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MX2021008146A - Polinucleotidos de arn encapsulado y metodos de uso. - Google Patents

Polinucleotidos de arn encapsulado y metodos de uso.

Info

Publication number
MX2021008146A
MX2021008146A MX2021008146A MX2021008146A MX2021008146A MX 2021008146 A MX2021008146 A MX 2021008146A MX 2021008146 A MX2021008146 A MX 2021008146A MX 2021008146 A MX2021008146 A MX 2021008146A MX 2021008146 A MX2021008146 A MX 2021008146A
Authority
MX
Mexico
Prior art keywords
polynuclotides
methods
encapsulated rna
recombinant rna
present disclosure
Prior art date
Application number
MX2021008146A
Other languages
English (en)
Inventor
Lorena Lerner
Mitchell H Finer
Christophe Quéva
Edward M Kennedy
Original Assignee
Oncorus Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Oncorus Inc filed Critical Oncorus Inc
Publication of MX2021008146A publication Critical patent/MX2021008146A/es

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/66—Microorganisms or materials therefrom
    • A61K35/76—Viruses; Subviral particles; Bacteriophages
    • A61K35/768—Oncolytic viruses not provided for in groups A61K35/761 - A61K35/766
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7088—Compounds having three or more nucleosides or nucleotides
    • A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/24—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing atoms other than carbon, hydrogen, oxygen, halogen, nitrogen or sulfur, e.g. cyclomethicone or phospholipids
    • A—HUMAN NECESSITIES
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
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    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
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    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
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    • C12N15/09—Recombinant DNA-technology
    • C12N15/87—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation
    • C12N15/88—Introduction of foreign genetic material using processes not otherwise provided for, e.g. co-transformation using microencapsulation, e.g. using amphiphile liposome vesicle
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    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0069—Oxidoreductases (1.) acting on single donors with incorporation of molecular oxygen, i.e. oxygenases (1.13)
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    • A61K9/513—Organic macromolecular compounds; Dendrimers
    • A61K9/5146—Organic macromolecular compounds; Dendrimers obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyethylene glycol, polyamines, polyanhydrides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/521—Chemokines
    • C—CHEMISTRY; METALLURGY
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
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    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • C—CHEMISTRY; METALLURGY
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
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    • C07K2319/00—Fusion polypeptide
    • C07K2319/61—Fusion polypeptide containing an enzyme fusion for detection (lacZ, luciferase)
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Abstract

La presente descripción se refiere a moléculas de ARN recombinante que codifican un virus oncolítico. La presente descripción se refiere además a la encapsulación de las moléculas de ARN recombinante y al uso de las partículas y/o moléculas de ARN recombinante para el tratamiento y prevención del cáncer.
MX2021008146A 2019-01-04 2020-01-03 Polinucleotidos de arn encapsulado y metodos de uso. MX2021008146A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962788504P 2019-01-04 2019-01-04
US201962895135P 2019-09-03 2019-09-03
PCT/US2020/012237 WO2020142725A1 (en) 2019-01-04 2020-01-03 Encapsulated rna polynucleotides and methods of use

Publications (1)

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MX2021008146A true MX2021008146A (es) 2021-10-13

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MX2021008146A MX2021008146A (es) 2019-01-04 2020-01-03 Polinucleotidos de arn encapsulado y metodos de uso.

