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MX2013003419A - Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12. - Google Patents

Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12.

Info

Publication number
MX2013003419A
MX2013003419A MX2013003419A MX2013003419A MX2013003419A MX 2013003419 A MX2013003419 A MX 2013003419A MX 2013003419 A MX2013003419 A MX 2013003419A MX 2013003419 A MX2013003419 A MX 2013003419A MX 2013003419 A MX2013003419 A MX 2013003419A
Authority
MX
Mexico
Prior art keywords
adc
bind
drug conjugates
antibody drug
proteins
Prior art date
Application number
MX2013003419A
Other languages
English (en)
Other versions
MX337873B (es
Inventor
Aya Jakobovits
Jean Gudas
Robert Kendall Morrison
Karen Jane Meyrick Morrison
Daulet Satpaev
Zili An
Michael Torgov
Original Assignee
Seattle Genetics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=45871300&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2013003419(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Seattle Genetics Inc filed Critical Seattle Genetics Inc
Publication of MX2013003419A publication Critical patent/MX2013003419A/es
Publication of MX337873B publication Critical patent/MX337873B/es

Links

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    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
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    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value

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Abstract

Se describen en la presente conjugados de anticuerpo fármaco (ADC's) que enlazan a la proteína 191P4D12 y variantes de la misma. La 191P4D12 exhibe expresión específica de tejido en el tejido adulto normal, y se expresa aberrantemente en los cánceres listados en la Tabla I. Consecuentemente, los ADC's de la invención proporcionan una composición terapéutica para el tratamiento de cáncer.
MX2013003419A 2010-09-29 2011-09-29 Conjugados de anticuerpo farmaco (adc) que enlazan a proteinas 191p4d12. MX337873B (es)

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