Nothing Special   »   [go: up one dir, main page]

MA42795B1 - Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus du vih - Google Patents

Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus du vih

Info

Publication number
MA42795B1
MA42795B1 MA42795A MA42795A MA42795B1 MA 42795 B1 MA42795 B1 MA 42795B1 MA 42795 A MA42795 A MA 42795A MA 42795 A MA42795 A MA 42795A MA 42795 B1 MA42795 B1 MA 42795B1
Authority
MA
Morocco
Prior art keywords
infection
therapeutic
prophylactic
hiv virus
compounds useful
Prior art date
Application number
MA42795A
Other languages
English (en)
Other versions
MA42795A (fr
Inventor
Dimitrios Stefanidis
John O Link
Michael Graupe
Steven J Henry
Charles William Rowe
Roland D Saito
Scott D Schroeder
Winston C Tse
Jennifer R Zhang
Original Assignee
Gilead Sciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=59714166&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA42795(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Gilead Sciences Inc filed Critical Gilead Sciences Inc
Publication of MA42795A publication Critical patent/MA42795A/fr
Publication of MA42795B1 publication Critical patent/MA42795B1/fr

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
    • A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/537—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines spiro-condensed or forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/675—Phosphorus compounds having nitrogen as a ring hetero atom, e.g. pyridoxal phosphate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7076—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines containing purines, e.g. adenosine, adenylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/02—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms
    • C07C317/08—Sulfones; Sulfoxides having sulfone or sulfoxide groups bound to acyclic carbon atoms of an acyclic unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/54—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F5/00—Compounds containing elements of Groups 3 or 13 of the Periodic Table
    • C07F5/02—Boron compounds
    • C07F5/025—Boronic and borinic acid compounds

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Virology (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Preparation (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Inorganic Chemistry (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

La présente invention concerne un composé de formule (ia), (ib), (iia), et (iib) : (ia) (ib) (iia) (iib) qui sont utiles dans le traitement d'une infection virale par retroviridae incluant une infection provoquée par le virus du vih.
MA42795A 2016-08-19 2017-08-17 Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus du vih MA42795B1 (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201662377312P 2016-08-19 2016-08-19
US201762457555P 2017-02-10 2017-02-10
PCT/US2017/047416 WO2018035359A1 (fr) 2016-08-19 2017-08-17 Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus du vih

Publications (2)

Publication Number Publication Date
MA42795A MA42795A (fr) 2019-07-03
MA42795B1 true MA42795B1 (fr) 2019-08-30

Family

ID=59714166

Family Applications (2)

Application Number Title Priority Date Filing Date
MA42795A MA42795B1 (fr) 2016-08-19 2017-08-17 Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus du vih
MA050673A MA50673A (fr) 2016-08-19 2017-08-17 Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus vih

Family Applications After (1)

Application Number Title Priority Date Filing Date
MA050673A MA50673A (fr) 2016-08-19 2017-08-17 Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus vih

Country Status (42)

