MA34484B1 - Formulations a base de nalbuphine et leurs utilisations - Google Patents

Formulations a base de nalbuphine et leurs utilisations

Info

Publication number: MA34484B1
Authority: MA; Morocco
Prior art keywords: nalbuphine; based formulations; hydrophilic; lubricant; pharmaceutically acceptable
Prior art date: 2010-08-20

Application number

MA35689A

Other languages

English (en)

French (fr)

Inventor

Christophe Lebon

Pascal Suplie

David Olivier Paul

Original Assignee

Debregeas Et Associes Pharma

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2010-08-20

Filing date

2011-08-18

Publication date

2013-08-01

Family has litigation

First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=43426302&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=MA34484(B1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.

2011-08-18 Application filed by Debregeas Et Associes Pharma filed Critical Debregeas Et Associes Pharma

2013-08-01 Publication of MA34484B1 publication Critical patent/MA34484B1/fr

Classifications

- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2009—Inorganic compounds
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2013—Organic compounds, e.g. phospholipids, fats
- A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/2004—Excipients; Inactive ingredients
- A61K9/2022—Organic macromolecular compounds
- A61K9/2027—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/20—Pills, tablets, discs, rods
- A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
- A61K9/2806—Coating materials
- A61K9/2833—Organic macromolecular compounds
- A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
- A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
- A61K9/167—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface
- A61K9/1676—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction with an outer layer or coating comprising drug; with chemically bound drugs or non-active substances on their surface having a drug-free core with discrete complete coating layer containing drug
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5005—Wall or coating material
- A61K9/5021—Organic macromolecular compounds
- A61K9/5036—Polysaccharides, e.g. gums, alginate; Cyclodextrin
- A61K9/5042—Cellulose; Cellulose derivatives, e.g. phthalate or acetate succinate esters of hydroxypropyl methylcellulose
- A61K9/5047—Cellulose ethers containing no ester groups, e.g. hydroxypropyl methylcellulose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
- A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
- A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
- A61K9/5078—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings with drug-free core

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Animal Behavior & Ethology (AREA)
Veterinary Medicine (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Medicinal Chemistry (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Organic Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Neurosurgery (AREA)
Neurology (AREA)
Biophysics (AREA)
Molecular Biology (AREA)
Emergency Medicine (AREA)
Addiction (AREA)
Psychiatry (AREA)
Pain & Pain Management (AREA)
Nutrition Science (AREA)
Inorganic Chemistry (AREA)
Physiology (AREA)
Rheumatology (AREA)
Medicinal Preparation (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

MA35689A 2010-08-20 2011-08-18 Formulations a base de nalbuphine et leurs utilisations MA34484B1 (fr)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR1056689A FR2963889B1 (fr)	2010-08-20	2010-08-20	Formulations a base de nalbuphine et leurs utilisations
PCT/FR2011/051929 WO2012022919A2 (fr)	2010-08-20	2011-08-18	Formulations à base de nalbuphine et leurs utilisations

Publications (1)

Publication Number	Publication Date
MA34484B1 true MA34484B1 (fr)	2013-08-01

Family

ID=43426302

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
MA35689A MA34484B1 (fr)	2010-08-20	2011-08-18	Formulations a base de nalbuphine et leurs utilisations

Country Status (31)

Country	Link
US (2)	US20130123294A1 (sl)
EP (1)	EP2605757B1 (sl)
JP (2)	JP2013534242A (sl)
KR (1)	KR101801424B1 (sl)
CN (1)	CN103025317B (sl)
AR (1)	AR082493A1 (sl)
AU (1)	AU2011290614B2 (sl)
BR (1)	BR112013004016A2 (sl)
CA (1)	CA2804333C (sl)
CL (1)	CL2013000477A1 (sl)
CY (1)	CY1116729T1 (sl)
DK (1)	DK2605757T3 (sl)
EA (1)	EA024945B1 (sl)
ES (1)	ES2548535T3 (sl)
FR (1)	FR2963889B1 (sl)
HR (1)	HRP20151021T1 (sl)
HU (1)	HUE027664T2 (sl)
IL (1)	IL224230A (sl)
MA (1)	MA34484B1 (sl)
MX (1)	MX354416B (sl)
NZ (1)	NZ605469A (sl)
PH (1)	PH12013500289A1 (sl)
PL (1)	PL2605757T3 (sl)
PT (1)	PT2605757E (sl)
RS (1)	RS54244B1 (sl)
SG (1)	SG187566A1 (sl)
SI (1)	SI2605757T1 (sl)
SM (1)	SMT201500257B (sl)
TW (1)	TWI522100B (sl)
UA (1)	UA110945C2 (sl)
WO (1)	WO2012022919A2 (sl)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
CN113842362A (zh)	2012-11-14	2021-12-28	格雷斯公司	含有生物活性材料与无序无机氧化物的组合物
US20140179727A1 (en)	2012-12-14	2014-06-26	Trevi Therapeutics, Inc.	Methods for treating pruritus
KR20220044385A (ko) *	2012-12-14	2022-04-07	트레비 테라퓨틱스, 인코포레이티드	소양증을 치료하는 방법
US8637538B1 (en)	2012-12-14	2014-01-28	Trevi Therapeutics, Inc.	Methods for treatment of pruritis
US8987289B2 (en)	2012-12-14	2015-03-24	Trevi Therapeutics, Inc.	Methods for treating pruritus
CA2919892C (en)	2013-08-12	2019-06-18	Pharmaceutical Manufacturing Research Services, Inc.	Extruded immediate release abuse deterrent pill
US10172797B2 (en)	2013-12-17	2019-01-08	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
US9492444B2 (en)	2013-12-17	2016-11-15	Pharmaceutical Manufacturing Research Services, Inc.	Extruded extended release abuse deterrent pill
EP3169315B1 (en)	2014-07-17	2020-06-24	Pharmaceutical Manufacturing Research Services, Inc.	Immediate release abuse deterrent liquid fill dosage form
EP3209282A4 (en)	2014-10-20	2018-05-23	Pharmaceutical Manufacturing Research Services, Inc.	Extended release abuse deterrent liquid fill dosage form
CN105560202B (zh) *	2016-03-11	2019-05-24	广州玻思韬控释药业有限公司	一种盐酸纳布啡凝胶骨架缓释片的制备方法及应用
CA3106995A1 (en)	2018-07-23	2020-01-30	Trevi Therapeutics, Inc.	Treatment of chronic cough, breathlessness, or dyspnea with nalbuphine compositions
SG11202102504WA (en)	2018-09-14	2021-04-29	Cara Therapeutics Inc	Oral formulations of kappa opioid receptor agonists
AU2021236662A1 (en)	2020-03-18	2022-11-10	Cara Therapeutics, Inc.	Oligosaccharide formulations of kappa opioid receptor agonists

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4282215A (en) *	1980-06-17	1981-08-04	E. I. Du Pont De Nemours And Company	Analgesic mixture of nalbuphine and acetylsalicylic acid, derivative or salt thereof
US4464378A (en)	1981-04-28	1984-08-07	University Of Kentucky Research Foundation	Method of administering narcotic antagonists and analgesics and novel dosage forms containing same
US4366159A (en) *	1981-09-08	1982-12-28	Michael Richard Magruder	Nalbuphine-narcotic analgesic composition and method of producing analgesia
US4477457A (en) *	1982-10-28	1984-10-16	E. I. Du Pont De Nemours And Company	Method for inducing anorexia using nalmetrene
US6210714B1 (en) *	1993-11-23	2001-04-03	Euro-Celtique S.A.	Immediate release tablet cores of acetaminophen having sustained-release coating
FI972718A0 (fi)	1996-07-02	1997-06-24	More Magic Software Mms Oy	Foerfaranden och arrangemang foer distribution av ett anvaendargraenssnitt
US6372254B1 (en) *	1998-04-02	2002-04-16	Impax Pharmaceuticals Inc.	Press coated, pulsatile drug delivery system suitable for oral administration
EP1117389A1 (en)	1998-09-08	2001-07-25	TheraTech, Inc.	Method of making pressure sensitive adhesive matrix patches containing hydrophilic salts of drugs
JP2001089373A (ja) *	1999-09-24	2001-04-03	Tanabe Seiyaku Co Ltd	経口投与製剤
JP2003516353A (ja) *	1999-12-08	2003-05-13	ファルマシアコーポレイション	ヴァルデコキシブ組成物
KR20010107754A (ko) *	2000-05-26	2001-12-07	민경윤	경구투여용 속용정의 제조 방법
US7323192B2 (en) *	2001-09-28	2008-01-29	Mcneil-Ppc, Inc.	Immediate release tablet
US6680067B2 (en)	2001-11-26	2004-01-20	Oliver Yoa-Pu Hu	Controlled-release pharmaceutical preparation containing nalbuphine and a process for preparing the same
RU2254852C1 (ru)	2004-01-23	2005-06-27	Ефим Давыдович Нежинский	Раствор для инъекций, обладающий выраженным анальгетическим действием, и способ его получения
US8394812B2 (en) *	2005-08-24	2013-03-12	Penwest Pharmaceuticals Co.	Sustained release formulations of nalbuphine
JP2009506059A (ja)	2005-08-24	2009-02-12	ペンウエストファーマシューティカルズカンパニー	ナルブフィンの徐放性製剤
EP2018178A4 (en) *	2006-04-25	2009-12-16	Michael Victor Voronkov	ADMINISTRATION OF AN AGONIST-ANTAGONIST COMPLEX TO PATIENTS WITH OPIOID DEPENDENCE
WO2008074098A1 (en) *	2006-12-21	2008-06-26	Alphapharm Pty Ltd	Pharmaceutical composition
US20080207667A1 (en) *	2007-02-23	2008-08-28	Rhame Robert W	Use of nalbuphine and related compounds to treat symptoms of respiratory problems
AU2010206724A1 (en) *	2009-01-22	2011-07-28	Nanotherapeutics, Inc.	Process for preparing particles of opioids and compositions produced thereby
WO2011041414A1 (en) *	2009-09-30	2011-04-07	Acura Pharmaceuticals, Inc.	Methods and compositions for deterring abuse