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US (1) US20220117902A1 (es)
EP (1) EP3906039A4 (es)
JP (2) JP2022516318A (es)
KR (1) KR20210113260A (es)
CN (1) CN113453699A (es)
AU (1) AU2020204989A1 (es)
BR (1) BR112021013155A2 (es)
CA (1) CA3124524A1 (es)
IL (1) IL284433A (es)
MX (1) MX2021008146A (es)
SG (1) SG11202107282VA (es)
TW (1) TW202043480A (es)
WO (1) WO2020142725A1 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
HUE066181T2 (hu) 2018-10-09 2024-07-28 Univ British Columbia Szerves oldószerektõl és detergensektõl mentes transzfekció-kompetens vezikulumokat tartalmazó készítmények és rendszerek, és az azokkal kapcsolatos eljárások
US20220267799A1 (en) * 2019-08-05 2022-08-25 Virogin Biotech Canada Ltd Genetically modified enterovirus vectors
CA3204244A1 (en) * 2021-01-06 2022-07-14 Lorena Lerner Encapsulated rna polynucleotides and methods of use
AU2022210419A1 (en) * 2021-01-19 2023-07-20 Seneca Therapeutics, Inc. Armed seneca valley virus oncolytic therapy compositions and methods thereof
AU2022227607A1 (en) * 2021-02-23 2023-08-24 Poseida Therapeutics, Inc. Compositions and methods for delivery of nucleic acids
US20240358652A1 (en) * 2021-08-17 2024-10-31 Monash University Lipid nanoparticle formulations
CN113980915B (zh) * 2021-11-04 2023-07-07 江苏省人民医院（南京医科大学第一附属医院） 一种新型的表达cxcl10的复制型溶瘤腺病毒和应用
FR3129833B1 (fr) 2021-12-03 2024-09-06 Univ Claude Bernard Lyon Nanoparticules pour la liberation d’acides nucleiques
CN118785924A (zh) * 2022-03-04 2024-10-15 益杰立科(上海)生物科技有限公司 靶向眼部细胞的递送系统和方法
WO2024009316A1 (en) * 2022-07-04 2024-01-11 Bharat Biotech International Limited Cationic lipid based composition, formulation and use for nucleic acid vaccine delivery and preparation thereof
CN115227674B (zh) * 2022-08-05 2023-07-04 武汉滨会生物科技股份有限公司 包封的溶瘤病毒遗传物质及其应用
WO2024086810A1 (en) * 2022-10-21 2024-04-25 Georgia Tech Research Corporation Lymphatic endothelial cell-specific lipid nanoparticle and uses thereof
WO2024226779A1 (en) * 2023-04-26 2024-10-31 Saliogen Therapeutics, Inc. Lipid nanoparticle (lnp) formulations

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7638318B2 (en) * 2003-09-26 2009-12-29 Norvartis Ag Seneca Valley virus based compositions and methods for treating disease
US20080160031A1 (en) * 2005-01-17 2008-07-03 Viralytics Limited Method and Composition for Treatment of Neoplasms
US10000757B2 (en) * 2005-05-27 2018-06-19 Ospedale San Raffaele S.R.L. Gene vector
EP2125032A4 (en) * 2007-02-20 2011-02-23 Mayo Foundation CANCER TREATMENT WITH VIRAL NUCLEIC ACID
JP2012509272A (ja) * 2008-11-17 2012-04-19 エンゾン ファーマシューティカルズ，インコーポレーテッド 核酸送達系のための放出性カチオン脂質
WO2013073480A1 (ja) * 2011-11-18 2013-05-23 日油株式会社 細胞内動態を改善したカチオン性脂質
MX2014014196A (es) * 2012-05-23 2015-08-14 Univ Ohio State Composiciones de nanoparticulas de albumina recubiertas con lipido y metodos de preparacion y metodo de uso de las mismas.
WO2014171526A1 (ja) * 2013-04-17 2014-10-23 国立大学法人九州大学 遺伝子改変コクサッキーウイルス
WO2016118724A1 (en) * 2015-01-21 2016-07-28 Moderna Therapeutics, Inc. Lipid nanoparticle compositions
PT3408382T (pt) * 2016-01-27 2022-06-27 Oncorus Inc Vetores virais oncolíticos e seus usos
BR112019000015A2 (pt) * 2016-06-30 2019-04-24 Oncorus, Inc. distribuição por vírus oncolítico pseudotipado de polipeptídeos terapêuticos
JP7306653B2 (ja) * 2017-03-17 2023-07-11 国立大学法人千葉大学 構造強化されたＳ－ＴｕＤを用いた新規がん治療法
EP3594329A4 (en) * 2017-04-19 2021-02-24 The University Of Tokyo GENETICALLY MODIFIED COXSACKIE VIRUS, AND PHARMACEUTICAL COMPOSITION
US11033622B2 (en) * 2017-05-25 2021-06-15 Leidos, Inc. PD-1 and CTLA-4 dual inhibitor peptides
RU2020106730A (ru) * 2017-07-14 2021-08-16 Онкорус, Инк. Инкапсулированные полинуклеотиды и способы их применения

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