 |
2004-01-27 |
Becton, Dickinson And Company |
Amplification and detection of organisms of the Chlamydiaceae family
|
NL1016978C2
(nl)
|
2000-12-22 |
2002-06-25 |
Robert Jan Colenbrander |
Inrichting en werkwijze voor het verpakken en bereiden van voedsel en werkwijze voor het vervaardigen van een dergelijke inrichting.
|
EP1355916B1
(en)
|
2001-01-22 |
2007-01-10 |
Merck & Co., Inc. |
Nucleoside derivatives as inhibitors of rna-dependent rna viral polymerase
|
US8008459B2
(en)
|
2001-01-25 |
2011-08-30 |
Evolva Sa |
Concatemers of differentially expressed multiple genes
|
CA2474172C
(en)
|
2001-01-25 |
2012-07-10 |
Evolva Ltd. |
A library of a collection of cells
|
JP4454934B2
(ja)
|
2001-01-26 |
2010-04-21 |
コモンウェルス サイエンティフィック アンド インダストリアル リサーチ オーガニゼイション |
組換えクローニングを用いて効率のよいサイレンシング構築物を作製する方法および手段
|
US20050277133A1
(en)
|
2001-05-18 |
2005-12-15 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
WO2002097134A2
(en)
|
2001-05-25 |
2002-12-05 |
Isis Pharmaceuticals, Inc. |
Modified peptide nucleic acid
|
GB0113523D0
(en)
|
2001-06-04 |
2001-07-25 |
Torotrak Dev Ltd |
An Hydraulic control circuit for a continuosly variable transmission
|
US20030069410A1
(en)
|
2001-06-14 |
2003-04-10 |
Isis Pharmaceuticals, Inc. |
Methods for preparing oligonucleotides having chiral phosphorothioate linkages
|
US20050019915A1
(en)
|
2001-06-21 |
2005-01-27 |
Bennett C. Frank |
Antisense modulation of superoxide dismutase 1, soluble expression
|
RU2316347C2
(ru)
|
2001-06-29 |
2008-02-10 |
Чирон Корпорейшн |
Композиция для стимуляции иммунного ответа (варианты), способы ее получения, применения и способы стимуляции иммунного ответа с использованием этих композиций
|
WO2003004602A2
(en)
|
2001-07-03 |
2003-01-16 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
US7205399B1
(en)
|
2001-07-06 |
2007-04-17 |
Sirna Therapeutics, Inc. |
Methods and reagents for oligonucleotide synthesis
|
US6440739B1
(en)
|
2001-07-17 |
2002-08-27 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of glioma-associated oncogene-2 expression
|
US7425545B2
(en)
|
2001-07-25 |
2008-09-16 |
Isis Pharmaceuticals, Inc. |
Modulation of C-reactive protein expression
|
US7407943B2
(en)
|
2001-08-01 |
2008-08-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein B expression
|
US6455308B1
(en)
|
2001-08-01 |
2002-09-24 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of serum amyloid A4 expression
|
US7888324B2
(en)
|
2001-08-01 |
2011-02-15 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
US7227014B2
(en)
|
2001-08-07 |
2007-06-05 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein (a) expression
|
US7259150B2
(en)
|
2001-08-07 |
2007-08-21 |
Isis Pharmaceuticals, Inc. |
Modulation of apolipoprotein (a) expression
|
AU2002361468A1
(en)
|
2001-08-14 |
2003-03-18 |
The Government Of The United States Of America As Represented By The Secretary Of Health And Human S |
Method for rapid generation of mature dendritic cells
|
EP1418877A2
(en)
|
2001-08-24 |
2004-05-19 |
Massachusetts Institute Of Technology |
Reagents that facilitate the purification of compounds synthesized on a solid support
|
US7049122B2
(en)
|
2001-09-21 |
2006-05-23 |
Academia Sinica |
Mutant-type lipases and applications thereof
|
US6933288B2
(en)
|
2002-02-04 |
2005-08-23 |
Isis Pharmaceuticals, Inc. |
Pyranosyl cytosines: pharmaceutical formulations and methods
|
JP4348044B2
(ja)
|
2002-02-12 |
2009-10-21 |
株式会社キラルジェン |
立体規則性の高いジヌクレオシドホスホロチオエートの製造法
|
US20030159938A1
(en)
|
2002-02-15 |
2003-08-28 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
US20040149587A1
(en)
|
2002-02-15 |
2004-08-05 |
George Hradil |
Electroplating solution containing organic acid complexing agent
|
US8232383B2
(en)
|
2002-02-20 |
2012-07-31 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
US20050096284A1
(en)
|
2002-02-20 |
2005-05-05 |
Sirna Therapeutics, Inc. |
RNA interference mediated treatment of polyglutamine (polyQ) repeat expansion diseases using short interfering nucleic acid (siNA)
|
EP1485396A2
(en)
|
2002-02-28 |
2004-12-15 |
Biota, Inc. |
Nucleoside 5'-monophosphate mimics and their prodrugs
|
WO2003072757A2
(en)
|
2002-02-28 |
2003-09-04 |
Biota, Inc. |
Nucleotide mimics and their prodrugs
|
US7288376B2
(en)
|
2002-03-22 |
2007-10-30 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants useful for prediction of predisposition to aspergillosis
|
US20040102394A1
(en)
|
2002-11-23 |
2004-05-27 |
Isis Pharmaceuticals Inc. |
Modulation of huntingtin interacting protein 2 expression
|
US7247621B2
(en)
|
2002-04-30 |
2007-07-24 |
Valeant Research & Development |
Antiviral phosphonate compounds and methods therefor
|
AU2003237875A1
(en)
|
2002-05-15 |
2003-12-02 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of apolipoprotein b expression
|
AU2003241621A1
(en)
|
2002-05-24 |
2003-12-12 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
US20040014957A1
(en)
|
2002-05-24 |
2004-01-22 |
Anne Eldrup |
Oligonucleotides having modified nucleoside units
|
US7507808B2
(en)
|
2002-12-12 |
2009-03-24 |
Isis Pharmaceuticals, Inc. |
Modulation of endothelial lipase expression
|
AU2003248708A1
(en)
|
2002-06-17 |
2003-12-31 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds that include carbocyclic nucleosides and their use in gene modulation
|
WO2004000351A1
(en)
|
2002-06-20 |
2003-12-31 |
Cytos Biotechnology Ag |
Packaged virus-like particles for use as adjuvants: method of preparation and use
|
WO2004003228A1
(en)
|
2002-07-01 |
2004-01-08 |
Unisearch Limited |
Genotyping method
|
EP2333062A1
(en)
|
2002-07-10 |
2011-06-15 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA-interference by single-stranded RNA molecules
|
US20040023905A1
(en)
|
2002-07-31 |
2004-02-05 |
Isis Pharmaceuticals Inc. |
Antisense modulation of LAR expression
|
US20080274989A1
(en)
|
2002-08-05 |
2008-11-06 |
University Of Iowa Research Foundation |
Rna Interference Suppression of Neurodegenerative Diseases and Methods of Use Thereof
|
US20050042646A1
(en)
|
2002-08-05 |
2005-02-24 |
Davidson Beverly L. |
RNA interference suppresion of neurodegenerative diseases and methods of use thereof
|
US20050255086A1
(en)
|
2002-08-05 |
2005-11-17 |
Davidson Beverly L |
Nucleic acid silencing of Huntington's Disease gene
|
WO2004014933A1
(en)
|
2002-08-07 |
2004-02-19 |
University Of Massachusetts |
Compositions for rna interference and methods of use thereof
|
AU2003259735A1
(en)
|
2002-08-08 |
2004-02-25 |
Sirna Therapeutics, Inc. |
Small-mer compositions and methods of use
|
AR040996A1
(es)
|
2002-08-19 |
2005-04-27 |
Coley Pharm Group Inc |
Acidos nucleicos inmunoestimuladores
|
US7414116B2
(en)
|
