Dellinger et al., 1987 - Google Patents
A New Method for Synthesizing RNA on Silica SupportsDellinger et al., 1987
- Document ID
- 3854628197465705782
- Author
- Dellinger D
- Caruthers M
- Publication year
- Publication venue
- Genetic Engineering: Principles and Methods Volume 9
External Links
Snippet
Until recently we perceived that there was only a minimal need for methods for chemical synthesis of RNA. This was because almost any RNA sequence could be synthesized using either the 8P6 or T7 promoter and an appropriate DNA duplex (1, 2). However, several …
- 229920000160 (ribonucleotides)n+m 0 title abstract description 43
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/16—Purine radicals
- C07H19/20—Purine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
- C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
- C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
- C07H19/06—Pyrimidine radicals
- C07H19/10—Pyrimidine radicals with the saccharide radical esterified by phosphoric or polyphosphoric acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/02—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with ribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
- C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic System
- C07F9/02—Phosphorus compounds
- C07F9/06—Phosphorus compounds without P-C bonds
- C07F9/22—Amides of acids of phosphorus
- C07F9/24—Esteramides
- C07F9/2404—Esteramides the ester moiety containing a substituent or a structure which is considered as characteristic
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H23/00—Compounds containing boron, silicon, or a metal, e.g. chelates, vitamin B12
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
- C07H15/02—Acyclic radicals, not substituted by cyclic structures
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/11—Compounds covalently bound to a solid support
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0101985B1 (en) | Oligonucleotide derivatives and production thereof | |
| US4659774A (en) | Support for solid-phase oligonucleotide synthesis | |
| US5625050A (en) | Modified oligonucleotides and intermediates useful in nucleic acid therapeutics | |
| US4959463A (en) | Intermediates | |
| US6291669B1 (en) | Solid phase synthesis | |
| US5602244A (en) | Polynucleotide phosphorodithioate compounds | |
| Usman et al. | The automated chemical synthesis of long oligoribuncleotides using 2'-O-silylated ribonucleoside 3'-O-phosphoramidites on a controlled-pore glass support: synthesis of a 43-nucleotide sequence similar to the 3'-half molecule of an Escherichia coli formylmethionine tRNA | |
| US5750666A (en) | Polynucleotide phosphorodithioate compounds | |
| US5589586A (en) | Nucleosides attached to a solid support through a 3'-silyl linkage and their use in oligonucleotide synthesis | |
| JPS6365677B2 (en) | ||
| JPH0359914B2 (en) | ||
| CA2091559A1 (en) | Method of linking nucleosides with a siloxane bridge | |
| WO1997031009A1 (en) | Solid phase synthesis of oligonucleotide n3'→p5' phosphoramidates | |
| CA2330192A1 (en) | Activators for oligonucleotide synthesis | |
| EP0090789A1 (en) | Chemical DNA synthesis | |
| EP1319013A2 (en) | Linker phosphoramidites for oligonucleotide synthesis | |
| JP2002511840A (en) | Liquid phase synthesis of oligonucleotides and peptides | |
| EP1272501B1 (en) | Process for the preparation of phosphorothioate triesters | |
| JP2836961B2 (en) | Method for synthesizing ribonucleic acid (RNA) using novel deprotecting agent | |
| US5864031A (en) | Process for preparing 5-dithio-modified oligonucleotides | |
| Dellinger et al. | A New Method for Synthesizing RNA on Silica Supports | |
| KR100228606B1 (en) | Chemical synthesis of oligonucleotides | |
| Noyori et al. | Organometallic methodologies for nucleic acid synthesis | |
| Caruthers | Modern methods of nucleic acid synthesis on polymeric supports | |
| Gait | Biological chemistry. Part (ii) Nucleic acids.(b) Oligonucleotides and polynucleotides |