MX2015005637A - Tratamiento o prevención de eventos cardiovasculares mediante la administración de un derivado de colchicina. - Google Patents
Tratamiento o prevención de eventos cardiovasculares mediante la administración de un derivado de colchicina.Info
- Publication number
- MX2015005637A MX2015005637A MX2015005637A MX2015005637A MX2015005637A MX 2015005637 A MX2015005637 A MX 2015005637A MX 2015005637 A MX2015005637 A MX 2015005637A MX 2015005637 A MX2015005637 A MX 2015005637A MX 2015005637 A MX2015005637 A MX 2015005637A
- Authority
- MX
- Mexico
- Prior art keywords
- alkyl
- prevention
- treatment
- optionally substituted
- formula
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/16—Amides, e.g. hydroxamic acids
- A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/366—Lactones having six-membered rings, e.g. delta-lactones
- A61K31/37—Coumarins, e.g. psoralen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/4365—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system having sulfur as a ring hetero atom, e.g. ticlopidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/60—Salicylic acid; Derivatives thereof
- A61K31/612—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid
- A61K31/616—Salicylic acid; Derivatives thereof having the hydroxy group in position 2 esterified, e.g. salicylsulfuric acid by carboxylic acids, e.g. acetylsalicylic acid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Urology & Nephrology (AREA)
- Vascular Medicine (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Rheumatology (AREA)
- Pain & Pain Management (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Dermatology (AREA)
Abstract
Un método de tratamiento o prevención de un evento cardiovascular en un sujeto con enfermedad vascular ateroesclerótica que comprende los pasos de: b) administrar una cantidad terapéuticamente efectiva de un compuesto de la fórmula (I), un derivado de colchicina conocido y/o una sal del mismo (ver Fórmula) en la cual: R1, R2, R3, R4, R9, R10, R11 y R12 representan independientemente hidrógeno, C1-4 alquilo, C2-4 alquenilo, C3-6 cicloalquilo, halógeno, C1-4 haloalquilo, nitro, amino, C2-4 acilamino, C1-4 alquilo o dialquilamino, hidroxilo, C1-4 alcoxi, C1-4 alquiltio, un grupo de la fórmula - SO2N(Rx)2 o SO2RX donde Rx es C1-4 alquilo, C1-4 aciloxi, o fenilo opcionalmente sustituido, fenoxi opcionalmente sustituido; R7 y R8 representan independientemente hidrógeno, C1-4 alquilo o C1-4 acilo; y R5', R5'', R6' y R6'' representan independientemente hidrógeno, C1-4 alquilo, C2-4 alquenilo, C3-6 cicloalquilo, halógeno, C1-4 haloalquilo, nitro, amino, C2-4 acilamino, hidroxilo, C1-4 alcoxi o C1-4 alquiltio un grupo de la fórmula -SO2N(Rx)2 o SO2RX donde Rx es C1-4 alquilo, C1-4 aciloxi, o fenilo opcionalmente sustituido.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2012904828A AU2012904828A0 (en) | 2012-11-02 | Treatment and Prevention of Coronary Thrombosis | |
| AU2012904868A AU2012904868A0 (en) | 2012-11-05 | Treatment or Prevention of Cardiovascular Events | |
| PCT/AU2013/001261 WO2014066944A1 (en) | 2012-11-02 | 2013-11-01 | Treatment or prevention of cardiovascular events via the administration of a colchicine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX2015005637A true MX2015005637A (es) | 2016-02-03 |
Family
ID=50626218
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009511A MX2020009511A (es) | 2012-11-02 | 2013-11-01 | Tratamiento o prevención de eventos cardiovasculares. |
