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MX2010003113A - Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. - Google Patents

Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina.

Info

Publication number
MX2010003113A
MX2010003113A MX2010003113A MX2010003113A MX2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A MX 2010003113 A MX2010003113 A MX 2010003113A
Authority
MX
Mexico
Prior art keywords
compounds
receptor antagonists
chemokine receptor
octahydropentalene
conditions
Prior art date
Application number
MX2010003113A
Other languages
English (en)
Inventor
Anna M Ericsson
Dawn M George
Graham K Ansell
Lu Wang
Biqin Li
Original Assignee
Abbott Lab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Abbott Lab filed Critical Abbott Lab
Publication of MX2010003113A publication Critical patent/MX2010003113A/es

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    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
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Abstract

La presente invenci?n est? dirigida a compuestos novedosos de la F?rmula (I), sales farmac?uticamente aceptables de los mismos, prof?rmacos de los mismos, metabolitos biol?gicamente activos de los mismos, is?meros de los mismos o estereois?meros de los mismos, en donde las variables son como se define aqu?. Los compuestos de la F?rmula (I) son ?tiles como antagonistas del receptor de quimiocina y como tales pueden ser ?tiles para tratar ciertas condiciones y enfermedades, especialmente condiciones y enfermedades inflamatorias y trastornos y condiciones proliferativas, por ejemplo, artritis reumatoide, osteoartritis, esclerosis m?ltiple y asma.
MX2010003113A 2007-09-25 2008-09-25 Compuestos de octahidropentaleno como antagonistas del receptor de quimiocina. MX2010003113A (es)

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PCT/US2008/011146 WO2009042193A1 (en) 2007-09-25 2008-09-25 Octahydropentalene compounds as chemokine receptor antagonists

