MX2014008019A - Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. - Google Patents
Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo.Info
- Publication number
- MX2014008019A MX2014008019A MX2014008019A MX2014008019A MX2014008019A MX 2014008019 A MX2014008019 A MX 2014008019A MX 2014008019 A MX2014008019 A MX 2014008019A MX 2014008019 A MX2014008019 A MX 2014008019A MX 2014008019 A MX2014008019 A MX 2014008019A
- Authority
- MX
- Mexico
- Prior art keywords
- chloro
- fluoro
- carboxylate
- methoxyphenyl
- pyridine
- Prior art date
Links
- KDHKOPYYWOHESS-UHFFFAOYSA-N halauxifen-methyl Chemical compound NC1=C(Cl)C(C(=O)OC)=NC(C=2C(=C(OC)C(Cl)=CC=2)F)=C1 KDHKOPYYWOHESS-UHFFFAOYSA-N 0.000 title abstract 3
- GDJCQSNQOHRAGY-UHFFFAOYSA-N (4-chloro-2-fluoro-3-methoxyphenyl)boronic acid Chemical compound COC1=C(Cl)C=CC(B(O)O)=C1F GDJCQSNQOHRAGY-UHFFFAOYSA-N 0.000 abstract 3
- NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 abstract 2
- UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 abstract 2
- 239000008346 aqueous phase Substances 0.000 abstract 2
- 239000012074 organic phase Substances 0.000 abstract 2
- 239000007864 aqueous solution Substances 0.000 abstract 1
- CSKIJJZFXAACON-UHFFFAOYSA-N methyl 4-acetamido-3,6-dichloropyridine-2-carboxylate Chemical compound COC(=O)C1=NC(Cl)=CC(NC(C)=O)=C1Cl CSKIJJZFXAACON-UHFFFAOYSA-N 0.000 abstract 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
- C07D213/79—Acids; Esters
- C07D213/803—Processes of preparation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
- C07F5/02—Boron compounds
- C07F5/025—Boronic and borinic acid compounds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Pyridine Compounds (AREA)
- Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
Abstract
Métodos para la producción de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 - metoxifenil)piridin-2-carboxilato de metilo. Un método comprende el agregado de metil isobutil cetona a una solución acuosa que comprende ácido 4-cloro-2-fluor-3- metoxifenil- bórico para formar una fase orgánica que comprende el ácido 4-cloro-2-fluor-3-metoxifenil bórico y una fase acuosa. La fase orgánica y la fase acuosa se separan. El ácido 4-cloro-2-fluor-3-metoxifenilbórico se hace reaccionar con 4-(acetilamino)-3,6-dicloropiridin-2-carboxilato de metilo en metil isobutil cetona para producir 4-(acetilamino)-3-cloro-6-(4-c loro-2-fluor-3-metoxifenil)piridin-2- carboxilato de metilo, que se desacetila para producir 4-amino-3-cloro-6-(4-cloro-2-fluor-3-m etoxifenilo)piridin-2-carboxilato de metilo.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161582166P | 2011-12-30 | 2011-12-30 | |
| PCT/US2012/072071 WO2013102078A1 (en) | 2011-12-30 | 2012-12-28 | Methods of producing methyl 4-amino-3-chloro-6-(4-chloro-2-fluoro-3-methoxyphenyl)pyridine-2-carboxylate |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014008019A true MX2014008019A (es) | 2014-12-08 |
| MX340947B MX340947B (es) | 2016-08-01 |
Family
ID=48695351
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2014008019A MX340947B (es) | 2011-12-30 | 2012-12-28 | Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US8754110B2 (es) |
| EP (1) | EP2797890B1 (es) |
| JP (1) | JP6092250B2 (es) |
| KR (1) | KR102065543B1 (es) |
| AR (1) | AR089628A1 (es) |
| AU (1) | AU2012362268B2 (es) |
| BR (1) | BR112014015962B8 (es) |
| CA (1) | CA2861611C (es) |
| CO (1) | CO7010843A2 (es) |
| IL (1) | IL233412B (es) |
| IN (1) | IN2014DN05767A (es) |
| MX (1) | MX340947B (es) |
| NZ (1) | NZ627192A (es) |
| PL (1) | PL2797890T3 (es) |
| RU (1) | RU2616621C2 (es) |