| MX2015005637A MX2015005637A (es) | 2012-11-02 | 2013-11-01 | Tratamiento o prevención de eventos cardiovasculares mediante la administración de un derivado de colchicina. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2020009511A MX2020009511A (es) | 2012-11-02 | 2013-11-01 | Tratamiento o prevención de eventos cardiovasculares. |
Country Status (24)
| Country | Link |
|---|---|
| US (15) | US10265281B2 (es) |
| EP (2) | EP3964205A1 (es) |
| JP (1) | JP6356684B2 (es) |
| KR (5) | KR20240074883A (es) |
| CN (2) | CN104918613B (es) |
| AU (5) | AU2013337605B2 (es) |
| BR (1) | BR112015010063B1 (es) |
| CA (1) | CA2894417C (es) |
| CL (1) | CL2015001154A1 (es) |
| DK (1) | DK2914255T3 (es) |
| EA (1) | EA032515B1 (es) |
| ES (1) | ES2900740T3 (es) |
| HR (1) | HRP20211644T1 (es) |
| HU (1) | HUE056810T2 (es) |
| IL (1) | IL238519B (es) |
| LT (1) | LT2914255T (es) |
| MX (2) | MX2020009511A (es) |
| MY (1) | MY177898A (es) |
| NZ (2) | NZ747657A (es) |
| PL (1) | PL2914255T3 (es) |
| PT (1) | PT2914255T (es) |
| SG (2) | SG10201703586PA (es) |
| SI (1) | SI2914255T1 (es) |
| WO (1) | WO2014066944A1 (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3964205A1 (en) | 2012-11-02 | 2022-03-09 | Murray & Poole Enterprises, Ltd | Treatment or prevention of cardiovascular events |
| MA38576B2 (fr) | 2013-11-26 | 2020-02-28 | Murray And Poole Enterprises Ltd | Formulations de colchicine à libération prolongée et procédés d'utilisation de ces dernières |
| WO2016166732A1 (en) * | 2015-04-17 | 2016-10-20 | Murray And Poole Enterprises Limited | Colchicine salicylate and uses thereof |
| US9907751B2 (en) | 2016-03-10 | 2018-03-06 | RxOMEG Therapeutics LLC | Composition and method of use of colchicine oral liquid |
| US10226423B1 (en) | 2017-12-20 | 2019-03-12 | RxOMEG Therapeutics LLC | Colchicine drug-to-drug interactions |
| EP3746061A1 (en) | 2018-02-02 | 2020-12-09 | Murray & Poole Enterprises, Ltd | Use of colchicine to inhibit tumor growth and metastases |
| KR102112456B1 (ko) | 2019-11-13 | 2020-05-19 | 주식회사 에이스바이오메드 | 간 질환 치료용 또는 치료 효과 증진을 위한 콜히친 복합제제 |
| EP3821889A1 (en) * | 2019-11-15 | 2021-05-19 | Institut de Cardiologie de Montréal | Methods for using low-dose colchicine after myocarial infarction |
| CA3187080A1 (en) | 2019-11-15 | 2021-01-26 | Institut De Cardiologie De Montreal | Early administration of low-dose colchicine after myocardial infarction |
| KR20210095249A (ko) | 2020-01-22 | 2021-08-02 | 주식회사 에이스바이오메드 | 간 질환 치료용 또는 치료 효과 증진을 위한 콜히친 복합제제 |
| KR102150821B1 (ko) | 2020-01-22 | 2020-09-03 | 주식회사 에이스바이오메드 | 간 질환 치료용 또는 치료 효과 증진을 위한 콜히친 복합제제 |
| KR102177781B1 (ko) | 2020-04-27 | 2020-11-12 | 주식회사 에이스바이오메드 | 간 질환 치료용 또는 치료 효과 증진을 위한 콜히친, 우르소데옥시콜산 및 비페닐디메틸디카르복실레이트의 복합제제 |
| WO2022132786A1 (en) * | 2020-12-15 | 2022-06-23 | Romeg Therapeutics Llc | Methods and compositions for treating pericarditis |
| WO2022212655A1 (en) * | 2021-03-31 | 2022-10-06 | Amarin Pharmaceuticals Ireland Limited | Compositions comprising epa and colchicine and methods of using the same for reducing the risk of cardiovascular events in a subject |
| US11986452B2 (en) | 2021-04-21 | 2024-05-21 | Amarin Pharmaceuticals Ireland Limited | Methods of reducing the risk of heart failure |
| CN114656429A (zh) * | 2021-11-18 | 2022-06-24 | 江苏新元素医药科技有限公司 | 一类抗炎镇痛化合物及其用途 |
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| KR20150002799A (ko) | 2012-04-13 | 2015-01-07 | 사이머베이 쎄라퓨틱스, 인코퍼레이티드 | 할로페네이트 또는 할로펜산 및 소염제를 이용한 통풍 환자에서의 고요산혈증 치료 방법 |
| EP3964205A1 (en) | 2012-11-02 | 2022-03-09 | Murray & Poole Enterprises, Ltd | Treatment or prevention of cardiovascular events |
