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MX2009002121A - Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico. - Google Patents

Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico.

Info

Publication number
MX2009002121A
MX2009002121A MX2009002121A MX2009002121A MX2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A MX 2009002121 A MX2009002121 A MX 2009002121A
Authority
MX
Mexico
Prior art keywords
snac
manufacture
hydroxybenzoyl
amino
formation
Prior art date
Application number
MX2009002121A
Other languages
English (en)
Inventor
William Elliott Bay
Yi Ren
Pingsheng Zhang
Joseph Norman Bernadino
George Frederick Klein
Original Assignee
Hoffmann La Roche
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Hoffmann La Roche filed Critical Hoffmann La Roche
Publication of MX2009002121A publication Critical patent/MX2009002121A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/10—Preparation of carboxylic acid amides from compounds not provided for in groups C07C231/02 - C07C231/08
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/12—Preparation of carboxylic acid amides by reactions not involving the formation of carboxamide groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C231/00—Preparation of carboxylic acid amides
    • C07C231/22—Separation; Purification; Stabilisation; Use of additives
    • C07C231/24—Separation; Purification
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/42—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/44—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/58—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C235/60—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to carbon atoms of six-membered aromatic rings and singly-bound oxygen atoms bound to the same carbon skeleton with carbon atoms of carboxamide groups and singly-bound oxygen atoms bound to carbon atoms of the same non-condensed six-membered aromatic ring with carbon atoms of carboxamide groups and singly-bound oxygen atoms, bound in ortho-position to carbon atoms of the same non-condensed six-membered aromatic ring having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
    • C07C235/70—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton
    • C07C235/84—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups and doubly-bound oxygen atoms bound to the same carbon skeleton with the carbon atom of at least one of the carboxamide groups bound to a carbon atom of a six-membered aromatic ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F1/00—Compounds containing elements of Groups 1 or 11 of the Periodic Table
    • C07F1/04—Sodium compounds

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)

Abstract

La presente invención describe métodos mejorados para la síntesis de ácido N-(8-[2-hidroxibenzoil]-amino)caprílico. Ciertos compuestos se han encontrado útiles para prevenir la formación de una impureza coloreada cuando se incluyen en una reacción de hidrólisis de éster. También se ha encontrado que la conducción de hidrólisis de éster en condiciones anaeróbicas minimiza la formación de la impureza de color. También se describen métodos mejorados para sintetizar la sal de sodio de ácido N-(8-[2-hidroxibenzoil]-amino)caprílico.
MX2009002121A 2006-09-07 2007-08-30 Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico. MX2009002121A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US84277506P 2006-09-07 2006-09-07
PCT/EP2007/059037 WO2008028859A1 (en) 2006-09-07 2007-08-30 A process for the manufacture of snac (salcaprozate sodium)

Publications (1)

Publication Number Publication Date
MX2009002121A true MX2009002121A (es) 2009-05-20

Family

ID=38702068

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2009002121A MX2009002121A (es) 2006-09-07 2007-08-30 Proceso para la manufactura del acido n-(8-[2-hidroxibenzoil]-amin o)caprilico.

Country Status (12)

