Nothing Special   »   [go: up one dir, main page]

MD20140086A2 - Derivaţi macrociclici pentru tratamentul bolilor proliferative - Google Patents

Derivaţi macrociclici pentru tratamentul bolilor proliferative

Info

Publication number
MD20140086A2
MD20140086A2 MDA20140086A MD20140086A MD20140086A2 MD 20140086 A2 MD20140086 A2 MD 20140086A2 MD A20140086 A MDA20140086 A MD A20140086A MD 20140086 A MD20140086 A MD 20140086A MD 20140086 A2 MD20140086 A2 MD 20140086A2
Authority
MD
Moldova
Prior art keywords
treatment
compounds
proliferative diseases
salts
macrocyclic derivatives
Prior art date
Application number
MDA20140086A
Other languages
English (en)
Moldavian (mo)
Russian (ru)
Other versions
MD4590B1 (ro
MD4590C1 (ro
Inventor
Саймон Бейли
Бенджамин Джозеф БЁРК
Майкл Раймонд КОЛЛИНС
Цзинжун Джин Цуй
Джудит Гейл Дил
Роберт Луис Хоффман
Циньхуа Хуан
Тед Уильям ДЖОНСОН
Роберт Стивен Кания
Джон Чарльз Кат
Фыонг Тхи Куи Ле
Мишель Энн Мактиг
Синтия Луиза Палмер
Пол Фрэнсис Ричардсон
Нил Уильям СЕЙЧ
Original Assignee
Pfizer Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=48142828&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MD20140086(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Pfizer Inc. filed Critical Pfizer Inc.
Publication of MD20140086A2 publication Critical patent/MD20140086A2/ro
Publication of MD4590B1 publication Critical patent/MD4590B1/ro
Publication of MD4590C1 publication Critical patent/MD4590C1/ro

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/22—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains four or more hetero rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/18—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D273/00—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00
    • C07D273/02—Heterocyclic compounds containing rings having nitrogen and oxygen atoms as the only ring hetero atoms, not provided for by groups C07D261/00 - C07D271/00 having two nitrogen atoms and only one oxygen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)

Abstract

Invenţia se referă la compuşi cu formula (Φ)cu semnificaţiile definite în continuare în documentul dat şi la sărurile farmaceutice acceptabile ale acestora, la compoziţii farmaceutice ce conţin compuşii (Φ) şi sărurile lor şi la utilizarea acestora. Compuşii şi sărurile (Φ) inhibă kinaza limfomului anaplastic (ALK) şi/sau EML4-ALK şi sunt utili pentru tratamentul sau ameliorarea tulburarilor proliferative celulare anormale, cum ar fi cancerul.
MDA20140086A 2012-03-06 2013-02-20 Derivaţi macrociclici pentru tratamentul bolilor proliferative MD4590C1 (ro)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201261607485P 2012-03-06 2012-03-06
US201361759307P 2013-01-31 2013-01-31
PCT/IB2013/051391 WO2013132376A1 (en) 2012-03-06 2013-02-20 Macrocyclic derivatives for the treatment of proliferative diseases

Publications (3)

Publication Number Publication Date
MD20140086A2 true MD20140086A2 (ro) 2015-01-31
MD4590B1 MD4590B1 (ro) 2018-08-31
MD4590C1 MD4590C1 (ro) 2019-03-31

Family

ID=48142828

Family Applications (1)

Application Number Title Priority Date Filing Date
MDA20140086A MD4590C1 (ro) 2012-03-06 2013-02-20 Derivaţi macrociclici pentru tratamentul bolilor proliferative

Country Status (46)