Country Link
US (3) US10071985B2 (fr)
EP (3) EP3597646B1 (fr)
JP (4) JP6716785B2 (fr)
KR (4) KR20230011471A (fr)
CN (2) CN111793061A (fr)
AU (4) AU2017312102B2 (fr)
BR (2) BR122020001791B1 (fr)
CA (1) CA3021227C (fr)
CL (1) CL2019000415A1 (fr)
CO (1) CO2019001379A2 (fr)
CR (1) CR20190084A (fr)
CY (2) CY1122296T1 (fr)
DK (2) DK3347352T3 (fr)
DO (1) DOP2019000033A (fr)
EC (1) ECSP19011209A (fr)
ES (2) ES2746374T3 (fr)
FI (1) FI3597646T3 (fr)
FR (1) FR22C1063I2 (fr)
HK (1) HK1256904B (fr)
HR (1) HRP20231018T1 (fr)
HU (3) HUE063811T2 (fr)
IL (1) IL264644B (fr)
JO (1) JOP20180123A1 (fr)
LT (3) LT3347352T (fr)
MA (2) MA42795B1 (fr)
MX (1) MX369307B (fr)
MY (1) MY191466A (fr)
NL (1) NL301212I2 (fr)
NO (1) NO2022059I1 (fr)
NZ (1) NZ750706A (fr)
PE (2) PE20211427A1 (fr)
PH (1) PH12019500335A1 (fr)
PL (2) PL3597646T3 (fr)
PT (2) PT3347352T (fr)
SA (1) SA519401123B1 (fr)
SG (2) SG10201912535VA (fr)
SI (2) SI3347352T1 (fr)
TW (3) TW202138365A (fr)
UA (1) UA121630C2 (fr)
UY (1) UY37367A (fr)
WO (1) WO2018035359A1 (fr)
ZA (1) ZA201901430B (fr)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ES2553449T3 (es) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
WO2015130964A1 (fr) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Composés thérapeutiques
CN111793061A (zh) 2016-08-19 2020-10-20 吉利德科学公司 用于预防性或治疗性治疗hiv病毒感染的治疗性化合物
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
AR112413A1 (es) * 2017-08-17 2019-10-23 Gilead Sciences Inc Formas sólidas de un inhibidor de la cápside del vih
KR102587510B1 (ko) 2018-02-15 2023-10-11 길리애드 사이언시즈, 인코포레이티드 피리딘 유도체 및 hiv 감염을 치료하기 위한 그의 용도
EP3752496B1 (fr) * 2018-02-16 2023-07-05 Gilead Sciences, Inc. Procédés et intermédiaires pour préparer un composé thérapeutique utile dans le traitement d'une infection virale par retroviridae
WO2019246545A1 (fr) * 2018-06-21 2019-12-26 Drexel University Inhibiteurs de protéine capsidique du vih-1 à petites molécules et leurs procédés d'utilisation
EP3823621A1 (fr) * 2018-07-16 2021-05-26 Gilead Sciences, Inc. Inhibiteurs de capsides pour le traitement du vih
EP3833436A1 (fr) * 2018-08-09 2021-06-16 VIIV Healthcare UK (No.5) Limited Inhibiteurs de la réplication du virus de l'immunodéficience humaine
US20220089598A1 (en) 2018-09-14 2022-03-24 Viiv Healthcare Uk (No. 5) Limited Inhibitors of human immunodeficiency virus replication
JP7433303B2 (ja) 2018-09-20 2024-02-19 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤
ES2971987T3 (es) 2018-10-24 2024-06-10 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de inmunodeficiencia humana
US11541055B2 (en) 2018-10-24 2023-01-03 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
JP7500555B2 (ja) 2018-10-25 2024-06-17 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド ヒト免疫不全ウイルス複製の阻害剤
JP7526174B2 (ja) * 2018-10-29 2024-07-31 ヴィーブ ヘルスケア ユーケー（ナンバー５）リミテッド キナゾリニル－インダゾール誘導体及びそのヒト免疫不全ウイルス複製の阻害剤としてのその使用
US20210395248A1 (en) 2018-11-05 2021-12-23 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
US20210379071A1 (en) 2018-11-05 2021-12-09 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
KR20210137434A (ko) 2019-01-25 2021-11-17 브라운 유니버시티 연령 관련 염증 및 장애를 치료, 예방 또는 역전시키기 위한 조성물 및 방법
UY38559A (es) 2019-02-01 2020-07-31 Viiv Healthcare Uk No 5 Ltd Inhibidores de la replicación del virus de la inmunodeficiencia humana
US20220211704A1 (en) 2019-04-30 2022-07-07 Viiv Healthcare Uk (No. 5) Limited Inhibitors of human immunodeficiency virus replication
RU2717101C1 (ru) 2019-06-03 2020-03-18 Андрей Александрович Иващенко Анелированные 9-гидрокси-1,8-диоксо-1,3,4,8-тетрагидро-2Н-пиридо[1,2-a]пиразин-7-карбоксамиды - ингибиторы интегразы ВИЧ, способы их получения и применения
PL3986561T3 (pl) 2019-06-19 2024-06-10 VIIV Healthcare UK (No.5) Limited Pochodne pirydo[2,3-d]pirymidyny jako inhibitory replikacji ludzkiego wirusa niedoboru odporności