Country Link
US (3) US10875826B2 (es)
EP (1) EP2064175B1 (es)
JP (1) JP5021033B2 (es)
KR (1) KR101081149B1 (es)
CN (1) CN101506147B (es)
AU (1) AU2007293916B2 (es)
BR (1) BRPI0716539A2 (es)
CA (1) CA2662080C (es)
ES (1) ES2498519T3 (es)
IL (1) IL197014A (es)
MX (1) MX2009002121A (es)
WO (1) WO2008028859A1 (es)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2057112B1 (en) * 2006-08-31 2018-12-19 Emisphere Technologies, Inc. Compounds and compositions for delivering active agents
KR101081149B1 (ko) * 2006-09-07 2011-11-07 에미스페어 테크놀로지스, 인코포레이티드 Ｓｎａｃ(살카프로제이트 나트륨)의 제조 방법
EP3326620B1 (en) 2010-12-16 2020-03-04 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist and a salt of n-(8-(2- hydroxybenzoyl)amino)caprylic acid
JP6022538B2 (ja) 2011-04-12 2016-11-09 ノヴォ ノルディスク アー／エス 二重アシル化されたｇｌｐ−１誘導体
DK2827845T3 (en) 2012-03-22 2019-04-01 Novo Nordisk As COMPOSITIONS INCLUDING A PROCEDURE AND PREPARING THEREOF
CA2868188A1 (en) 2012-03-22 2013-09-26 Novo Nordisk A/S Compositions of glp-1 peptides and preparation thereof
US10335369B2 (en) 2012-03-22 2019-07-02 Novo Nordisk A/S Compositions comprising a delivery agent and preparation thereof
US9993430B2 (en) 2012-06-20 2018-06-12 Novo Nordisk A/S Tablet formulation comprising semaglutide and a delivery agent
KR102272671B1 (ko) 2013-05-02 2021-07-06 노보 노르디스크 에이/에스 Glp-1 화합물의 경구 투여
WO2016047206A1 (ja) * 2014-09-25 2016-03-31 ダイキン工業株式会社 Ｈｆｃとｈｆｏとを含有する組成物
CN105566141B (zh) * 2015-12-17 2018-01-26 蚌埠丰原医药科技发展有限公司 一种门冬氨酸缩合物的制备方法
TWI797133B (zh) 2017-06-09 2023-04-01 丹麥商諾佛 儂迪克股份有限公司 用於經口投予的固體組成物
US20200165313A1 (en) 2017-07-19 2020-05-28 Novo Nordisk A/S Egf(a) analogues, preparation, formulations and uses thereof
KR102647171B1 (ko) 2018-02-02 2024-03-15 노보 노르디스크 에이/에스 Glp-1 작용제 및 n-(8-(2-하이드록시벤조일)아미노)카프릴산의 염을 포함하는 고형 조성물
TWI829687B (zh) 2018-05-07 2024-01-21 丹麥商諾佛 儂迪克股份有限公司 包含glp-1促效劑與n-(8-(2-羥基苯甲醯基)胺基)辛酸之鹽的固體組成物
CN108689876B (zh) * 2018-06-28 2020-11-27 苏州东南药业股份有限公司 一种8-(2-羟基苯甲酰胺基)辛酸钠的制备方法
EP4009958A1 (en) 2019-08-07 2022-06-15 Novo Nordisk A/S Solid compositions comprising an egf(a) derivative and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
EP4025353B1 (en) 2019-09-06 2024-11-06 Novo Nordisk A/S Method and equipment for fractionation of granules for use in pharmaceutical compositions
EP4414031A2 (en) 2019-11-06 2024-08-14 Novo Nordisk A/S Glp-1 receptor agonists in dementia
WO2021089761A1 (en) 2019-11-07 2021-05-14 Novo Nordisk A/S Solid compositions comprising a pcsk9 inhibitor and a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