| WO (1) | WO2013102078A1 (es) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6290788B2 (ja) * | 2011-12-30 | 2018-03-07 | ダウ アグロサイエンシィズ エルエルシー | ４−クロロ−２−フルオロ−３−置換−フェニルボロン酸ピナコールエステルの形成方法およびその使用方法 |
| US20140170058A1 (en) * | 2012-12-13 | 2014-06-19 | Dow Agrosciences Llc | Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates |
| CN105899521A (zh) | 2013-09-05 | 2016-08-24 | 陶氏益农公司 | 制备硼基化芳烃的方法 |
| TW201625354A (zh) | 2014-06-16 | 2016-07-16 | 陶氏農業科學公司 | 用於製備氧硼基化芳烴之方法 |
| WO2016191245A1 (en) * | 2015-05-22 | 2016-12-01 | Dow Agrosciences Llc | Recovery and/or reuse of palladium catalyst after a suzuki coupling |
| CN105851037B (zh) * | 2016-05-17 | 2018-09-07 | 陕西上格之路生物科学有限公司 | 一种含氟氯吡啶酯的三元除草组合物 |
| WO2017201377A1 (en) * | 2016-05-19 | 2017-11-23 | Dow Agrosciences Llc | Synthesis of 6-aryl-4-aminopicolinates and 2-aryl-6-aminopyrimidine-4-carboxylates by direct suzuki coupling |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7145040B2 (en) | 2004-07-02 | 2006-12-05 | Bristol-Myers Squibb Co. | Process for the preparation of amino acids useful in the preparation of peptide receptor modulators |
| KR101379625B1 (ko) * | 2006-01-13 | 2014-03-31 | 다우 아그로사이언시즈 엘엘씨 | 6-(다-치환 아릴)-4-아미노피콜리네이트 및 그의제초제로서의 용도 |
| AU2007204887B2 (en) | 2006-01-13 | 2011-06-23 | Corteva Agriscience Llc | 2-(poly-substituted aryl)-6-amino-5-halo-4-pyrimidinecarboxylic acids and their use as herbicides |
| PL2327695T3 (pl) * | 2007-10-02 | 2013-02-28 | Dow Agrosciences Llc | Podstawione kwasy 4-amino-pikolinowe i ich zastosowanie jako herbicydów |
| MX2010007619A (es) | 2008-01-11 | 2010-08-04 | Dow Agrosciences Llc | Proceso para la desprotonacion y funcionalizacion selectiva de 1-fluoro-2-sustituido-3-clorobencenos. |
| GB0902474D0 (en) * | 2009-02-13 | 2009-04-01 | Syngenta Ltd | Chemical compounds |
| US8252938B2 (en) * | 2009-06-08 | 2012-08-28 | Dow Agrosciences, Llc. | Process for the preparation of 6-(aryl)-4-aminopicolinates |
| WO2011063072A2 (en) * | 2009-11-19 | 2011-05-26 | Lexicon Pharmaceuticals, Inc. | Process for the preparation of substituted phenylalanines |
| JP6290788B2 (ja) * | 2011-12-30 | 2018-03-07 | ダウ アグロサイエンシィズ エルエルシー | ４−クロロ−２−フルオロ−３−置換−フェニルボロン酸ピナコールエステルの形成方法およびその使用方法 |
| US20140170058A1 (en) * | 2012-12-13 | 2014-06-19 | Dow Agrosciences Llc | Process for the removal of palladium from 4-amino-3-halo-5-fluoro-6-(aryl) pyridine-2-carboxylates and 4-amino-3-halo-6-(aryl)pyridine-2-carboxylates |
-
2012
- 2012-12-28 NZ NZ627192A patent/NZ627192A/en unknown
- 2012-12-28 PL PL12862450T patent/PL2797890T3/pl unknown
- 2012-12-28 KR KR1020147020894A patent/KR102065543B1/ko active IP Right Grant
- 2012-12-28 WO PCT/US2012/072071 patent/WO2013102078A1/en active Application Filing
- 2012-12-28 BR BR112014015962A patent/BR112014015962B8/pt active IP Right Grant
- 2012-12-28 US US13/729,995 patent/US8754110B2/en active Active
- 2012-12-28 EP EP12862450.9A patent/EP2797890B1/en active Active
- 2012-12-28 RU RU2014131451A patent/RU2616621C2/ru active
- 2012-12-28 AU AU2012362268A patent/AU2012362268B2/en active Active
- 2012-12-28 JP JP2014550511A patent/JP6092250B2/ja active Active
- 2012-12-28 CA CA2861611A patent/CA2861611C/en active Active
- 2012-12-28 MX MX2014008019A patent/MX340947B/es active IP Right Grant
- 2012-12-28 IN IN5767DEN2014 patent/IN2014DN05767A/en unknown
-
2013
- 2013-01-02 AR ARP130100011A patent/AR089628A1/es active IP Right Grant
-
2014
- 2014-06-26 IL IL233412A patent/IL233412B/en active IP Right Grant
- 2014-07-18 CO CO14156063A patent/CO7010843A2/es unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2861611C (en) | 2020-04-21 |
| EP2797890A1 (en) | 2014-11-05 |