Country Link
US (2) US8680111B2 (ro)
EP (1) EP2822953B9 (ro)
JP (2) JP5823066B2 (ro)
KR (1) KR101692600B1 (ro)
CN (1) CN104169286B (ro)
AP (1) AP2014007881A0 (ro)
AR (1) AR090230A1 (ro)
AU (1) AU2013229173B2 (ro)
BR (1) BR112014022106B1 (ro)
CA (1) CA2863892C (ro)
CL (1) CL2014002084A1 (ro)
CO (1) CO7061081A2 (ro)
CR (1) CR20140370A (ro)
CY (2) CY1118771T1 (ro)
DK (1) DK2822953T5 (ro)
DO (1) DOP2014000188A (ro)
EA (1) EA026155B9 (ro)
ES (1) ES2621220T3 (ro)
FR (1) FR19C1062I2 (ro)
GE (1) GEP201606560B (ro)
GT (1) GT201400187A (ro)
HK (1) HK1199247A1 (ro)
HR (1) HRP20170287T2 (ro)
HU (2) HUE034118T2 (ro)
IL (1) IL234062A (ro)
LT (2) LT2822953T (ro)
LU (1) LUC00131I2 (ro)
MD (1) MD4590C1 (ro)
ME (1) ME02630B (ro)
MX (1) MX350844B (ro)
MY (1) MY169142A (ro)
NI (1) NI201400102A (ro)
NL (1) NL301006I2 (ro)
NO (1) NO2019034I1 (ro)
NZ (1) NZ627900A (ro)
PE (1) PE20142339A1 (ro)
PH (1) PH12014501992A1 (ro)
PL (1) PL2822953T3 (ro)
PT (1) PT2822953T (ro)
RS (1) RS55814B1 (ro)
SG (1) SG11201404451TA (ro)
SI (1) SI2822953T1 (ro)
TW (1) TWI476199B (ro)
UY (1) UY34657A (ro)
WO (1) WO2013132376A1 (ro)
ZA (1) ZA201406244B (ro)

