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MX2010004297A - Antagonistas de glucagon. - Google Patents

Antagonistas de glucagon.

Info

Publication number
MX2010004297A
MX2010004297A MX2010004297A MX2010004297A MX2010004297A MX 2010004297 A MX2010004297 A MX 2010004297A MX 2010004297 A MX2010004297 A MX 2010004297A MX 2010004297 A MX2010004297 A MX 2010004297A MX 2010004297 A MX2010004297 A MX 2010004297A
Authority
MX
Mexico
Prior art keywords
glucagon
peptide
amino acid
glucagon antagonists
pla
Prior art date
Application number
MX2010004297A
Other languages
English (en)
Inventor
Richard D Dimarchi
Bin Yang
Original Assignee
Univ Indiana Res & Tech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Indiana Res & Tech Corp filed Critical Univ Indiana Res & Tech Corp
Publication of MX2010004297A publication Critical patent/MX2010004297A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/605—Glucagons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/04—Anorexiants; Antiobesity agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • General Chemical & Material Sciences (AREA)
  • Obesity (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Toxicology (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Emergency Medicine (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Se proporcionan antagonistas de glucagón que comprenden sustituciones de aminoácido y/o modificaciones químicas a la secuencia de glucagón. En una modalidad, los antagonistas de glucagón comprenden un péptido de glucagón nativo que se ha modificado por la supresión de los primeros dos a cinco residuos de aminoácido del N-terminal y (i) una sustitución de aminoácido en la posición 9 (de acuerdo con la numeración del glucagón nativo) o (ii) sustitución del Phe en la posición 6 (de acuerdo con la numeración del glucagón nativo) con ácido fenil láctico (PLA). En otra modalidad, los antagonistas de glucagón comprenden la estructura A-B-C como es descrita en la presente, en donde A es PLA, un derivado oxi del mismo, o un péptido de 2-6 aminoácidos en el cual dos aminoácidos consecutivos del péptido se enlazan por la vía de un enlace de éster o éter.
MX2010004297A 2007-10-30 2008-10-23 Antagonistas de glucagon. MX2010004297A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98378307P 2007-10-30 2007-10-30
PCT/US2008/080973 WO2009058662A2 (en) 2007-10-30 2008-10-23 Glucagon antagonists

Publications (1)

Publication Number Publication Date
MX2010004297A true MX2010004297A (es) 2010-05-03

Family

ID=40591715

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2010004297A MX2010004297A (es) 2007-10-30 2008-10-23 Antagonistas de glucagon.

Country Status (13)

Country Link
US (1) US8981047B2 (es)
EP (1) EP2217701B9 (es)
JP (1) JP5669582B2 (es)
AR (1) AR069110A1 (es)
AU (1) AU2008318986B2 (es)
CA (1) CA2707861A1 (es)
CL (1) CL2008003222A1 (es)
ES (1) ES2509883T3 (es)
HK (1) HK1143994A1 (es)
MX (1) MX2010004297A (es)
PE (1) PE20091393A1 (es)
TW (1) TW200920404A (es)
WO (1) WO2009058662A2 (es)

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