MEP54308A - Aerosol formulation for inhalation comprising a tiotropium salt - Google Patents
Aerosol formulation for inhalation comprising a tiotropium saltInfo
- Publication number
- MEP54308A MEP54308A MEP-543/08A MEP54308A MEP54308A ME P54308 A MEP54308 A ME P54308A ME P54308 A MEP54308 A ME P54308A ME P54308 A MEP54308 A ME P54308A
- Authority
- ME
- Montenegro
- Prior art keywords
- inhalation
- aerosol formulation
- tiotropium salt
- active substance
- tiotropium
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/007—Pulmonary tract; Aromatherapy
- A61K9/0073—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
- A61K9/0078—Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a nebulizer such as a jet nebulizer, ultrasonic nebulizer, e.g. in the form of aqueous drug solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/439—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
- A61K31/5375—1,4-Oxazines, e.g. morpholine
- A61K31/5386—1,4-Oxazines, e.g. morpholine spiro-condensed or forming part of bridged ring systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Epidemiology (AREA)
- Pulmonology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Dispersion Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Otolaryngology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Cosmetics (AREA)
- Nozzles (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Abstract
Ovaj pronalazak odnosi se na aerosolnu formulaciju bez potisnog gasa, farmaceutski prihvatljive soli tiotropijuma, rastvorene u vodi. Formulacija, na osnovu pronalaska, naročito je pogodna za prevođenje djelotvorne supstance u stanje magle, pomoću atomizera (raspršivača, sprejera), da bi djelotvorna supstanca mogla da se primijeni inhalativno, prvenstveno kod astme i COPD-a.The present invention relates to a propellant-free aerosol formulation, a pharmaceutically acceptable salt of tiotropium, dissolved in water. The formulation according to the invention is particularly suitable for converting the active substance into a mist, by means of an atomizer (nebulizer, spray), so that the active substance can be administered by inhalation, primarily in asthma and COPD.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE10216036A DE10216036A1 (en) | 2002-04-11 | 2002-04-11 | Aerosol formulation for inhalation containing a tiotropium salt |
YUP-879/04A RS50923B (en) | 2002-04-11 | 2003-04-02 | Aerosol formulation for inhalation comprising tiotropiumbromide |
PCT/EP2003/003438 WO2003084519A2 (en) | 2002-04-11 | 2003-04-02 | Aerosol formulation for inhalation comprising a tiotropium salt |
Publications (2)
Publication Number | Publication Date |
---|---|
MEP54308A true MEP54308A (en) | 2011-05-10 |
ME00359B ME00359B (en) | 2011-10-10 |
Family
ID=28458728
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MEP-2008-543A ME00359B (en) | 2002-04-11 | 2003-04-02 | Aerosol formulation for inhalation comprising a tiotropium salt |
Country Status (33)
Country | Link |
---|---|
EP (2) | EP1949892A1 (en) |
JP (1) | JP2005531528A (en) |
KR (1) | KR100997219B1 (en) |
CN (1) | CN1309378C (en) |
AR (1) | AR039286A1 (en) |
AT (1) | ATE389391T1 (en) |
AU (1) | AU2003222791B2 (en) |
BR (1) | BR0309080A (en) |
CA (1) | CA2473815C (en) |
CO (1) | CO5611150A2 (en) |
CY (1) | CY1108133T1 (en) |
DE (2) | DE10216036A1 (en) |
DK (1) | DK1496876T3 (en) |
EA (1) | EA007228B1 (en) |
EC (1) | ECSP045358A (en) |
ES (1) | ES2303897T3 (en) |
HK (1) | HK1078793A1 (en) |
HR (1) | HRP20040932B1 (en) |
ME (1) | ME00359B (en) |
MX (1) | MXPA04009818A (en) |
MY (1) | MY137249A (en) |
NO (1) | NO334915B1 (en) |
PE (1) | PE20030970A1 (en) |
PL (1) | PL371204A1 (en) |
PT (1) | PT1496876E (en) |
RS (1) | RS50923B (en) |
SA (1) | SA03240192B1 (en) |
SI (1) | SI1496876T1 (en) |
TW (1) | TWI344851B (en) |
UA (1) | UA78994C2 (en) |
UY (1) | UY27754A1 (en) |
WO (1) | WO2003084519A2 (en) |
ZA (1) | ZA200405721B (en) |
Families Citing this family (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US8686148B2 (en) | 2003-11-03 | 2014-04-01 | Boehringer Ingelheim International Gmbh | Process for preparing new tiotropium salts, new tiotropium salts as such and pharmaceutical compositions thereof |
NZ566399A (en) * | 2005-08-06 | 2011-07-29 | Boehringer Ingelheim Int | Use of tiotropium salts in the treatment of severe persistant asthma |
US20070088030A1 (en) | 2005-10-10 | 2007-04-19 | Barbara Niklaus-Humke | Aerosol formulations for the inhalation of beta-agonists |
EP1905440A1 (en) * | 2006-09-06 | 2008-04-02 | Boehringer Ingelheim Pharma GmbH & Co. KG | Use of a pharmaceutical composition comprising an anticholinergic for killing microorganisms and for treating respiratory tract infections |
EP2044967A1 (en) * | 2007-10-01 | 2009-04-08 | Boehringer Ingelheim Pharma GmbH & Co. KG | Atomiser |
JP6335798B2 (en) | 2012-02-28 | 2018-05-30 | ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング | New propellant-containing tiotropium formulation |