EP4038068A1 (fr) 2019-10-01 2022-08-10 VIIV Healthcare UK (No.5) Limited Dérivés de-4-oxo-3,4-dihydropyrido[2,3-d]pyrimidin-2-yle n-substitués utilisés comme inhibiteurs de la réplication du virus de l'immunodéficience humaine
WO2021064570A1 (fr) 2019-10-01 2021-04-08 VIIV Healthcare UK (No.5) Limited Dérivés de 6-oxo-1,6-dihydropyrimidine-2-yl n-substitués utilisés en tant qu'inhibiteurs de la réplication du virus de l'immunodéficience humaine
TW202128648A (zh) 2019-10-04 2021-08-01 英商Ｖｉｉｖ醫療保健英國(Ｎｏ 5)有限公司 人類免疫不全病毒複製之抑制劑
JP2022551691A (ja) 2019-10-08 2022-12-13 ビーブ、ヘルスケア、ユーケー、（ナンバー５）、リミテッド ヒト免疫不全ウイルスの複製阻害剤
CA3157275A1 (fr) * 2019-11-26 2021-06-03 Elena BEKERMAN Inhibiteurs de capside pour la prevention du vih
WO2021107066A1 (fr) 2019-11-28 2021-06-03 塩野義製薬株式会社 Agent pharmaceutique prophylactique et thérapeutique pour maladies infectieuses à vih, caractérisé en ce qu'il comprend une combinaison d'un inhibiteur d'intégrase et d'un agent anti-vih
US20230023968A1 (en) * 2019-11-29 2023-01-26 Jiangsu Hengrui Medicine Co., Ltd. Fused pyridine ring derivative, preparation method therefor, and pharmaceutical use thereof
CN116098917A (zh) * 2020-02-27 2023-05-12 河南真实生物科技有限公司 核苷类化合物在治疗冠状病毒感染性疾病中的用途
US20230355626A1 (en) 2020-03-06 2023-11-09 VIIV Healthcare UK (No.5) Limited Inhibitors of human immunodeficiency virus replication
EP4114527A1 (fr) 2020-03-06 2023-01-11 VIIV Healthcare UK (No.5) Limited Inhibiteurs de la réplication du virus de l'immunodéficience humaine
AR121620A1 (es) 2020-03-20 2022-06-22 Gilead Sciences Inc Profármacos de nucleósidos 4’-c-sustituidos-2-halo-2’-deoxiadenosina y métodos de preparación y uso de los mismos
EP4135702A1 (fr) 2020-04-15 2023-02-22 VIIV Healthcare UK (No.5) Limited Inhibiteurs de la réplication du virus de l'immunodéficience humaine
EP4153181A1 (fr) 2020-05-21 2023-03-29 Gilead Sciences, Inc. Compositions pharmaceutiques contenant du bictégravir
CN115996925A (zh) * 2020-06-25 2023-04-21 吉利德科学公司 用于治疗hiv的衣壳抑制剂
TW202406932A (zh) 2020-10-22 2024-02-16 美商基利科學股份有限公司 介白素2-Fc融合蛋白及使用方法
AU2021377614A1 (en) 2020-11-11 2023-06-22 Gilead Sciences, Inc. METHODS OF IDENTIFYING HIV PATIENTS SENSITIVE TO THERAPY WITH gp120 CD4 BINDING SITE-DIRECTED ANTIBODIES
WO2022159877A1 (fr) * 2021-01-25 2022-07-28 Brii Biosciences, Inc. Polythérapie contre le vih comprenant un dérivé d'adénosine et des inhibiteurs de capside
CN118159529A (zh) * 2021-05-28 2024-06-07 江苏恒瑞医药股份有限公司 一种稠合吡啶环衍生物的可药用盐、晶型及其制备方法
KR20230018690A (ko) 2021-07-30 2023-02-07 (주) 에빅스젠 둥근이질풀 추출물을 유효성분으로 포함하는, 바이러스성 질환 치료 및 개선용 조성물
KR20230019059A (ko) 2021-07-30 2023-02-07 (주) 에빅스젠 연전초 추출물을 유효성분으로 포함하는, 바이러스성 질환 완화 및 개선용 조성물
TW202342448A (zh) 2021-12-03 2023-11-01 美商基利科學股份有限公司 用於ｈｉｖ病毒感染之治療性化合物
EP4440702A1 (fr) 2021-12-03 2024-10-09 Gilead Sciences, Inc. Composés thérapeutiques contre l'infection par le virus du vih
TW202342447A (zh) * 2021-12-03 2023-11-01 美商基利科學股份有限公司 用於ｈｉｖ病毒感染之治療性化合物
TWI843506B (zh) 2022-04-06 2024-05-21 美商基利科學股份有限公司 橋聯三環胺甲醯基吡啶酮化合物及其用途
TW202402280A (zh) * 2022-07-01 2024-01-16 美商基利科學股份有限公司 可用於ｈｉｖ病毒感染之疾病預防性或治療性治療的治療性化合物
WO2024044477A1 (fr) 2022-08-26 2024-02-29 Gilead Sciences, Inc. Régime de dosage et de planification pour anticorps largement neutralisants
WO2024076915A1 (fr) 2022-10-04 2024-04-11 Gilead Sciences, Inc. Analogues de 4'-thionucléosides et leur utilisation pharmaceutique
KR20240061218A (ko) 2022-10-31 2024-05-08 주식회사 이보드 복합 단열재 및 제조방법
WO2024163262A2 (fr) 2023-01-30 2024-08-08 Merck Sharp & Dohme Llc Promédicaments d'inhibiteurs nucléosidiques substitués en 4' de la transcriptase inverse
WO2024220624A1 (fr) 2023-04-19 2024-10-24 Gilead Sciences, Inc. Schéma posologique d'inhibiteur de capside
CN116675675A (zh) * 2023-06-05 2023-09-01 北京康立生医药技术开发有限公司 一种艾滋病治疗药物来那卡帕韦中间体化合物的制备方法

Family Cites Families (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816570A (en) 1982-11-30 1989-03-28 The Board Of Regents Of The University Of Texas System Biologically reversible phosphate and phosphonate protective groups
US4968788A (en) 1986-04-04 1990-11-06 Board Of Regents, The University Of Texas System Biologically reversible phosphate and phosphonate protective gruops
JP3347723B2 (ja) 1990-06-13 2002-11-20 グラツィエル，アーノルド 含リンプロドラッグ
ATE167679T1 (de) 1990-09-14 1998-07-15 Acad Of Science Czech Republic Wirkstoffvorläufer von phosphonaten
US5922695A (en) 1996-07-26 1999-07-13 Gilead Sciences, Inc. Antiviral phosphonomethyoxy nucleotide analogs having increased oral bioavarilability
US5935946A (en) 1997-07-25 1999-08-10 Gilead Sciences, Inc. Nucleotide analog composition and synthesis method
SI2682397T1 (sl) 2000-07-21 2017-08-31 Gilead Sciences, Inc. Predzdravila fosfonatnih nukleotidnih analogov in postopki za selekcijo in izdelavo le-teh
JP4300108B2 (ja) 2001-06-27 2009-07-22 スミスクライン ビーチャム コーポレーション ジペプチジルペプチダーゼ阻害剤としてのピロリジン類
ATE370943T1 (de) 2001-06-27 2007-09-15 Smithkline Beecham Corp Fluoropyrrolidine als dipeptidyl-peptidase inhibitoren
SI1441734T1 (sl) 2001-10-26 2007-08-31 Angeletti P Ist Richerche Bio Dihidropirimidin karboksamidni inhibitorji HIV-integraze
US7642277B2 (en) 2002-12-04 2010-01-05 Boehringer Ingelheim International Gmbh Non-nucleoside reverse transcriptase inhibitors
US20040186151A1 (en) 2003-02-12 2004-09-23 Mjalli Adnan M.M. Substituted azole derivatives as therapeutic agents
SG182849A1 (en) 2003-04-25 2012-08-30 Gilead Sciences Inc Antiviral phosphonate analogs
DE602005023224D1 (de) 2004-02-27 2010-10-07 Schering Corp Neuartige Verbindungen als Hemmer von Hepatitis C-Virus NS3-Serinprotease
US7429604B2 (en) 2004-06-15 2008-09-30 Bristol Myers Squibb Company Six-membered heterocycles useful as serine protease inhibitors
US7453002B2 (en) 2004-06-15 2008-11-18 Bristol-Myers Squibb Company Five-membered heterocycles useful as serine protease inhibitors
US7871991B2 (en) 2004-07-27 2011-01-18 Gilead Sciences, Inc. Phosphonate analogs of HIV inhibitor compounds
US8067587B2 (en) 2005-07-28 2011-11-29 Lenroc Company Process for the production of monoalkali metal cyanurates
EP1912989A2 (fr) 2005-08-05 2008-04-23 AstraZeneca AB Benzimidazoles tricycliques et leur utilisation comme modulateurs du recepteur metabotropique du glutamate
AU2006325754B2 (en) 2005-12-14 2012-04-12 Bristol-Myers Squibb Company Arylpropionamide, arylacrylamide, arylpropynamide, or arylmethylurea analogs as factor XIa inhibitors
JP5269761B2 (ja) 2006-04-12 2013-08-21 メルク・シャープ・アンド・ドーム・コーポレーション ピリジルアミドｔ型カルシウムチャンネルアンタゴニスト
US7647464B2 (en) 2006-04-28 2010-01-12 At&T Intellectual Property, I,L.P. Methods, systems, and products for recording media to a restoration server
WO2008013622A2 (fr) 2006-07-27 2008-01-31 E. I. Du Pont De Nemours And Company Amides azocycliques fongicides
US8124811B2 (en) 2007-03-20 2012-02-28 Allylix, Inc. Fragrance and methods for production of 5-epi-β-vetivone, 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-2,6-dien-8-one, and 2-isopropyl-6,10-dimethyl-spiro[4.5]deca-1,6-dien-8-one
CN101702908A (zh) 2007-03-23 2010-05-05 麻萨诸塞州大学 Hiv-1蛋白酶抑制剂
EP2162432A2 (fr) 2007-06-29 2010-03-17 Gilead Sciences, Inc. Composés antiviraux
AU2008274185B2 (en) 2007-07-12 2014-07-03 Janssen Sciences Ireland Uc Crystalline form of (E) 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2 pyrimidinyl]amino]benzonitrile
CN101754974B (zh) 2007-07-19 2016-02-03 Msd意大利有限公司 作为抗病毒剂的大环化合物
JP2011500808A (ja) 2007-10-24 2011-01-06 メルク・シャープ・エンド・ドーム・コーポレイション 複素環アミドｔ型カルシウムチャネルアンタゴニスト
MX2010004530A (es) 2007-10-24 2010-05-14 Merck Sharp & Dohme Antagonistas de los canales de calcio tipo t de heterociclo fenil amida.
CA2707418C (fr) 2007-11-16 2013-11-19 Boehringer Ingelheim International Gmbh Inhibiteurs de la replication du virus de l'immunodeficience humaine
ES2380648T3 (es) 2008-03-13 2012-05-17 Bristol-Myers Squibb Company Derivados de piridazina como inhibidores del factor XIA
ES2467108T3 (es) 2008-12-09 2014-06-11 Gilead Sciences, Inc. Moduladores de receptores tipo toll
SG173822A1 (en) 2009-02-25 2011-09-29 Bigtec Private Ltd Probes and primers for detection of chikungunya
US8338441B2 (en) 2009-05-15 2012-12-25 Gilead Sciences, Inc. Inhibitors of human immunodeficiency virus replication
US20110274648A1 (en) 2009-11-11 2011-11-10 Bristol-Myers Squibb Company Hepatitis C Virus Inhibitors
WO2011094890A1 (fr) 2010-02-02 2011-08-11 Argusina Inc. Dérivés phénylalanines et leur utilisation comme modulateurs non peptidiques du récepteur de glp-1
WO2011139637A1 (fr) 2010-05-03 2011-11-10 Philadelphia Health & Education Corporation Modulateurs à petite molécule de stabilité de capside de vih-1 et procédés pour ceux-ci
WO2011143772A1 (fr) 2010-05-21 2011-11-24 Boehringer Ingelheim International Gmbh Inhibiteurs de la réplication du vih
CA2802308C (fr) 2010-07-02 2018-08-28 Lianhong Xu Derives d'acide napht-2-ylacetique dans le traitement du sida
AP2013006707A0 (en) 2010-07-02 2013-02-28 Gilead Sciences Inc 2-Quinolinyl-acetic acid derivatives as HIV antiviral compounds
CN102464654B (zh) 2010-11-12 2016-01-13 上海泓博智源医药技术有限公司 抗病毒化合物
KR102129247B1 (ko) 2011-03-23 2020-07-06 트레베나, 인코포레이티드. 오피오이드 수용체 리간드와 그 용도 및 제조방법
KR20140027295A (ko) 2011-04-21 2014-03-06 길리애드 사이언시즈, 인코포레이티드 벤조티아졸 화합물 및 이들의 약학적 용도
ES2553449T3 (es) 2011-07-06 2015-12-09 Gilead Sciences, Inc. Compuestos para el tratamiento de VIH
CN102863512B (zh) 2011-07-07 2016-04-20 上海泓博智源医药技术有限公司 抗病毒化合物
JP5651275B2 (ja) 2011-08-16 2015-01-07 ギリアード サイエンシス インコーポレーテッド テノホビルアラフェナミドヘミフマレート
WO2013091096A1 (fr) 2011-12-20 2013-06-27 Boehringer Ingelheim International Gmbh Composés tricycliques condensés en tant qu'inhibiteurs de la réplication du vih
CN105121418A (zh) 2012-04-20 2015-12-02 吉利德科学公司 苯并噻唑-6-基乙酸衍生物及其治疗hiv感染的用途
GB201213087D0 (en) 2012-07-24 2012-09-05 Medical Res Council Inhibition of HIV-1 infection
US9447134B2 (en) 2012-08-17 2016-09-20 Brandeis University Compounds and methods for treating mammalian gastrointestinal microbial infections
SI3608325T1 (sl) 2012-12-21 2022-09-30 Gilead Sciences, Inc. Policiklične-karbamoilpiridonske spojine in njihova farmacevtska uporaba
RU2015131006A (ru) 2012-12-27 2017-01-30 Джапан Тобакко Инк. ЗАМЕЩЕННОЕ ПРОИЗВОДНОЕ СПИРОПИРИДО[1,2-a]ПИРАЗИНА И ЕГО ПРИМЕНЕНИЕ В МЕДИЦИНЕ В КАЧЕСТВЕ ИНГИБИТОРА ИНТЕГРАЗЫ ВИРУСА ИММУНОДЕФИЦИТА ЧЕЛОВЕКА (ВИЧ)
US9220710B2 (en) 2013-01-09 2015-12-29 Gilead Sciences, Inc. Therapeutic compounds
EP2943493B1 (fr) 2013-01-09 2017-08-02 Gilead Sciences, Inc. Composés thérapeutiques pour le traitement d'infections virales
TW201443037A (zh) * 2013-01-09 2014-11-16 Gilead Sciences Inc 治療用化合物
EP2769722A1 (fr) 2013-02-22 2014-08-27 Ruprecht-Karls-Universität Heidelberg Composés utilisés pour inhiber un assemblage de capside du VIH
US20140296266A1 (en) 2013-03-01 2014-10-02 Gilead Sciences, Inc. Therapeutic compounds
TWI706945B (zh) * 2013-03-01 2020-10-11 美商基利科學股份有限公司 供治療反轉錄病毒科病毒感染之治療性化合物
GB201312991D0 (en) 2013-07-19 2013-09-04 Isis Innovation Process
EA029259B1 (ru) 2013-10-24 2018-02-28 Бристол-Маерс Сквибб Компани Ингибиторы репликации вируса иммунодефицита
WO2015130964A1 (fr) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Composés thérapeutiques
WO2015130966A1 (fr) 2014-02-28 2015-09-03 Gilead Sciences, Inc. Agents antiviraux
JP6491321B2 (ja) * 2014-08-29 2019-03-27 ギリアード サイエンシーズ， インコーポレイテッド 抗レトロウイルス剤
WO2016040084A1 (fr) 2014-09-09 2016-03-17 Bristol-Myers Squibb Company Inhibiteurs de la réplication du virus de l'immunodéficience humaine
ES2735087T3 (es) 2014-12-24 2019-12-16 Gilead Sciences Inc Compuestos de pirimidina fusionados para el tratamiento de VIH
TW202237569A (zh) 2014-12-24 2022-10-01 美商基利科學股份有限公司 喹唑啉化合物
UY36648A (es) 2015-04-23 2016-11-30 Bristol Myers Squibb Company Una Corporación Del Estado De Delaware Inhibidores de la replicación del virus de inmunodeficiencia humana
EP3286166B1 (fr) 2015-04-23 2020-05-13 VIIV Healthcare UK (No.5) Limited Inhibiteurs de la réplication du virus de l'immunodéficience humaine
KR101974793B1 (ko) * 2015-07-06 2019-05-02 길리애드 사이언시즈, 인코포레이티드 Cot 조정제 및 그의 사용 방법
US10171985B1 (en) 2015-07-22 2019-01-01 Ginko LLC Method and apparatus for data sharing
CN111793061A (zh) 2016-08-19 2020-10-20 吉利德科学公司 用于预防性或治疗性治疗hiv病毒感染的治疗性化合物
JOP20180009A1 (ar) 2017-02-06 2019-01-30 Gilead Sciences Inc مركبات مثبط فيروس hiv
TW201906834A (zh) 2017-05-02 2019-02-16 英商Viiv醫療保健英國(No.5)有限公司 人類免疫不全病毒複製之抑制劑
AR112413A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas sólidas de un inhibidor de la cápside del vih
AR112412A1 (es) 2017-08-17 2019-10-23 Gilead Sciences Inc Formas de sal de colina de un inhibidor de la cápside del vih
KR102587510B1 (ko) 2018-02-15 2023-10-11 길리애드 사이언시즈, 인코포레이티드 피리딘 유도체 및 hiv 감염을 치료하기 위한 그의 용도
EP3752496B1 (fr) 2018-02-16 2023-07-05 Gilead Sciences, Inc. Procédés et intermédiaires pour préparer un composé thérapeutique utile dans le traitement d'une infection virale par retroviridae
US10911396B2 (en) 2018-06-28 2021-02-02 Paypal, Inc. Mid-tier messaging system
EP3823621A1 (fr) 2018-07-16 2021-05-26 Gilead Sciences, Inc. Inhibiteurs de capsides pour le traitement du vih
CA3157275A1 (fr) 2019-11-26 2021-06-03 Elena BEKERMAN Inhibiteurs de capside pour la prevention du vih
CN115996925A (zh) 2020-06-25 2023-04-21 吉利德科学公司 用于治疗hiv的衣壳抑制剂

Also Published As

Publication number Publication date
US10654827B2 (en) 2020-05-19
EP3347352B1 (fr) 2019-07-03
HK1256904B (zh) 2020-07-17
MA42795A (fr) 2019-07-03
AU2020202331A1 (en) 2020-04-23
FI3597646T3 (fi) 2023-09-07
NL301212I1 (fr) 2023-01-12
SA519401123B1 (ar) 2022-11-09
US20200262815A1 (en) 2020-08-20
TW201811327A (zh) 2018-04-01
ES2746374T3 (es) 2020-03-05
DOP2019000033A (es) 2019-03-15
EP3597646A1 (fr) 2020-01-22
NO2022059I1 (no) 2022-12-16
FR22C1063I1 (fr) 2023-02-03
LTPA2023501I1 (fr) 2023-02-10
IL264644B (en) 2019-09-26
MX369307B (es) 2019-11-05
PE20190910A1 (es) 2019-06-26
MY191466A (en) 2022-06-28
PL3347352T3 (pl) 2019-12-31
AU2020202331B2 (en) 2021-05-27
ECSP19011209A (es) 2019-02-28
BR112018071678B1 (pt) 2021-01-26
CA3021227C (fr) 2020-11-03
EP4265299A2 (fr) 2023-10-25
LT3597646T (lt) 2023-09-25
NZ750706A (en) 2020-07-31
PT3347352T (pt) 2019-09-24
TWI715944B (zh) 2021-01-11
JP6716785B2 (ja) 2020-07-01
CY1122296T1 (el) 2021-01-27
AU2021221855B2 (en) 2023-08-31
CR20190084A (es) 2019-05-02
KR20200131351A (ko) 2020-11-23
US20180051005A1 (en) 2018-02-22
TW202342449A (zh) 2023-11-01
UY37367A (es) 2018-03-23
ES2954514T3 (es) 2023-11-22
BR122020001791B1 (pt) 2022-01-25
KR102180740B1 (ko) 2020-11-20
FR22C1063I2 (fr) 2023-12-15
JP2023011754A (ja) 2023-01-24
EP3347352A1 (fr) 2018-07-18
PE20211427A1 (es) 2021-08-03
CO2019001379A2 (es) 2019-02-19
DK3347352T3 (da) 2019-08-26
KR20240070646A (ko) 2024-05-21
SG10201912535VA (en) 2020-02-27
EP4265299A3 (fr) 2024-01-17
CN111793061A (zh) 2020-10-20
DK3597646T3 (da) 2023-09-04
HUE045137T2 (hu) 2019-12-30
JOP20180123A1 (ar) 2019-01-30
AU2017312102B2 (en) 2020-03-05
CY2022039I2 (el) 2023-01-27
CN109890808B (zh) 2020-08-07
PH12019500335A1 (en) 2019-11-11
SI3347352T1 (sl) 2019-08-30
HRP20231018T1 (hr) 2023-12-08
HUE063811T2 (hu) 2024-02-28
CN109890808A (zh) 2019-06-14
JP2019528280A (ja) 2019-10-10
ZA201901430B (en) 2021-09-29
UA121630C2 (fr) 2020-06-25
WO2018035359A1 (fr) 2018-02-22
TW202138365A (zh) 2021-10-16
HUS2200053I1 (hu) 2023-01-28
JP2020111592A (ja) 2020-07-27
CA3021227A1 (fr) 2018-02-22
MA50673A (fr) 2020-08-05
NL301212I2 (nl) 2023-04-06
AU2021221855A1 (en) 2021-09-23
JP2021008516A (ja) 2021-01-28
MX2018012905A (es) 2019-01-30
US10071985B2 (en) 2018-09-11
LT3347352T (lt) 2019-08-12
BR112018071678A2 (pt) 2019-02-19
TWI664966B (zh) 2019-07-11
KR20230011471A (ko) 2023-01-20
AU2017312102A1 (en) 2019-03-07
AU2023271739A1 (en) 2023-12-14
SI3597646T1 (sl) 2023-10-30
US11993583B2 (en) 2024-05-28
TW201922711A (zh) 2019-06-16
CL2019000415A1 (es) 2019-06-21
PT3597646T (pt) 2023-09-11
EP3597646B1 (fr) 2023-06-21
AU2020202331C1 (en) 2021-08-26
SG11201808944QA (en) 2018-11-29
US20180370950A1 (en) 2018-12-27
CY2022039I1 (el) 2023-01-27
KR20190039431A (ko) 2019-04-11
PL3597646T3 (pl) 2023-12-11