2002-08-23 |
2008-08-19 |
Illumina Cambridge Limited |
Labelled nucleotides
|
AU2003267785C1
(en)
|
2002-09-13 |
2009-12-24 |
Replicor, Inc. |
Non-sequence complementary antiviral oligonucleotides
|
US7030230B2
(en)
|
2002-10-25 |
2006-04-18 |
Isis Pharmaceuticals, Inc. |
Process of purifying phosphoramidites
|
AU2003283647B2
(en)
|
2002-10-29 |
2010-04-15 |
Coley Pharmaceutical Gmbh |
Use of CPG oligonucleotides in the treatment of hepatitis C virus infection
|
WO2004042018A2
(en)
|
2002-11-01 |
2004-05-21 |
The Regents Of The University Of Colorado |
Dopamine neurons from human embryonic stem cells
|
WO2004044139A2
(en)
|
2002-11-05 |
2004-05-27 |
Isis Parmaceuticals, Inc. |
Modified oligonucleotides for use in rna interference
|
AU2003291721A1
(en)
|
2002-11-05 |
2004-06-03 |
Isis Pharmaceuticals, Inc. |
Phosphorous-linked oligomeric compounds and their use in gene modulation
|
CA2505090A1
(en)
|
2002-11-05 |
2004-05-27 |
Isis Pharmaceuticals, Inc. |
Conjugated oligomeric compounds and their use in gene modulation
|
WO2004041889A2
(en)
|
2002-11-05 |
2004-05-21 |
Isis Pharmaceuticals, Inc. |
Polycyclic sugar surrogate-containing oligomeric compounds and compositions for use in gene modulation
|
US7381527B2
(en)
|
2002-11-06 |
2008-06-03 |
Council Of Scientific And Industrial Research |
Method of detection of SP-A2 gene variants
|
CA2505801A1
(en)
|
2002-11-13 |
2004-05-27 |
Rosanne Crooke |
Antisense modulation of apolipoprotein b expression
|
US7511131B2
(en)
|
2002-11-13 |
2009-03-31 |
Genzyme Corporation |
Antisense modulation of apolipoprotein B expression
|
EP2314691A3
(en)
|
2002-11-14 |
2012-01-18 |
Dharmacon, Inc. |
Fuctional and hyperfunctional siRNA
|
AU2003225705A1
(en)
|
2003-03-07 |
2004-09-30 |
Ribapharm Inc. |
Cytidine analogs and methods of use
|
ATE479752T1
(de)
|
2003-03-07 |
2010-09-15 |
Alnylam Pharmaceuticals Inc |
Therapeutische zusammensetzungen
|
CA2524255C
(en)
|
2003-03-21 |
2014-02-11 |
Academisch Ziekenhuis Leiden |
Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
|
GB0306657D0
(en)
|
2003-03-24 |
2003-04-30 |
Avecia Ltd |
Process and compounds
|
US7537767B2
(en)
|
2003-03-26 |
2009-05-26 |
Cytis Biotechnology Ag |
Melan-A- carrier conjugates
|
AU2004223736B2
(en)
|
2003-03-26 |
2010-05-27 |
Cytos Biotechnology Ag |
Melan-A peptide analogue-virus-like-particle conjugates
|
ITRM20030149A1
(it)
|
2003-04-02 |
2004-10-03 |
Giuliani Spa |
Oligonucleotidi (odn) antisenso per smad7 e loro usi in campo medico
|
US7598227B2
(en)
|
2003-04-16 |
2009-10-06 |
Isis Pharmaceuticals Inc. |
Modulation of apolipoprotein C-III expression
|
US20050261237A1
(en)
|
2003-04-25 |
2005-11-24 |
Boojamra Constantine G |
Nucleoside phosphonate analogs
|
US20090247488A1
(en)
|
2003-04-25 |
2009-10-01 |
Carina Cannizzaro |
Anti-inflammatory phosphonate compounds
|
CN101410120A
(zh)
|
2003-04-25 |
2009-04-15 |
吉里德科学公司 |
抗炎的膦酸酯化合物
|
DK1628685T3
(da)
|
2003-04-25 |
2011-03-21 |
Gilead Sciences Inc |
Antivirale phosphonatanaloge
|
WO2004096233A2
(en)
|
2003-04-25 |
2004-11-11 |
Gilead Sciences, Inc. |
Nucleoside phosphonate conjugates
|
KR20060061930A
(ko)
|
2003-04-25 |
2006-06-08 |
길리애드 사이언시즈, 인코포레이티드 |
항암성 포스포네이트 유사체
|
US7432261B2
(en)
|
2003-04-25 |
2008-10-07 |
Gilead Sciences, Inc. |
Anti-inflammatory phosphonate compounds
|
WO2005002626A2
(en)
|
2003-04-25 |
2005-01-13 |
Gilead Sciences, Inc. |
Therapeutic phosphonate compounds
|
US7470724B2
(en)
|
2003-04-25 |
2008-12-30 |
Gilead Sciences, Inc. |
Phosphonate compounds having immuno-modulatory activity
|
US7452901B2
(en)
|
2003-04-25 |
2008-11-18 |
Gilead Sciences, Inc. |
Anti-cancer phosphonate analogs
|
US7407965B2
(en)
|
2003-04-25 |
2008-08-05 |
Gilead Sciences, Inc. |
Phosphonate analogs for treating metabolic diseases
|
US7045306B2
(en)
|
2003-04-28 |
2006-05-16 |
The General Hospital Corporation |
Method for identifying compounds in vitro that modulate the dysregulation of transcription of transcription mediated by mutant huntingtin protein
|
US7214491B2
(en)
|
2003-05-07 |
2007-05-08 |
E. I. Du Pont De Nemours And Company |
Δ-12 desaturase gene suitable for altering levels of polyunsaturated fatty acids in oleaginous yeasts
|
JP4179562B2
(ja)
|
2003-05-14 |
2008-11-12 |
独立行政法人科学技術振興機構 |
ハンチンチン遺伝子の発現抑制
|
EP1633307A4
(en)
*
|
2003-06-03 |
2009-06-24 |
Isis Pharmaceuticals Inc |
MODULATION OF SURVIVIN EXPRESSION
|
BRPI0411514A
(pt)
|
2003-06-20 |
2006-08-01 |
Coley Pharm Gmbh |
antagonistas de receptor toll-like de molécula pequena
|
EP2530157B1
(en)
|
2003-07-31 |
2016-09-28 |
Regulus Therapeutics Inc. |
Oligomeric compounds and compositions for use in modulation of miRNAs
|
JP2005089441A
(ja)
|
2003-08-08 |
2005-04-07 |
Toudai Tlo Ltd |
立体規則性の高いリン原子修飾ヌクレオチド類縁体の製造法
|
JP2011088935A
(ja)
|
2003-08-08 |
2011-05-06 |
Chiralgen Ltd |
リン原子修飾ヌクレオチド類縁体の製造のための光学活性ヌクレオシド3’−ホスホロアミダイト
|
US7825235B2
(en)
|
2003-08-18 |
2010-11-02 |
Isis Pharmaceuticals, Inc. |
Modulation of diacylglycerol acyltransferase 2 expression
|
BRPI0413684A
(pt)
|
2003-08-21 |
2006-10-24 |
Univ Griffith |
compostos, composição farmacêutica e respectivos métodos de preparação, de tratamento de infecção microbiana e de extermìnio de microrganismo e usos
|
BRPI0413682A
(pt)
|
2003-08-21 |
2006-10-24 |
Univ Griffith |
compostos, composição farmacêutica e respectivos métodos de preparação, de tratamento de infecção microbiana e de extermìnio de microrganismo e usos
|
CN1863813B
(zh)
|
2003-08-27 |
2011-03-30 |
生物区科学管理控股有限公司 |
作为治疗剂的三环核苷或核苷酸
|
JP4731324B2
(ja)
|
2003-08-28 |
2011-07-20 |
武 今西 |
N−o結合性架橋構造型新規人工核酸
|
JP4616175B2
(ja)
|
2003-09-02 |
2011-01-19 |
株式会社キラルジェン |
5’−ホスフィチル化モノマーおよびh−ホスホネートオリゴヌクレオチド誘導体の製造方法
|
WO2005023828A1
(ja)
|
2003-09-02 |
2005-03-17 |
Takeshi Wada |
リボヌクレオチド又はリボヌクレオチド誘導体の製造方法
|
PT3342425T
(pt)
|
2003-09-09 |
2020-03-05 |
Geron Corp |
Oligonucleótidos modificados por inibição da telomerase
|
US20050053981A1
(en)
|
2003-09-09 |
2005-03-10 |
Swayze Eric E. |
Gapped oligomeric compounds having linked bicyclic sugar moieties at the termini
|
US20050074801A1
(en)
|
2003-09-09 |
2005-04-07 |
Monia Brett P. |
Chimeric oligomeric compounds comprising alternating regions of northern and southern conformational geometry
|
US8680063B2
(en)
|
2003-09-12 |
2014-03-25 |
University Of Massachusetts |
RNA interference for the treatment of gain-of-function disorders
|
WO2008005562A2
(en)
|
2006-07-07 |
2008-01-10 |
University Of Massachusetts |
Rna silencing compositions and methods for the treatment of huntington's disease
|
ES2969371T3
(es)
|
2003-09-12 |
2024-05-17 |
Univ Massachusetts |
Interferencia por ARN para el tratamiento de trastornos de ganancia de función
|
GB0323968D0
