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MX2010008197A - Nuevas piridinonas y piridazinonas. - Google Patents

Nuevas piridinonas y piridazinonas.

Info

Publication number
MX2010008197A
MX2010008197A MX2010008197A MX2010008197A MX2010008197A MX 2010008197 A MX2010008197 A MX 2010008197A MX 2010008197 A MX2010008197 A MX 2010008197A MX 2010008197 A MX2010008197 A MX 2010008197A MX 2010008197 A MX2010008197 A MX 2010008197A
Authority
MX
Mexico
Prior art keywords
btk
compounds
phenyl
iii
pyridazinones
Prior art date
Application number
MX2010008197A
Other languages
English (en)
Inventor
Nolan James Dewdney
Zachary Kevin Sweeney
Michael Soth
Timothy D Owens
Joshua Kennedy-Smith
Rama K Kondru
Bradley E Loe
Yan Lou
Joel Mcintosh
Joshua Paul Gergely Taygerly
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2010008197A publication Critical patent/MX2010008197A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Engineering & Computer Science (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta solicitud se refiere a derivados de 5-fenil-1H-piridin-2-ona y 6-fenil-2H-piridazin-3-ona de las fórmulas genéricas I-III: (ver formulas) en las que las variables R, X, Y1, Y2, Y3, Y4, n y m tienen los significados definidos anteriormente, que inhiben la Btk. Los elementos aquí descritos son útiles para modular la actividad de la Btk y tratar enfermedades asociadas con una actividad excesiva de la Btk. Además, estos compuestos son útiles para tratar enfermedades inflamatorias y autoinmunitarios asociadas con la proliferación aberrante de células B, por ejemplo la artritis reumatoide. Se describen también composiciones que contienen los compuestos de las fórmulas I-III y por lo menos un vehículo, diluyente o excipiente.
MX2010008197A 2008-02-05 2009-01-27 Nuevas piridinonas y piridazinonas. MX2010008197A (es)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2620408P 2008-02-05 2008-02-05
US12251008P 2008-12-15 2008-12-15
PCT/EP2009/050875 WO2009098144A1 (en) 2008-02-05 2009-01-27 Novel pyridinones and pyridazinones

Publications (1)

Publication Number Publication Date
MX2010008197A true MX2010008197A (es) 2010-08-23

Family

ID=40413736

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010008197A MX2010008197A (es) 2008-02-05 2009-01-27 Nuevas piridinonas y piridazinonas.

Country Status (30)

Country Link
EP (1) EP2242749B1 (es)
JP (1) JP5259739B2 (es)
KR (1) KR101308803B1 (es)
CN (1) CN101932573B (es)
AR (1) AR070408A1 (es)
AU (1) AU2009211514B2 (es)
BR (1) BRPI0907915A2 (es)
CA (1) CA2710462C (es)
CL (1) CL2009000229A1 (es)
CO (1) CO6290767A2 (es)
CR (1) CR11598A (es)
CY (1) CY1114114T1 (es)
DK (1) DK2242749T3 (es)
EC (1) ECSP10010384A (es)
ES (1) ES2420846T3 (es)
HK (1) HK1146826A1 (es)
HR (1) HRP20130615T1 (es)
IL (1) IL206357A (es)
MA (1) MA32064B1 (es)
MX (1) MX2010008197A (es)
MY (1) MY158411A (es)
NZ (1) NZ586916A (es)
PE (1) PE20091484A1 (es)
PL (1) PL2242749T3 (es)
PT (1) PT2242749E (es)
RU (1) RU2505538C2 (es)
SI (1) SI2242749T1 (es)
TW (1) TWI382024B (es)
WO (1) WO2009098144A1 (es)
ZA (1) ZA201005539B (es)

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CA2771822C (en) 2009-09-04 2020-08-11 Daniel A. Erlanson Bruton's tyrosine kinase inhibitors
JP5832524B2 (ja) * 2010-05-07 2015-12-16 ジーアイリード コネチカット インコーポレーテッドＧｉｌｅａｄ Ｃｏｎｎｅｃｔｉｃｕｔ，Ｉｎｃ． ピリドン及びアザピリドン化合物、並びにそれらの使用方法
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AR082590A1 (es) * 2010-08-12 2012-12-19 Hoffmann La Roche Inhibidores de la tirosina-quinasa de bruton
BR112013029620A2 (pt) 2011-05-17 2016-09-06 Hoffmann La Roche inibidores de tirosina quinase de bruton
CN103748088A (zh) * 2011-08-17 2014-04-23 弗·哈夫曼-拉罗切有限公司 酪氨酸激酶抑制剂
UA111756C2 (uk) 2011-11-03 2016-06-10 Ф. Хоффманн-Ля Рош Аг Сполуки гетероарилпіридону та азапіридону як інгібітори тирозинкінази брутона
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Also Published As

Publication number Publication date
ECSP10010384A (es) 2010-09-30
RU2010136665A (ru) 2012-03-20
DK2242749T3 (da) 2013-06-17
CN101932573A (zh) 2010-12-29
KR101308803B1 (ko) 2013-09-13
MA32064B1 (fr) 2011-02-01
IL206357A0 (en) 2010-12-30
AU2009211514A1 (en) 2009-08-13
IL206357A (en) 2013-12-31
JP5259739B2 (ja) 2013-08-07
ES2420846T3 (es) 2013-08-27
RU2505538C2 (ru) 2014-01-27
JP2011511027A (ja) 2011-04-07
WO2009098144A1 (en) 2009-08-13
AU2009211514B2 (en) 2014-02-20
CR11598A (es) 2010-10-27
PE20091484A1 (es) 2009-10-03
MY158411A (en) 2016-10-14
CN101932573B (zh) 2014-06-11
CA2710462A1 (en) 2009-08-13
CA2710462C (en) 2015-11-24
CY1114114T1 (el) 2016-07-27
PL2242749T3 (pl) 2013-09-30
AR070408A1 (es) 2010-04-07
HK1146826A1 (en) 2011-07-15
BRPI0907915A2 (pt) 2015-07-28
EP2242749B1 (en) 2013-04-10
NZ586916A (en) 2012-06-29
ZA201005539B (en) 2011-04-28
KR20100093130A (ko) 2010-08-24
CO6290767A2 (es) 2011-06-20
TWI382024B (zh) 2013-01-11
CL2009000229A1 (es) 2010-06-04
EP2242749A1 (en) 2010-10-27
HRP20130615T1 (en) 2013-08-31
SI2242749T1 (sl) 2013-07-31
TW200938538A (en) 2009-09-16
PT2242749E (pt) 2013-07-16

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