MX2016015181A - Combinacion de un anticuerpo del receptor 4 de quimiocina anti-cc y un agonista de 4-1 bb para el tratamiento del cancer. - Google Patents
Combinacion de un anticuerpo del receptor 4 de quimiocina anti-cc y un agonista de 4-1 bb para el tratamiento del cancer.Info
- Publication number
- MX2016015181A MX2016015181A MX2016015181A MX2016015181A MX2016015181A MX 2016015181 A MX2016015181 A MX 2016015181A MX 2016015181 A MX2016015181 A MX 2016015181A MX 2016015181 A MX2016015181 A MX 2016015181A MX 2016015181 A MX2016015181 A MX 2016015181A
- Authority
- MX
- Mexico
- Prior art keywords
- agonist
- combination
- treating cancer
- ccr4 antibody
- antibody
- Prior art date
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
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- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
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- A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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- C07—ORGANIC CHEMISTRY
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- C07K16/303—Liver or Pancreas
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3038—Kidney, bladder
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- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
- C07K16/3046—Stomach, Intestines
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- C07—ORGANIC CHEMISTRY
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- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K16/3053—Skin, nerves, brain
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- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
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- C07K2317/565—Complementarity determining region [CDR]
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- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
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- Chemical & Material Sciences (AREA)
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- Medicinal Preparation (AREA)
Abstract
La presente descripción describe terapias de combinación que comprenden un anticuerpo que se une específicamente a CCR4 humano y un agonista selectivo de 4-1BB, y el uso de las terapias de combinación para el tratamiento de cáncer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201462001534P | 2014-05-21 | 2014-05-21 | |
PCT/US2015/031081 WO2015179236A1 (en) | 2014-05-21 | 2015-05-15 | Combination of an anti-ccr4 antibody and a 4-1bb agonist for treating cancer |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2016015181A true MX2016015181A (es) | 2017-05-25 |
Family
ID=53284562
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2016015181A MX2016015181A (es) | 2014-05-21 | 2015-05-15 | Combinacion de un anticuerpo del receptor 4 de quimiocina anti-cc y un agonista de 4-1 bb para el tratamiento del cancer. |
Country Status (12)
Country | Link |
---|---|
US (1) | US10023649B2 (es) |
EP (1) | EP3145956A1 (es) |
JP (1) | JP2017517506A (es) |
KR (1) | KR20170004006A (es) |
CN (1) | CN106413751A (es) |
AU (1) | AU2015264528A1 (es) |
BR (1) | BR112016026993A2 (es) |
CA (1) | CA2949214A1 (es) |
IL (1) | IL248540A0 (es) |
MX (1) | MX2016015181A (es) |
RU (1) | RU2016146993A (es) |
WO (1) | WO2015179236A1 (es) |
Families Citing this family (31)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR101503341B1 (ko) | 2014-03-12 | 2015-03-18 | 국립암센터 | 자가암항원 특이적 cd8+ t 세포의 분리 및 증식방법 |
MX2018008995A (es) * | 2016-01-25 | 2019-01-10 | Pfizer | Combinacion de un agonista de ox40 y un agonista de 4-1bb para tratar el cancer. |