(en)
|
2003-10-13 |
2003-11-19 |
Glaxosmithkline Biolog Sa |
Immunogenic compositions
|
SG122973A1
(en)
|
2003-10-30 |
2006-06-29 |
Coley Pharm Gmbh |
C-class oligonucleotide analogs with enhanced immunostimulatory potency
|
US20050239102A1
(en)
|
2003-10-31 |
2005-10-27 |
Verdine Gregory L |
Nucleic acid binding oligonucleotides
|
US7846436B2
(en)
*
|
2003-11-28 |
2010-12-07 |
Chemgenes Corporation |
Oligonucleotides and related compounds
|
WO2005063983A1
(en)
|
2003-12-29 |
2005-07-14 |
Galapagos Genomics N.V. |
Modulators of bone homeostasis identified in a high-throughput screen
|
WO2005070859A1
(ja)
|
2004-01-27 |
2005-08-04 |
Takeshi Wada |
フルオラス担体およびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
US20050176045A1
(en)
|
2004-02-06 |
2005-08-11 |
Dharmacon, Inc. |
SNP discriminatory siRNA
|
US20080221303A1
(en)
|
2004-02-18 |
2008-09-11 |
Jehoshua Katzhendler |
Method for the Preparation of Peptide-Oligonucleotide Conjugates
|
JP3976742B2
(ja)
|
2004-02-27 |
2007-09-19 |
江守商事株式会社 |
インターフェロンアルファを誘導する免疫刺激オリゴヌクレオチド
|
WO2005085272A1
(ja)
|
2004-03-05 |
2005-09-15 |
Takeshi Wada |
ボラノホスフェートモノマーおよびそれを用いたオリゴヌクレオチド誘導体の製造方法
|
JP4865544B2
(ja)
|
2004-03-25 |
2012-02-01 |
株式会社キラルジェン |
立体規則性の高いリボヌクレオチド類縁体及びデオキシリボヌクレオチド類縁体の製造法
|
WO2005097817A2
(en)
|
2004-04-05 |
2005-10-20 |
Alnylam Pharmaceuticals, Inc. |
Process and reagents for oligonucleotide synthesis and purification
|
US20050244869A1
(en)
|
2004-04-05 |
2005-11-03 |
Brown-Driver Vickie L |
Modulation of transthyretin expression
|
TWI350168B
(en)
|
2004-05-07 |
2011-10-11 |
Incyte Corp |
Amido compounds and their use as pharmaceuticals
|
CA2572795A1
(en)
|
2004-05-27 |
2005-12-08 |
The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services |
Differential expression of molecules associated with acute stroke
|
US7759318B1
(en)
|
2004-05-28 |
2010-07-20 |
Isis Pharmaceuticals, Inc. |
Identification of novel pathways, genes and promoter motifs regulating adipogenesis
|
JP2008501693A
(ja)
|
2004-06-03 |
2008-01-24 |
アイシス ファーマシューティカルズ、インク. |
遺伝子調節で使用するための個別に調節された鎖を有する二本鎖組成物
|
EP4047096A1
(en)
|
2004-06-28 |
2022-08-24 |
The University Of Western Australia |
Antisense oligonucleotides for inducing exon skipping and methods of use thereof
|
PT2409713E
(pt)
|
2004-08-10 |
2015-10-09 |
Genzyme Corp |
Oligonucleótidos para utilização em modulação dos níveis de lipoproteínas e colesterol em humanos
|
EP1795536B1
(en)
|
2004-08-26 |
2012-05-02 |
Nippon Shinyaku Co., Ltd. |
Phosphoramidite compound and method for producing oligo-rna
|
WO2006029258A2
(en)
|
2004-09-07 |
2006-03-16 |
Archemix Corp. |
Aptamer medicinal chemistry
|
US7884086B2
(en)
|
2004-09-08 |
2011-02-08 |
Isis Pharmaceuticals, Inc. |
Conjugates for use in hepatocyte free uptake assays
|
US20090203132A1
(en)
|
2004-09-09 |
2009-08-13 |
Swayze Eric E |
Pyrrolidinyl groups for attaching conjugates to oligomeric compounds
|
EP2397563A3
(en)
|
2004-09-17 |
2012-07-18 |
Isis Pharmaceuticals, Inc. |
Enhanced antisense oligonucleotides
|
WO2006044531A2
(en)
|
2004-10-13 |
2006-04-27 |
Isis Parmaceuticals, Inc. |
Antisense modulation of ptp1b expression
|
US8212012B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
US8212011B2
(en)
|
2004-11-03 |
2012-07-03 |
University Of Kansas |
Novobiocin analogues
|
US7622451B2
(en)
|
2004-11-03 |
2009-11-24 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
WO2010096650A1
(en)
|
2009-02-20 |
2010-08-26 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
US9120774B2
(en)
|
2004-11-03 |
2015-09-01 |
University Of Kansas |
Novobiocin analogues having modified sugar moieties
|
US7608594B2
(en)
|
2004-11-03 |
2009-10-27 |
University Of Kansas |
Novobiocin analogues as anticancer agents
|
KR100721928B1
(ko)
|
2004-11-05 |
2007-05-28 |
주식회사 바이오씨에스 |
CpG 올리고데옥시뉴클레오티드를 함유하는 피부질환의치료 또는 예방용 약학적 조성물
|
EP1657307A1
(en)
|
2004-11-16 |
2006-05-17 |
Immunotech S.A. |
Oligonucleotides that induce the secretion of GM-CSF
|
JP4981681B2
(ja)
|
2004-12-09 |
2012-07-25 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
哺乳類における免疫応答誘導組成物および方法、ならびに短鎖干渉rnaなどのオリゴヌクレオチド剤に対する免疫応答の回避方法
|
US9809824B2
(en)
|
2004-12-13 |
2017-11-07 |
The United States Of America, Represented By The Secretary, Department Of Health And Human Services |
CpG oligonucleotide prodrugs, compositions thereof and associated therapeutic methods
|
WO2006066260A2
(en)
|
2004-12-17 |
2006-06-22 |
Thiosense, Inc. |
Compositions of and methods for producing phosphorus-chiral monomers and oligomers
|
US20070099851A1
(en)
|
2004-12-30 |
2007-05-03 |
Linn Gregory S |
Stable analogues of ribose-1-phosphate and methods for treating diabetes and other metabolic disorders
|
US20060183763A1
(en)
|
2004-12-31 |
2006-08-17 |
Pfizer Inc |
Novel pyrrolidyl derivatives of heteroaromatic compounds
|
JP4836145B2
(ja)
|
2005-01-28 |
2011-12-14 |
クウォン,ヒュン−ジョ |
マイコバクテリアに由来する、免疫機能刺激用、免疫疾患治療用、アトピー性皮膚炎治療用および/または正常免疫細胞保護用オリゴヌクレオチド
|
AU2006216493A1
(en)
|
2005-02-24 |
2006-08-31 |
Coley Pharmaceutical Gmbh |
Immunostimulatory oligonucleotides
|
CN101189249B
(zh)
|
2005-04-01 |
2013-04-17 |
加利福尼亚大学董事会 |
膦酰基-戊-2-烯-1-基核苷和类似物
|
DE602006004578D1
(de)
|
2005-05-05 |
2009-02-12 |
Antisense Pharma Gmbh |
Verwendung von tgf-beta2 antisense oligonukleotiden
|
WO2006121960A2
(en)
|
2005-05-06 |
2006-11-16 |
Medtronic, Inc. |
Methods and sequences to suppress primate huntington gene expression
|
US7902352B2
(en)
|
2005-05-06 |
2011-03-08 |
Medtronic, Inc. |
Isolated nucleic acid duplex for reducing huntington gene expression
|
PT3308788T
(pt)
|
2005-06-23 |
2019-01-30 |
Cold Spring Harbor Laboratory |
Composições e métodos para a modulação do splicing de smn2
|
US9133517B2
(en)
|
2005-06-28 |
2015-09-15 |
Medtronics, Inc. |
Methods and sequences to preferentially suppress expression of mutated huntingtin
|
ATE522626T1
(de)
|
2005-06-28 |
2011-09-15 |
Medtronic Inc |
Verfahren und nukleotid-sequenzen, die bevorzugt die expression eines mutierten huntingtin-genes unterdrücken
|
US20090162316A1
(en)
|
2005-07-05 |
2009-06-25 |
Harvard University |
Liver targeted conjugates
|
JP4984634B2
(ja)
|
2005-07-21 |
2012-07-25 |
ソニー株式会社 |
物理情報取得方法および物理情報取得装置
|
DK1924252T3
(da)
|
2005-07-28 |
2011-11-14 |
Id Fish Technology Inc |
Fremgangsmåde til forbedring af cellepermeabilitet for fremmede partikler
|
AU2006284855B2
(en)
|
2005-08-29 |
2011-10-13 |
Regulus Therapeutics Inc. |
Methods for use in modulating miR-122a
|
EP1937312B1
(en)
|
2005-08-30 |
2016-06-29 |
Ionis Pharmaceuticals, Inc. |
Chimeric oligomeric compounds for modulation of splicing
|
US7700567B2
(en)
|
2005-09-29 |
2010-04-20 |
Supergen, Inc. |
Oligonucleotide analogues incorporating 5-aza-cytosine therein
