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MX2009008534A - Antagonistas novedosos del receptor de glucagon. - Google Patents

Antagonistas novedosos del receptor de glucagon.

Info

Publication number
MX2009008534A
MX2009008534A MX2009008534A MX2009008534A MX2009008534A MX 2009008534 A MX2009008534 A MX 2009008534A MX 2009008534 A MX2009008534 A MX 2009008534A MX 2009008534 A MX2009008534 A MX 2009008534A MX 2009008534 A MX2009008534 A MX 2009008534A
Authority
MX
Mexico
Prior art keywords
glucagon receptor
present
provides
crystals
formula
Prior art date
Application number
MX2009008534A
Other languages
English (en)
Inventor
Qun Dang
Scott J Hecker
Jorge E Gomez-Galeno
Raja K Reddy
Paul D Vanpoelje
Robert Huerta Lemus
Thanh Huu Nguyen
Matthew P Grote
Venkat Reddy Mali
Mingwei Chen
Zhili Sun
Serge Henri Boyer
Haiqing Li
William Craigo
Original Assignee
Metabasis Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Metabasis Therapeutics Inc filed Critical Metabasis Therapeutics Inc
Publication of MX2009008534A publication Critical patent/MX2009008534A/es

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    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A61K31/166—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide having the carbon of a carboxamide group directly attached to the aromatic ring, e.g. procainamide, procarbazine, metoclopramide, labetalol
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Abstract

La presente invención proporciona compuestos novedosos de la fórmula I y sales y co-cristales farmacéuticamente aceptables de los mismos los cuales tienen actividad antagonista o agonista inversa del receptor de glucagón; la presente invención proporciona además composiciones farmacéuticas que comprenden también métodos para tratar, prevenir, retardar el inico o reducir el riesgo de desarrollo o progreso de una enfermedad o afección para la cual uno o más antagonistas del receptor de glucagón se indica, incluyendo diabetes de tipos I y II, resistencia a la insulina e hiperglicemia; la presente invención también proporciona procesos para hacer los compuestos de la fórmula I, incluyendo sales y co-cristales de los mismos, y composiciones farmacéuticas que comprenden los mismos.
MX2009008534A 2007-02-09 2008-02-11 Antagonistas novedosos del receptor de glucagon. MX2009008534A (es)

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US98928707P 2007-11-20 2007-11-20
PCT/US2008/053581 WO2008098244A1 (en) 2007-02-09 2008-02-11 Novel antagonists of the glucagon receptor

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