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MD4462C1 - Cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Klebsiella pneumoniae şi Pseudomonas aeruginosa - Google Patents

Cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Klebsiella pneumoniae şi Pseudomonas aeruginosa

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Publication number
MD4462C1
MD4462C1 MDA20160021A MD20160021A MD4462C1 MD 4462 C1 MD4462 C1 MD 4462C1 MD A20160021 A MDA20160021 A MD A20160021A MD 20160021 A MD20160021 A MD 20160021A MD 4462 C1 MD4462 C1 MD 4462C1
Authority
MD
Moldova
Prior art keywords
nickel
hydrazinecarbothioamido
ethylidene
dimethylphenyl
hydroxyphenyl
Prior art date
Application number
MDA20160021A
Other languages
English (en)
Russian (ru)
Other versions
MD4462B1 (ro
Inventor
Дорин ИСТРАТИ
Аурелиан ГУЛЯ
Виктор ЦАПКОВ
Елена ЗАРИЧУК
Алена КОТОВАЯ
Original Assignee
Государственный Университет Молд0
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Государственный Университет Молд0 filed Critical Государственный Университет Молд0
Priority to MDA20160021A priority Critical patent/MD4462C1/ro
Publication of MD4462B1 publication Critical patent/MD4462B1/ro
Publication of MD4462C1 publication Critical patent/MD4462C1/ro

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  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Invenţia se referă la chimie şi medicină, şi anume la un compus coordinativ nou de nichel, biologic activ, din clasa tiosemicarbazonaţilor metalelor de tranziţie şi poate găsi aplicare în medicină şi medicina veterinară în calitate de preparat cu acţiune antimicrobiană sau în calitate de ingredient la crearea mediilor nutritive selective de cultivare a microorganismelor.Esenţa invenţiei constă în obţinerea unui compus coordinativ cu activitate antibacteriană înaltă cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel cu formula:Acest compus manifestă o activitate bacteriostatică şi bactericidă faţă de bacteriile gram-negative din speciile Klebsiella pneumoniae şiPseudomonas aeruginosa în limitele concentraţiilor de 0,7…3,0 µg/mL.
MDA20160021A 2016-02-29 2016-02-29 Cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Klebsiella pneumoniae şi Pseudomonas aeruginosa MD4462C1 (ro)

Priority Applications (1)

Application Number Priority Date Filing Date Title
MDA20160021A MD4462C1 (ro) 2016-02-29 2016-02-29 Cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Klebsiella pneumoniae şi Pseudomonas aeruginosa

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
MDA20160021A MD4462C1 (ro) 2016-02-29 2016-02-29 Cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Klebsiella pneumoniae şi Pseudomonas aeruginosa

Publications (2)

Publication Number Publication Date
MD4462B1 MD4462B1 (ro) 2017-01-31
MD4462C1 true MD4462C1 (ro) 2017-08-31

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Family Applications (1)

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MDA20160021A MD4462C1 (ro) 2016-02-29 2016-02-29 Cloro-{N-(3,4-dimetilfenil)-2-[1-(2-hidroxifenil)etiliden]-hidrazincarbotioamido(1-)}nichel, care manifestă activitate antimicrobiană faţă de bacteriile din speciile Klebsiella pneumoniae şi Pseudomonas aeruginosa

Country Status (1)

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MD (1) MD4462C1 (ro)

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD2942B2 (ro) * 2004-04-27 2005-12-31 Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova Di(µ-O)-bis(3,5-dibromsalicilidentiosemicarbazonatocupru)
MD2939F1 (ro) * 2005-01-11 2005-12-31 Universitatea De Stat Din Moldova Saliciliden tiosemicarbazido-[6-(4-aminobenzensulfamido)-3-metoxipiridazin]-nichel
MD4112B1 (ro) * 2010-05-17 2011-05-31 Univ De Stat Din Moldova Compuşi coordinativi ai cuprului cu 4-(dimetilfenil)-tiosemicarbazonele 2-formilpiridinei

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MD2942B2 (ro) * 2004-04-27 2005-12-31 Universitatea De Stat De Medicina Si Farmacie "Nicolae Testemitanu" Din Republica Moldova Di(µ-O)-bis(3,5-dibromsalicilidentiosemicarbazonatocupru)
MD2939F1 (ro) * 2005-01-11 2005-12-31 Universitatea De Stat Din Moldova Saliciliden tiosemicarbazido-[6-(4-aminobenzensulfamido)-3-metoxipiridazin]-nichel
MD4112B1 (ro) * 2010-05-17 2011-05-31 Univ De Stat Din Moldova Compuşi coordinativi ai cuprului cu 4-(dimetilfenil)-tiosemicarbazonele 2-formilpiridinei

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
Devesh Kumar, Vipin Kumar Singh. Application of metal complexes of schiff base with special reference to thiosemicarbazone: a review. Journal of Drug Discovery and Therapeutics 2 (13 2014, 24-32) Availble online at www.jddt.in , regăsit în Internet la 2016.11.22, url: http://www.google.com/url?sa=t&rct=j&q=&esrc=s&source=web&cd=32&ved=0ahUKEwj6wPaQi7zQAhUGVxQKHYulD2Y4HhAWCCAwAQ&url=http%3A%2F%2Fisj.sjournals.net%2Findex.php%2FJDDT%2Farticle%2Fdownload%2F1104%2F1060&usg=AFQjCNFcnk5b_bPfXlQAISAHBrDAitW_EQ&sig2=pKK-bSuabIt-imBDOV6BGQ&bvm=bv.139250283,d.d24&cad=rja pag. 28-29, chapter "As antibacterial agent:" *
Gulea A. et al. In vitro antileukemia, antibacterial and antifungal activities of some 3d metal complexes: Chemical synthesis and structure - activity relationships. J. of Enzyme Inhibition and Medicinal chemistry, December 2008; 23(6): 806-818. DOI: 10.1080/14756360701743002 Regăsit în Internet la 2016.11.21, url: https://www.academia.edu/6324552/In_vitro_antileukemia_antibacterial_and_antifungal_activities_of_some_3d_metal_complexes_Chemical_synthesis_and_structure_activity_relationships Tables I and III *
Lakshmi Narayana Suvaru et al. A Critical Review on Analytical and Biological Applications of Thio- and Phenylthiosemicarbazones. Asian Journal of Chemistry, vol. 24, No. 5 (2012), 1889-1898 Regăsit în Internet la 2016.11.23, url: http://www.asianjournalofchemistry.co.in/User/ViewFreeArticle.aspx?ArticleID=24_5_1 pag. 1891 and 1896 *

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KA4A Patent for invention lapsed due to non-payment of fees (with right of restoration)
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