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MX2016013668A - Inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. - Google Patents

Inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.

Info

Publication number
MX2016013668A
MX2016013668A MX2016013668A MX2016013668A MX2016013668A MX 2016013668 A MX2016013668 A MX 2016013668A MX 2016013668 A MX2016013668 A MX 2016013668A MX 2016013668 A MX2016013668 A MX 2016013668A MX 2016013668 A MX2016013668 A MX 2016013668A
Authority
MX
Mexico
Prior art keywords
irak inhibitors
inhibitors
irak
compounds
compositions
Prior art date
Application number
MX2016013668A
Other languages
English (en)
Inventor
E Masse Craig
robert greenwood Jeremy
L Romero Donna
Robinson Shaughnessy
Shelley Mee
C Harriman Geraldine
Original Assignee
Nimbus Iris Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Nimbus Iris Inc filed Critical Nimbus Iris Inc
Publication of MX2016013668A publication Critical patent/MX2016013668A/es

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    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
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    • C07D239/70—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings condensed with carbocyclic rings or ring systems
    • C07D239/72—Quinazolines; Hydrogenated quinazolines
    • C07D239/86—Quinazolines; Hydrogenated quinazolines with hetero atoms directly attached in position 4
    • C07D239/94—Nitrogen atoms
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
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Abstract

La presente invención se refiere a compuestos de quinazolina y quinolina, composiciones de los mismos, y métodos para usar los mismos. También se describe la actividad de tales compuestos como inhibidores de las enzimas de IRAK.
MX2016013668A 2014-04-22 2015-04-21 Inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos. MX2016013668A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201461982645P 2014-04-22 2014-04-22
PCT/US2015/026876 WO2015164374A1 (en) 2014-04-22 2015-04-21 Irak inhibitors and uses thereof

Publications (1)

Publication Number Publication Date
MX2016013668A true MX2016013668A (es) 2017-01-20

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MX2016013668A MX2016013668A (es) 2014-04-22 2015-04-21 Inhibidores de cinasas asociadas al receptor de interleucina-1 (irak) y usos de los mismos.

Country Status (11)

Country Link
US (1) US20150329498A1 (es)
EP (1) EP3134091A4 (es)
JP (1) JP2017513954A (es)
KR (1) KR20160145803A (es)
CN (1) CN106413715A (es)
BR (1) BR112016024414A2 (es)
CA (1) CA2945819A1 (es)
MX (1) MX2016013668A (es)
RU (1) RU2016140870A (es)
TW (1) TW201625556A (es)
WO (1) WO2015164374A1 (es)

Families Citing this family (37)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016053769A1 (en) 2014-09-30 2016-04-07 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
WO2016053771A1 (en) * 2014-09-30 2016-04-07 Merck Sharp & Dohme Corp. Inhibitors of irak4 activity
MX2018004109A (es) 2015-10-05 2018-09-27 Univ Columbia Activadores de flujo autofágico y fosfolipasa d y depuración de acumulaciones de proteína que incluyen tau y tratamiento de proteinopatías.
SG10201508795XA (en) * 2015-10-23 2017-05-30 Agency Science Tech & Res Method for treating cancer
JP2019519485A (ja) * 2016-05-04 2019-07-11 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ インドールアミン２，３−ジオキシゲナーゼ阻害剤およびその使用方法
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