MA43823A - Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation - Google Patents
Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisationInfo
- Publication number
- MA43823A MA43823A MA043823A MA43823A MA43823A MA 43823 A MA43823 A MA 43823A MA 043823 A MA043823 A MA 043823A MA 43823 A MA43823 A MA 43823A MA 43823 A MA43823 A MA 43823A
- Authority
- MA
- Morocco
- Prior art keywords
- menin
- mll
- methods
- bridged bicyclic
- bicyclic inhibitors
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Medicinal Chemistry (AREA)
- Epidemiology (AREA)
- Hematology (AREA)
- Oncology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662309362P | 2016-03-16 | 2016-03-16 | |
| US201662431387P | 2016-12-07 | 2016-12-07 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MA43823A true MA43823A (fr) | 2018-11-28 |
Family
ID=59851929
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MA043823A MA43823A (fr) | 2016-03-16 | 2017-03-15 | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
Country Status (17)
| Country | Link |
|---|---|
| US (2) | US10752639B2 (fr) |
| EP (1) | EP3429585B1 (fr) |
| JP (1) | JP7000333B2 (fr) |
| KR (1) | KR102419524B1 (fr) |
| CN (1) | CN109640987B (fr) |
| AU (1) | AU2017235462B2 (fr) |
| BR (1) | BR112018068702A2 (fr) |
| CA (1) | CA3015845A1 (fr) |
| HK (1) | HK1258821A1 (fr) |
| IL (1) | IL261625B (fr) |
| MA (1) | MA43823A (fr) |
| MX (1) | MX2018011092A (fr) |
| PH (1) | PH12018501955A1 (fr) |
| SG (1) | SG11201807834WA (fr) |
| TW (1) | TWI743096B (fr) |
| WO (1) | WO2017161002A1 (fr) |
| ZA (1) | ZA201805845B (fr) |
Families Citing this family (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2016040330A1 (fr) | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Composés de thiénopyrimidine et de thiénopyridine et leurs procédés d'utilisation |
| US10588907B2 (en) | 2015-06-04 | 2020-03-17 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| HRP20230537T1 (hr) | 2016-03-16 | 2023-08-04 | Kura Oncology, Inc. | Supstituirani derivati tieno[2,3-d]pirimidina kao inhibitori za menin-mll i postupci za uporabu |
| EP3429585B1 (fr) | 2016-03-16 | 2021-11-24 | Kura Oncology, Inc. | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
| BR112018072570A2 (pt) | 2016-05-02 | 2019-02-19 | Univ Michigan Regents | piperidinas como inibidores de menina |
| AU2017326485B2 (en) | 2016-09-14 | 2021-04-22 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
| SI3512857T1 (sl) | 2016-09-14 | 2021-07-30 | Janssen Pharmaceutica Nv | Spiro biciklični zaviralci interakcije menin-MLL |
| US12084462B2 (en) | 2016-09-14 | 2024-09-10 | Janssen Pharmaceutica Nv | Spiro bicyclic inhibitors of menin-MLL interaction |