JP2023502004A (ja) 2019-11-07 2023-01-20 ノヴォ ノルディスク アー／エス Ｇｌｐ－１作動薬、ｓｇｌｔ２阻害剤、およびｎ－（８－（２－ヒドロキシベンゾイル）アミノ）カプリル酸の塩を含む固形組成物
IT202000003251A1 (it) 2020-02-18 2021-08-18 Dipharma Francis Srl Preparazione di un analgesico non steroideo
US11478533B2 (en) 2020-04-27 2022-10-25 Novo Nordisk A/S Semaglutide for use in medicine
US20230165939A1 (en) 2020-04-29 2023-06-01 Novo Nordisk A/S Solid compositions comprising a glp-1 agonist and histidine
CN112661663B (zh) * 2020-05-29 2021-09-17 杭州先为达生物科技有限公司 N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途
WO2021238088A1 (zh) 2020-05-29 2021-12-02 杭州先为达生物科技有限公司 N-[8-(2-羟基苯甲酰基)氨基]辛酸钾晶体多晶型物及其制备方法和用途
US20230383037A1 (en) 2020-10-16 2023-11-30 Josho Gakuen Educational Foundation Composition
JP2024505911A (ja) 2021-01-29 2024-02-08 ノボ・ノルデイスク・エー／エス アミド形成によるサルカプロジン酸の新規合成
EP4323330A1 (en) 2021-04-16 2024-02-21 Navinta III Inc Process for the preparation of highly pure salcaprozic acid and pharmaceutically acceptable salts thereof
US11667614B2 (en) 2021-04-16 2023-06-06 Navinta III Inc. Process for the preparation of highly pure Salcaprozic Acid and pharmaceutically acceptable salts thereof
WO2022226217A1 (en) 2021-04-22 2022-10-27 Civi Biopharma, Inc. Oral delivery of oligonucleotides
WO2022264166A1 (en) 2021-06-14 2022-12-22 Mylan Laboratories Limited Process for the preparation of pure salcaprozate sodium
EP4360645A1 (en) 2021-06-25 2024-05-01 Gan & Lee Pharmaceuticals Co., Ltd. Pharmaceutical composition containing glp-1 compound
EP4370102A1 (en) 2021-07-15 2024-05-22 Novo Nordisk A/S Tablet comprising a salt of n-(8-(2-hydroxybenzoyl)amino)caprylic acid
MX2023015360A (es) 2021-07-16 2024-04-22 Novo Nordisk As Forma polimórfica a de n-(8-(2- hidroxibenzoil)amino)caprilato de sodio.
WO2023012263A1 (en) 2021-08-04 2023-02-09 Novo Nordisk A/S Solid oral peptide formulations
CN115160178A (zh) * 2022-07-29 2022-10-11 成都普康唯新生物科技有限公司 一种8-(2-羟基苯甲酰胺基)辛酸钠无水晶型的制备方法
CN115108936A (zh) * 2022-07-29 2022-09-27 成都普康唯新生物科技有限公司 无水体系制备8-(2-羟基苯甲酰胺基)辛酸钠无水晶型的方法
WO2024110614A1 (en) 2022-11-25 2024-05-30 Novo Nordisk A/S Oral administration of peptide therapeutics, such as glp-1
WO2024141760A1 (en) 2022-12-30 2024-07-04 Algipharma As Compositions and methods to increase the systemic bioavailability of a polypeptide therapeutic agent undergoing oral administration
CN117466765B (zh) * 2023-12-27 2024-03-15 成都道合尔医药技术有限公司 8-(2-羟基苯甲酰胺基)辛酸钠及其合成方法
CN118561711A (zh) * 2024-07-31 2024-08-30 爱斯特（成都）生物制药股份有限公司 一种制备n-[8-(2-羟基苯甲酰基)氨基]辛酸及其盐的方法