|
US20070077993A1
(en)
|
2005-09-30 |
2007-04-05 |
Midgley Timothy M |
Method and apparatus for collecting user game play data and crediting users in a gaming environment
|
AU2006304205C1
(en)
|
2005-10-12 |
2012-11-15 |
Idera Pharmaceuticals, Inc. |
Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response
|
US9308252B2
(en)
|
2005-10-27 |
2016-04-12 |
Cook Biotech, Inc. |
Extracellular matrix materials as vaccine adjuvants for diseases associated with infectious pathogens or toxins
|
JP5111385B2
(ja)
|
2005-10-28 |
2013-01-09 |
アルナイラム ファーマシューティカルズ, インコーポレイテッド |
ハンチンチン遺伝子の発現を抑制するための組成物および方法
|
CN101466834B
(zh)
|
2005-10-28 |
2013-09-25 |
东曹株式会社 |
制备类胡萝卜素合成性微生物的方法和生产类胡萝卜素的方法
|
RU2008118144A
(ru)
|
2005-11-11 |
2009-11-20 |
Пфайзер Инк. (US) |
Комбинации иммуномодулирующих олигоодезоксинуклеотидов и способы их применения
|
WO2007064291A1
(en)
|
2005-11-30 |
2007-06-07 |
Jyoti Chattopadhyaya |
Method and compounds for rna synthesis
|
WO2007064954A2
(en)
|
2005-12-02 |
2007-06-07 |
Isis Pharmaceuticals, Inc. |
Antibacterial 4,5-substituted aminoglycoside analogs having multiple substituents
|
US8076303B2
(en)
|
2005-12-13 |
2011-12-13 |
Spring Bank Pharmaceuticals, Inc. |
Nucleotide and oligonucleotide prodrugs
|
DK1979356T3
(da)
|
2005-12-21 |
2013-11-18 |
Pfizer Prod Inc |
Carbonylaminopyrrolopyrazoler, kraftige kinaseinhibitorer
|
JP5425474B2
(ja)
|
2006-01-26 |
2014-02-26 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
ハンチンチン対する、組成物及びその使用
|
ES2516815T3
(es)
|
2006-01-27 |
2014-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en la posición 6
|
US20080045473A1
(en)
|
2006-02-15 |
2008-02-21 |
Coley Pharmaceutical Gmbh |
Compositions and methods for oligonucleotide formulations
|
JP4713514B2
(ja)
|
2006-02-20 |
2011-06-29 |
エフ.ホフマン−ラ ロシュ アーゲー |
改善された標識試薬
|
US8383660B2
(en)
|
2006-03-10 |
2013-02-26 |
Pfizer Inc. |
Dibenzyl amine compounds and derivatives
|
CA2647827A1
(en)
|
2006-03-31 |
2007-10-11 |
Applied Biosystems Inc. |
Reagents useful for synthesizing rhodamine-labeled oligonucleotides
|
US8088582B2
(en)
|
2006-04-06 |
2012-01-03 |
Ibis Biosciences, Inc. |
Compositions for the use in identification of fungi
|
CA2649636A1
(en)
|
2006-04-20 |
2007-11-01 |
F. Hoffmann-La Roche Ag |
Diazepan derivatives modulators of chemokine receptors
|
EP2020449B1
(en)
|
2006-04-24 |
2012-09-26 |
Sigma Alimentos, S.A. De C.V. |
Method for detection and multiple, simultaneous quantification of pathogens by means of real-time polymerase chain reaction
|
AU2007243412A1
(en)
|
2006-04-25 |
2007-11-08 |
Immune Disease Institute Inc. |
Targeted delivery to leukocytes using non-protein carriers
|
GB0608838D0
(en)
|
2006-05-04 |
2006-06-14 |
Novartis Ag |
Organic compounds
|
US8158598B2
(en)
|
2006-05-05 |
2012-04-17 |
Isis Pharmaceuticals, Inc. |
Compositions and their uses directed to PTPR alpha
|
WO2007131237A2
(en)
|
2006-05-05 |
2007-11-15 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression of ptp1b
|
US20090012120A1
(en)
|
2006-05-10 |
2009-01-08 |
Board Of Trustees Of Michigan State University |
Synthesis of N-heterocycles, beta-amino acids, and allyl amines via aza-payne mediated reaction of ylides and hydroxy aziridines
|
US7666854B2
(en)
|
2006-05-11 |
2010-02-23 |
Isis Pharmaceuticals, Inc. |
Bis-modified bicyclic nucleic acid analogs
|
ES2389737T3
(es)
|
2006-05-11 |
2012-10-31 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos modificados en 5'
|
WO2007139190A1
(ja)
|
2006-05-31 |
2007-12-06 |
Toray Industries, Inc. |
免疫刺激オリゴヌクレオチド及びその医薬用途
|
US8097596B2
(en)
|
2006-06-30 |
2012-01-17 |
Lakewood-Amedex, Inc. |
Compositions and methods for the treatment of muscle wasting
|
AU2007272906B2
(en)
|
2006-07-12 |
2013-01-31 |
The Regents Of The University Of California |
Transducible delivery of nucleic acids by reversible phosphotriester charge neutralization protecting groups
|
EP2051977A2
(en)
|
2006-07-20 |
2009-04-29 |
Amgen Inc. |
SUBSTITUTED AZOLE AROMATIC HETEROCYCLES AS INHIBITORS OF LLbeta-HSD-1
|
GB0614947D0
(en)
|
2006-07-27 |
2006-09-06 |
Isis Innovation |
Epitope reduction therapy
|
CA2660052A1
(en)
|
2006-08-04 |
2008-02-07 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for the modulation of jnk proteins
|
AT504194B1
(de)
|
2006-09-07 |
2008-07-15 |
Oesterr Rotes Kreuz |
Bakteriennachweis
|
US8138330B2
(en)
|
2006-09-11 |
2012-03-20 |
Sigma-Aldrich Co. Llc |
Process for the synthesis of oligonucleotides
|
PT2078080E
(pt)
|
2006-09-27 |
2015-09-18 |
Coley Pharm Gmbh |
Análogos dos oligonucleotídeos cpg que contêm análogos t hidrofóbicos com atividade imunoestimulante potenciada
|
EP2410053B2
(en)
|
2006-10-18 |
2020-07-15 |
Ionis Pharmaceuticals, Inc. |
Antisense compounds
|
WO2008051763A1
(en)
|
2006-10-23 |
2008-05-02 |
Irm Llc |
Cathepsin proteases inhibitors
|
CA2667297A1
(en)
|
2006-10-26 |
2008-11-20 |
Coley Pharmaceutical Gmbh |
Oligoribonucleotides and uses thereof
|
FR2908414B1
(fr)
|
2006-11-13 |
2012-01-20 |
Centre Nat Rech Scient |
Immobilisation de proteines membranaires sur un support par l'intermediaire d'une molecule amphiphile
|
CA2669917A1
(en)
|
2006-11-17 |
2008-05-22 |
Dawn M. George |
Aminopyrrolidines as chemokine receptor antagonists
|
US8084437B2
(en)
|
2006-11-27 |
2011-12-27 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
US8093222B2
(en)
|
2006-11-27 |
2012-01-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
MX2009006230A
(es)
|
2006-12-12 |
2009-06-22 |
Idera Pharmaceuticals Inc |
Agonistas sinteticos de receptores de tipo toll 9.
|
UY30892A1
(es)
|
2007-02-07 |
2008-09-02 |
Smithkline Beckman Corp |
Inhibidores de la actividad akt
|
WO2008101157A1
(en)
|
2007-02-15 |
2008-08-21 |
Isis Pharmaceuticals, Inc. |
5'-substituted-2'-f modified nucleosides and oligomeric compounds prepared therefrom
|
AU2008230886B9
(en)
|
2007-03-24 |
2014-09-04 |
Kastle Therapeutics, Llc |
Administering antisense oligonucleotides complementary to human apolipoprotein B
|
US7960353B2
(en)
|
2007-05-10 |
2011-06-14 |
University Of Kansas |
Novobiocin analogues as neuroprotective agents and in the treatment of autoimmune disorders
|
DK2158316T3
(en)
|
2007-05-11 |
2015-07-20 |
Adynxx Inc |
Gene expression and pain
|
EP2149571A4
(en)
|
2007-05-24 |
2010-09-01 |
Kyorin Seiyaku Kk |
MUTILINE DERIVATIVE WITH A RINGED, HETEROCYCLIC AND AROMATIC CARBOXYLIC ACID STRUCTURE IN A SUBSTITUTE AT POSITION 14
|
GB0710186D0
(en)
|
2007-05-29 |
2007-07-04 |
Texas Instr Denmark |
PWM loop with minimum allasing error property
|
ES2388590T3
(es)
|
2007-05-30 |
2012-10-16 |
Isis Pharmaceuticals, Inc. |
Análogos de ácidos nucleicos bicíclicos con puente aminometileno N-sustituido.