| MX2019007067A (es) | 2016-12-15 | 2019-10-15 | Janssen Pharmaceutica Nv | Inhibidores de azepano de la interacción menina-mll. |
| EA201991448A1 (ru) | 2017-01-06 | 2019-12-30 | Янссен Фармацевтика Нв | Азепановые ингибиторы взаимодействия менин-mll |
| CN110691779B (zh) * | 2017-03-24 | 2023-10-10 | 库拉肿瘤学公司 | 治疗血液系统恶性肿瘤和尤因肉瘤的方法 |
| KR20190133224A (ko) | 2017-03-31 | 2019-12-02 | 더 리젠츠 오브 더 유니버시티 오브 미시간 | 공유 메닌 억제제로서의 피페리딘 |
| US11542248B2 (en) | 2017-06-08 | 2023-01-03 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| WO2019060365A1 (fr) * | 2017-09-20 | 2019-03-28 | Kura Oncology, Inc. | Inhibiteurs substitués de ménine-mll et méthodes d'utilisation |
| US11396517B1 (en) | 2017-12-20 | 2022-07-26 | Janssen Pharmaceutica Nv | Exo-aza spiro inhibitors of menin-MLL interaction |
| CN110204552B (zh) * | 2018-02-28 | 2021-08-17 | 中国科学院上海药物研究所 | 一类噻吩并[3,2-d]嘧啶衍生物、其制备方法、药物组合物与用途 |
| CN112105621B (zh) | 2018-03-30 | 2024-02-20 | 住友制药株式会社 | 光学活性桥型环状仲胺衍生物 |
| JP2022503792A (ja) * | 2018-09-26 | 2022-01-12 | クラ オンコロジー，インク． | メニン阻害剤を用いた血液悪性腫瘍の処置 |
| CN110964016B (zh) * | 2018-09-29 | 2021-05-28 | 南京药捷安康生物科技有限公司 | 氨基降茨烷衍生物及其制备方法与应用 |
| KR20210100612A (ko) | 2018-12-06 | 2021-08-17 | 다이이찌 산쿄 가부시키가이샤 | 시클로알칸-1,3-디아민 유도체 |
| WO2020142557A1 (fr) | 2018-12-31 | 2020-07-09 | Biomea Fusion, Llc | Inhibiteurs irréversibles de l'interaction ménine-mll |
| US11174263B2 (en) * | 2018-12-31 | 2021-11-16 | Biomea Fusion, Inc. | Inhibitors of menin-MLL interaction |
| SG11202108798XA (en) | 2019-02-15 | 2021-09-29 | Bristol Myers Squibb Co | Substituted amide compounds useful as farnesoid x receptor modulators |
| CN111297863B (zh) * | 2020-03-30 | 2021-06-25 | 四川大学华西医院 | menin-MLL抑制剂在制备治疗子宫内膜癌的药物中的应用 |
| EP4132932A4 (fr) * | 2020-04-07 | 2024-04-17 | Syndax Pharmaceuticals, Inc. | Combinaisons d'inhibiteurs de ménine et d'inhibiteurs de cyp3a4 et procédés d'utilisation associés |
| BR112023021040A2 (pt) | 2021-05-08 | 2024-02-06 | Janssen Pharmaceutica Nv | Derivados espiro substituídos |
| KR20240006542A (ko) | 2021-05-08 | 2024-01-15 | 얀센 파마슈티카 엔브이 | 치환된 스피로 유도체 |
| AU2022274325A1 (en) | 2021-05-14 | 2023-10-05 | Syndax Pharmaceuticals, Inc. | Inhibitors of the menin-mll interaction |
| CN117396476A (zh) | 2021-06-01 | 2024-01-12 | 詹森药业有限公司 | 取代的苯基-1H-吡咯并[2,3-c]吡啶衍生物 |
| JP2024521902A (ja) | 2021-06-03 | 2024-06-04 | ヤンセン ファーマシューティカ エヌ．ベー． | スピロ環状アミンで置換されたピリダジン又は１，２，４－トリアジン |
| TW202315636A (zh) | 2021-06-17 | 2023-04-16 | 比利時商健生藥品公司 | （ｒ）－ｎ－乙基－５－氟－ｎ－異丙基－２－（（５－（２－（６－（（２－甲氧基乙基）（甲基）胺基）－２－甲基己－３－基）－２，６－二氮雜螺［３．４］辛－６－基）－１，２，４－三𠯤－６－基）氧基）苯甲醯胺苯磺酸鹽 |
