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MX2013010576A - Moduladores de receptores de hormonas nucleares. - Google Patents

Moduladores de receptores de hormonas nucleares.

Info

Publication number
MX2013010576A
MX2013010576A MX2013010576A MX2013010576A MX2013010576A MX 2013010576 A MX2013010576 A MX 2013010576A MX 2013010576 A MX2013010576 A MX 2013010576A MX 2013010576 A MX2013010576 A MX 2013010576A MX 2013010576 A MX2013010576 A MX 2013010576A
Authority
MX
Mexico
Prior art keywords
hormone receptor
receptor modulators
nuclear hormone
stereoisomers
isomers
Prior art date
Application number
MX2013010576A
Other languages
English (en)
Inventor
David C Ihle
Kevin P Cusack
Thomas D Gordon
Martin E Hayes
Eric C Breinlinger
Anna M Ericsson
Bin Li
Lei Wang
Gloria Y Martinez
Andrew Burchat
Adrian D Hobson
Kelly D Mullen
Michael Friedman
Michael J Morytko
Original Assignee
Abbvie Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=46828945&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013010576(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Abbvie Inc filed Critical Abbvie Inc
Publication of MX2013010576A publication Critical patent/MX2013010576A/es

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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
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    • C07D213/72—Nitrogen atoms
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Abstract

La invención proporciona un compuesto de la Fórmula (I), sales farmacéuticamente aceptables, pro-fármacos, metabolitos biológicamente activos, estereolsómeros e isómeros de los mismos, en donde las variables se definen en la presente. Los compuestos de la invención son útiles para tratar condiciones inmunológicas y oncológicas.
MX2013010576A 2011-03-15 2012-03-15 Moduladores de receptores de hormonas nucleares. MX2013010576A (es)

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PCT/US2012/029184 WO2012125797A1 (en) 2011-03-15 2012-03-15 Nuclear hormone receptor modulators

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EP2240451B1 (en) 2008-01-04 2017-08-09 Intellikine, LLC Isoquinolinone derivatives substituted with a purine useful as PI3K inhibitors
US8193182B2 (en) 2008-01-04 2012-06-05 Intellikine, Inc. Substituted isoquinolin-1(2H)-ones, and methods of use thereof
MX347708B (es) 2011-01-10 2017-05-09 Infinity Pharmaceuticals Inc Proceso para preparar isoquinolinonas y formas solidas de isoquinolinonas.
US8828998B2 (en) 2012-06-25 2014-09-09 Infinity Pharmaceuticals, Inc. Treatment of lupus, fibrotic conditions, and inflammatory myopathies and other disorders using PI3 kinase inhibitors
TW201422590A (zh) 2012-09-07 2014-06-16 Abbvie Inc 雜環核激素受體調節劑
EP2935284A4 (en) 2012-12-21 2016-04-27 Abbvie Inc HETEROCYCLIC MODULATORS OF HORMONE NUCLEAR RECEPTORS
US9643947B2 (en) 2013-08-28 2017-05-09 Northwestern University 7-membered fused heterocycles and methods of their synthesis
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UA125216C2 (uk) 2016-06-24 2022-02-02 Інфініті Фармасьютікалз, Інк. Комбінована терапія
KR101849301B1 (ko) * 2018-01-29 2018-04-16 전북대학교 산학협력단 식나무 추출물을 포함하는 안구 건조증 예방 또는 치료용 조성물
US11234971B2 (en) 2018-12-19 2022-02-01 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
US11389432B2 (en) 2018-12-19 2022-07-19 Corcept Therapeutics Incorporated Methods of treating cancer comprising administration of a glucocorticoid receptor modulator and a cancer chemotherapy agent
ES2969253T3 (es) * 2019-04-11 2024-05-17 Bristol Myers Squibb Co Las opciones sintéticas novedosas hacia la fabricación de (6R,10S)-10-{4-[5-cloro-2-(4-cloro-1H-1,2,3-triazol-1-il)fenil]-6-oxo-1(6H)-pirimidinil}-1-(difluorometil)-6-metil-1,4,7,8,9,10-hexahidro-11,15-(meteno)pirazolo[4,3-b][1,7]diazaciclotetradecin-5(6H)-ona
CA3164134A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
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