Families Citing this family (78)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3239134B1 (en) 2013-01-31 2020-12-23 Vertex Pharmaceuticals Incorporated Pyridone amides as modulators of sodium channels
EP3013835B1 (en) 2013-06-28 2017-12-13 Pfizer Inc Solid forms of a macrocyclic kinase inhibitor
CN104513253A (zh) * 2013-10-01 2015-04-15 南京波尔泰药业科技有限公司 用于治疗增殖性疾病的大环化合物
BR122020007729B1 (pt) 2013-12-13 2023-05-09 Vertex Pharmaceuticals Incorporated Prófármacos de piridona amidas, suas formas cristalinas e processo de preparo dos mesmos
LT3097107T (lt) * 2014-01-24 2019-07-25 Turning Point Therapeutics, Inc. Diarilo makrociklai, kaip proteinkinazių moduliatoriai
US10231965B2 (en) 2014-02-20 2019-03-19 Ignyta, Inc. Molecules for administration to ROS1 mutant cancer cells
CN103772272A (zh) * 2014-03-04 2014-05-07 定陶县友帮化工有限公司 2-boc-氨基-3-羟基-5-溴吡啶的合成方法
WO2016026423A1 (en) * 2014-08-20 2016-02-25 Teligene Ltd Substituted macrocycles useful as kinases inhibitors and methods of use thereof
US10159663B2 (en) * 2014-08-20 2018-12-25 Teligene Ltd. Substituted macrocycles useful as kinases inhibitors and methods of use thereof
MX2017004515A (es) 2014-10-13 2017-10-31 Atrin Pharmaceuticals LLC Inhibidores de proteína-cinasas relacionados a ataxia-telengiectasia y rad3 (atr).
KR102595599B1 (ko) 2014-12-02 2023-11-02 이그니타, 인코포레이티드 신경모세포종의 치료를 위한 병용
AU2016207431B2 (en) * 2015-01-16 2021-05-06 Chugai Seiyaku Kabushiki Kaisha Combination drug
US10316044B2 (en) * 2015-07-02 2019-06-11 Tp Therapeutics, Inc. Chiral diaryl macrocycles as modulators of protein kinases
BR112018000297A2 (pt) 2015-07-06 2018-09-04 Tp Therapeutics Inc polimorfo de macrociclo de diarila
CN108026109B (zh) 2015-07-21 2021-03-02 特普医药公司 手性二芳基大环及其用途
HUE052790T2 (hu) * 2015-07-31 2021-05-28 Pfizer Lorlatinib szabad bázis kristályos formája
US20180282415A1 (en) 2015-09-30 2018-10-04 Merck Patent Gmbh Combination of a PD-1 Axis Binding Antagonist and an ALK Inhibitor for Treating ALK-Negative Cancer
MX2018007266A (es) 2015-12-18 2018-11-09 Ignyta Inc Combinaciones para el tratamiento del cancer.
ES2812336T3 (es) * 2016-03-03 2021-03-16 Shenzhen Targetrx Inc Macrocíclico y composición que comprende el mismo
CN105646355A (zh) * 2016-04-07 2016-06-08 戊言医药科技（上海）有限公司 3-(羟甲基)-1-甲基-吡唑-5-甲腈的制备方法
CN105732355A (zh) * 2016-04-07 2016-07-06 戊言医药科技（上海）有限公司 1-(5-氟-2-碘苯基)乙酮的制备方法
WO2017175091A1 (en) 2016-04-08 2017-10-12 Pfizer Inc. Crystalline forms of lorlatinib maleate
US10301324B2 (en) 2016-04-12 2019-05-28 Atrin Pharmaceuticals LLC Ataxia telengiectasia and rad3-related (ATR) inhibitors and methods of their use
CN105801603B (zh) * 2016-04-13 2018-10-02 成都倍特药业有限公司 一种具有大环结构的alk抑制剂及其制备方法
AU2017302019A1 (en) 2016-07-28 2019-02-07 Turning Point Therapeutics, Inc. Macrocycle kinase inhibitors