2010
- 2010-08-20 FR FR1056689A patent/FR2963889B1/fr not_active Expired - Fee Related
2011
- 2011-08-18 AU AU2011290614A patent/AU2011290614B2/en not_active Ceased
- 2011-08-18 DK DK11758519.0T patent/DK2605757T3/en active
- 2011-08-18 KR KR1020137002467A patent/KR101801424B1/ko active IP Right Grant
- 2011-08-18 PH PH1/2013/500289A patent/PH12013500289A1/en unknown
- 2011-08-18 CA CA2804333A patent/CA2804333C/fr not_active Expired - Fee Related
- 2011-08-18 WO PCT/FR2011/051929 patent/WO2012022919A2/fr active Application Filing
- 2011-08-18 BR BR112013004016A patent/BR112013004016A2/pt not_active IP Right Cessation
- 2011-08-18 JP JP2013524474A patent/JP2013534242A/ja active Pending
- 2011-08-18 SG SG2013004379A patent/SG187566A1/en unknown
- 2011-08-18 MX MX2013001985A patent/MX354416B/es active IP Right Grant
- 2011-08-18 PL PL11758519T patent/PL2605757T3/pl unknown
- 2011-08-18 UA UAA201303394A patent/UA110945C2/uk unknown
- 2011-08-18 US US13/810,358 patent/US20130123294A1/en not_active Abandoned
- 2011-08-18 PT PT117585190T patent/PT2605757E/pt unknown
- 2011-08-18 SI SI201130612T patent/SI2605757T1/sl unknown
- 2011-08-18 EP EP11758519.0A patent/EP2605757B1/fr active Active
- 2011-08-18 ES ES11758519.0T patent/ES2548535T3/es active Active
- 2011-08-18 RS RS20150601A patent/RS54244B1/en unknown
- 2011-08-18 HU HUE11758519A patent/HUE027664T2/en unknown
- 2011-08-18 MA MA35689A patent/MA34484B1/fr unknown
- 2011-08-18 NZ NZ605469A patent/NZ605469A/en not_active IP Right Cessation
- 2011-08-18 CN CN201180035176.5A patent/CN103025317B/zh not_active Expired - Fee Related
- 2011-08-18 EA EA201300258A patent/EA024945B1/ru not_active IP Right Cessation
- 2011-08-19 AR ARP110103019A patent/AR082493A1/es unknown
- 2011-08-19 TW TW100129750A patent/TWI522100B/zh not_active IP Right Cessation
2013
- 2013-01-15 IL IL224230A patent/IL224230A/en active IP Right Grant
- 2013-02-18 CL CL2013000477A patent/CL2013000477A1/es unknown
2015
- 2015-09-28 HR HRP20151021TT patent/HRP20151021T1/hr unknown
- 2015-09-29 CY CY20151100862T patent/CY1116729T1/el unknown
- 2015-10-20 SM SM201500257T patent/SMT201500257B/it unknown
2016
- 2016-04-20 JP JP2016084673A patent/JP6173521B2/ja not_active Expired - Fee Related
- 2016-06-01 US US15/170,033 patent/US10441585B2/en not_active Expired - Fee Related