| IL310717A (en) | 2021-08-20 | 2024-04-01 | Biomea Fusion Inc | Crystalline form of N-[4-[4-(4-morpholinyl)-7H-PYRROLO[2,3-D]PYRIMIDIN-6-YL]PHENYL]-4-[[3(R)-[(1-OXO ] -2-PROPEN-1-YL)AMINO]-1-PIPERIDINYL]METHYL]-2-PYRIDINECARBOXAMIDE, IRREVERSIBLE MENIN-MLL INHIBITOR FOR CANCER TREATMENT |
| WO2023220098A1 (fr) * | 2022-05-09 | 2023-11-16 | Syndax Pharmaceuticals, Inc. | Inhibiteurs de ménine-mll pour le traitement du cancer |
| WO2024110649A1 (fr) | 2022-11-24 | 2024-05-30 | Oryzon Genomics, S.A. | Combinaisons d'inhibiteurs de lsd1 et d'inhibiteurs de ménine pour le traitement du cancer |
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| WO2014164543A1 (fr) | 2013-03-13 | 2014-10-09 | The Regents Of The University Of Michigan | Compositions comprenant des composés thiénopyrimidine et thiénopyridine et procédés d'utilisation associés |
| WO2014160478A1 (fr) | 2013-03-13 | 2014-10-02 | Flatley Discovery Lab | Composés et procédés pour le traitement de fibrose kystique |
| US9212180B2 (en) * | 2013-06-12 | 2015-12-15 | The Regents Of The University Of Michigan | Menin-MLL inhibitors and methods of use thereof |
| AU2015240535A1 (en) * | 2014-04-04 | 2016-10-20 | Syros Pharmaceuticals, Inc. | Inhibitors of cyclin-dependent kinase 7 (CDK7) |
| WO2015191701A1 (fr) | 2014-06-10 | 2015-12-17 | The Trustees Of The University Of Pennsylvania | Échafaudages pour inhibiteurs d'interactions ménine-mll |
| WO2016040330A1 (fr) * | 2014-09-09 | 2016-03-17 | The Regents Of The University Of Michigan | Composés de thiénopyrimidine et de thiénopyridine et leurs procédés d'utilisation |
| TWI703150B (zh) | 2015-06-04 | 2020-09-01 | 美商庫拉腫瘤技術股份有限公司 | 用於抑制ｍｅｎｉｎ及ｍｌｌ蛋白之交互作用的方法及組合物 |
| US10588907B2 (en) | 2015-06-04 | 2020-03-17 | Kura Oncology, Inc. | Methods and compositions for inhibiting the interaction of menin with MLL proteins |
| JP2018538330A (ja) | 2015-12-22 | 2018-12-27 | ヴァイティー ファーマシューティカルズ，インコーポレイテッド | ｍｅｎｉｎ−ＭＬＬ相互作用の阻害剤 |
| EP3407884A4 (fr) | 2016-01-26 | 2019-09-11 | Memorial Sloan-Kettering Cancer Center | Inhibition de l'expression génique leucémogénique dans la leucémie mutantenpm1 |
| EP3429585B1 (fr) | 2016-03-16 | 2021-11-24 | Kura Oncology, Inc. | Inhibiteurs bicycliques pontés de ménine-mll et méthodes d'utilisation |
| HRP20230537T1 (hr) | 2016-03-16 | 2023-08-04 | Kura Oncology, Inc. | Supstituirani derivati tieno[2,3-d]pirimidina kao inhibitori za menin-mll i postupci za uporabu |
| BR112018072570A2 (pt) | 2016-05-02 | 2019-02-19 | Univ Michigan Regents | piperidinas como inibidores de menina |
| WO2017207387A1 (fr) | 2016-05-31 | 2017-12-07 | Bayer Pharma Aktiengesellschaft | Dérivés d'azétidine spiro condensés en tant qu'inhibiteurs de l'interaction ménine-mml1 |
| CN109743875B (zh) | 2016-06-10 | 2022-04-29 | 生命医药有限责任公司 | Menin-mll相互作用的抑制剂 |
