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MX2009011769A - Derivados de piridona como inhibidores de mapk p38a. - Google Patents

Derivados de piridona como inhibidores de mapk p38a.

Info

Publication number
MX2009011769A
MX2009011769A MX2009011769A MX2009011769A MX2009011769A MX 2009011769 A MX2009011769 A MX 2009011769A MX 2009011769 A MX2009011769 A MX 2009011769A MX 2009011769 A MX2009011769 A MX 2009011769A MX 2009011769 A MX2009011769 A MX 2009011769A
Authority
MX
Mexico
Prior art keywords
formula
lower alkyl
mapk inhibitors
pyridone derivatives
group represented
Prior art date
Application number
MX2009011769A
Other languages
English (en)
Inventor
Hitoshi Yamazaki
Chiyoshi Kasahara
Original Assignee
Astellas Pharma Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astellas Pharma Inc filed Critical Astellas Pharma Inc
Publication of MX2009011769A publication Critical patent/MX2009011769A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D213/78—Carbon atoms having three bonds to hetero atoms, with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C07D213/81—Amides; Imides
    • C07D213/82—Amides; Imides in position 3
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4412—Non condensed pyridines; Hydrogenated derivatives thereof having oxo groups directly attached to the heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

Un compuesto representado por la fórmula (I): (ver fórmula I) en donde R1 es alquilo inferior, cicloalquilo o anillo hidrocarbonado aromático, cada uno de los cuales está opcionalmente sustituido con uno o más sustituyentes; R2 es un átomo de hidrógeno, un átomo de halógeno, alquilo inferior, haloalquilo inferior o alcoxi inferior; y R3 es (1) un grupo representado por la fórmula: (ver fórmula) en donde R4 es alquilo inferior, etc.; (2) un grupo representado por la fórmula: (ver fórmula) en donde R5 es alquilo inferior, etc.; (3) un grupo representado por la fórmula: (ver fórmula) en donde R6 es alquilo inferior, etc.; o (4) un grupo seleccionado de un átomo de halógeno, carboxi, hidroxi y alcoxi inferior, o una de sus sales.
MX2009011769A 2007-05-03 2008-05-02 Derivados de piridona como inhibidores de mapk p38a. MX2009011769A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US91584507P 2007-05-03 2007-05-03
PCT/JP2008/058689 WO2008140066A2 (en) 2007-05-03 2008-05-02 Pyridone derivatives as p38a mapk inhibitors

Publications (1)

Publication Number Publication Date
MX2009011769A true MX2009011769A (es) 2009-11-13

Family

ID=39865639

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009011769A MX2009011769A (es) 2007-05-03 2008-05-02 Derivados de piridona como inhibidores de mapk p38a.

Country Status (15)

Country Link
US (1) US8173684B2 (es)
EP (1) EP2155683B8 (es)
JP (1) JP2010526026A (es)
KR (1) KR20100016563A (es)
CN (1) CN101675034A (es)
AR (1) AR066421A1 (es)
AT (1) ATE502013T1 (es)
CA (1) CA2686091A1 (es)
DE (1) DE602008005581D1 (es)
ES (1) ES2363109T3 (es)
MX (1) MX2009011769A (es)
PL (1) PL2155683T3 (es)
PT (1) PT2155683E (es)
TW (1) TW200904421A (es)
WO (1) WO2008140066A2 (es)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8304413B2 (en) 2008-06-03 2012-11-06 Intermune, Inc. Compounds and methods for treating inflammatory and fibrotic disorders
WO2012002577A1 (ja) 2010-06-30 2012-01-05 富士フイルム株式会社 新規なニコチンアミド誘導体またはその塩
US20130269064A1 (en) * 2010-11-23 2013-10-10 Syngenta Participations Ag Insecticidal compounds
CN104024226B (zh) 2011-12-28 2016-06-01 富士胶片株式会社 新型的烟酰胺衍生物或其盐
AR092742A1 (es) 2012-10-02 2015-04-29 Intermune Inc Piridinonas antifibroticas
MX2016012808A (es) 2014-04-02 2017-01-05 Intermune Inc Piridinonas anti-fibroticas.
CN104961803B (zh) * 2015-07-08 2017-11-28 中国人民解放军军事医学科学院基础医学研究所 一种治疗心肌缺血再灌注损伤的多肽药物
CN104961804B (zh) * 2015-07-08 2017-12-01 中国人民解放军军事医学科学院基础医学研究所 p38α拮抗肽突变体及其应用
CN109640970B (zh) 2016-06-23 2023-05-23 马里兰大学巴尔的摩分校 选择性p38α特异性MAPK抑制剂
CN107033134B (zh) * 2017-05-03 2020-02-21 贵州大学 含吡啶盐和1,3,4-噁二唑基的双酰胺类化合物及其制备方法及应用
WO2020118194A1 (en) 2018-12-07 2020-06-11 University Of Maryland, Baltimore NON-ATP/CATALYTIC SITE p38 MITOGEN ACTIVATED PROTEIN KINASE INHIBITORS
US20220363643A1 (en) * 2019-10-04 2022-11-17 Institut National De La Sante Et De La Recherche Medicale (Inserm) Novel pyridin-2(1h)one derivatives, their preparation and their use for the treatment of pain
CA3179288A1 (en) 2020-05-18 2021-11-25 Adam Galan P38alpha mitogen-activated protein kinase inhibitors
JP2023546835A (ja) 2020-10-29 2023-11-08 ジーニー ライフサイエンシズ インコーポレイテッド 結晶性５－（ジメチルアミノ）－ｎ－（４－（モルホリノメチル）フェニル）ナフタレン－１－スルホンアミド二塩酸塩二水和物
US11555020B2 (en) 2021-03-23 2023-01-17 Gen1E Lifesciences Inc. Substituted naphthyl p38α mitogen-activated protein kinase inhibitors

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9816837D0 (en) 1998-08-04 1998-09-30 Zeneca Ltd Amide derivatives
JP4973191B2 (ja) 2004-11-10 2012-07-11 小野薬品工業株式会社 含窒素複素環化合物およびその医薬用途
WO2006122154A2 (en) * 2005-05-10 2006-11-16 Intermune, Inc. Pyridone derivatives for modulating stress-activated protein kinase system
EP1919919A1 (en) * 2005-09-01 2008-05-14 Astellas Pharma Inc. Pyridazinone derivatives used for the treatment of pain

Also Published As

Publication number Publication date
EP2155683B8 (en) 2011-09-21
KR20100016563A (ko) 2010-02-12
PL2155683T3 (pl) 2011-08-31
US8173684B2 (en) 2012-05-08
PT2155683E (pt) 2011-04-11
JP2010526026A (ja) 2010-07-29
WO2008140066A2 (en) 2008-11-20
EP2155683B1 (en) 2011-03-16
EP2155683A2 (en) 2010-02-24
WO2008140066A3 (en) 2008-12-31
CN101675034A (zh) 2010-03-17
CA2686091A1 (en) 2008-11-20
TW200904421A (en) 2009-02-01
DE602008005581D1 (de) 2011-04-28
AR066421A1 (es) 2009-08-19
US20100063098A1 (en) 2010-03-11
ATE502013T1 (de) 2011-04-15
ES2363109T3 (es) 2011-07-20

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