US11071721B2 (en) * 2016-12-02 2021-07-27 Genentech, Inc. Bicyclic amide compounds and methods of use thereof
WO2018137679A1 (en) * 2017-01-25 2018-08-02 Teligene Ltd Process for the Preparation of (10R) -7- (2-aminoacetyl) amino-12-fluoro-2, 10, 16-trimethyl-15-oxo-10, 15, 16, 17-tetrahydro-2H-8, 4- (metheno) pyrazolo [4, 3-h] [2, 5, 11] -benzoxadiazacyclotetradecine-3-carbonitrile
TWI808958B (zh) 2017-01-25 2023-07-21 美商特普醫葯公司 涉及二芳基巨環化合物之組合療法
AU2018271110A1 (en) 2017-05-16 2019-12-05 Vertex Pharmaceuticals Incorporated Deuterated pyridone amides and prodrugs thereof as modulators of sodium channels
WO2019002132A1 (en) 2017-06-30 2019-01-03 Bayer Animal Health Gmbh NEW AZAQUINOLINE DERIVATIVES
IL271759B2 (en) 2017-07-19 2024-01-01 Ignyta Inc Pharmaceutical preparations that include anthraxtinib
LT3658148T (lt) 2017-07-28 2024-09-10 Turning Point Therapeutics, Inc. Makrocikliniai junginiai ir jų panaudojimas
EP3694863B1 (en) 2017-10-10 2023-06-21 Pfizer Inc. Crystalline form of lorlatinib free base hydrate
CN111225662B (zh) 2017-10-17 2022-11-22 伊尼塔公司 药物组合物和剂型
US11179412B2 (en) 2017-12-04 2021-11-23 University of Pittsburgh—of the Commonwealth System of Higher Education Methods of treating conditions involving elevated inflammatory response
JP7194188B2 (ja) 2017-12-19 2022-12-21 ターニング・ポイント・セラピューティクス・インコーポレイテッド 疾患を治療するための大環状化合物
EP3752152A1 (en) 2018-02-12 2020-12-23 Vertex Pharmaceuticals Incorporated A method of treating pain
US11760701B2 (en) 2018-02-27 2023-09-19 The Research Foundation For The State University Of New Yrok Difluoromethoxylation and trifluoromethoxylation compositions and methods for synthesizing same
EP3784675A1 (en) 2018-04-23 2021-03-03 Pliva Hrvatska D.O.O. Solid state forms of lorlatinib and their preparation
WO2019210835A1 (zh) * 2018-05-04 2019-11-07 正大天晴药业集团股份有限公司 作为蛋白激酶调节剂的二芳基大环化合物
CN108621206B (zh) * 2018-05-07 2020-08-14 昆山国显光电有限公司 手套箱系统以及手套箱系统的保养方法
CA3113408A1 (en) * 2018-09-18 2020-03-26 Kabushiki Kaisha Yakult Honsha Cancer combination therapy using quinoline carboxamide derivative
CN109232607A (zh) * 2018-09-20 2019-01-18 沈阳药科大学 劳拉替尼的合成方法
CN109081810A (zh) * 2018-09-20 2018-12-25 沈阳药科大学 1-甲基-3–((甲氨基)甲基)-1h-吡唑-5-腈的合成方法
US12077528B2 (en) 2018-11-28 2024-09-03 Shenzhen Targetrx, Inc. Preparation method for deuterated macrocyclic compound
BR112021011894A2 (pt) 2018-12-21 2021-09-08 Daiichi Sankyo Company, Limited Composição farmacêutica
CN109651398B (zh) * 2019-01-25 2021-07-30 安庆多辉生物科技有限公司 一种合成劳拉替尼的溴代物中间体及催化合成劳拉替尼的方法
CN109651418A (zh) * 2019-01-25 2019-04-19 安庆多辉生物科技有限公司 一种劳拉替尼原料药合成中间体及有机金属钯催化偶联制备劳拉替尼的方法
CN109651397A (zh) * 2019-01-25 2019-04-19 安庆多辉生物科技有限公司 一种劳拉替尼中间体及制备劳拉替尼的方法
CN111499514B (zh) * 2019-01-31 2024-09-20 连云港润众制药有限公司 一种罗沙司他中间体的制备方法
US11976069B2 (en) 2019-03-21 2024-05-07 Merck Sharp & Dohme Llc Inhibitors of histone deacetylase useful for the treatment or prevention of HIV infection