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Families Citing this family (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ATE547101T1 (de) 2000-08-04 2012-03-15 Dmi Biosciences Inc Verfahren zur verwendung von diketopiperazinen und zusammensetzungen, die diese enthalten
CN104095851A (zh) 2003-05-15 2014-10-15 安皮奥制药股份有限公司 T-细胞介导的疾病的治疗
WO2009146320A1 (en) 2008-05-27 2009-12-03 Dmi Life Sciences, Inc. Therapeutic methods and compounds
ES2332645B1 (es) * 2009-06-30 2010-10-18 Grifols, S.A. Utilizacion de alfa-1-antitripsina para la preparacion de medicamentos para el tratamiento del sindrome de fatiga cronica.
USRE49251E1 (en) 2010-01-04 2022-10-18 Mapi Pharma Ltd. Depot systems comprising glatiramer or pharmacologically acceptable salt thereof
JP5941047B2 (ja) * 2010-09-07 2016-06-29 アンピオ ファーマシューティカルズ，インコーポレイテッド 疾患を治療するための医薬品及び同医薬品を含むキット
EP2613786A4 (en) 2010-09-07 2013-10-23 Dmi Acquisition Corp TREATMENT OF DISEASES
CN101926998B (zh) * 2010-09-10 2013-09-04 中国科学院水生生物研究所 肾上腺素受体激动剂诱导胚胎型珠蛋白表达及其用途
EP2663304B1 (en) 2011-01-11 2019-11-20 Dimerix Bioscience Pty Ltd Combination therapy
WO2013010453A1 (en) * 2011-07-15 2013-01-24 Abbott Laboratories Chemoking receptor antagonists
KR20140075772A (ko) 2011-10-10 2014-06-19 앰피오 파마슈티컬스 인코퍼레이티드 면역 내성을 증가시킨 이식 의료 장비, 및 그의 제조 및 이식 방법
CN103841987B (zh) 2011-10-10 2015-06-17 安皮奥制药股份有限公司 退行性关节病的治疗
KR20140095479A (ko) 2011-10-28 2014-08-01 앰피오 파마슈티컬스 인코퍼레이티드 비염의 치료
WO2013149376A1 (en) 2012-04-02 2013-10-10 Abbott Laboratories Chemokine receptor antagonists
US8822460B2 (en) * 2012-04-06 2014-09-02 Janssen Pharmaceutica Nv Fused cyclopentyl antagonists of CCR2
WO2014014901A1 (en) * 2012-07-19 2014-01-23 Janssen Pharmaceutica Nv Octahydro-cyclopentapyrrolyl antagonists of ccr2
SG11201506267XA (en) 2013-03-15 2015-09-29 Ampio Pharmaceuticals Inc Compositions for the mobilization, homing, expansion and differentiation of stem cells and methods of using the same
KR102027663B1 (ko) 2013-05-06 2019-10-01 가오슝 창 궁 메모리얼 하스피털 약학적 조성물 및 이의 용도
CN106604915A (zh) 2014-08-18 2017-04-26 安皮奥制药股份有限公司 关节病症的治疗
TWI595006B (zh) * 2014-12-09 2017-08-11 禮納特神經系統科學公司 抗ｐｄ－１抗體類和使用彼等之方法
JP6506845B2 (ja) * 2014-12-30 2019-04-24 エフ．ホフマン−ラ ロシュ アーゲーＦ． Ｈｏｆｆｍａｎｎ−Ｌａ Ｒｏｃｈｅ Ａｋｔｉｅｎｇｅｓｅｌｌｓｃｈａｆｔ Ｂ型肝炎ウイルス感染症の治療及び予防のための新規テトラヒドロピリドピリミジン類及びテトラヒドロピリドピリジン類
EP3310375A4 (en) 2015-06-22 2019-02-20 Ampio Pharmaceuticals, Inc. USE OF LOW MOLECULAR WEIGHT HUMAN SERUM ALBUMIN FRACTIONS FOR TREATING DISEASES
RU2622747C2 (ru) * 2015-10-22 2017-06-19 федеральное государственное бюджетное учреждение "Федеральный научно-исследовательский центр эпидемиологии и микробиологии имени почетного академика Н.Ф. Гамалеи" Министерства здравоохранения Российской Федерации (ФГБУ "ФНИЦЭМ им. Н.Ф. Гамалеи" Минздрава России) Способ и средство для лечения реактивного артрита хламидийной этиологии
US12097292B2 (en) 2016-08-28 2024-09-24 Mapi Pharma Ltd. Process for preparing microparticles containing glatiramer acetate
EP3595652A4 (en) 2017-03-17 2020-12-23 Emory University LIVER RECEPTOR HOMOLOGY 1 (LRH-1) MODULATORS AND USES THEREOF
WO2018178973A1 (en) 2017-03-26 2018-10-04 Mapi Pharma Ltd. Glatiramer depot systems for treating progressive forms of multiple sclerosis
JP7414529B2 (ja) 2017-06-07 2024-01-16 シファメド・ホールディングス・エルエルシー 血管内流体移動デバイス、システム、および使用方法
WO2019094963A1 (en) 2017-11-13 2019-05-16 Shifamed Holdings, Llc Intravascular fluid movement devices, systems, and methods of use
JP7410034B2 (ja) 2018-02-01 2024-01-09 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに使用および製造の方法
CA3105982A1 (en) * 2018-07-11 2020-01-16 Rubedo Life Sciences, Inc. Senolytic compositions and uses thereof
JP2022540616A (ja) 2019-07-12 2022-09-16 シファメド・ホールディングス・エルエルシー 血管内血液ポンプならびに製造および使用の方法
US11654275B2 (en) 2019-07-22 2023-05-23 Shifamed Holdings, Llc Intravascular blood pumps with struts and methods of use and manufacture
EP4034221B1 (en) 2019-09-25 2024-11-13 Shifamed Holdings, LLC Catheter blood pumps and collapsible pump housings
WO2021062260A1 (en) 2019-09-25 2021-04-01 Shifamed Holdings, Llc Catheter blood pumps and collapsible blood conduits
EP4034192A4 (en) 2019-09-25 2023-11-29 Shifamed Holdings, LLC INTRAVASCULAR BLOOD PUMP SYSTEMS AND METHODS OF USE AND CONTROL THEREOF
WO2023192362A1 (en) * 2022-03-31 2023-10-05 Incelldx, Inc. Methods of treating a subject for myalgic encephalomyelitis/chronic fatigue syndrome (me/cfs) and compositions for use in the same

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ZA893284B (en) 1988-05-04 1990-03-28 Igen Inc Peptide analogs and their use as haptens to elicit catalytic antibodies
US6090382A (en) * 1996-02-09 2000-07-18 Basf Aktiengesellschaft Human antibodies that bind human TNFα
US6906072B1 (en) * 2000-01-20 2005-06-14 Eisai Co., Ltd. Piperazine compound and pharmaceutical composition containing the compound
US6710064B2 (en) * 2000-12-01 2004-03-23 Bristol-Myers Squibb Co. Hydantoin compounds useful as anti-inflammatory agents
JP4554608B2 (ja) 2003-07-03 2010-09-29 パナソニック株式会社 送信装置
CN100574686C (zh) * 2003-08-19 2009-12-30 皇家飞利浦电子股份有限公司 包括一个发泡构件的饮料制造装置
US7163937B2 (en) * 2003-08-21 2007-01-16 Bristol-Myers Squibb Company Cyclic derivatives as modulators of chemokine receptor activity
DE10348022A1 (de) 2003-10-15 2005-05-25 Imtm Gmbh Neue Dipeptidylpeptidase IV-Inhibitoren zur funktionellen Beeinflussung unterschiedlicher Zellen und zur Behandlung immunologischer, entzündlicher, neuronaler und anderer Erkrankungen
KR100859027B1 (ko) * 2003-12-18 2008-09-17 인사이트 코포레이션 케모킨 수용체의 조절제로서의3-사이클로알킬아미노피롤리딘 유도체
WO2005115392A2 (en) * 2004-05-11 2005-12-08 Incyte Corporation 3-(4-heteroarylcyclohexylamino) cyclopentanecarboxamides as modulators of chemokine receptors

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