MX2019014914A - Sintesis de 3'-desoxiadenosina-5'-0-[fenil(benciloxi-l-alaninil)]f osfato (nuc-7738). - Google Patents
Sintesis de 3'-desoxiadenosina-5'-0-[fenil(benciloxi-l-alaninil)]f osfato (nuc-7738).Info
- Publication number
- MX2019014914A MX2019014914A MX2019014914A MX2019014914A MX2019014914A MX 2019014914 A MX2019014914 A MX 2019014914A MX 2019014914 A MX2019014914 A MX 2019014914A MX 2019014914 A MX2019014914 A MX 2019014914A MX 2019014914 A MX2019014914 A MX 2019014914A
- Authority
- MX
- Mexico
- Prior art keywords
- deoxyadenosine
- alaninyl
- nuc
- benzyloxy
- phenyl
- Prior art date
Links
- 229910019142 PO4 Inorganic materials 0.000 title abstract 2
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 title abstract 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 title abstract 2
- 239000010452 phosphate Substances 0.000 title abstract 2
- 230000015572 biosynthetic process Effects 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 abstract 2
- 230000001093 anti-cancer Effects 0.000 abstract 1
- OFEZSBMBBKLLBJ-BAJZRUMYSA-N cordycepin Chemical class C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)C[C@H]1O OFEZSBMBBKLLBJ-BAJZRUMYSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H1/00—Processes for the preparation of sugar derivatives
- C07H1/02—Phosphorylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
- C07H19/207—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids the phosphoric or polyphosphoric acids being esterified by a further hydroxylic compound, e.g. flavine adenine dinucleotide or nicotinamide-adenine dinucleotide
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P20/00—Technologies relating to chemical industry
- Y02P20/50—Improvements relating to the production of bulk chemicals
- Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Saccharide Compounds (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Abstract
La presente invención está relacionada generalmente a un proceso novedoso para la preparación de derivados de 3'-desoxiadenosina, y particularmente NUC-7738 (3'-desoxiadenosina-5'-O-[fenil(benzilo xi-L-alaninil)] fosfato) un ProTide anticancerígeno de desoxiadenosina.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1709471.5A GB201709471D0 (en) | 2017-06-14 | 2017-06-14 | Diastereoselective synthesis of hosphate derivatives |
| PCT/GB2018/051641 WO2018229495A1 (en) | 2017-06-14 | 2018-06-14 | Synthesis of 3'-deoxyadenosine-5'-0-[phenyl(benzyloxy-l-alaninyl)]phosphate (nuc-7738) |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2019014914A true MX2019014914A (es) | 2020-02-13 |
Family
ID=59358400
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019014914A MX2019014914A (es) | 2017-06-14 | 2018-06-14 | Sintesis de 3'-desoxiadenosina-5'-0-[fenil(benciloxi-l-alaninil)]f osfato (nuc-7738). |
| MX2019014907A MX2019014907A (es) | 2017-06-14 | 2018-06-14 | Sintesis de derivados de fosfato. |
| MX2022003822A MX2022003822A (es) | 2017-06-14 | 2019-12-10 | Sintesis de derivados de fosfato. |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2019014907A MX2019014907A (es) | 2017-06-14 | 2018-06-14 | Sintesis de derivados de fosfato. |
| MX2022003822A MX2022003822A (es) | 2017-06-14 | 2019-12-10 | Sintesis de derivados de fosfato. |
Country Status (18)
| Country | Link |
|---|---|
| US (3) | US11897913B2 (es) |
| EP (2) | EP3638685A1 (es) |
| JP (4) | JP7248209B2 (es) |
| KR (2) | KR20240127483A (es) |
| CN (3) | CN110785425B (es) |
| AU (3) | AU2018284131B2 (es) |
| BR (1) | BR112019026747A2 (es) |
| CA (2) | CA3064177A1 (es) |
| CL (1) | CL2019003632A1 (es) |
| EA (1) | EA201992873A1 (es) |
| GB (1) | GB201709471D0 (es) |
| IL (3) | IL271159B2 (es) |
| MA (1) | MA49379A (es) |
| MX (3) | MX2019014914A (es) |
| PH (1) | PH12019502825A1 (es) |
| SA (1) | SA519410795B1 (es) |
| SG (1) | SG11201911543UA (es) |
| WO (2) | WO2018229495A1 (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8933053B2 (en) | 2011-03-01 | 2015-01-13 | Nucana Biomed Limited | Phosphoramidate derivatives of 5-fluoro-2′-deoxyuridine for use in the treatment of cancer |
| MX2020004054A (es) | 2014-06-25 | 2021-11-30 | NuCana plc | Formulacion que comprende un profarmaco de gemcitabina. |
| SG11201702369UA (en) * | 2014-11-28 | 2017-04-27 | Nucana Biomed Ltd | New 2' and/or 5' amino-acid ester phosphoramidate 3'-deoxy adenosine derivatives as anti-cancer compounds |
| LT3386998T (lt) | 2015-12-11 | 2022-01-25 | NuCana plc | Fosfato darinių ir gemcitabino provaisto nuc-1031 diastereoselektyvi sintezė |
| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| GB201709471D0 (en) | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| GB201715011D0 (en) | 2017-09-18 | 2017-11-01 | Nucana Biomed Ltd | Floxuridine synthesis |
| CN112409421A (zh) * | 2020-12-01 | 2021-02-26 | 上海兆维科技发展有限公司 | 一种3’-磷酸酯核苷的制备方法 |
| IL316821A (en) | 2022-05-12 | 2025-01-01 | NuCana plc | Cancer treatment with NUC-7738 |
| WO2024121527A1 (en) | 2022-12-07 | 2024-06-13 | NuCana plc | Synthesis of nucleoside derivative nuc-3373 |
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| US4668777A (en) * | 1981-03-27 | 1987-05-26 | University Patents, Inc. | Phosphoramidite nucleoside compounds |
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| CN106539810B (zh) | 2015-09-16 | 2021-03-09 | 济南高合医疗科技有限公司 | 一种富集了nuc-1031单一异构体的组合物及其制备方法和用途 |
| CN106543252A (zh) | 2015-09-16 | 2017-03-29 | 博瑞生物医药（苏州）股份有限公司 | 核苷氨基磷酸酯类前药的制备方法及其中间体 |
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| GB201522764D0 (en) | 2015-12-23 | 2016-02-03 | Nucana Biomed Ltd | Formulations of phosphate derivatives |
| MX2018007772A (es) | 2015-12-23 | 2019-07-04 | NuCana plc | Terapia de combinacion. |
| GB201609601D0 (en) | 2016-06-01 | 2016-07-13 | Nucana Biomed Ltd | Phosphoramidate compounds |
| GB201609602D0 (en) * | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Chemical compounds |
| GB201609600D0 (en) | 2016-06-01 | 2016-07-13 | Nucuna Biomed Ltd | Cancer treatments |
| GB201709471D0 (en) * | 2017-06-14 | 2017-07-26 | Nucana Biomed Ltd | Diastereoselective synthesis of hosphate derivatives |
| GB201713916D0 (en) | 2017-08-30 | 2017-10-11 | Nucana Biomed Ltd | Treatment regimens |
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2017
- 2017-06-14 GB GBGB1709471.5A patent/GB201709471D0/en not_active Ceased
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2018
- 2018-06-14 EA EA201992873A patent/EA201992873A1/ru unknown
- 2018-06-14 SG SG11201911543UA patent/SG11201911543UA/en unknown
- 2018-06-14 US US16/623,272 patent/US11897913B2/en active Active
- 2018-06-14 MX MX2019014914A patent/MX2019014914A/es unknown
- 2018-06-14 IL IL271159A patent/IL271159B2/en unknown
- 2018-06-14 JP JP2019569336A patent/JP7248209B2/ja active Active
- 2018-06-14 MA MA049379A patent/MA49379A/fr unknown
- 2018-06-14 MX MX2019014907A patent/MX2019014907A/es unknown
- 2018-06-14 KR KR1020247026745A patent/KR20240127483A/ko not_active Application Discontinuation
- 2018-06-14 CN CN201880039189.1A patent/CN110785425B/zh active Active
- 2018-06-14 IL IL312228A patent/IL312228B1/en unknown
- 2018-06-14 EP EP18735381.8A patent/EP3638685A1/en active Pending
- 2018-06-14 AU AU2018284131A patent/AU2018284131B2/en active Active
- 2018-06-14 CA CA3064177A patent/CA3064177A1/en active Pending
- 2018-06-14 JP JP2019569286A patent/JP7279991B2/ja active Active
- 2018-06-14 EP EP18735380.0A patent/EP3638684A2/en active Pending
- 2018-06-14 CA CA3065682A patent/CA3065682A1/en active Pending
- 2018-06-14 IL IL302559A patent/IL302559B2/en unknown
- 2018-06-14 CN CN202311430904.3A patent/CN117486959A/zh active Pending
- 2018-06-14 KR KR1020197036989A patent/KR102695300B1/ko active IP Right Grant
- 2018-06-14 US US16/623,263 patent/US11414452B2/en active Active
- 2018-06-14 WO PCT/GB2018/051641 patent/WO2018229495A1/en unknown
- 2018-06-14 CN CN201880039747.4A patent/CN110753697B/zh active Active
- 2018-06-14 BR BR112019026747-6A patent/BR112019026747A2/pt unknown
- 2018-06-14 PH PH1/2019/502825A patent/PH12019502825A1/en unknown
- 2018-06-14 WO PCT/GB2018/051638 patent/WO2018229493A2/en active Application Filing
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2019
- 2019-12-10 MX MX2022003822A patent/MX2022003822A/es unknown
- 2019-12-11 CL CL2019003632A patent/CL2019003632A1/es unknown
- 2019-12-12 SA SA519410795A patent/SA519410795B1/ar unknown
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2022
- 2022-06-30 AU AU2022204691A patent/AU2022204691B2/en active Active
- 2022-08-15 US US17/888,312 patent/US12054511B2/en active Active
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2023
- 2023-05-02 JP JP2023076006A patent/JP7525687B2/ja active Active
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2024
- 2024-01-24 AU AU2024200428A patent/AU2024200428A1/en active Pending
- 2024-07-18 JP JP2024114519A patent/JP2024138523A/ja active Pending
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