| KR20140117444A (ko) | 2014-10-07 |
| US20130172566A1 (en) | 2013-07-04 |
| BR112014015962B1 (pt) | 2019-12-17 |
| KR102065543B1 (ko) | 2020-01-13 |
| CO7010843A2 (es) | 2014-07-31 |
| JP6092250B2 (ja) | 2017-03-08 |
| EP2797890A4 (en) | 2015-09-23 |
| BR112014015962B8 (pt) | 2022-10-11 |
| EP2797890B1 (en) | 2016-10-05 |
| RU2616621C2 (ru) | 2017-04-18 |
| US8754110B2 (en) | 2014-06-17 |
| IL233412A0 (en) | 2014-08-31 |
| AU2012362268A1 (en) | 2014-07-31 |
| MX340947B (es) | 2016-08-01 |
| JP2015504059A (ja) | 2015-02-05 |
| PL2797890T3 (pl) | 2017-06-30 |
| RU2014131451A (ru) | 2016-02-20 |
| AU2012362268B2 (en) | 2016-11-17 |
| IL233412B (en) | 2019-01-31 |
| NZ627192A (en) | 2015-09-25 |
| IN2014DN05767A (es) | 2015-04-10 |
| CA2861611A1 (en) | 2013-07-04 |
| WO2013102078A1 (en) | 2013-07-04 |
| BR112014015962A2 (pt) | 2017-06-13 |
| AR089628A1 (es) | 2014-09-03 |
| BR112014015962A8 (pt) | 2017-07-04 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| MX2014008019A (es) | Metodos para la produccion de 4-amino-3-cloro-6-(4-cloro-2-fluor-3 -metoxifenil) piridin-2-carboxilato de metilo. | |
| CY1123208T1 (el) | Κυκλικα παραγωγα εστερων βορονικου οξεος, μεθοδος για την παρασκευη και θεραπευτικες χρησεις αυτων | |
| TN2013000411A1 (en) | Branched 3-phenylpropionic acid derivatives and the use thereof | |
| WO2012103279A3 (en) | Methods and compositions for the synthesis of multimerizing agents | |
| TN2013000347A1 (en) | Production method of optically active dihydrobenzofuran derivative | |
| EP2857406A4 (en) | PURIFIED METAL COMPLEX HAVING OXALIC ACID AS A LIGAND AND PROCESS FOR PRODUCING A PURIFIED SOLUTION OF THE METAL COMPLEX IN A NONAQUEOUS SOLVENT | |
| EP2801611A4 (en) | MICRO-ORGANISM FOR THE PRODUCTION OF L-AMINO ACID AND PROCESS FOR THE PRODUCTION OF L-AMINO ACIDS THEREWITH | |
| IL223951A0 (en) | (2-aryloxy- acetylamino) phenyl-propionic acid derivatives, method for producing same and use thereof as pharmaceuticals | |
| MY163169A (en) | Process for the preparation of an accelerator solution | |
| IL233926B (en) | A method for producing derivatives of 5,3-bis(fluoroalkyl)-pyrazole-4-carboxylic acid and 5,3-bis(fluoroalkyl)-pyrazoles | |
| EP2896694A4 (en) | GLUCIDE OXIDASE AND METHOD FOR PRODUCTION AND USE | |
| MY174468A (en) | Bio-based arcylic acid and its derivatives | |
| IN2014DN07958A (es) | ||
| NZ631764A (en) | Improved casein products and c02 reversible acidification methods used for their production. | |
| PH12016500913A1 (en) | Soap bar | |
| WO2013019051A3 (ko) | 미생물로부터 레티노이드를 생산하는 방법 | |
| EA201590471A1 (ru) | Глазированные пищевые продукты с шоколадной сердцевиной и способ их получения | |
| EP2876155A4 (en) | PROCESS FOR THE PREPARATION OF 2,3-BANDANDIOL USING IMPROVED STRAINS OF RAOULTELLA PLANTICOLA | |
| EP2907571A4 (en) | METHOD FOR PRODUCING A CATALYST FOR USE IN THE PREPARATION OF A METHYLAMINE COMPOUND AND A METHOD FOR PRODUCING THE METHYLAMINE COMPOUND | |
| TH153165A (th) | วิธีการผลิตเมธิล 4-อะมิโน-3-คลอโร-6-(4-คลอโร-2-ฟลูออโร-3-เมธอกซิเฟนิล)พิริดีน-2-คาร์บอกซิเลท | |
| WO2015011722A3 (en) | Zolpidem, method of preparation and an intermediate therein | |
| EP2813208A4 (en) | ASCORBIC ACID DERIVATIVE COMPOSITION AND METHOD FOR PRODUCING THE SAME, ASCORBIC ACID DERIVATIVE SOLUTION, AND EXTERNAL SKIN PREPARATION | |
| AU2012256709A1 (en) | Method for producing acrylamide aqueous solution | |
| TH1401003758A (th) | วิธีการผลิตเมธิล 4-อะมิโน-3-คลอโร-6-(4-คลอโร-2-ฟลูออโร-3-เมธอกซิเฟนิล)พิริดีน-2-คาร์บอกซิเลท | |
| UA81294U (ru) | Способ получения металлофуллеренов |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |