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MA54948A - Dérivés thiéno[3,2-b]-pyrrole[3,2-d]pyridazinones et leur utilisation comme dérivés de pkm2 pour le traitement de troubles associés au cancer, à l'obésité et au diabète - Google Patents

Dérivés thiéno[3,2-b]-pyrrole[3,2-d]pyridazinones et leur utilisation comme dérivés de pkm2 pour le traitement de troubles associés au cancer, à l'obésité et au diabète

Info

Publication number
MA54948A
MA54948A MA054948A MA54948A MA54948A MA 54948 A MA54948 A MA 54948A MA 054948 A MA054948 A MA 054948A MA 54948 A MA54948 A MA 54948A MA 54948 A MA54948 A MA 54948A
Authority
MA
Morocco
Prior art keywords
derivatives
pkm2
thieno
pyrrole
obesity
Prior art date
Application number
MA054948A
Other languages
English (en)
Inventor
Jingjing Ji
Tao Liu
Zhihua Sui
Original Assignee
Agios Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agios Pharmaceuticals Inc filed Critical Agios Pharmaceuticals Inc
Publication of MA54948A publication Critical patent/MA54948A/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D495/14—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A61K31/5025—Pyridazines; Hydrogenated pyridazines ortho- or peri-condensed with heterocyclic ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
    • C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D495/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains three hetero rings
    • C07D498/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
    • C07D513/12—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains three hetero rings
    • C07D513/14—Ortho-condensed systems

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Emergency Medicine (AREA)
  • Endocrinology (AREA)
  • Obesity (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
MA054948A 2019-02-13 2020-02-12 Dérivés thiéno[3,2-b]-pyrrole[3,2-d]pyridazinones et leur utilisation comme dérivés de pkm2 pour le traitement de troubles associés au cancer, à l'obésité et au diabète MA54948A (fr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201962805040P 2019-02-13 2019-02-13

Publications (1)

Publication Number Publication Date
MA54948A true MA54948A (fr) 2021-12-22

Family

ID=69941460

Family Applications (1)

Application Number Title Priority Date Filing Date
MA054948A MA54948A (fr) 2019-02-13 2020-02-12 Dérivés thiéno[3,2-b]-pyrrole[3,2-d]pyridazinones et leur utilisation comme dérivés de pkm2 pour le traitement de troubles associés au cancer, à l'obésité et au diabète

Country Status (14)

Country Link
US (1) US20220127267A1 (fr)
EP (1) EP3924056A1 (fr)
JP (1) JP2022520090A (fr)
KR (1) KR20210128435A (fr)
CN (1) CN113646050A (fr)
AU (1) AU2020221837A1 (fr)
BR (1) BR112021015996A2 (fr)
CA (1) CA3129829A1 (fr)
CO (1) CO2021011919A2 (fr)
IL (1) IL285445A (fr)
MA (1) MA54948A (fr)
MX (1) MX2021009743A (fr)
SG (1) SG11202108744WA (fr)
WO (1) WO2020167976A1 (fr)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT3668513T (pt) 2017-08-15 2022-01-21 Agios Pharmaceuticals Inc Ativadores da piruvato quinase para uso no tratamento de distúrbios do sangue
JP2023535027A (ja) * 2020-07-21 2023-08-15 ザ・リージェンツ・オブ・ザ・ユニバーシティ・オブ・ミシガン ピルビン酸キナーゼを活性化するための組成物及び方法
WO2022170200A1 (fr) 2021-02-08 2022-08-11 Global Blood Therapeutics, Inc. Dérivés de 1-(2-sulfonyl-2,6-dihydropyrrolo[3,4-c]pyrazol-5-yl]-éthanone servant d'activateurs de pyruvate kinase (pkr) et de pkm2 pour le traitement de la drépanocytose
JP2024539573A (ja) 2021-09-30 2024-10-29 シトリクス・セラピューティクス・リミテッド 新規化合物
WO2023079294A1 (fr) 2021-11-05 2023-05-11 Sitryx Therapeutics Limited Dérivés de phtalazine utilisés comme modulateurs de la pyruvate kinase
AU2022418385A1 (en) 2021-12-22 2024-05-30 Sitryx Therapeutics Limited Phthalazine derivatives as pyruvate kinase modulators
CN118434720A (zh) 2021-12-22 2024-08-02 西特瑞治疗有限公司 作为丙酮酸激酶调节剂的酞嗪衍生物
CN115487190A (zh) * 2022-11-01 2022-12-20 复旦大学附属中山医院 丙酮酸激酶m2激活剂在制备治疗系统性红斑狼疮的药物中的应用
CN116808223A (zh) * 2023-08-04 2023-09-29 复旦大学附属中山医院 丙酮酸激酶m2激活剂在制备治疗银屑病的药物中的应用

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8841305B2 (en) * 2008-10-09 2014-09-23 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Activators of the human pyruvate kinase M2 receptor
TWI598337B (zh) 2009-06-29 2017-09-11 阿吉歐斯製藥公司 治療化合物及組成物
US9404081B2 (en) * 2011-05-03 2016-08-02 Agios Pharmaceuticals, Inc. Pyruvate kinase activators for use in therapy
KR101873543B1 (ko) 2011-05-03 2018-07-02 아지오스 파마슈티컬스 아이엔씨. 치료에 사용하기 위한 피루베이트 키나아제 활성제
EP3372230B1 (fr) * 2011-05-03 2020-08-12 Agios Pharmaceuticals, Inc. Activateurs de pyruvate kinase destinés à être utilisés pour allonger la durée de vie des érythrocytes et traiter l'anémie
EP2877214B1 (fr) 2012-07-26 2019-04-24 Joslin Diabetes Center, Inc. Prédiction de complications diabétiques
PT3668513T (pt) * 2017-08-15 2022-01-21 Agios Pharmaceuticals Inc Ativadores da piruvato quinase para uso no tratamento de distúrbios do sangue

Also Published As

Publication number Publication date
KR20210128435A (ko) 2021-10-26
MX2021009743A (es) 2021-11-12
US20220127267A1 (en) 2022-04-28
CA3129829A1 (fr) 2020-08-20
SG11202108744WA (en) 2021-09-29
BR112021015996A2 (pt) 2021-11-09
CN113646050A (zh) 2021-11-12
IL285445A (en) 2021-09-30
WO2020167976A1 (fr) 2020-08-20
CO2021011919A2 (es) 2021-12-10
AU2020221837A1 (en) 2021-09-02
JP2022520090A (ja) 2022-03-28
EP3924056A1 (fr) 2021-12-22

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