MX2018009551A - Estructuras descelularizadas de la pared celular de plantas y hongos y uso de las mismas como materiales de andamio. - Google Patents
Estructuras descelularizadas de la pared celular de plantas y hongos y uso de las mismas como materiales de andamio.Info
- Publication number
- MX2018009551A MX2018009551A MX2018009551A MX2018009551A MX2018009551A MX 2018009551 A MX2018009551 A MX 2018009551A MX 2018009551 A MX2018009551 A MX 2018009551A MX 2018009551 A MX2018009551 A MX 2018009551A MX 2018009551 A MX2018009551 A MX 2018009551A
- Authority
- MX
- Mexico
- Prior art keywords
- tissue
- decellularised
- fungus
- plants
- scaffold
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/96—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution
- A61K8/97—Cosmetics or similar toiletry preparations characterised by the composition containing materials, or derivatives thereof of undetermined constitution from algae, fungi, lichens or plants; from derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3637—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the origin of the biological material other than human or animal, e.g. plant extracts, algae
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/507—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials for artificial blood vessels
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/52—Hydrogels or hydrocolloids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/54—Biologically active materials, e.g. therapeutic substances
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
- A61L27/60—Materials for use in artificial skin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0062—General methods for three-dimensional culture
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
- A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
- A61L2300/412—Tissue-regenerating or healing or proliferative agents
- A61L2300/414—Growth factors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/02—Materials or treatment for tissue regeneration for reconstruction of bones; weight-bearing implants
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/16—Materials or treatment for tissue regeneration for reconstruction of eye parts, e.g. intraocular lens, cornea
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/32—Materials or treatment for tissue regeneration for nerve reconstruction
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/40—Preparation and treatment of biological tissue for implantation, e.g. decellularisation, cross-linking
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Biomedical Technology (AREA)
- Epidemiology (AREA)
- Transplantation (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Botany (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Zoology (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Cell Biology (AREA)
- General Chemical & Material Sciences (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dispersion Chemistry (AREA)
- Vascular Medicine (AREA)
- Ophthalmology & Optometry (AREA)
- Mycology (AREA)
- Birds (AREA)
- Materials For Medical Uses (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
En la presente divulgación se proporciona biomateriales de andamiaje que comprenden un tejido vegetal o fúngico descelularizado del que son retirados los materiales celulares y ácidos nucleicos del tejido, el tejido vegetal o fúngico descelularizado comprende una estructura porosa tridimensional a base de celulosa o quitina; también se proporcionan los métodos para preparar tales materiales de andamiaje, así como los usos de los mismos como un andamio implantable para soportar el crecimiento celular animal, para promover la regeneración tisular, para promover la angiogénesis, para un procedimiento de reemplazo de tejidos y/o como un implante celular para cirugía; adicionalmente se describe el tratamiento terapéutico y/o los métodos cosméticos que emplean tales andamiajes.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201662294671P | 2016-02-12 | 2016-02-12 | |
PCT/CA2017/050163 WO2017136950A1 (en) | 2016-02-12 | 2017-02-10 | Decellularised cell wall structures from plants and fungus and use thereof as scaffold materials |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2018009551A true MX2018009551A (es) | 2019-05-06 |
Family
ID=59563678
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2018009551A MX2018009551A (es) | 2016-02-12 | 2017-02-10 | Estructuras descelularizadas de la pared celular de plantas y hongos y uso de las mismas como materiales de andamio. |
Country Status (11)
Country | Link |
---|---|
US (3) | US11045582B2 (es) |
EP (1) | EP3413939B1 (es) |
JP (2) | JP6957486B2 (es) |
CN (1) | CN109152863A (es) |
AU (2) | AU2017218476B2 (es) |
BR (1) | BR112018016050B1 (es) |
CA (1) | CA3014256C (es) |
ES (1) | ES2953657T3 (es) |
IL (2) | IL260993B (es) |
MX (1) | MX2018009551A (es) |
WO (1) | WO2017136950A1 (es) |
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US9485917B2 (en) | 2006-12-15 | 2016-11-08 | Ecovative Design, LLC | Method for producing grown materials and products made thereby |
