MX2024009679A - Preparacion de nuevos derivados de alcoholes triterpenicos con biodisponibilidad mejorada para el tratamiento de cancer, inflamacion y dolor. - Google Patents
Preparacion de nuevos derivados de alcoholes triterpenicos con biodisponibilidad mejorada para el tratamiento de cancer, inflamacion y dolor.Info
- Publication number
- MX2024009679A MX2024009679A MX2024009679A MX2024009679A MX2024009679A MX 2024009679 A MX2024009679 A MX 2024009679A MX 2024009679 A MX2024009679 A MX 2024009679A MX 2024009679 A MX2024009679 A MX 2024009679A MX 2024009679 A MX2024009679 A MX 2024009679A
- Authority
- MX
- Mexico
- Prior art keywords
- cancer
- inflammation
- preparation
- alcohol derivatives
- pain treatment
- Prior art date
Links
- 206010061218 Inflammation Diseases 0.000 title 1
- 206010028980 Neoplasm Diseases 0.000 title 1
- 208000002193 Pain Diseases 0.000 title 1
- 201000011510 cancer Diseases 0.000 title 1
- 230000004054 inflammatory process Effects 0.000 title 1
- -1 triterpene alcohol derivatives Chemical class 0.000 title 1
- 102000009516 Protein Serine-Threonine Kinases Human genes 0.000 abstract 1
- 108010009341 Protein Serine-Threonine Kinases Proteins 0.000 abstract 1
- 230000004913 activation Effects 0.000 abstract 1
- 239000000730 antalgic agent Substances 0.000 abstract 1
- 230000001093 anti-cancer Effects 0.000 abstract 1
- 239000002260 anti-inflammatory agent Substances 0.000 abstract 1
- 230000003110 anti-inflammatory effect Effects 0.000 abstract 1
- 239000002246 antineoplastic agent Substances 0.000 abstract 1
- 230000005764 inhibitory process Effects 0.000 abstract 1
- ZRPNFEVAKYBZFA-XXAVSGDJSA-N lanosta-8,24-dien-3-ol Chemical compound CC([C@@H]1CC2)(C)[C@@H](O)CC[C@]1(C)C1=C2[C@]2(C)CC[C@H]([C@@H](CCC=C(C)C)C)C2CC1 ZRPNFEVAKYBZFA-XXAVSGDJSA-N 0.000 abstract 1
- 150000003505 terpenes Chemical class 0.000 abstract 1
- 235000007586 terpenes Nutrition 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
- A61K31/575—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of three or more carbon atoms, e.g. cholane, cholestane, ergosterol, sitosterol
Landscapes
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
La invención se refiere generalmente a los usos farmacéuticos de los 3-oles terpénicos tetracíclicos, como por ejemplo el lanosta-8,24-dien-3-ol, que llevan porciones polares y/o cargadas, como agentes antiinflamatorios, anticancerígenos y analgésicos a través de la inhibición de la activación desordenada de las serina-treonina proteína cinasas, particularmente la PKC.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US202263307348P | 2022-02-07 | 2022-02-07 | |
| PCT/BR2023/050041 WO2023147640A1 (en) | 2022-02-07 | 2023-02-07 | Preparation of novel triterpene alcohol derivatives with enhanced bioavailability for cancer, inflammation and pain treatment |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2024009679A true MX2024009679A (es) | 2024-08-15 |
Family
ID=87553096
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2024009679A MX2024009679A (es) | 2022-02-07 | 2023-02-07 | Preparacion de nuevos derivados de alcoholes triterpenicos con biodisponibilidad mejorada para el tratamiento de cancer, inflamacion y dolor. |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN118660902A (es) |
| MX (1) | MX2024009679A (es) |
| WO (1) | WO2023147640A1 (es) |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH04183773A (ja) * | 1990-11-19 | 1992-06-30 | Yoshikawa Seiyu Kk | ケイ皮酸ステロール系紫外線防止剤 |
| JP3219432B2 (ja) * | 1991-09-12 | 2001-10-15 | クローダジャパン株式会社 | 皮膚外用剤 |
| EP1438324A4 (en) * | 2001-09-26 | 2005-06-22 | Univ Waikato | CO-HALOGENATION OF SELECTED DOUBLE BINDING COMPOUNDS USING N-HALO-SUCCINIMIDE |
| ITMI20031322A1 (it) * | 2003-06-27 | 2004-12-28 | Vama Farmacosmetica S R L | Sali degli acidi di ciclopentaperidrofenantrene 3-beta-carbossilici, procedimento per la preparazione di questi sali, emulsionante di base preparato con gli stessi, emulsione olio/acqua ottenuta con questo emulsionante di base e preparati per l'impie |
| WO2006007676A1 (en) * | 2004-07-21 | 2006-01-26 | Amazônia Fitomedicamentos Ltda. | Combination of active fractions from the plants euphorbia tirucalli l and ficos carica l. and method of treating cancer and aids |
| MX2007004955A (es) * | 2004-11-08 | 2007-06-14 | Transave Inc | Metodo de tratar cancer con formulaciones de compeusto de platino a base de lipido administradas intraperitonealmente. |
| WO2007115181A2 (en) * | 2006-04-03 | 2007-10-11 | Eastman Chemical Company | Compounds exhibiting efflux inhibitor activity and compositions and uses thereof |
| CA2732850C (en) * | 2008-08-05 | 2016-06-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical uses of lanosta-8,24-dien-3-ols |
| WO2011086424A1 (en) * | 2010-01-15 | 2011-07-21 | Amazonia Fitomedicamentos Ltda | Pharmaceutical use of multicyclic compounds mixtures as concomitant anti-cancer, anti-inflammatory and anti-pain agents |
| CA2919258C (en) * | 2013-07-25 | 2022-06-21 | Cheryl Lee EBERTING | Formulations for epidermal repair |
| AU2018212270B2 (en) * | 2017-01-25 | 2020-07-02 | Guangzhou Ocusun Ophthalmic Biotechnology Co., Ltd. | Lanosterol prodrug compound and preparation method therefor and use thereof |
| CN109833319B (zh) * | 2017-11-29 | 2021-06-29 | 清华大学 | 化合物在防治代谢性疾病中的应用 |
| MX2021000900A (es) * | 2018-07-25 | 2021-06-15 | Guangzhou Ocusun Ophthalmic Biotechnology Co Ltd | Forma cristalina de compuesto profarmaco de lanosterol y aplicacion de la misma. |
| WO2020177714A1 (zh) * | 2019-03-04 | 2020-09-10 | 中山大学中山眼科中心 | 一种羊毛甾醇前药化合物的组合物及其制备方法和应用 |
-
2023
- 2023-02-07 WO PCT/BR2023/050041 patent/WO2023147640A1/en active Application Filing
- 2023-02-07 MX MX2024009679A patent/MX2024009679A/es unknown
- 2023-02-07 CN CN202380020794.5A patent/CN118660902A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| CN118660902A (zh) | 2024-09-17 |
| WO2023147640A1 (en) | 2023-08-10 |
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