Family Cites Families (36)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3840570A (en) * 1970-12-07 1974-10-08 Procter & Gamble Process for preparing sterols from tall oil pitch
DE3623397A1 (de) 1986-07-11 1988-01-14 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US5717109A (en) 1994-09-08 1998-02-10 Eli Lilly And Company Excitatory amino acid receptor antagonists
US5650386A (en) 1995-03-31 1997-07-22 Emisphere Technologies, Inc. Compositions for oral delivery of active agents
GB2320248B (en) 1995-09-11 1999-04-14 Emisphere Tech Inc Method for preparing omega-aminoalkanoic acid derivatives from cycloalkanones
JPH09188661A (ja) * 1996-01-10 1997-07-22 Kao Corp ポリオキシアルキレン脂肪酸アミド硫酸エステル塩の製造方法
US6096273A (en) 1996-11-05 2000-08-01 Clinical Micro Sensors Electrodes linked via conductive oligomers to nucleic acids
US7393645B2 (en) 1996-11-05 2008-07-01 Clinical Micro Sensors, Inc. Compositions for the electronic detection of analytes utilizing monolayers
US7381525B1 (en) 1997-03-07 2008-06-03 Clinical Micro Sensors, Inc. AC/DC voltage apparatus for detection of nucleic acids
WO1999014238A1 (en) 1997-09-18 1999-03-25 Hyundai Pharm. Ind. Co., Ltd. Process for the preparation of calcitonin
CA2361716C (en) * 1999-02-05 2009-04-28 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides
DE60017888T2 (de) 1999-04-05 2006-01-19 Emisphere Technologies, Inc. Dinatrium-salze, monohydrate und ethanol-solvate
US6492408B1 (en) 1999-07-21 2002-12-10 Boehringer Ingelheim Pharmaceuticals, Inc. Small molecules useful in the treatment of inflammatory disease
CA2402719C (en) 2000-03-21 2012-03-20 Emisphere Technologies, Inc. Method of preparing alkylated salicylamides via a dicarboxylate intermediate
AU2001275231A1 (en) 2000-06-02 2001-12-11 Emisphere Technologies, Inc. Method of preparing salicylamides
US6949577B2 (en) 2000-09-13 2005-09-27 Pfizer, Inc. Pharmaceuticals
GB0107924D0 (en) 2001-03-29 2001-05-23 Angeletti P Ist Richerche Bio Inhibitor of hepatitis C virus NS3 protease
WO2003077857A2 (en) 2002-03-15 2003-09-25 Merck & Co., Inc. N-(substituted benzyl)-8-hydroxy-1,6-naphthyridine-7- carboxamides useful as hiv integrase inhibitors
CN100418948C (zh) 2003-07-15 2008-09-17 麦克公司 羟基吡啶cgrp受体抗拮抗剂
US7524813B2 (en) 2003-10-10 2009-04-28 Novo Nordisk Health Care Ag Selectively conjugated peptides and methods of making the same
JP2005298463A (ja) * 2004-04-07 2005-10-27 Matsumoto Yushi Seiyaku Co Ltd 開環重合方法
JP4903690B2 (ja) 2004-05-06 2012-03-28 エミスフェアー・テクノロジーズ・インク Ｎ−［８−（２−ヒドリキシベンゾイル）アミノ］カプリル酸一ナトリウムの結晶多形体
PE20060653A1 (es) 2004-08-31 2006-09-27 Glaxo Group Ltd Derivados triciclicos condensados como moduladores del receptor 5-ht1
JP5011683B2 (ja) * 2004-09-06 2012-08-29 Ｄｉｃ株式会社 多価ヒドロキシ化合物、エポキシ樹脂、及びそれらの製造法、エポキシ樹脂組成物と硬化物
WO2006067587A2 (en) 2004-12-22 2006-06-29 Pfizer Limited Nonnucleoside inhibitors of hiv-1 reverse transcriptase
ATE445622T1 (de) 2005-03-29 2009-10-15 Hetero Drugs Ltd Verbessertes verfahren zur herstellung von cefixim
BRPI0619848A2 (pt) 2005-12-14 2011-10-18 Medivir Ab (2,5-dioxoimidazolidin-1-ila)-n-hidróxi-acetamidas como inibidores de metaloproteinase
US8198448B2 (en) 2006-07-14 2012-06-12 Amgen Inc. Fused heterocyclic derivatives and methods of use
PE20080403A1 (es) 2006-07-14 2008-04-25 Amgen Inc Derivados heterociclicos fusionados y metodos de uso
US8217177B2 (en) 2006-07-14 2012-07-10 Amgen Inc. Fused heterocyclic derivatives and methods of use
KR101081149B1 (ko) * 2006-09-07 2011-11-07 에미스페어 테크놀로지스, 인코포레이티드 Ｓｎａｃ(살카프로제이트 나트륨)의 제조 방법
FR2912145B1 (fr) 2007-02-02 2009-03-06 Servier Lab Nouveaux derives tricycliques,leur procede de preparation et les compositions pharmaceutiques qui les contiennent
AR065804A1 (es) 2007-03-23 2009-07-01 Smithkline Beecham Corp Compuesto de indol carboxamida, composicion farmaceutica que lo comprende y uso de dicho compuesto para preparar un medicamento
US8258312B2 (en) 2007-06-27 2012-09-04 Mylan Laboratories Ltd Process for preparing pure valsartan
RU2478105C2 (ru) 2007-07-31 2013-03-27 Глитек, Инк. Способ получения пептида
CN101367750B (zh) 2007-08-14 2012-05-23 中国人民解放军军事医学科学院毒物药物研究所 (1s,2s,3s,4r)-3-[(1s)-1-乙酰氨-2-乙基-丁基]-4-胍基-2-羟基-环戊基-1-羧酸水合物及其医药用途

Also Published As

Publication number Publication date
CA2662080A1 (en) 2008-03-13
JP5021033B2 (ja) 2012-09-05
KR20090060997A (ko) 2009-06-15
CA2662080C (en) 2012-07-17
IL197014A (en) 2013-01-31
US20080064890A1 (en) 2008-03-13
BRPI0716539A2 (pt) 2016-11-01
CN101506147A (zh) 2009-08-12
ES2498519T3 (es) 2014-09-24
CN101506147B (zh) 2012-03-21
WO2008028859A1 (en) 2008-03-13
US20200071263A1 (en) 2020-03-05
US10875826B2 (en) 2020-12-29
EP2064175A1 (en) 2009-06-03
KR101081149B1 (ko) 2011-11-07
EP2064175B1 (en) 2014-08-06
AU2007293916A1 (en) 2008-03-13
AU2007293916B2 (en) 2011-02-03
US20210070691A1 (en) 2021-03-11
US7544833B2 (en) 2009-06-09
IL197014A0 (en) 2009-11-18
JP2010502667A (ja) 2010-01-28

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