|
KR20100038295A
(ko)
|
2007-06-05 |
2010-04-14 |
엔에스아베 필리알 아프 뉴로서치 스웨덴 아베 스베리게 |
피질 카테콜아민성 신경 전달의 조정자로서의 이치환된 페닐피롤리딘
|
DK2173760T4
(en)
|
2007-06-08 |
2016-02-08 |
Isis Pharmaceuticals Inc |
Carbocyclic bicyclic nukleinsyreanaloge
|
US20100298280A1
(en)
|
2007-06-13 |
2010-11-25 |
Petra Kioschis-Schneider |
Compounds for the Modulation of Huntingtin Aggregation, Methods and Means for Identifying Such Compounds
|
EP2014769B1
(en)
|
2007-06-18 |
2010-03-31 |
Commissariat à l'Energie Atomique |
Reversible siRNAa-based silencing of mutated and endogenous wild-type huntingtin gene and its application for the treatment of Huntington's disease
|
GB0712494D0
(en)
|
2007-06-27 |
2007-08-08 |
Isis Innovation |
Substrate reduction therapy
|
DK2176280T4
(en)
|
2007-07-05 |
2015-07-20 |
Isis Pharmaceuticals Inc |
6-Disubstituerede bicykliske nukleinsyreanaloge
|
EP2348112B1
(en)
|
2007-07-09 |
2018-11-28 |
Idera Pharmaceuticals, Inc. |
Stabilized immune modulatory RNA (SIMRA) compounds
|
TWI413530B
(zh)
|
2007-07-20 |
2013-11-01 |
Kao Corp |
有機聚矽氧
|
WO2009015479A1
(en)
|
2007-07-31 |
2009-02-05 |
University Of Saskatchewan |
Genetic variation in pro-melanin-concentrating hormone gene affects carcass traits in cattle
|
US7812003B2
(en)
|
2007-08-02 |
2010-10-12 |
Safe Stephen H |
Antisense microRNA and uses therefor
|
JP2010536787A
(ja)
|
2007-08-15 |
2010-12-02 |
イデラ ファーマシューティカルズ インコーポレイテッド |
Toll様受容体モジュレータ
|
WO2009046141A2
(en)
|
2007-10-01 |
2009-04-09 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of fibroblast growth factor receptor 4 expression
|
KR100886139B1
(ko)
|
2007-11-13 |
2009-02-27 |
주식회사 삼천리제약 |
올리고뉴클레오타이드의 제조방법
|
TW200930375A
(en)
|
2007-12-21 |
2009-07-16 |
Exelixis Inc |
Benzofuropyrimidinones
|
TWI340765B
(en)
|
2007-12-26 |
2011-04-21 |
Ind Tech Res Inst |
Oligonucleotide sequences and dna chip for identifying filamentous microorganisms and the identification method thereof
|
WO2009089659A1
(en)
|
2008-01-18 |
2009-07-23 |
Shanghai Targetdrug Co., Ltd. |
Pyrollidine-based compounds
|
WO2009098197A1
(en)
|
2008-02-04 |
2009-08-13 |
Biofocus Dpi B.V. |
Target sequences and methods to identify the same, useful in treatment of neurodegenerative diseases
|
JP2009190983A
(ja)
|
2008-02-12 |
2009-08-27 |
Tokyo Institute Of Technology |
オリゴヌクレオチド誘導体
|
EP2282744B1
(en)
|
2008-03-21 |
2018-01-17 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising tricyclic nucleosides and methods for their use
|
WO2009120878A2
(en)
|
2008-03-26 |
2009-10-01 |
Alnylam Pharmaceuticals, Inc. |
Non-natural ribonucleotides, and methods of use thereof
|
KR101806314B1
(ko)
|
2008-04-03 |
2017-12-07 |
스프링 뱅크 파마슈티칼스, 인크. |
바이러스 감염증을 치료하기 위한 조성물 및 방법
|
WO2009124238A1
(en)
|
2008-04-04 |
2009-10-08 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds comprising neutrally linked terminal bicyclic nucleosides
|
US8350022B2
(en)
|
2008-04-04 |
2013-01-08 |
Universitaet Hamburg |
Method for the stereoselective synthesis of phosphorus compounds
|
US8679750B2
(en)
|
2008-05-09 |
2014-03-25 |
The University Of British Columbia |
Methods and compositions for the treatment of Huntington'S disease
|
CA2726866A1
(en)
|
2008-05-09 |
2009-11-12 |
The University Of British Columbia |
Methods and compositions for the treatment of huntington's disease
|
EP2300102B1
(en)
|
2008-05-15 |
2014-01-08 |
Dynavax Technologies Corporation |
Immunostimulatory sequences containing CpG for use in the treatment of allergic rhinitis
|
WO2009143387A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc. |
Modulation of smrt expression
|
WO2009143391A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc |
Methods for modulation expression of creb
|
WO2009143390A2
(en)
|
2008-05-22 |
2009-11-26 |
Isis Pharmaceuticals, Inc. |
Methods for modulating expression of rbp4
|
WO2009148605A2
(en)
|
2008-06-04 |
2009-12-10 |
Isis Pharmaceuticals, Inc. |
Methods for treating hypercholesterolemia
|
AU2009266806A1
(en)
|
2008-07-03 |
2010-01-07 |
Exelixis Inc. |
CDK modulators
|
US8410070B2
(en)
|
2008-09-12 |
2013-04-02 |
University Of Louisville Research Foundation, Inc. |
Compositions and methods for treating cancer, inhibiting proliferation, and inducing cell death
|
US8163707B2
(en)
|
2008-09-15 |
2012-04-24 |
Enanta Pharmaceuticals, Inc. |
4′-allene-substituted nucleoside derivatives
|
WO2010039543A2
(en)
|
2008-09-23 |
2010-04-08 |
Traversa Therapeutics, Inc. |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating rna interference
|
WO2010036696A1
(en)
|
2008-09-24 |
2010-04-01 |
Isis Pharmaceuticals, Inc. |
Cyclohexenyl nucleic acid analogs
|
EP2356129B1
(en)
|
2008-09-24 |
2013-04-03 |
Isis Pharmaceuticals, Inc. |
Substituted alpha-l-bicyclic nucleosides
|
JP2012504962A
(ja)
|
2008-10-07 |
2012-03-01 |
プレジデント・アンド・フェロウズ・オブ・ハーバード・カレッジ |
テロメラーゼ阻害剤およびその使用方法
|
DK2350279T3
(en)
|
2008-10-22 |
2016-02-15 |
Quark Pharmaceuticals Inc |
METHODS OF TREATING EYE DISEASES
|
US8883752B2
(en)
|
2008-10-24 |
2014-11-11 |
Isis Pharmaceuticals, Inc. |
5′ and 2′ BIS-substituted nucleosides and oligomeric compounds prepared therefrom
|
WO2010048585A2
(en)
|
2008-10-24 |
2010-04-29 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and methods
|
WO2010064146A2
(en)
|
2008-12-02 |
2010-06-10 |
Chiralgen, Ltd. |
Method for the synthesis of phosphorus atom modified nucleic acids
|
JP2012513450A
(ja)
|
2008-12-23 |
2012-06-14 |
ギリンダス・アメリカ・インコーポレイテッド |
硫化剤およびオリゴヌクレオチドを合成するためのその使用
|
WO2010080953A1
(en)
|
2009-01-08 |
2010-07-15 |
Isis Pharmaceuticals, Inc. |
Transgenic murine model of human lipoprotein metabolism, hypercholesterolemia and cardiovascular disease
|
KR20100087540A
(ko)
|
2009-01-28 |
2010-08-05 |
삼성전자주식회사 |
잉크젯 기록용 잉크 조성물
|
WO2010091301A1
(en)
|
2009-02-06 |
2010-08-12 |
Isis Pharmaceuticals, Inc. |
Oligomeric compounds and excipients
|
EP2396409A2
(en)
|
2009-02-10 |
2011-12-21 |
Idera Pharmaceuticals, Inc. |
Synthetic rna-based agonists of tlr7
|
US8975389B2
(en)
|
2009-03-02 |
2015-03-10 |
Alnylam Pharmaceuticals, Inc. |
Nucleic acid chemical modifications
|
WO2010107838A1
(en)
|
2009-03-16 |
2010-09-23 |
Isis Pharmaceuticals, Inc. |
Targeting apolipoprotein b for the reduction of apolipoprotein c-iii
|
DK2415777T3
(en)
|
2009-03-31 |
2015-08-24 |
Takeda Pharmaceutical |
A process for the preparation of nucleoside
|
US8987222B2
(en)
|
2009-04-08 |
2015-03-24 |
University Of Massachusetts |
Single nucleotide polymorphism (SNP) targeting therapies for the treatment of huntington'S disease
|
US20120156138A1
(en)
|
2009-04-14 |
2012-06-21 |
Smith Larry J |
Methods and Compositions for the Treatment of Medical Conditions Involving Cellular Reprogramming
|
WO2010129853A2