CN112533927A (zh) * 2019-05-14 2021-03-19 苏州韬略生物科技有限公司 可用作激酶抑制剂的被取代的大环
EP3999514A1 (en) * 2019-07-18 2022-05-25 Pliva Hrvatska D.O.O. Crystalline lorlatinib : fumaric acid and solid state form thereof
CN112321604A (zh) * 2019-08-05 2021-02-05 华东理工大学 大环类jak2抑制剂及其应用
CN110483551B (zh) * 2019-08-30 2021-10-22 北京赛思源生物医药技术有限公司 一种劳拉替尼游离碱的晶体
WO2021069571A1 (en) 2019-10-10 2021-04-15 Sandoz Ag Polymorph of lorlatinib
CN112812128B (zh) * 2019-11-18 2024-04-02 正大天晴药业集团股份有限公司 作为alk和ros调节剂的大环化合物
CN112824417A (zh) * 2019-11-21 2021-05-21 上海天慈国际药业有限公司 一种劳拉替尼的制备方法
WO2021113627A1 (en) 2019-12-06 2021-06-10 Vertex Pharmaceuticals Incorporated Substituted tetrahydrofurans as modulators of sodium channels
CN111170908B (zh) * 2020-01-09 2021-08-17 北京印刷学院 一种2，4-二甲基-3-甲磺酰基卤苯的合成方法
WO2021176349A1 (en) 2020-03-05 2021-09-10 Pfizer Inc. Combination of an anaplastic lymphoma kinase inhibitor and a cyclin dependent kinase inhibitor
KR102699528B1 (ko) 2020-05-05 2024-08-30 뉴베일런트, 아이엔씨. 헤테로방향족 거대환식 에터 화학치료제
JP7519464B2 (ja) * 2020-05-05 2024-07-19 ヌバレント， インク． ヘテロ芳香族大環状エーテル化学療法剤
US20230174554A1 (en) * 2020-05-18 2023-06-08 Shenzhen TargetRx. Inc. Solid form of macrocyclic compound, preparation therefor and use thereof
KR20230037564A (ko) * 2020-07-10 2023-03-16 블로썸힐 테라퓨틱스, 인크. 거대고리 화합물 및 그의 용도
JP2023553835A (ja) * 2020-12-17 2023-12-26 ブロッサムヒル・セラピューティクス・インコーポレイテッド 大環状化合物およびそれらの使用
CN114805371B (zh) * 2021-01-19 2024-05-24 江苏开元药业有限公司 含2-氨基嘧啶大环类化合物及其制备方法和用途
WO2022182845A1 (en) * 2021-02-25 2022-09-01 Blossomhill Therapeutics, Inc. Macrocycles and their use
US20240382592A1 (en) 2021-04-09 2024-11-21 Institut National de la Santé et de la Recherche Médicale Methods for the treatment of anaplastic large cell lymphoma
CN115246843A (zh) * 2021-04-26 2022-10-28 苏州东南药业股份有限公司 一类十四元稠环衍生物及其应用
CR20230586A (es) 2021-06-04 2024-05-07 Vertex Pharma N-(hydroxyalquil (hetero)aril) tetrahidrofurano carboxamidas como moduladores de canales de sodio
MX2024003738A (es) * 2021-10-01 2024-06-19 Nuvalent Inc Formas solidas, composiciones farmaceuticas y preparacion de compuestos de eter macrociclico heteroaromatico.
WO2023156983A1 (en) 2022-02-21 2023-08-24 Universidade Nova De Lisboa Compounds and compositions for neurodegenerative diseases
EP4230201A1 (en) 2022-02-21 2023-08-23 Universidade Nova De Lisboa Composition for treating neurodegenerative diseases
WO2024086634A1 (en) * 2022-10-19 2024-04-25 Nuvalent, Inc. Heteroaromatic macrocyclic ether chemotherapeutic agents
CN115746023B (zh) * 2022-10-27 2024-08-09 复旦大学 一种作为蛋白激酶抑制剂的含吲唑结构的杂环大环化合物及其制备方法
WO2024046512A2 (zh) * 2022-12-01 2024-03-07 中国医药研究开发中心有限公司 含氮大环类化合物及其制备方法和医药用途
WO2024146541A1 (en) * 2023-01-03 2024-07-11 Guangdong Newopp Biopharmaceuticals Co., Ltd. Macrocyclic compounds as usp1 inhibitors