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US20150101509A1 (en) | 2013-10-14 | 2015-04-16 | Gavin R. McIntyre | Method of Manufacturing a Stiff Engineered Composite |
US11883275B2 (en) | 2014-06-11 | 2024-01-30 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
US11638640B2 (en) | 2014-06-11 | 2023-05-02 | Bard Shannon Limited | In vivo tissue engineering devices, methods and regenerative and cellular medicine employing scaffolds made of absorbable material |
US10537070B2 (en) | 2015-04-15 | 2020-01-21 | Ecovative Design Llc | Process for the production of mycelial composite surfaces in a roll-to-roll format |
WO2017151684A1 (en) | 2016-03-01 | 2017-09-08 | Sustainable Bioproducts Holdings, Llc | Filamentous fungal biomats, methods of their production and methods of their use |
AU2018243372A1 (en) | 2017-03-31 | 2019-10-31 | Ecovative Design, Llc. | Solution based post-processing methods for mycological biopolymer material and mycological product made thereby |
US10774227B2 (en) * | 2017-04-25 | 2020-09-15 | Cellheal As | Preparation and applications of biocompatible conductive inks based on cellulose nanofibrils for 3D printing of conductive biomedical devices and for use as models for study of neurodegenerative disorders and connection between brain/neurons and communication or other electronic devices |
TWI612966B (zh) * | 2017-06-06 | 2018-02-01 | 景鑫生物科技股份有限公司 | 南洋山蘇水萃物的用途 |
US11266085B2 (en) | 2017-11-14 | 2022-03-08 | Ecovative Design Llc | Increased homogeneity of mycological biopolymer grown into void space |
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JP2022533181A (ja) * | 2019-05-14 | 2022-07-21 | スパイダーワート インク. | 高密度マイクロチャネル |
US20220236255A1 (en) * | 2019-06-28 | 2022-07-28 | Arizona Board Of Regents On Behalf Of The University Of Arizona | Self-Contained Responsive Biological Systems and Methods |
KR102334114B1 (ko) * | 2019-11-25 | 2021-12-02 | 영남대학교 산학협력단 | 진균을 이용한 스캐폴드 제조 및 이를 이용한 조직 재생방법 |
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WO2007070660A2 (en) | 2005-12-13 | 2007-06-21 | President And Fellows Of Harvard College | Scaffolds for cell transplantation |
GB2466073A (en) * | 2008-12-12 | 2010-06-16 | Univ Manchester | Tissue repair scaffold |
WO2011123798A2 (en) * | 2010-04-01 | 2011-10-06 | The Johns Hopkins University | Three-dimensional scaffolds, methods for fabricating the same, and methods of treating a peripheral nerve or spinal or spinal cord injury |
JP2013528786A (ja) | 2010-04-08 | 2013-07-11 | キアゲン ゲーエムベーハー | 核酸を単離および精製するためのクロマトグラフィーデバイスおよび方法 |
CN113699105A (zh) | 2011-12-23 | 2021-11-26 | 人类起源公司 | 包含脱细胞并再群体化的胎盘血管支架的类器官 |
GB201212771D0 (en) | 2012-07-18 | 2012-08-29 | Northwick Park Inst For Medcal Res Ltd | Implant and method for producing an implant |
BR112015023641A2 (pt) | 2013-03-15 | 2017-07-18 | Miromatrix Medical Inc | uso de micropartículas e células endotelial com descelularização de órgãos e tecidos |
GB201310773D0 (en) | 2013-06-17 | 2013-07-31 | Northwick Park Inst For Medcal Res Ltd | Implant and method of producing an implant |
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2017
- 2017-02-10 BR BR112018016050-4A patent/BR112018016050B1/pt active IP Right Grant
- 2017-02-10 US US16/076,990 patent/US11045582B2/en active Active
- 2017-02-10 AU AU2017218476A patent/AU2017218476B2/en active Active
- 2017-02-10 CN CN201780023019.XA patent/CN109152863A/zh active Pending
- 2017-02-10 CA CA3014256A patent/CA3014256C/en active Active
- 2017-02-10 ES ES17749878T patent/ES2953657T3/es active Active
- 2017-02-10 MX MX2018009551A patent/MX2018009551A/es unknown
- 2017-02-10 JP JP2018541257A patent/JP6957486B2/ja active Active
- 2017-02-10 WO PCT/CA2017/050163 patent/WO2017136950A1/en active Application Filing
- 2017-02-10 EP EP17749878.9A patent/EP3413939B1/en active Active
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- 2021-09-29 US US17/488,454 patent/US12138364B2/en active Active
- 2021-10-06 JP JP2021164938A patent/JP2022002536A/ja active Pending
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EP3413939A4 (en) | 2019-10-30 |
IL284915A (en) | 2021-08-31 |
US11167062B2 (en) | 2021-11-09 |
EP3413939B1 (en) | 2023-06-07 |
JP2022002536A (ja) | 2022-01-11 |
AU2022200696B2 (en) | 2023-09-28 |
BR112018016050B1 (pt) | 2022-04-12 |
US20220016317A1 (en) | 2022-01-20 |
ES2953657T3 (es) | 2023-11-15 |
WO2017136950A1 (en) | 2017-08-17 |
AU2022200696A1 (en) | 2022-02-24 |
EP3413939C0 (en) | 2023-06-07 |
US20210001007A1 (en) | 2021-01-07 |
BR112018016050A2 (pt) | 2018-12-26 |
CN109152863A (zh) | 2019-01-04 |
IL284915B (en) | 2022-02-01 |
EP3413939A1 (en) | 2018-12-19 |
CA3014256A1 (en) | 2017-08-17 |
AU2017218476A1 (en) | 2018-09-27 |
AU2017218476B2 (en) | 2022-02-17 |
US20190060520A1 (en) | 2019-02-28 |
JP2019509723A (ja) | 2019-04-11 |
US11045582B2 (en) | 2021-06-29 |
CA3014256C (en) | 2024-04-23 |
US12138364B2 (en) | 2024-11-12 |
IL260993B (en) | 2021-08-31 |
JP6957486B2 (ja) | 2021-11-02 |
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