(en)
|
2009-05-07 |
2010-11-11 |
The Regents Of The University Of California |
TRANSDUCIBLE DELIVERY OF NUCLEIC ACIDS USING MODIFIED dsRNA BINDING DOMAINS
|
CN102459302A
(zh)
|
2009-06-01 |
2012-05-16 |
加利福尼亚大学董事会 |
核酸递送组合物及其使用方法
|
CA2764374C
(en)
|
2009-06-05 |
2019-11-19 |
Infectious Disease Research Institute |
Synthetic glucopyranosyl lipid adjuvants
|
JP5707396B2
(ja)
|
2009-06-17 |
2015-04-30 |
アイシス ファーマシューティカルズ, インコーポレーテッド |
被験体におけるsmn2スプライシングのモジュレーションのための組成物および方法
|
JP5670097B2
(ja)
|
2009-06-19 |
2015-02-18 |
花王株式会社 |
二層分離型毛髪化粧料
|
US20120108800A1
(en)
|
2009-06-23 |
2012-05-03 |
Shumpei Murata |
Method for synthesizing nucleic acid
|
US8329024B2
(en)
|
2009-07-06 |
2012-12-11 |
Ada Technologies, Inc. |
Electrochemical device and method for long-term measurement of hypohalites
|
RU2612521C2
(ru)
|
2009-07-06 |
2017-03-09 |
Онтории, Инк. |
Новые пролекарства нуклеиновых кислот и способы их применения
|
WO2011005860A2
(en)
|
2009-07-07 |
2011-01-13 |
Alnylam Pharmaceuticals, Inc. |
5' phosphate mimics
|
US20110009477A1
(en)
|
2009-07-08 |
2011-01-13 |
Idera Pharmaceuticals, Inc. |
Oligonucleotide-based compounds as inhibitors of toll-like receptors
|
EP2458005A1
(en)
|
2009-07-23 |
2012-05-30 |
Galaxy Pharma Inc. |
Fgf21 cis-element binding substance
|
WO2011015572A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
WO2011015573A1
(en)
|
2009-08-03 |
2011-02-10 |
Galapagos Nv |
Molecular targets and compounds, and methods to identify the same, useful in the treatment of neurodegenerative diseases
|
UA107360C2
(en)
|
2009-08-05 |
2014-12-25 |
Biogen Idec Inc |
Bicyclic aryl sphingosine 1-phosphate analogs
|
US9012421B2
(en)
|
2009-08-06 |
2015-04-21 |
Isis Pharmaceuticals, Inc. |
Bicyclic cyclohexose nucleic acid analogs
|
US8927553B2
(en)
|
2009-08-10 |
2015-01-06 |
Daljit Singh Dhanoa |
Deuterium-enriched alkyl sulfonamides and uses thereof
|
NZ624783A
(en)
|
2009-09-11 |
2015-12-24 |
Isis Pharmaceuticals Inc |
Modulation of huntingtin expression
|
EP2479182B8
(en)
|
2009-09-16 |
2016-07-13 |
Wave Life Sciences Japan, Inc. |
Novel protecting group for synthesizing rna and derivative thereof
|
WO2011038288A1
(en)
|
2009-09-25 |
2011-03-31 |
Isis Pharmaceuticals, Inc. |
Modulation of ttc39 expression to increase hdl
|
ES2426407T3
(es)
|
2009-10-15 |
2013-10-23 |
Pfizer Inc. |
Compuestos de pirrolo[2,3-d]pirimidina
|
TWI475051B
(zh)
|
2009-11-18 |
2015-03-01 |
Kao Corp |
Organic polysiloxane
|
JP5809408B2
(ja)
|
2009-11-25 |
2015-11-10 |
花王株式会社 |
毛髪化粧料
|
US8735417B2
(en)
|
2009-12-17 |
2014-05-27 |
Merck Sharp & Dohme Corp. |
Aminopyrimidines as Syk inhibitors
|
BR112012016912A2
(pt)
|
2009-12-28 |
2016-04-05 |
Achira Labs Pvt Ltd |
composição de gel de diagnóstico, método para preparar uma composição de gel de diagnóstico
|
CN111700901A
(zh)
|
2010-01-08 |
2020-09-25 |
Ionis制药公司 |
血管生成素样3表达的调节
|
US8750507B2
(en)
|
2010-01-25 |
2014-06-10 |
Cisco Technology, Inc. |
Dynamic group creation for managed key servers
|
EP3561060A1
(en)
|
2010-02-08 |
2019-10-30 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
AU2011213563B2
(en)
|
2010-02-08 |
2015-12-24 |
Ionis Pharmaceuticals, Inc. |
Selective reduction of allelic variants
|
RS53745B1
(en)
|
2010-02-10 |
2015-06-30 |
Glaxosmithkline Llc |
6-AMINO-2 - {[(1S) -1-METYLBUTIL] OKSI} -9- [5- (1-PIPERIDINIL) PENTIL] -7,9-DIHIDRO-8H-PURIN-8-ON-MALEAT
|
US8859755B2
(en)
|
2010-03-05 |
2014-10-14 |
Chiralgen, Ltd. |
Method for preparing ribonucleoside phosphorothioate
|
WO2011127175A1
(en)
|
2010-04-06 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cd130 (gp130) expression
|
CA2795750A1
(en)
|
2010-04-07 |
2011-10-13 |
Isis Pharmaceuticals, Inc. |
Modulation of cetp expression
|
WO2011133871A2
(en)
|
2010-04-22 |
2011-10-27 |
Alnylam Pharmaceuticals, Inc. |
5'-end derivatives
|
EP2625186B1
(en)
|
2010-04-28 |
2016-07-27 |
Ionis Pharmaceuticals, Inc. |
5' modified nucleosides and oligomeric compounds prepared therefrom
|
CN103154014B
(zh)
|
2010-04-28 |
2015-03-25 |
Isis制药公司 |
修饰核苷、其类似物以及由它们制备的寡聚化合物
|
US20130156845A1
(en)
|
2010-04-29 |
2013-06-20 |
Alnylam Pharmaceuticals, Inc. |
Lipid formulated single stranded rna
|
EP2563921B1
(en)
|
2010-04-30 |
2016-11-23 |
Cellectis |
Method for modulating double-strand break-induced homologous recombination
|
GB201008902D0
(en)
|
2010-05-27 |
2010-07-14 |
Imp Innovations Ltd |
Membrane enhanced polymer sythesis
|
EP3406730B1
(en)
|
2010-08-31 |
2022-02-23 |
Sirna Therapeutics, Inc. |
Novel single chemical entities and methods for delivery of oligonucleotides
|
JP5868324B2
(ja)
|
2010-09-24 |
2016-02-24 |
株式会社Wave Life Sciences Japan |
不斉補助基
|
JP5996431B2
(ja)
|
2010-09-30 |
2016-09-21 |
Lsipファンド運営合同会社 |
優性変異遺伝子発現抑制剤
|
KR101381048B1
(ko)
|
2010-10-20 |
2014-04-14 |
씨제이제일제당 (주) |
O-포스포세린 생산 균주 및 이로부터 생산된 o-포스포세린으로부터 l-시스테인 또는 이의 유도체의 생산방법
|
EP3766975A1
(en)
|
2010-10-29 |
2021-01-20 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using short interfering nucleic acid (sina)
|
DK2638163T3
(en)
|
2010-11-12 |
2017-07-24 |
Massachusetts Gen Hospital |
POLYCOMB-ASSOCIATED NON-CODING RNAs
|
JP6093924B2
(ja)
|
2010-11-30 |
2017-03-15 |
株式会社Wave Life Sciences Japan |
2’−o−修飾rna
|
US20140050778A1
(en)
|
2010-12-28 |
2014-02-20 |
University Of Rochester |
Nucleic acid binding compounds, methods of making, and use thereof
|
EP3467109A1
(en)
|
2011-02-08 |
2019-04-10 |
Ionis Pharmaceuticals, Inc. |
Oligomeric compounds comprising bicyclic nucleotides and uses thereof
|
US9181544B2
(en)
|
2011-02-12 |
2015-11-10 |
University Of Iowa Research Foundation |
Therapeutic compounds
|
WO2012151324A1
(en)
|
2011-05-02 |
2012-11-08 |
Isis Pharmaceuticals, Inc. |
Antisense compounds targeting genes associated with usher syndrome
|
FR2975600B1
(fr)
|
2011-05-24 |
2013-07-05 |
Assist Publ Hopitaux De Paris |
Agents pour le traitement de tumeurs
|
SG10201700554VA
(en)
|
2011-07-19 |
2017-03-30 |
Wave Life Sciences Pte Ltd |
Methods for the synthesis of functionalized nucleic acids
|
AR088140A1
(es)
|
2011-07-19 |
2014-05-14 |
Univ Idaho |
Sonda y metodo para direccionar acidos nucleicos
|
DK2742135T4
(da)
|
2011-08-11 |
2020-07-13 |
Ionis Pharmaceuticals Inc |
Bindingsmodificerede gapped oligomeriske forbindelser og anvendelser deraf
|
WO2013033223A1
(en)
|
2011-08-29 |
2013-03-07 |
Isis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
US20140080896A1
(en)
|
2011-08-30 |
2014-03-20 |
The Regents Of The University Of California |
Identification of small molecules that facilitate therapeutic exon skipping
|
EP2751284B1
(en)
|
2011-08-31 |
2017-01-11 |
The University Of Manchester |
Method for diagnosing a neurodegenerative disease.