Similar Documents

Publication Publication Date Title
MA42795B1 (fr) Composés thérapeutiques utiles pour le traitement prophylactique ou thérapeutique d'une infection par le virus du vih
NZ729150A (en) Antiretroviral agents
MA41338A (fr) Composés de pyrazine pour le traitement de maladies infectieuses
MA39809B1 (fr) Derives de nucleoside substitues en 4' en tant qu'inhibiteurs de la transcriptase inverse du vih
EA202092248A1 (ru) Замещенные соединения 4-аминоизоиндолин-1,3-диона, их композиции и способы лечения ими
PH12020550531A1 (en) Novel, highly active pyrazolo-piperidine substituted indole2-carboxamides active against the hepatitis b virus (hbv)
EA201791872A1 (ru) Полициклические карбамоилпиридоновые соединения и их фармацевтическое применение
EA202091113A1 (ru) Новые высокоактивные аминотиазолзамещенные индол-2-карбоксамиды, активные в отношении вируса гепатита b (hbv)
EA201691261A1 (ru) Новые дигидрохинолизиноны для лечения и профилактики инфекции, вызванной вирусом гепатита b
MA35833B1 (fr) Dérivés de bétuline
EA201691726A1 (ru) Новые 6-конденсированные гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201592126A1 (ru) 6-мостиковые гетероарилдигидропиримидины для лечения и профилактики заражения вирусом гепатита b
EA201590384A1 (ru) 6-аминокислота-гетероарилдигидропиримидины для лечения и профилактики инфекции вируса гепатита в
MA54386B1 (fr) Modulateurs de trex1
JOP20170169A1 (ar) مركبات بيريدازين ثلاثية الحلقة مندمجة تفيد في علاج العدوى بفيروس أورثوميكسو
MA38315B1 (fr) Composés tétracycliques substitués par un hétérocycle et procédés pour les utiliser pour le traitement de maladies virales
MA34968B1 (fr) Urées asymétriques et utilisations médicales de celles-ci
EA201490213A1 (ru) Бензофурановые соединения для лечения инфекций вирусом гепатита с
FR3033701B1 (fr) Nouvelles compositions antivirales pour le traitement de la grippe
MA39337A1 (fr) Modulateurs de pyrazines de gpr6
EA201990295A1 (ru) Терапевтические соединения, которые можно применять для профилактического или терапевтического лечения инфекции вирусом вич
FR3058640B1 (fr) Composes pour leur utilisation dans le traitement de la grippe
EA202192969A1 (ru) Новые оксалилпиперазины, активные против вируса гепатита b (вгв)
EA202192967A1 (ru) Новые индол-2-карбоксамиды, активные против вируса гепатита b (вгв)
EA202192965A1 (ru) Новые индолизин-2-карбоксамиды, активные против вируса гепатита b (вгв)