SG11201810509PA (en) | 2016-06-20 | 2018-12-28 | Kymab Ltd | Anti-pd-l1 antibodies |
JP7080234B2 (ja) * | 2016-11-23 | 2022-06-03 | トランスレイショナル・ドラッグ・ディベロップメント・エルエルシー | ベンズアミドおよび活性化合物組成物および使用方法 |
SG10201914064QA (en) | 2017-01-06 | 2020-03-30 | Eutilex Co Ltd | Anti-human 4-1 bb antibodies and use thereof |
ES2776926T3 (es) * | 2017-03-29 | 2020-08-03 | Shionogi & Co | Composición medicinal para tratamiento del cáncer |
WO2018226336A1 (en) | 2017-06-09 | 2018-12-13 | Providence Health & Services - Oregon | Utilization of cd39 and cd103 for identification of human tumor reactive cells for treatment of cancer |
KR102714165B1 (ko) | 2017-07-11 | 2024-10-10 | 콤파스 테라퓨틱스 엘엘씨 | 인간 cd137에 결합하는 작동자 항체 및 이의 용도 |
WO2019072274A1 (zh) * | 2017-10-12 | 2019-04-18 | 瑞阳(苏州)生物科技有限公司 | 一种激动型4-1bb单克隆抗体 |
CN109651507B (zh) | 2017-10-12 | 2021-11-26 | 瑞阳(苏州)生物科技有限公司 | 一种激动型4-1bb单克隆抗体 |
WO2019089753A2 (en) | 2017-10-31 | 2019-05-09 | Compass Therapeutics Llc | Cd137 antibodies and pd-1 antagonists and uses thereof |
CN111918652A (zh) | 2017-11-06 | 2020-11-10 | 拉普特医疗公司 | 用于治疗eb病毒阳性的癌症的趋化因子受体调节剂 |
WO2019100052A2 (en) | 2017-11-20 | 2019-05-23 | Compass Therapeutics Llc | Cd137 antibodies and tumor antigen-targeting antibodies and uses thereof |
WO2019109238A1 (en) | 2017-12-05 | 2019-06-13 | Lyvgen Biopharma Co., Ltd. | Anti-cd137 antibodies and uses thereof |
US20210363266A1 (en) * | 2018-01-22 | 2021-11-25 | Jiangsu Hengrui Medicine Co., Ltd. | Anti-4-1bb antibody, antigen-binding fragment thereof and medical use thereof |
AU2019236372B2 (en) * | 2018-03-13 | 2024-06-20 | F. Hoffmann-La Roche Ag | Therapeutic combination of 4-1 BB agonists with anti-CD20 antibodies |
WO2019196868A1 (en) * | 2018-04-10 | 2019-10-17 | Wuxi Biologics (Shanghai) Co., Ltd. | A monoclonal antibody against human 4-1bb, method for preparing the same, and use thereof |
WO2019241730A2 (en) | 2018-06-15 | 2019-12-19 | Flagship Pioneering Innovations V, Inc. | Increasing immune activity through modulation of postcellular signaling factors |
KR20220003572A (ko) | 2019-04-24 | 2022-01-10 | 하이델베르크 파마 리서치 게엠베하 | 아마톡신 항체-약물 결합체 및 이의 용도 |
WO2020227159A2 (en) | 2019-05-03 | 2020-11-12 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity |
EP3966252A4 (en) | 2019-05-10 | 2023-01-25 | Lyvgen Biopharma Holdings Limited | HUMANIZED ANTI-CD137 ANTIBODIES AND THEIR USES |
US20230114107A1 (en) | 2019-12-17 | 2023-04-13 | Flagship Pioneering Innovations V, Inc. | Combination anti-cancer therapies with inducers of iron-dependent cellular disassembly |
EP4090675A4 (en) * | 2020-01-13 | 2024-02-21 | CytoDyn Inc. | CCR5 BINDING AGENT FOR THE TREATMENT OF CCR5-POSITIVE METASTATIC BREAST CANCER |
PE20231067A1 (es) * | 2020-02-14 | 2023-07-17 | Jounce Therapeutics Inc | Anticuerpos y proteinas de fusion que se unen a ccr8 y usos de estos |
WO2022006179A1 (en) | 2020-06-29 | 2022-01-06 | Flagship Pioneering Innovations V, Inc. | Viruses engineered to promote thanotransmission and their use in treating cancer |
CA3198591A1 (en) * | 2020-10-13 | 2022-04-21 | Board Of Regents, The University Of Texas System | Combinatorial immunotherapeutic methods and compositions for pancreatic ductal adenocarcinoma treatment |
EP4313109A1 (en) | 2021-03-31 | 2024-02-07 | Flagship Pioneering Innovations V, Inc. | Thanotransmission polypeptides and their use in treating cancer |
CA3218590A1 (en) | 2021-06-07 | 2022-12-15 | Providence Health & Services - Oregon | Cxcr5, pd-1, and icos expressing tumor reactive cd4 t cells and their use |
WO2023278641A1 (en) | 2021-06-29 | 2023-01-05 | Flagship Pioneering Innovations V, Inc. | Immune cells engineered to promote thanotransmission and uses thereof |