| WO2018024602A1 (fr) | 2016-08-04 | 2018-02-08 | Bayer Aktiengesellschaft | 2,7-diazaspiro [4,4] nonanes |
| AU2017326485B2 (en) | 2016-09-14 | 2021-04-22 | Janssen Pharmaceutica Nv | Fused bicyclic inhibitors of menin-MLL interaction |
| TWI738864B (zh) | 2016-09-14 | 2021-09-11 | 比利時商健生藥品公司 | Ｍｅｎｉｎ-ｍｌｌ相互作用之螺二環抑制劑 |
| AU2017326006B2 (en) | 2016-09-16 | 2021-10-28 | Vitae Pharmaceuticals, LLC. | Inhibitors of the menin-MLL interaction |
-
2017
- 2017-03-15 EP EP17767444.7A patent/EP3429585B1/fr active Active
- 2017-03-15 SG SG11201807834WA patent/SG11201807834WA/en unknown
- 2017-03-15 WO PCT/US2017/022535 patent/WO2017161002A1/fr active Application Filing
- 2017-03-15 TW TW106108619A patent/TWI743096B/zh active
- 2017-03-15 AU AU2017235462A patent/AU2017235462B2/en active Active
- 2017-03-15 JP JP2018544323A patent/JP7000333B2/ja active Active
- 2017-03-15 KR KR1020187029700A patent/KR102419524B1/ko active IP Right Grant
- 2017-03-15 BR BR112018068702A patent/BR112018068702A2/pt not_active Application Discontinuation
- 2017-03-15 MA MA043823A patent/MA43823A/fr unknown
- 2017-03-15 CA CA3015845A patent/CA3015845A1/fr active Pending
- 2017-03-15 US US16/082,645 patent/US10752639B2/en active Active
- 2017-03-15 CN CN201780030449.4A patent/CN109640987B/zh active Active
- 2017-03-15 MX MX2018011092A patent/MX2018011092A/es unknown
-
2018
- 2018-08-30 ZA ZA2018/05845A patent/ZA201805845B/en unknown
- 2018-09-05 IL IL261625A patent/IL261625B/en unknown
- 2018-09-11 PH PH12018501955A patent/PH12018501955A1/en unknown
-
2019
- 2019-01-23 HK HK19101198.7A patent/HK1258821A1/zh unknown
-
2020
- 2020-07-13 US US16/927,844 patent/US11555041B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| KR20180127406A (ko) | 2018-11-28 |
| IL261625A (en) | 2018-10-31 |
| PH12018501955A1 (en) | 2019-06-17 |
| CA3015845A1 (fr) | 2017-09-21 |
| MX2018011092A (es) | 2018-11-22 |
| ZA201805845B (en) | 2023-03-29 |
| US10752639B2 (en) | 2020-08-25 |
| KR102419524B1 (ko) | 2022-07-08 |
| AU2017235462B2 (en) | 2021-07-01 |
| EP3429585A4 (fr) | 2019-10-09 |
| TW201742870A (zh) | 2017-12-16 |
| IL261625B (en) | 2021-08-31 |
| AU2017235462A1 (en) | 2018-09-27 |
| BR112018068702A2 (pt) | 2019-01-15 |
| HK1258821A1 (zh) | 2019-11-22 |
| JP2019508426A (ja) | 2019-03-28 |
| US20190092783A1 (en) | 2019-03-28 |
| JP7000333B2 (ja) | 2022-02-10 |
| TWI743096B (zh) | 2021-10-21 |
| SG11201807834WA (en) | 2018-10-30 |
| CN109640987A (zh) | 2019-04-16 |
| US20210107917A1 (en) | 2021-04-15 |
| WO2017161002A1 (fr) | 2017-09-21 |
| EP3429585A1 (fr) | 2019-01-23 |
| US11555041B2 (en) | 2023-01-17 |
| EP3429585B1 (fr) | 2021-11-24 |
| CN109640987B (zh) | 2022-12-02 |
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