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021884A2 (en) * 2004-08-26 2006-03-02 Pfizer Inc. Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
US20110256546A1 (en) * 2010-04-15 2011-10-20 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (alk) kinase inhibitors
WO2011138751A2 (en) * 2010-05-04 2011-11-10 Pfizer Inc. Heterocyclic derivatives as alk inhibitors

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR0166088B1 (ko) 1990-01-23 1999-01-15 . 수용해도가 증가된 시클로덱스트린 유도체 및 이의 용도
US5376645A (en) 1990-01-23 1994-12-27 University Of Kansas Derivatives of cyclodextrins exhibiting enhanced aqueous solubility and the use thereof
GB9518953D0 (en) 1995-09-15 1995-11-15 Pfizer Ltd Pharmaceutical formulations
WO2000035298A1 (en) 1996-11-27 2000-06-22 Wm. Wrigley Jr. Company Chewing gum containing medicament active agents
GB9711643D0 (en) 1997-06-05 1997-07-30 Janssen Pharmaceutica Nv Glass thermoplastic systems
DE10239042A1 (de) 2002-08-21 2004-03-04 Schering Ag Makrozyclische Pyrimidine, deren Herstellung und Verwendung als Arzneimittel
PT2476667E (pt) 2003-02-26 2014-09-18 Sugen Inc Compostos de aminoheteroarilo como inibidores da proteína quinase
WO2004078682A2 (en) 2003-03-05 2004-09-16 Irm Llc Cyclic compounds and compositions as protein kinase inhibitors
PA8603801A1 (es) * 2003-05-27 2004-12-16 Janssen Pharmaceutica Nv Derivados de la quinazolina
RU2346996C2 (ru) 2004-06-29 2009-02-20 ЮРОПИЭН НИКЕЛЬ ПиЭлСи Усовершенствованное выщелачивание основных металлов
US7456170B2 (en) 2004-08-25 2008-11-25 Pfizer Inc. Triazolobenzodiazepines and their use as vasopressin antagonists
JP4167295B2 (ja) 2004-08-26 2008-10-15 ファイザー・インク プロテインキナーゼ阻害薬としてのピラゾール置換アミノへテロアリール化合物
EP1710246A1 (en) 2005-04-08 2006-10-11 Schering Aktiengesellschaft Sulfoximine-pyrimidine Macrocycles and the salts thereof, a process for making them, and their pharmaceutical use against cancer
WO2007066185A2 (en) 2005-12-05 2007-06-14 Pfizer Products Inc. Polymorphs of a c-met/hgfr inhibitor
DK1959955T3 (da) 2005-12-05 2011-02-07 Pfizer Prod Inc Fremgangsmåde til behandling af abnorm cellevækst
EP2120578B1 (en) 2007-01-19 2014-11-19 Xcovery, INC. Kinase inhibitor compounds
BRPI0808524A2 (pt) 2007-03-01 2014-11-11 Chugai Pharmaceutical Co Ltd Composto macrocíclico
AU2008224633A1 (en) * 2007-03-13 2008-09-18 Pfizer Products Inc. Erythromycin-based macrolides
JP2011511005A (ja) * 2008-02-04 2011-04-07 オーエスアイ・フアーマスーテイカルズ・インコーポレーテツド ２−アミノピリジン系キナーゼ阻害薬
CA2722326A1 (en) 2008-04-24 2009-10-29 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
BRPI0913349A2 (pt) * 2008-06-06 2015-11-24 Sanofi Aventis derivados de ureia e sulfamida macrocíclicos como inibidores de tafia
JP5749645B2 (ja) * 2008-09-08 2015-07-15 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ タンパク質キナーゼ阻害剤としての大環状ピリミジン
US8765727B2 (en) * 2009-01-23 2014-07-01 Incyte Corporation Macrocyclic compounds and their use as kinase inhibitors
US20120258993A1 (en) 2009-10-21 2012-10-11 Sigma-Tau Industrie Farmaceutiche Riunite S.P.A. Non-natural macrocyclic amide hdac6 inhibitor compounds and their uses as therapeutic agents
ES2628418T3 (es) * 2010-05-20 2017-08-02 Array Biopharma, Inc. Compuestos macrocíclicos como inhibidores de la TRK cinasa
WO2012016186A1 (en) 2010-07-29 2012-02-02 President And Fellows Of Harvard College Macrocyclic kinase inhibitors and uses thereof
EP2686323A1 (en) 2011-03-16 2014-01-22 Cephalon, Inc. Macrocyclic compounds as alk, fak and jak2 inhibitors

