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MX2014010494A - Derivados de pirazolo-triazina como inhibidores selectivos de cinasas dependientes de ciclina. - Google Patents

Derivados de pirazolo-triazina como inhibidores selectivos de cinasas dependientes de ciclina.

Info

Publication number
MX2014010494A
MX2014010494A MX2014010494A MX2014010494A MX2014010494A MX 2014010494 A MX2014010494 A MX 2014010494A MX 2014010494 A MX2014010494 A MX 2014010494A MX 2014010494 A MX2014010494 A MX 2014010494A MX 2014010494 A MX2014010494 A MX 2014010494A
Authority
MX
Mexico
Prior art keywords
pyrazolo
triazine derivatives
diseases
inhinitors
dependent kinase
Prior art date
Application number
MX2014010494A
Other languages
English (en)
Other versions
MX347359B (es
Inventor
Jan Eickhoff
Gunther Zischinsky
Uwe Koch
Original Assignee
Lead Discovery Center Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Lead Discovery Center Gmbh filed Critical Lead Discovery Center Gmbh
Publication of MX2014010494A publication Critical patent/MX2014010494A/es
Publication of MX347359B publication Critical patent/MX347359B/es

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
    • C07D491/107—Spiro-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
    • A—HUMAN NECESSITIES
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    • A61P35/00—Antineoplastic agents
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    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • A61P9/00—Drugs for disorders of the cardiovascular system
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    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/10—Spiro-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00

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Abstract

La presente invención se refiere a derivados de pirazolo[1,5-a] [1,3,5] triazina y/o sales farmacéuticamente aceptables de los mismos; el uso de estos derivados como agentes farmacéuticamente activos, especialmente para la profilaxis y/o tratamiento de enfermedades infecciosas, incluidas las enfermedades oportunistas, enfermedades inmunológicas, enfermedades autoinmunes, enfermedades cardiovasculares, enfermedades proliferativas celulares, inflamación, disfunción eréctil y accidente cerebrovascular; y composiciones farmacéuticas que contienen al menos uno de dichos derivados de pirazolo[1,5-a] [1,3,5] triazina y/o sales farmacéuticamente aceptables de los mismos. Además, la presente invención se refiere al uso de dichos derivados de pirazolo [1,5-a] [1,3,5] triazina como inhibidores de una proteína cinasa.
MX2014010494A 2012-03-01 2013-03-01 Derivados de pirazolo-triazina como inhibidores selectivos de cinasas dependientes de ciclina. MX347359B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP12157751.4A EP2634190A1 (en) 2012-03-01 2012-03-01 Pyrazolo-triazine derivatives as selective cyclin-dependent kinase inhinitors
PCT/EP2013/054224 WO2013128028A1 (en) 2012-03-01 2013-03-01 Pyrazolo - triazine derivatives as selective cyclin- dependent kinase inhinitors

Publications (2)

Publication Number Publication Date
MX2014010494A true MX2014010494A (es) 2015-04-08
MX347359B MX347359B (es) 2017-04-06

Family

ID=47757629

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MX2014010494A MX347359B (es) 2012-03-01 2013-03-01 Derivados de pirazolo-triazina como inhibidores selectivos de cinasas dependientes de ciclina.

Country Status (18)

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US (1) US9567345B2 (es)
EP (2) EP2634190A1 (es)
JP (1) JP6182549B2 (es)
KR (1) KR101821452B1 (es)
CN (1) CN104350054B (es)
AU (1) AU2013224848B2 (es)
BR (1) BR112014021189B1 (es)
CA (1) CA2865946C (es)
DK (1) DK2820020T3 (es)
ES (1) ES2583231T3 (es)
HK (1) HK1206014A1 (es)
HU (1) HUE029264T2 (es)
IL (1) IL234183A (es)
MX (1) MX347359B (es)
RU (1) RU2645347C2 (es)
SG (1) SG11201405129RA (es)
WO (1) WO2013128028A1 (es)
ZA (1) ZA201406078B (es)

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TW202146416A (zh) * 2019-12-11 2021-12-16 德商拜耳廠股份有限公司 吡唑并三𠯤
GB201918541D0 (en) * 2019-12-16 2020-01-29 Carrick Therapeutics Ltd Therapeutic compounds and their use
CN110950871B (zh) * 2019-12-25 2022-05-17 陕西师范大学 2-取代-4-芳氨基吡唑并三嗪衍生物及制备抗肿瘤药物的应用
WO2022136174A1 (en) * 2020-12-21 2022-06-30 Janssen Pharmaceutica Nv Tricyclic pyrimidines as cyclin-dependent kinase 7 (cdk7) inhibitors
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US20150018329A1 (en) 2015-01-15
CN104350054B (zh) 2017-06-13
CA2865946C (en) 2020-01-21
HK1206014A1 (en) 2015-12-31
ES2583231T3 (es) 2016-09-19
IL234183A (en) 2016-11-30
MX347359B (es) 2017-04-06
WO2013128028A8 (en) 2014-10-02
JP6182549B2 (ja) 2017-08-16
KR20140131994A (ko) 2014-11-14
WO2013128028A1 (en) 2013-09-06
SG11201405129RA (en) 2014-09-26
CA2865946A1 (en) 2013-09-06
US9567345B2 (en) 2017-02-14
DK2820020T3 (en) 2016-07-04
HUE029264T2 (en) 2017-02-28
JP2015511952A (ja) 2015-04-23
AU2013224848B2 (en) 2017-06-29
BR112014021189B1 (pt) 2022-08-16
RU2014139705A (ru) 2016-04-20
ZA201406078B (en) 2016-08-31
AU2013224848A1 (en) 2014-08-28
CN104350054A (zh) 2015-02-11
EP2820020B1 (en) 2016-04-06
BR112014021189A2 (es) 2017-06-20
RU2645347C2 (ru) 2018-02-21
EP2820020A1 (en) 2015-01-07
EP2634190A1 (en) 2013-09-04
KR101821452B1 (ko) 2018-01-23

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