|
US20140255936A1
(en)
|
2011-09-09 |
2014-09-11 |
Mayo Foundation For Medical Education And Research |
Detecting frontotemporal dementia and amyotrophic lateral sclerosis
|
EP3858847A1
(en)
|
2011-11-30 |
2021-08-04 |
Sarepta Therapeutics, Inc. |
Oligonucleotides for treating expanded repeat diseases
|
KR200460641Y1
(ko)
|
2011-12-07 |
2012-06-04 |
이형호 |
휴대가 용이한 와인 잔
|
CA2895077A1
(en)
|
2011-12-12 |
2013-06-20 |
Beverly Packard |
In vivo delivery of oligonucleotides
|
IN2014CN04590A
(es)
|
2011-12-16 |
2015-09-18 |
Nat Univ Corp Tokyo Med & Dent |
|
CN102675386B
(zh)
|
2011-12-24 |
2014-07-02 |
河南科技大学 |
一种龙胆苦苷分离提纯方法
|
WO2013134558A1
(en)
|
2012-03-07 |
2013-09-12 |
The Texas A & M University System |
Cancer treatment targeting non-coding rna overexpression
|
KR102068856B1
(ko)
|
2012-03-13 |
2020-01-21 |
길리애드 사이언시즈, 인코포레이티드 |
항바이러스 치료를 위한 2'-치환된 카바-뉴클레오시드 유사체
|
KR20130114435A
(ko)
|
2012-04-09 |
2013-10-17 |
삼성전자주식회사 |
다수의 전극을 갖는 생분자 검출 장치
|
PT2841578T
(pt)
|
2012-04-23 |
2017-08-10 |
Biomarin Tech Bv |
Resumo
|
NZ702744A
(en)
|
2012-05-22 |
2016-12-23 |
Idenix Pharmaceuticals Llc |
D-amino acid compounds for liver disease
|
US9284344B2
(en)
|
2012-05-30 |
2016-03-15 |
Hokkaido System Science Co., Ltd. |
Oligonucleotide synthesis method using highly dispersible liquid-phase support
|
WO2014010250A1
(en)
|
2012-07-13 |
2014-01-16 |
Chiralgen, Ltd. |
Asymmetric auxiliary group
|
WO2014012081A2
(en)
|
2012-07-13 |
2014-01-16 |
Ontorii, Inc. |
Chiral control
|
US9617547B2
(en)
|
2012-07-13 |
2017-04-11 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant
|
EP2879718B1
(en)
|
2012-08-06 |
2023-06-07 |
Alnylam Pharmaceuticals, Inc. |
Processes for the preparation of carbohydrate conjugated rna agents
|
WO2014028739A1
(en)
|
2012-08-15 |
2014-02-20 |
Isis Pharmaceuticals, Inc. |
Method of preparing oligomeric compounds using modified capping protocols
|
EP3459549B1
(en)
|
2012-10-12 |
2022-04-06 |
Ionis Pharmaceuticals, Inc. |
Selective antisense compounds and uses thereof
|
FI2906696T4
(fi)
|
2012-10-15 |
2023-03-18 |
|
Menetelmiä c9orf72:n ilmentymisen moduloimiseksi
|
EP2906258A4
(en)
|
2012-10-15 |
2016-08-10 |
Ionis Pharmaceuticals Inc |
COMPOSITIONS FOR MODULATING THE EXPRESSION OF C90RF72
|
US10577604B2
(en)
|
2012-10-15 |
2020-03-03 |
Ionis Pharmaceuticals, Inc. |
Methods for monitoring C9ORF72 expression
|
CA2889717A1
(en)
|
2012-10-29 |
2014-05-08 |
Cocrystal Pharma, Inc. |
Pyrimidine nucleotides and their monophosphate prodrugs for treatment of viral infections and cancer
|
EP2725029A1
(en)
|
2012-10-29 |
2014-04-30 |
Laboratoire Biodim |
New antibacterial compounds and biological applications thereof
|
JP6358955B2
(ja)
|
2012-10-31 |
2018-07-18 |
武田薬品工業株式会社 |
新規修飾核酸
|
SG10201804331TA
(en)
|
2012-11-15 |
2018-07-30 |
Roche Innovation Ct Copenhagen As |
Oligonucleotide conjugates
|
EP2922955B1
(en)
|
2012-11-26 |
2019-03-06 |
Roche Innovation Center Copenhagen A/S |
Compositions and methods for modulation of fgfr3 expression
|
WO2014099941A1
(en)
|
2012-12-19 |
2014-06-26 |
Idenix Pharmaceuticals, Inc. |
4'-fluoro nucleosides for the treatment of hcv
|
WO2014118272A1
(en)
|
2013-01-30 |
2014-08-07 |
Santaris Pharma A/S |
Antimir-122 oligonucleotide carbohydrate conjugates
|
RU2018108405A
(ru)
|
2013-01-30 |
2019-02-26 |
Ф. Хоффманн-Ля Рош Аг |
Конъюгаты углевода и lna-олигонуклеотида
|
ES2817050T3
(es)
|
2013-02-04 |
2021-04-06 |
Ionis Pharmaceuticals Inc |
Compuestos antisentido selectivos y usos de los mismos
|
EP2958998B1
(en)
|
2013-02-22 |
2017-12-27 |
Sirna Therapeutics, Inc. |
Short interfering nucleic acid (sina) molecules containing a 2' internucleoside linkage
|
CN105008533A
(zh)
|
2013-03-01 |
2015-10-28 |
国立大学法人东京医科齿科大学 |
嵌合单链反义多核苷酸和双链反义试剂
|
MX2015013628A
(es)
|
2013-03-28 |
2016-02-18 |
Syngenta Ltd |
Metodos para controlar las plagas resistentes a neonicotinoides.
|
EA201500984A1
(ru)
|
2013-03-28 |
2016-04-29 |
Зингента Партисипейшнс Аг |
Способы контроля устойчивых к неоникотиноидам вредителей
|
JP6995478B2
(ja)
|
2013-05-01 |
2022-01-14 |
アイオーニス ファーマシューティカルズ, インコーポレーテッド |
Hbvおよびttr発現を調節するための組成物および方法
|
WO2014189142A1
(ja)
|
2013-05-24 |
2014-11-27 |
味の素株式会社 |
モルフォリノオリゴヌクレオチドの製造方法
|
CN105247052A
(zh)
|
2013-05-24 |
2016-01-13 |
罗氏创新中心哥本哈根有限公司 |
B-细胞cll/淋巴瘤11a(bcl11a)的寡核苷酸调节剂及其用途
|
WO2014192310A1
(en)
|
2013-05-30 |
2014-12-04 |
National University Corporation Tokyo Medical And Dental University |
Double-stranded agents for delivering therapeutic oligonucleotides
|
JP6604544B2
(ja)
|
2013-06-16 |
2019-11-13 |
国立大学法人 東京医科歯科大学 |
エクソンスキッピング効果を有する二本鎖アンチセンス核酸
|
JP6694382B2
(ja)
|
2013-06-21 |
2020-05-13 |
アイオーニス ファーマシューティカルズ, インコーポレーテッドIonis Pharmaceuticals,Inc. |
標的核酸を調節するための組成物および方法
|
DK3013959T3
(da)
|
2013-06-27 |
2020-02-17 |
Roche Innovation Ct Copenhagen As |
Antisense-oligomerer og konjugater målrettet pcsk9
|
TWI772856B
(zh)
|
2013-07-19 |
2022-08-01 |
美商百健Ma公司 |
用於調節τ蛋白表現之組合物
|
WO2015013673A1
(en)
|
2013-07-25 |
2015-01-29 |
Aurasense Therapeutics, Llc |
Spherical nucleic acid-based constructs as immunostimulatory agents for prophylactic and therapeutic use
|
US10435430B2
(en)
|
2013-07-31 |
2019-10-08 |
Ionis Pharmaceuticals, Inc. |
Methods and compounds useful in conditions related to repeat expansion
|
CN105579442A
(zh)
|
2013-09-06 |
2016-05-11 |
先正达参股股份有限公司 |
杀虫化合物
|
EP3052511A4
(en)
|
2013-10-02 |
2017-05-31 |
Moderna Therapeutics, Inc. |
Polynucleotide molecules and uses thereof
|
US10323076B2
(en)
|
2013-10-03 |
2019-06-18 |
Modernatx, Inc. |
Polynucleotides encoding low density lipoprotein receptor
|
US9988627B2
(en)
|
2013-10-04 |
2018-06-05 |
Novartis Ag |
Formats for organic compounds for use in RNA interference
|
WO2015054676A2
(en)
|
2013-10-11 |
2015-04-16 |
Isis Pharmaceuticals, Inc. |
Compositions for modulating c9orf72 expression
|
US20160237432A1
(en)
|
2013-10-14 |
2016-08-18 |
Ionis Pharmaceuticals, Inc. |
Methods for modulating expression of c9orf72 antisense transcript
|
WO2015057727A1
(en)
|
2013-10-14 |
2015-04-23 |
Isis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
RU2693891C1
(ru)
|
2013-11-11 |
2019-07-05 |
Сангамо Байосайенсиз, Инк. |
Способы и композиции для лечения болезни хантингтона
|
JP2017501684A
(ja)
|
2013-11-14 |
2017-01-19 |
ロシュ・イノベーション・センター・コペンハーゲン・アクティーゼルスカブRoche Innovation Center Copenhagen A/S |
Apobアンチセンスコンジュゲート化合物
|
US20150167017A1
(en)
|
2013-12-13 |
2015-06-18 |
Moderna Therapeutics, Inc. |
Alternative nucleic acid molecules and uses thereof
|
JPWO2015108048A1
(ja)
|
2014-01-15 |
2017-03-23 |
株式会社新日本科学 |
抗腫瘍作用を有するキラル核酸アジュバンド及び抗腫瘍剤
|
WO2015108046A1
(ja)
|
2014-01-15 |
2015-07-23 |
株式会社新日本科学 |
抗アレルギー作用を有するキラル核酸アジュバンド及び抗アレルギー剤
|
EP3095461A4
(en)
|
2014-01-15 |
2017-08-23 |
Shin Nippon Biomedical Laboratories, Ltd. |
Chiral nucleic acid adjuvant having immunity induction activity, and immunity induction activator
|
AU2015207773B2
(en)
|
2014-01-16 |
2021-06-17 |
Wave Life Sciences Ltd. |
Chiral design
|
EP4410805A2
(en)
|
2014-03-18 |
2024-08-07 |
University of Massachusetts |
Raav-based compositions and methods for treating amyotrophic lateral sclerosis
|
US9926556B2
(en)
|
2014-04-28 |
2018-03-27 |
Ionis Pharmaceuticals, Inc. |
Linkage modified oligomeric compounds
|
US9382540B2
(en)
|
2014-05-01 |
2016-07-05 |
Isis Pharmaceuticals, Inc |
Compositions and methods for modulating angiopoietin-like 3 expression
|
US11110154B2
(en)
|
2014-05-08 |
2021-09-07 |
Sangamo Therapeutics, Inc. |
Methods and compositions for treating Huntington's Disease
|
US9523093B2
(en)
|
2014-05-20 |
2016-12-20 |
University Of Iowa Research Foundation |
Huntington's disease therapeutic compounds
|
US20160017327A1
(en)
|
2014-07-11 |
2016-01-21 |
The Johns Hopkins University |
Phosphorodiamidate morpholino oligomers (pmos) and their use in suppression of mutant huntingtin expression and attenuation of neurotoxicity