RU2493827C1 (en) * | 2012-10-03 | 2013-09-27 | Шолекс Девелопмент Гмбх | Stable combined solution of fenoterol hydrobromide and ipratropium bromide |
WO2015065223A1 (en) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Stable solution of fenoterol hydrobromide |
WO2015065219A1 (en) * | 2013-10-28 | 2015-05-07 | Шолекс Девелопмент Гмбх | Ipratropium bromide solution |
GB201507686D0 (en) * | 2015-05-05 | 2015-06-17 | Norton Healthcare Ltd | A stable tiotropium nebuliser solution |
KR102476726B1 (en) * | 2016-11-16 | 2022-12-12 | 글렌마크 스페셜티 에스. 에이. | Nebulized Tiotropium |
CN115209872B (en) * | 2020-03-19 | 2024-08-02 | 广州谷森制药有限公司 | Inhalable formulation containing levosalbutamol tartrate |
CN114259481A (en) * | 2021-11-26 | 2022-04-01 | 南京华盖制药有限公司 | Compound inhalation solution of odaterol |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE3931041C2 (en) | 1989-09-16 | 2000-04-06 | Boehringer Ingelheim Kg | Esters of thienyl carboxylic acids with amino alcohols, their quaternization products, processes for their preparation and medicaments containing them |
SG45171A1 (en) | 1990-03-21 | 1998-01-16 | Boehringer Ingelheim Int | Atomising devices and methods |
IL107120A (en) | 1992-09-29 | 1997-09-30 | Boehringer Ingelheim Int | Atomising nozzle and filter and spray generating device |
DE19536902A1 (en) | 1995-10-04 | 1997-04-10 | Boehringer Ingelheim Int | Miniature fluid pressure generating device |
DE19536903C2 (en) | 1995-10-04 | 1998-09-10 | Boehringer Ingelheim Int | Device for holding a fluidic component |
DE19545226C1 (en) | 1995-12-05 | 1997-06-19 | Boehringer Ingelheim Int | Locking mechanism for a spring-operated output |
DE19653969A1 (en) * | 1996-12-20 | 1998-06-25 | Boehringer Ingelheim Kg | New aqueous pharmaceutical preparation for the production of propellant-free aerosols |
DE19742439C1 (en) | 1997-09-26 | 1998-10-22 | Boehringer Ingelheim Int | Fluid micro-filter |
DE19847968A1 (en) * | 1998-10-17 | 2000-04-20 | Boehringer Ingelheim Pharma | Separate storage of an active material and a solvent comprises a closure cap and a container, with a chamber attached to the unit. |
CN100396285C (en) * | 2000-10-31 | 2008-06-25 | 贝林格尔英格海姆法玛两合公司 | Inhalative solution formulation containing tiotropium salt |
-
2002
- 2002-04-11 DE DE10216036A patent/DE10216036A1/en not_active Withdrawn
-
2003
- 2003-02-04 UA UA20041109194A patent/UA78994C2/en unknown
- 2003-04-02 DK DK03718724T patent/DK1496876T3/en active
- 2003-04-02 ES ES03718724T patent/ES2303897T3/en not_active Expired - Lifetime
- 2003-04-02 ME MEP-2008-543A patent/ME00359B/en unknown
- 2003-04-02 PT PT03718724T patent/PT1496876E/en unknown
- 2003-04-02 CN CNB038082330A patent/CN1309378C/en not_active Ceased
- 2003-04-02 EP EP08152138A patent/EP1949892A1/en not_active Withdrawn
- 2003-04-02 PL PL03371204A patent/PL371204A1/en not_active Application Discontinuation
- 2003-04-02 DE DE50309414T patent/DE50309414D1/en not_active Expired - Lifetime
- 2003-04-02 KR KR1020047016052A patent/KR100997219B1/en active IP Right Grant
- 2003-04-02 RS YUP-879/04A patent/RS50923B/en unknown
- 2003-04-02 EP EP03718724A patent/EP1496876B1/en not_active Expired - Lifetime
- 2003-04-02 MX MXPA04009818A patent/MXPA04009818A/en active IP Right Grant
- 2003-04-02 SI SI200331206T patent/SI1496876T1/en unknown
- 2003-04-02 AU AU2003222791A patent/AU2003222791B2/en not_active Expired
- 2003-04-02 AT AT03718724T patent/ATE389391T1/en active
- 2003-04-02 WO PCT/EP2003/003438 patent/WO2003084519A2/en active IP Right Grant
- 2003-04-02 EA EA200401305A patent/EA007228B1/en not_active IP Right Cessation
- 2003-04-02 BR BR0309080-9A patent/BR0309080A/en active Pending
- 2003-04-02 JP JP2003581759A patent/JP2005531528A/en active Pending
- 2003-04-02 CA CA2473815A patent/CA2473815C/en not_active Expired - Fee Related
- 2003-04-09 MY MYPI20031314A patent/MY137249A/en unknown
- 2003-04-09 PE PE2003000359A patent/PE20030970A1/en not_active Application Discontinuation
- 2003-04-09 UY UY27754A patent/UY27754A1/en not_active Application Discontinuation
- 2003-04-10 TW TW092108240A patent/TWI344851B/en not_active IP Right Cessation
- 2003-04-11 AR ARP030101267A patent/AR039286A1/en active Pending
- 2003-07-07 SA SA03240192A patent/SA03240192B1/en unknown
-
2004
- 2004-07-19 ZA ZA200405721A patent/ZA200405721B/en unknown
- 2004-09-23 NO NO20044001A patent/NO334915B1/en not_active IP Right Cessation
- 2004-10-07 HR HRP20040932AA patent/HRP20040932B1/en not_active IP Right Cessation
- 2004-10-08 CO CO04100971A patent/CO5611150A2/en active IP Right Grant
- 2004-10-11 EC EC2004005358A patent/ECSP045358A/en unknown
-
2005
- 2005-12-01 HK HK05110950A patent/HK1078793A1/en not_active IP Right Cessation
-
2008
- 2008-06-11 CY CY20081100623T patent/CY1108133T1/en unknown
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