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MX2008002234A - Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa. - Google Patents

Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa.

Info

Publication number
MX2008002234A
MX2008002234A MX2008002234A MX2008002234A MX2008002234A MX 2008002234 A MX2008002234 A MX 2008002234A MX 2008002234 A MX2008002234 A MX 2008002234A MX 2008002234 A MX2008002234 A MX 2008002234A MX 2008002234 A MX2008002234 A MX 2008002234A
Authority
MX
Mexico
Prior art keywords
bicyclic
sulfonamido
bridged
inhibitors
sub
Prior art date
Application number
MX2008002234A
Other languages
English (en)
Inventor
Andrei W Konradi
Christopher M Semko
Matthew N Mattson
Xiaocong Michael Ye
Original Assignee
Elan Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Elan Pharm Inc filed Critical Elan Pharm Inc
Publication of MX2008002234A publication Critical patent/MX2008002234A/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
    • C07D451/14—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing 9-azabicyclo [3.3.1] nonane ring systems, e.g. granatane, 2-aza-adamantane; Cyclic acetals thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed systems contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurosurgery (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Hospice & Palliative Care (AREA)
  • Epidemiology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)

Abstract

La invencion provee compuestos de sulfonamida N-biciclicos y sales de la Formula (I) donde A es como se describe en la especificacion, y R1 y R2 se combinan para formar un sistema de anillo [3.3.1] o [3.2.1]. Los compuestos de Formula I son utiles en el tratamiento o la prevencion de trastornos cognitivos, tales como la enfermedad de Alzheimer. La invencion ademas contempla composiciones farmaceuticas que comprenden compuestos de Formula (I) asi como metodos para tratar trastornos cognitivos, tales como la enfermedad de Alzheimer.
MX2008002234A 2005-08-19 2006-08-18 Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa. MX2008002234A (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US70996105P 2005-08-19 2005-08-19
PCT/US2006/032261 WO2007024651A2 (en) 2005-08-19 2006-08-18 Bridged n-bicyclic sulfonamido inhibitors of gamma secretase

Publications (1)

Publication Number Publication Date
MX2008002234A true MX2008002234A (es) 2008-03-27

Family

ID=37758487

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2008002234A MX2008002234A (es) 2005-08-19 2006-08-18 Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa.

Country Status (16)

Country Link
US (4) US20110178119A1 (es)
EP (2) EP1915371A4 (es)
JP (2) JP2009504773A (es)
KR (1) KR20080042135A (es)
CN (2) CN101426860A (es)
AR (1) AR056470A1 (es)
AU (2) AU2006279312A1 (es)
BR (1) BRPI0614944A2 (es)
CA (2) CA2618087A1 (es)
EC (1) ECSP088293A (es)
IL (2) IL189217A0 (es)
MX (1) MX2008002234A (es)
RU (2) RU2422443C2 (es)
TW (1) TW200740806A (es)
WO (2) WO2007024651A2 (es)
ZA (1) ZA200803521B (es)

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* Cited by examiner, † Cited by third party
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US7923465B2 (en) 2005-06-02 2011-04-12 Glenmark Pharmaceuticals S.A. Cannabinoid receptor ligands, pharmaceutical compositions containing them, and process for their preparation
MX2008002234A (es) * 2005-08-19 2008-03-27 Elan Pharm Inc Inhibidores de sulfonamida n-biciclico puenteados de gamma secretasa.
JP2009518301A (ja) 2005-12-01 2009-05-07 エラン ファーマシューティカルズ，インコーポレイテッド ５−（アリールスルホニル）−ピラゾロピペリジン
US7977368B2 (en) 2007-05-25 2011-07-12 Elan Pharmaceuticals, Inc. Pyrazolopyrrolidines as inhibitors of gamma secretase
CA2696285A1 (en) * 2007-08-15 2009-02-19 Schering Corporation Substituted bicyclic piperidinyl- and piperazinyl-sulfonamides useful to inhibit 11.beta.-hydroxysteroid dehydrogenase type-1
RU2544856C2 (ru) 2008-01-25 2015-03-20 Сергей Олегович Бачурин НОВЫЕ ПРОИЗВОДНЫЕ 2,3,4,5-ТЕТРАГИДРО-1-ПИРИДО[4,3-b]ИНДОЛА И СПОСОБЫ ИХ ПРИМЕНЕНИЯ
CN102046625B (zh) 2008-03-24 2015-04-08 梅迪维新技术公司 桥连杂环化合物及其使用方法
US8283358B2 (en) * 2008-09-05 2012-10-09 Elan Pharmaceuticals, Inc. N-sulfonamido polycyclic pyrazolyl compounds
CA2775216A1 (en) 2009-09-23 2011-03-31 Medivation Technologies, Inc. Bridged heterocyclic compounds and methods of use
CN102711468B (zh) 2009-09-23 2014-07-09 梅迪维新技术公司 吡啶并[4，3-b]吲哚化合物及其使用方法
TWI471095B (zh) 2009-12-21 2015-02-01 Nippon Soda Co 環胺化合物及殺蟎劑
AR081721A1 (es) 2010-02-25 2012-10-17 Nippon Soda Co Compuesto de amina ciclica y acaricida
JP2013536233A (ja) 2010-08-23 2013-09-19 アムジエン・インコーポレーテツド グルコキナーゼ調節タンパク質と相互作用する糖尿病治療用の化合物
EP2675459A4 (en) 2011-02-18 2014-08-06 Medivation Technologies Inc COMPOUNDS AND METHODS FOR TREATING DIABETES
US11325904B2 (en) 2011-08-02 2022-05-10 Buck Institute For Research On Aging Tropinol esters and related compounds to promote normal processing of APP
EP2690102A1 (en) 2012-07-24 2014-01-29 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Bicyclic aza-amides for treatment of psychiatric disorders
KR101999464B1 (ko) * 2015-05-25 2019-07-11 후아웨이 테크놀러지 컴퍼니 리미티드 광변색성 렌즈, 카메라 및 단말 장치

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Also Published As

Publication number Publication date
US20110003802A1 (en) 2011-01-06
US20110178119A1 (en) 2011-07-21
CA2618087A1 (en) 2007-03-01
RU2008110488A (ru) 2009-09-27
WO2007022502A3 (en) 2007-10-04
AU2006279312A1 (en) 2007-02-22
US7754712B2 (en) 2010-07-13
KR20080042135A (ko) 2008-05-14
IL190970A0 (en) 2009-02-11
WO2007022502A2 (en) 2007-02-22
WO2007024651A2 (en) 2007-03-01
US7345056B2 (en) 2008-03-18
BRPI0614944A2 (pt) 2011-04-26
AU2006283567A1 (en) 2007-03-01
WO2007024651A3 (en) 2007-07-12
EP1915371A2 (en) 2008-04-30
EP1915371A4 (en) 2010-09-15
CN101304997A (zh) 2008-11-12
EP1916985A4 (en) 2010-06-09
US20070049612A1 (en) 2007-03-01
ECSP088293A (es) 2008-04-28
CN101426860A (zh) 2009-05-06
IL189217A0 (en) 2008-06-05
CA2632670A1 (en) 2007-02-22
AR056470A1 (es) 2007-10-10
RU2008133306A (ru) 2010-02-20
ZA200803521B (en) 2009-12-30
JP2009506988A (ja) 2009-02-19
US20080090817A1 (en) 2008-04-17
TW200740806A (en) 2007-11-01
RU2422443C2 (ru) 2011-06-27
EP1916985A2 (en) 2008-05-07
JP2009504773A (ja) 2009-02-05

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