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MX2009013885A - Derivados de quinolina fusionados utiles como moduladores de acido gamma-aminobutirico. - Google Patents

Derivados de quinolina fusionados utiles como moduladores de acido gamma-aminobutirico.

Info

Publication number
MX2009013885A
MX2009013885A MX2009013885A MX2009013885A MX2009013885A MX 2009013885 A MX2009013885 A MX 2009013885A MX 2009013885 A MX2009013885 A MX 2009013885A MX 2009013885 A MX2009013885 A MX 2009013885A MX 2009013885 A MX2009013885 A MX 2009013885A
Authority
MX
Mexico
Prior art keywords
sup
derivatives useful
quinoline derivatives
gaba modulators
fused quinoline
Prior art date
Application number
MX2009013885A
Other languages
English (en)
Inventor
Marc Chapdelaine
Carey Horchler
Hui-Fang Chang
Bruce Thomas Dembofsky
Keith John Herzog
Richard Jon Schmiesing
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40084145&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MX2009013885(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of MX2009013885A publication Critical patent/MX2009013885A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
    • A61P25/16—Anti-Parkinson drugs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/22—Anxiolytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Psychiatry (AREA)
  • Pain & Pain Management (AREA)
  • Immunology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychology (AREA)
  • Rheumatology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Esta invención se refiere a compuestos nuevos que tienen la fórmula estructural (I) abajo: y sus sales farmacéuticamente aceptables, tautómeros o precursores hidrolizables in vivo, a composiciones y a métodos de uso de los mismos, en donde R1, R2, R3, R4, R5 y R6 se definen en la descripción. Estos compuestos nuevos proporcionan un tratamiento o profilaxis de trastornos de ansiedad, esquizofrenia, trastornos cognitivos y/o trastornos de estado de ánimo.
MX2009013885A 2007-06-19 2008-06-18 Derivados de quinolina fusionados utiles como moduladores de acido gamma-aminobutirico. MX2009013885A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US94487907P 2007-06-19 2007-06-19
PCT/GB2008/050456 WO2008155572A2 (en) 2007-06-19 2008-06-18 Fused quinoline derivatives useful as gaba modulators

Publications (1)

Publication Number Publication Date
MX2009013885A true MX2009013885A (es) 2010-01-27

Family

ID=40084145

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009013885A MX2009013885A (es) 2007-06-19 2008-06-18 Derivados de quinolina fusionados utiles como moduladores de acido gamma-aminobutirico.

Country Status (15)

Country Link
US (1) US20080318943A1 (es)
EP (1) EP2176263A2 (es)
JP (1) JP2010530405A (es)
KR (1) KR20100039339A (es)
CN (1) CN101778849A (es)
AR (1) AR067027A1 (es)
AU (1) AU2008264984A1 (es)
BR (1) BRPI0813379A2 (es)
CA (1) CA2691237A1 (es)
CL (1) CL2008001838A1 (es)
MX (1) MX2009013885A (es)
PE (1) PE20090693A1 (es)
TW (1) TW200904817A (es)
UY (1) UY31159A1 (es)
WO (1) WO2008155572A2 (es)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN102686225A (zh) * 2009-10-26 2012-09-19 西格诺药品有限公司 杂芳基化合物的合成和纯化方法
CA2900652C (en) 2013-02-15 2021-05-04 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9688688B2 (en) 2013-02-20 2017-06-27 Kala Pharmaceuticals, Inc. Crystalline forms of 4-((4-((4-fluoro-2-methyl-1H-indol-5-yl)oxy)-6-methoxyquinazolin-7-yl)oxy)-1-(2-oxa-7-azaspiro[3.5]nonan-7-yl)butan-1-one and uses thereof
WO2014130612A1 (en) 2013-02-20 2014-08-28 Kala Pharmaceuticals, Inc. Therapeutic compounds and uses thereof
US9890173B2 (en) 2013-11-01 2018-02-13 Kala Pharmaceuticals, Inc. Crystalline forms of therapeutic compounds and uses thereof
MX355330B (es) 2013-11-01 2018-04-16 Kala Pharmaceuticals Inc Formas cristalinas de compuestos terapeuticos y sus usos.
GB201322334D0 (en) 2013-12-17 2014-01-29 Agency Science Tech & Res Maleimide derivatives as modulators of WNT pathway
EP3246309B1 (en) 2015-01-13 2020-01-01 Nissan Chemical Corporation Method for treating tin compound in reaction mixture
CN109688818A (zh) 2016-09-08 2019-04-26 卡拉制药公司 治疗化合物的晶型及其用途
EP3509422A4 (en) 2016-09-08 2020-05-20 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
EP3509423A4 (en) 2016-09-08 2020-05-13 Kala Pharmaceuticals, Inc. CRYSTALLINE FORMS OF THERAPEUTIC COMPOUNDS AND USES THEREOF
CN108863917A (zh) * 2017-05-16 2018-11-23 穆云 一种2,5-二甲氧基吡啶的制备方法
KR102611830B1 (ko) * 2017-06-27 2023-12-11 바이엘 악티엔게젤샤프트 치환된 4-아미노인단 유도체의 제조 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT69828A (en) * 1979-01-22 1979-07-01 Lilly Co Eli Process for preparing octahydro-2h-pyrrolo-/3,4-g/quinolines
GB8610980D0 (en) * 1986-05-06 1986-06-11 Ici America Inc Heterocyclic fused tricyclic compounds
US5190951A (en) * 1990-10-19 1993-03-02 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
US5240934A (en) * 1990-10-19 1993-08-31 Ss Pharmaceutical Co., Ltd. Quinoline derivatives
RU2257385C2 (ru) * 2003-08-26 2005-07-27 ООО "Исследовательский институт химического разнообразия" 1,3-диоксо -2,3-дигидро-1h-пирроло[3,4-c]хинолины (варианты), фармацевтические композиции (варианты), способ их получения (варианты) и способы лечения (варианты)

Also Published As

Publication number Publication date
WO2008155572A2 (en) 2008-12-24
CN101778849A (zh) 2010-07-14
TW200904817A (en) 2009-02-01
EP2176263A2 (en) 2010-04-21
BRPI0813379A2 (pt) 2014-12-30
AU2008264984A1 (en) 2008-12-24
CA2691237A1 (en) 2008-12-24
AR067027A1 (es) 2009-09-30
KR20100039339A (ko) 2010-04-15
CL2008001838A1 (es) 2009-03-06
UY31159A1 (es) 2009-01-30
PE20090693A1 (es) 2009-07-17
WO2008155572A3 (en) 2009-02-26
JP2010530405A (ja) 2010-09-09
US20080318943A1 (en) 2008-12-25

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