Also Published As

Publication number	Publication date
CN103025317A (zh)	2013-04-03
NZ605469A (en)	2015-01-30
PT2605757E (pt)	2015-10-19
HUE027664T2 (en)	2016-10-28
CA2804333A1 (fr)	2012-02-23
SG187566A1 (en)	2013-03-28
JP2016166230A (ja)	2016-09-15
WO2012022919A2 (fr)	2012-02-23
BR112013004016A2 (pt)	2016-06-28
FR2963889B1 (fr)	2013-04-12
UA110945C2 (uk)	2016-03-10
WO2012022919A3 (fr)	2012-05-10
AU2011290614B2 (en)	2015-11-19
EA024945B1 (ru)	2016-11-30
JP2013534242A (ja)	2013-09-02
RS54244B1 (en)	2015-12-31
PH12013500289A1 (en)	2016-10-26
CL2013000477A1 (es)	2013-06-28
KR101801424B1 (ko)	2017-11-24
IL224230A (en)	2017-03-30
TWI522100B (zh)	2016-02-21
DK2605757T3 (en)	2015-10-05
MX2013001985A (es)	2013-05-09
AU2011290614A1 (en)	2013-01-31
EP2605757A2 (fr)	2013-06-26
CN103025317B (zh)	2016-08-17
PL2605757T3 (pl)	2015-12-31
EA201300258A1 (ru)	2013-06-28
TW201302198A (zh)	2013-01-16
US20160271124A1 (en)	2016-09-22
US20130123294A1 (en)	2013-05-16
FR2963889A1 (fr)	2012-02-24
KR20130099914A (ko)	2013-09-06
MX354416B (es)	2018-03-05
JP6173521B2 (ja)	2017-08-02
HRP20151021T1 (hr)	2015-11-06
US10441585B2 (en)	2019-10-15
ES2548535T3 (es)	2015-10-19
EP2605757B1 (fr)	2015-07-01
AR082493A1 (es)	2012-12-12
SMT201500257B (it)	2016-01-08
SI2605757T1 (sl)	2015-11-30
CY1116729T1 (el)	2017-03-15
CA2804333C (fr)	2019-03-19

Publication	Publication Date	Title
MA34484B1 (fr)	2013-08-01	Formulations a base de nalbuphine et leurs utilisations
MA34832B1 (fr)	2014-01-02	Compositions biodegradables d'administration de medicaments
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FR2949062B1 (fr)	2011-09-02	Nouvelles formulations pharmaceutiques contre le mesusage des medicaments
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CL2007002095A1 (es)	2008-01-18	Composicion farmaceutica topica que comprende 1-(2-metilpropil)-1h-imidazo[4,5-c]quinolin-4-amina; composicion empacada; metodo para esterilizarla; util para cicatrizar tejido donde la dermis se ha desgarrado.
WO2009074351A3 (en)	2009-11-12	Solid forms of tenofovir disoproxil
EP2093237A4 (en)	2012-06-27	Cancer therapeutic agent comprising anti-hb-egf antibody as active ingredient
DE60332629D1 (de)	2010-07-01	Phenyl-(4-(3-phenyl-1h-pyrazol-4-yl)-pyrimidin-2-yi)aminderivate
WO2012027065A3 (en)	2012-05-10	Combination therapy for treatment of disease
MA38576B2 (fr)	2020-02-28	Formulations de colchicine à libération prolongée et procédés d'utilisation de ces dernières
PT2043600T (pt)	2017-10-13	Formulações farmacêuticas para a libertação prolongada de princípio(s) ativo(s), assim como suas aplicações, nomeadamente terapêuticas
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EA201201202A1 (ru)	2013-04-30	Пероральная фармацевтическая композиция, содержащая этексилат дабигатрана
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BRPI0810192A2 (pt)	2014-12-30	Aspartato do ácido 1-ciclopropil-6-fluoro-7-(8-metoxiimino-2,6-diazaespir o [3,4] oct-6-il)-4-oxo-1,4-diidro- [1,8] naftiridina-3-carboxílico, método para preparação do mesmo e composição farmacêutica antimicrobiana compreendendo o mesmo.
MY166972A (en)	2018-07-27	Transdermal delivery system containing galantamine or salts thereof
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UA87291C2 (ru)	2009-07-10	Пероральное пленкообразное лекарственное средство дезоксипеганина и способ его применения