US20240174732A1 (en) | 2022-10-05 | 2024-05-30 | Flagship Pioneering Innovations V, Inc. | Nucleic acid molecules encoding trif and additional polypeptides and their use in treating cancer |
WO2024151687A1 (en) | 2023-01-09 | 2024-07-18 | Flagship Pioneering Innovations V, Inc. | Genetic switches and their use in treating cancer |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
ATE477273T1 (de) | 1998-12-01 | 2010-08-15 | Facet Biotech Corp | Humanisierte antikoerper gegen gamma-interferon |
CN1296960A (zh) * | 1999-11-22 | 2001-05-30 | 上海博容基因开发有限公司 | 一种新的多肽——人ccr4相关蛋白31和编码这种多肽的多核苷酸 |
DK1449850T3 (da) | 2001-08-31 | 2011-02-14 | Kyowa Hakko Kirin Co Ltd | Humane CDR-graftede antistoffer eller antistoffragmenter deraf |
CA2492561A1 (en) * | 2002-07-15 | 2004-01-22 | Mayo Foundation For Medical Education And Research | Treatment and prophylaxis with 4-1bb-binding agents |
AU2004294842B2 (en) | 2003-12-04 | 2010-05-13 | Kyowa Kirin Co., Ltd. | Medicine containing genetically modified antibody against chemokine receptor CCR4 |
GB0409799D0 (en) * | 2004-04-30 | 2004-06-09 | Isis Innovation | Method of generating improved immune response |
WO2006055697A2 (en) | 2004-11-17 | 2006-05-26 | Board Of Regents, The University Of Texas System | Cancer immunotherapy incorporating p53 |
WO2006088447A1 (en) * | 2005-02-15 | 2006-08-24 | Gtc Biotherapeutics, Inc. | An anti-cd137 antibody as an agent in the treatement of cancer and glycosylation variants thereof |
WO2006129163A1 (en) | 2005-06-03 | 2006-12-07 | Pfizer Products Inc. | Combinations of erbb2 inhibitors with other therapeutic agents in the treatment of cancer |
US8962806B2 (en) | 2007-12-28 | 2015-02-24 | Dana-Farber Cancer Institute, Inc. | Humanized monoclonal antibodies and methods of use |
GB0909906D0 (en) * | 2009-06-09 | 2009-07-22 | Affitech As | Antibodies |
NZ714128A (en) * | 2010-09-09 | 2017-10-27 | Pfizer | 4-1bb binding molecules |
MX361929B (es) | 2010-11-19 | 2018-12-19 | Eisai R&D Man Co Ltd Star | Anticuerpos anti-ligando de quimiocina cc 20 (ccl20) neutralizantes. |
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2015
- 2015-05-15 KR KR1020167035347A patent/KR20170004006A/ko unknown
- 2015-05-15 JP JP2016568497A patent/JP2017517506A/ja active Pending
- 2015-05-15 CN CN201580027437.7A patent/CN106413751A/zh active Pending
- 2015-05-15 BR BR112016026993A patent/BR112016026993A2/pt not_active Application Discontinuation
- 2015-05-15 EP EP15727159.4A patent/EP3145956A1/en not_active Withdrawn
- 2015-05-15 RU RU2016146993A patent/RU2016146993A/ru not_active Application Discontinuation
- 2015-05-15 MX MX2016015181A patent/MX2016015181A/es unknown
- 2015-05-15 AU AU2015264528A patent/AU2015264528A1/en not_active Abandoned
- 2015-05-15 CA CA2949214A patent/CA2949214A1/en not_active Abandoned
- 2015-05-15 WO PCT/US2015/031081 patent/WO2015179236A1/en active Application Filing
- 2015-05-15 US US15/312,515 patent/US10023649B2/en not_active Expired - Fee Related
-
2016
- 2016-10-27 IL IL248540A patent/IL248540A0/en unknown
Also Published As
Publication number | Publication date |
---|---|
JP2017517506A (ja) | 2017-06-29 |
BR112016026993A2 (pt) | 2017-10-31 |
WO2015179236A1 (en) | 2015-11-26 |
IL248540A0 (en) | 2016-12-29 |
EP3145956A1 (en) | 2017-03-29 |
US10023649B2 (en) | 2018-07-17 |
RU2016146993A (ru) | 2018-06-21 |
KR20170004006A (ko) | 2017-01-10 |
CA2949214A1 (en) | 2015-11-26 |
AU2015264528A1 (en) | 2016-11-03 |
US20170088627A1 (en) | 2017-03-30 |
CN106413751A (zh) | 2017-02-15 |
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