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Quek et al., 2018 - Google Patents

Clonal heterogeneity of acute myeloid leukemia treated with the IDH2 inhibitor enasidenib

Quek et al., 2018

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Document ID
3353904558611731296
Author
Quek L
David M
Kennedy A
Metzner M
Amatangelo M
Shih A
Stoilova B
Quivoron C
Heiblig M
Willekens C
Saada V
Alsafadi S
Vijayabaskar M
Peniket A
Bernard O
Agresta S
Yen K
MacBeth K
Stein E
Vassiliou G
Levine R
De Botton S
Thakurta A
Penard-Lacronique V
Vyas P
Publication year
Publication venue
Nature medicine

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Snippet

Mutations in the gene encoding isocitrate dehydrogenase 2 (IDH2) occur in several types of cancer, including acute myeloid leukemia (AML). In model systems, mutant IDH2 causes hematopoietic differentiation arrest. Enasidenib, a selective small-molecule inhibitor of …
Continue reading at www.ncbi.nlm.nih.gov (HTML) (other versions)

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