| MA38576B2 (fr) | 2013-11-26 | 2020-02-28 | Murray And Poole Enterprises Ltd | Formulations de colchicine à libération prolongée et procédés d'utilisation de ces dernières |
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2013
- 2013-11-01 EP EP21185610.9A patent/EP3964205A1/en active Pending
- 2013-11-01 KR KR1020247015728A patent/KR20240074883A/ko active Application Filing
- 2013-11-01 EA EA201500484A patent/EA032515B1/ru unknown
- 2013-11-01 NZ NZ747657A patent/NZ747657A/en unknown
- 2013-11-01 JP JP2015539999A patent/JP6356684B2/ja active Active
- 2013-11-01 SG SG10201703586PA patent/SG10201703586PA/en unknown
- 2013-11-01 KR KR1020217042615A patent/KR20220001518A/ko not_active Application Discontinuation
- 2013-11-01 KR KR1020217004356A patent/KR20210020170A/ko active Application Filing
- 2013-11-01 HR HRP20211644TT patent/HRP20211644T1/hr unknown
- 2013-11-01 NZ NZ707640A patent/NZ707640A/en unknown
- 2013-11-01 CN CN201380069087.1A patent/CN104918613B/zh active Active
- 2013-11-01 SI SI201331938T patent/SI2914255T1/sl unknown
- 2013-11-01 PT PT13851803T patent/PT2914255T/pt unknown
- 2013-11-01 KR KR1020157014487A patent/KR20150102969A/ko active Application Filing
- 2013-11-01 SG SG11201503440UA patent/SG11201503440UA/en unknown
- 2013-11-01 HU HUE13851803A patent/HUE056810T2/hu unknown
- 2013-11-01 CN CN201810381444.2A patent/CN108721265B/zh active Active
- 2013-11-01 BR BR112015010063-5A patent/BR112015010063B1/pt active IP Right Grant
- 2013-11-01 KR KR1020237010301A patent/KR102666548B1/ko active IP Right Grant
- 2013-11-01 AU AU2013337605A patent/AU2013337605B2/en active Active
- 2013-11-01 EP EP13851803.0A patent/EP2914255B1/en active Active
- 2013-11-01 US US14/440,147 patent/US10265281B2/en active Active
- 2013-11-01 PL PL13851803T patent/PL2914255T3/pl unknown
- 2013-11-01 MX MX2020009511A patent/MX2020009511A/es unknown
- 2013-11-01 ES ES13851803T patent/ES2900740T3/es active Active
- 2013-11-01 DK DK13851803.0T patent/DK2914255T3/da active
- 2013-11-01 MY MYPI2015001141A patent/MY177898A/en unknown
- 2013-11-01 CA CA2894417A patent/CA2894417C/en active Active
- 2013-11-01 MX MX2015005637A patent/MX2015005637A/es active IP Right Grant
- 2013-11-01 LT LTEPPCT/AU2013/001261T patent/LT2914255T/lt unknown
- 2013-11-01 WO PCT/AU2013/001261 patent/WO2014066944A1/en active Application Filing
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2015
- 2015-01-22 US US14/603,085 patent/US20150196514A1/en not_active Abandoned
- 2015-01-22 US US14/603,049 patent/US9744144B2/en active Active
- 2015-04-29 IL IL238519A patent/IL238519B/en active IP Right Grant
- 2015-04-30 CL CL2015001154A patent/CL2015001154A1/es unknown
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2017
- 2017-07-28 US US15/663,148 patent/US10206891B2/en active Active
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2018
- 2018-05-25 AU AU2018203715A patent/AU2018203715B2/en active Active
- 2018-12-21 US US16/229,504 patent/US20190117598A1/en not_active Abandoned
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2019
- 2019-04-22 US US16/390,606 patent/US10842761B2/en active Active
- 2019-08-26 US US16/550,692 patent/US10842762B2/en active Active
- 2019-09-19 AU AU2019232879A patent/AU2019232879B2/en active Active
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2020
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2021
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2023
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