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006021884A2 (en) * 2004-08-26 2006-03-02 Pfizer Inc. Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
US20060046991A1 (en) * 2004-08-26 2006-03-02 Agouron Pharmaceuticals, Inc. Enantiomerically pure aminoheteroaryl compounds as protein kinase inhibitors
US20110256546A1 (en) * 2010-04-15 2011-10-20 St. Jude Children's Research Hospital Methods and compositions for the diagnosis and treatment of cancer resistant to anaplastic lymphoma kinase (alk) kinase inhibitors
WO2011138751A2 (en) * 2010-05-04 2011-11-10 Pfizer Inc. Heterocyclic derivatives as alk inhibitors

Non-Patent Citations (13)

* Cited by examiner, † Cited by third party
Title
Choi YL et al. N. Engl. J. Med., 2010, 363, 18, р. 1734-1739 *
Iwahara T. et al. Oncogene, 1997, 14, р. 439-449 *
K.I.Milkiewicz et al. Inhibitors of anaplastic lymphoma kinase, 2010.01.01, vol. 20, p. 1653-1681 *
Kostich M et al. Genome Biology, 2002, 3, p. 1-12 *
Kwak et al. New Eng. J. of Med., 2010, 363, 18, р. 1693-1703 *
Mewng K. et al. PNAS, 2000, 97, p. 2603-2608 *
Perez-Pinera P. et al. J. Biol. Chem., 2007, 282, р. 28683-28690 *
Soda M. et al. Nature, 2007, 448, р. 561-567 *
Stoica G.E. et al. J. Biol. Chem., 2001, 276, p. 16772-16779 *
Stoica G.E. et al. J. Biol. Chem., 2002, 277, p. 35990-35999 *
Turner S.D. et al. Cell Signal, 2007, 19, р. 740-747 *
Vernersson E. et al. Gene Expression Patterns, 2006, 6, р. 448-461 *
Webb T.R. et al. Expert Reviews in Anticancer Therapy, 2009, 9, р. 331-355 *

Also Published As

Publication number Publication date
CY2019033I2 (el) 2019-11-27
MX2014010716A (es) 2014-09-22
CN104169286B (zh) 2016-06-08
PH12014501992B1 (en) 2014-11-24
PT2822953T (pt) 2017-04-06
GEP201606560B (en) 2016-10-25
EA026155B9 (ru) 2017-06-30
NI201400102A (es) 2015-03-05
CL2014002084A1 (es) 2014-11-03
CN104169286A (zh) 2014-11-26
DK2822953T3 (en) 2017-04-03
MX350844B (es) 2017-09-22
EP2822953B1 (en) 2017-02-01
FR19C1062I2 (fr) 2020-09-04
NO2019034I1 (no) 2019-08-19
RS55814B1 (sr) 2017-08-31
US9133215B2 (en) 2015-09-15
GT201400187A (es) 2015-10-15
CA2863892C (en) 2016-08-30
UY34657A (es) 2013-10-31
JP2015510879A (ja) 2015-04-13
ES2621220T3 (es) 2017-07-03
PL2822953T3 (pl) 2017-07-31
TWI476199B (zh) 2015-03-11
EA201491394A1 (ru) 2015-05-29
ES2621220T9 (es) 2017-11-23
LUC00131I2 (ro) 2020-07-16
PE20142339A1 (es) 2015-01-15
WO2013132376A1 (en) 2013-09-12
BR112014022106B1 (pt) 2022-08-02
AR090230A1 (es) 2014-10-29
HUS1900040I1 (hu) 2019-09-30
US20130252961A1 (en) 2013-09-26
HK1199247A1 (zh) 2015-06-26
AU2013229173B2 (en) 2017-06-01
PH12014501992A1 (en) 2014-11-24
TW201350484A (zh) 2013-12-16
DOP2014000188A (es) 2014-11-16
SG11201404451TA (en) 2014-09-26
SI2822953T1 (sl) 2017-04-26
CY1118771T1 (el) 2017-07-12
ZA201406244B (en) 2015-05-27
CR20140370A (es) 2014-08-21
MY169142A (en) 2019-02-18
EP2822953A1 (en) 2015-01-14
JP2016041709A (ja) 2016-03-31
FR19C1062I1 (ro) 2019-11-22
HRP20170287T1 (hr) 2017-04-21
LTPA2019519I1 (lt) 2019-11-11
IL234062A (en) 2017-08-31
LUC00131I1 (ro) 2019-10-11
HUE034118T2 (en) 2018-01-29
DK2822953T5 (en) 2017-09-11
KR101692600B1 (ko) 2017-01-03
US8680111B2 (en) 2014-03-25
CA2863892A1 (en) 2013-09-12
EA026155B1 (ru) 2017-03-31
MD4590B1 (ro) 2018-08-31
US20140135339A1 (en) 2014-05-15
AU2013229173A1 (en) 2014-08-21
EP2822953B9 (en) 2017-06-21
ME02630B (me) 2017-06-20
CO7061081A2 (es) 2014-09-19
AP2014007881A0 (en) 2014-08-31
JP6002825B2 (ja) 2016-10-05
HRP20170287T2 (hr) 2017-11-03
CY2019033I1 (el) 2019-11-27
KR20140137414A (ko) 2014-12-02
NZ627900A (en) 2016-08-26
NL301006I2 (nl) 2020-04-14
MD4590C1 (ro) 2019-03-31
BR112014022106A2 (pt) 2017-07-11
LT2822953T (lt) 2017-04-10
LTC2822953I2 (lt) 2020-12-28
JP5823066B2 (ja) 2015-11-25