|
JP2017524357A
(ja)
|
2014-07-16 |
2017-08-31 |
モデルナティエックス インコーポレイテッドModernaTX,Inc. |
キメラポリヌクレオチド
|
EP2982758A1
(en)
|
2014-08-04 |
2016-02-10 |
Centre Hospitalier Universitaire Vaudois (CHUV) |
Genome editing for the treatment of huntington's disease
|
ES2799409T3
(es)
|
2014-08-07 |
2020-12-17 |
Takeda Pharmaceuticals Co |
Lípido catiónico
|
WO2016024205A1
(en)
|
2014-08-15 |
2016-02-18 |
Pfizer Inc. |
Oligomers targeting hexanucleotide repeat expansion in human c9orf72 gene
|
WO2016027168A2
(en)
|
2014-08-20 |
2016-02-25 |
Lifesplice Pharma Llc |
Splice modulating oligonucleotides and methods of use thereof
|
WO2016037191A1
(en)
|
2014-09-05 |
2016-03-10 |
Health Research, Inc. |
Use of huntingtin-derived plasmids and peptides for active immunization as a huntington's disease (hd) therapeutic
|
EP3221451A1
(en)
|
2014-11-17 |
2017-09-27 |
Alnylam Pharmaceuticals, Inc. |
Apolipoprotein c3 (apoc3) irna compositions and methods of use thereof
|
US20180112217A1
(en)
|
2014-11-19 |
2018-04-26 |
Roche Innovation Center Copenhagen A/S |
Stereospecific Phosphorothioate LNA
|
WO2016096938A1
(en)
|
2014-12-16 |
2016-06-23 |
Roche Innovation Center Copenhagen A/S |
Chiral toxicity screening method
|
EA037696B1
(ru)
|
2014-12-24 |
2021-05-12 |
ЮНИКЕР АйПи Б.В. |
Супрессия гена гентингтина, индуцированная рнк-интерференцией
|
US9688707B2
(en)
|
2014-12-30 |
2017-06-27 |
Ionis Pharmaceuticals, Inc. |
Bicyclic morpholino compounds and oligomeric compounds prepared therefrom
|
WO2016112132A1
(en)
|
2015-01-06 |
2016-07-14 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating expression of c9orf72 antisense transcript
|
US20180023081A1
(en)
|
2015-02-04 |
2018-01-25 |
Bristol-Myers Squibb Company |
Lna oligonucleotides with alternating flanks
|
WO2016127000A1
(en)
|
2015-02-04 |
2016-08-11 |
Bristol-Myers Squibb Company |
Methods of selecting therapeutic molecules
|
JP2018505676A
(ja)
|
2015-02-04 |
2018-03-01 |
エフ.ホフマン−ラ ロシュ アーゲーF. Hoffmann−La Roche Aktiengesellschaft |
タウアンチセンスオリゴマー及びその使用
|
MY181458A
(en)
|
2015-02-10 |
2020-12-22 |
Genzyme Corp |
Variant rnai
|
EP3256587A2
(en)
|
2015-02-13 |
2017-12-20 |
Alnylam Pharmaceuticals, Inc. |
Patatin-like phospholipase domain containing 3 (pnpla3) irna compositions and methods of use thereof
|
WO2016138017A1
(en)
|
2015-02-23 |
2016-09-01 |
Ionis Pharmaceuticals, Inc. |
Compounds and methods for increasing antisense activity
|
WO2016141236A1
(en)
|
2015-03-03 |
2016-09-09 |
Ionis Pharmaceuticals, Inc. |
Compositions for modulating mecp2 expression
|
WO2016145142A1
(en)
|
2015-03-10 |
2016-09-15 |
Emory University |
Nucleotide and nucleoside therapeutics compositions and uses related thereto
|
WO2016154096A1
(en)
|
2015-03-20 |
2016-09-29 |
Ionis Pharmaceuticals, Inc. |
Modulation of smggds expression
|
CN116004624A
(zh)
|
2015-04-03 |
2023-04-25 |
马萨诸塞大学 |
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|
US10851371B2
(en)
|
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Modulation of SMN expression
|
US10407678B2
(en)
|
2015-04-16 |
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|
KR102104163B1
(ko)
|
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|
WO2016209862A1
(en)
|
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|
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(en)
|
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Modified crispr rna and modified single crispr rna and uses thereof
|
US10494632B2
(en)
|
2015-07-10 |
2019-12-03 |
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|
SG10202006563PA
(en)
|
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|
DK3324980T3
(da)
|
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Multimålrettede enkeltenhedskonjugater
|
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(fr)
|
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Compositions d'oligonucléotides et procédés associés
|
US20180216114A1
(en)
|
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2018-08-02 |
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|
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(ja)
|
2015-07-31 |
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TTR関連疾患を治療または予防するためのトランスサイレチン(TTR)iRNA組成物およびその使用方法
|
KR20180043819A
(ko)
|
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2018-04-30 |
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|
IL310959A
(en)
|
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Methods and preparations for treating a disorder related to the PCSK9 gene
|
CN108368507B
(zh)
|
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阿尔尼拉姆医药品有限公司 |
程序性细胞死亡1配体1(PD-L1)的iRNA组合物及其使用方法
|
WO2017048620A1
(en)
|
2015-09-14 |
2017-03-23 |
Alnylam Pharmaceuticals, Inc. |
Polynucleotide agents targeting patatin-like phospholipase domain containing 3 (pnpla3) and methods of use thereof
|
US10874686B2
(en)
|
2015-10-01 |
2020-12-29 |
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Anthranilyl-adenosinemonosulfamate analogs and uses thereof
|
EP3356447A4
(en)
|
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2019-06-12 |
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INHIBITORS OF MENACHINONE BIOSYNTHESIS
|
CN108136041B
(zh)
|
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罗氏创新中心哥本哈根有限公司 |
寡核苷酸缀合方法
|
MX2018003992A
(es)
|
2015-10-09 |
2018-08-01 |
Wave Life Sciences Ltd |
Composiciones oligonucleotidicas y sus metodos.
|
WO2017067970A1
(en)
|
2015-10-22 |
2017-04-27 |
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In vitro toxicity screening assay
|
WO2017068087A1
(en)
|
2015-10-22 |
2017-04-27 |
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|
WO2017079291A1
(en)
|
2015-11-02 |
2017-05-11 |
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|
RU2742007C2
(ru)
|
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Олигонуклеотиды для индуцирования отцовской экспрессии ube3a
|
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(ja)
|
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|
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(en)
|
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Oligonucleotides for reduction of PD-L1 expression
|
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(en)
|
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Acyl-protected l-lna-guanosine monomers
|
WO2017165489A1
(en)
|
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|
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(en)
|
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Methods for reducing c9orf72 expression
|
EP3442983A1
(en)
|
2016-04-14 |
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|
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(fr)
|
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|
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(fr)
|
2016-05-04 |
2019-03-13 |
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Procédés et compositions d'agents biologiquement actifs
|
US11261209B2
(en)
|
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Enhanced coupling of stereodefined oxazaphospholidine phosphoramidite monomers to nucleoside or oligonucleotide
|
US10752891B2
(en)
|
2016-05-13 |
2020-08-25 |
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Protein-based sample collection matrices and devices
|
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(en)
|
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|
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(en)
|
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|
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(ja)
|
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|
US20190264267A1
(en)
|
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|
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(zh)
|
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|