Similar Documents

Publication Publication Date Title
MD20140086A2 (ro) Derivaţi macrociclici pentru tratamentul bolilor proliferative
MX361815B (es) Compuestos pirazolopirimidinicos como inhibidores de cinasas.
MY199894A (en) Prmt5 inhibitors and uses thereof
MY158494A (en) Pharmaceutically active compounds as axl inhibitors
UA117830C2 (uk) Похідні біпіразолу як інгібітори jak
PH12014500867A1 (en) Anticancer pyridopyrazines via the inhibition of fgfr kinases
PH12016502378A1 (en) Substituted dihydroisoquinolinone compounds
TN2013000348A1 (en) Compounds and compositions as trk inhibitors
MX2013011908A (es) Composiciones y usos terapeuticos de inhibidores de cinasa epsilon relacionados con cinasa i-kappa b (ikk) y cinasa 1 de union tank.
MY177344A (en) Compounds and their methods of use
NZ604480A (en) Morpholino pyrimidines and their use in therapy
MX360404B (es) Compuestos para inhibir la proliferacion celular en canceres transmitidos por egfr.
MX2013001361A (es) 4-(1h-indol-3-il) - pirimidina como inhibidores de alk.
JO3115B1 (ar) مركبات بيريدازينون واستخدامها كمثبطات daao
MX2013011931A (es) Compuestos de cromenona como inhibidores de pi 3-quinasa para el tratamiento del cancer.
MX2012000166A (es) Compuestos de quinazolina que contienen fosforo y metodos de uso de los mismos.
NZ706591A (en) Oxazolidin-2-one-pyrimidine derivatives
MX2014000964A (es) Derivados aza heterociclicos sustituidos.
MX2012008328A (es) Derivados de pirazina.
MX2016003522A (es) Derivados de quinazolinas y su uso como inhibidores de la adn metiltransferasa.
MX2012013879A (es) Derivados de hidroxipiridona, composiciones farmceuticas de los mismos y su uso terapeutico para tratar enfermedades proliferativas.
UA109793C2 (uk) Арилсульфонаміди для лікування захворювань центральної нервової системи (цнс)
UA110293C2 (en) Macrocyclic derivatives for the treatment of proliferative diseases
CU20140107A7 (es) Derivados macrocíclicos para el tratamiento de enfermedades
TN2014000077A1 (en) Pyridazinone compounds and their use as daao inhibitors

Legal Events

Date Code Title Description
FG4A Patent for invention issued