Nothing Special   »   [go: up one dir, main page]

Nagamatsu et al., 1999 - Google Patents

Facile and general syntheses of 3-and/or 5-substituted 7-β-d-ribofuranosyl-7H-[1, 2, 4] triazolo [3, 4-i] purines as a new class of potential xanthine oxidase inhibitors

Nagamatsu et al., 1999

Document ID
3262578816809262350
Author
Nagamatsu T
Yamasaki H
Akiyama T
Hara S
Mori K
Kusakabe H
Publication year
Publication venue
Synthesis

External Links

Snippet

Novel, general, and facile syntheses of 3-and/or 5-substituted 7-bD-ribofuranosyl-7H-[1, 2, 4] triazolo [3, 4-i] purines (5–8) via compounds 4 as a new class of potential xanthine oxidase inhibitors are described. The key intermediates 4b–j were prepared by oxidative cyclization …
Continue reading at www.thieme-connect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulfur or nitrogen atoms
    • C07D239/48—Two nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulfur or nitrogen atoms
    • C07D239/60—Three or more oxygen or sulfur atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
    • C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
    • C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
    • C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
    • C07D239/46—Two or more oxygen, sulfur or nitrogen atoms
    • C07D239/47—One nitrogen atom and one oxygen or sulfur atom, e.g. cytosine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00
    • C07D487/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by C07D451/00 - C07D477/00 in which the condensed system contains three hetero rings
    • C07D487/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/38—Nitrogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/12—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains three hetero rings
    • C07D471/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/12—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains three hetero rings
    • C07D491/14—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/06—Peri-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/04—Ortho-condensed systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/40—Heterocyclic compounds containing purine ring systems with halogen atoms or perhalogeno-alkyl radicals directly attached in positions 2 or 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom

Similar Documents

Publication Publication Date Title
EP0929553B1 (en) Pyrimidine derivatives and processes for the preparation thereof
Shamroukh et al. Synthesis, isomerization, and antimicrobial evaluation of some pyrazolopyranotriazolopyrimidine derivatives
AU2011258555B2 (en) Process for the preparation of 5-Substituted-8-alkoxy[1,2,4]triazolo[1,5-c]pyrimidin-2-amines
Nagamatsu et al. Novel xanthine oxidase inhibitor studies. Part 3. 1 Convenient and general syntheses of 3-substituted 7 H-pyrazolo [4, 3-e]-1, 2, 4-triazolo [4, 3-c] pyrimidin-5 (6 H)-ones as a new class of potential xanthine oxidase inhibitors
Al-Kamali et al. Synthesis and antibacterial activity of some novel thieno [2, 3-c] pyridazines using 3-amino-5-phenyl-2-ethoxycarbonylthieno [2, 3-c] pyridazine as a starting material
US5663339A (en) Process for preparing 5-substituted pyrrolo-[2,3-D] pyrimidines
FI95259B (en) Process for the preparation of pharmaceutically active 7-substituted-2-amino-3,5-dihydro-4H-pyrrolo / 3,2-d / pyrimidin-4-ones
Nagamatsu et al. Facile and general syntheses of 3-and/or 5-substituted 7-β-d-ribofuranosyl-7H-[1, 2, 4] triazolo [3, 4-i] purines as a new class of potential xanthine oxidase inhibitors
Gibson et al. Specific inhibitors in vitamin biosynthesis. Part 10. Synthesis of 7-and 8-substituted 7-deazaguanines
Ho 5‐(1‐Pyrrolyl)‐2‐Phenylthieno [2, 3‐d] Pyrimidine as Building Block in Heterocyclic Synthesis: Novel Synthesis of Some Pyrazoles, Pyrimidines, Imidazo [1, 2‐a] Pyrimidines, Pyrazolo [1, 5‐a] Pyrimidines, Pyrido‐(Pyrimido) Pyrazolo [1, 5‐a] Pyrimidines, 1, 2, 4‐Triazolo [1, 5‐a] Pyrimidine and a 1, 2, 3, 4‐Tetrazolo [1, 5‐a] Pyrimidine Derivative
Khan et al. Condensed heterocycles: synthesis and antifungal activity of. pi.-deficient pyrimidines linked with. pi.-rich heterocycles
Nagamatsu et al. Facile and general syntheses of 3-and/or 5-substituted 7 H-pyrazolo [4, 3-e]-1, 2, 4-triazolo [4, 3-c] pyrimidines as a new class of potential xanthine oxidase inhibitors
Loakes et al. A Dimroth rearrangement of pyrimidine nucleosides
Abd El-Salam et al. Synthesis, Structural Characterization of Some Pyrazolo [3, 4-d] pyrimidine Derivatives as Anti-inflammatory Agents
Anderson et al. Pyridopyrimidines. 6. Nucleophilic substitutions in the pyrido [2, 3-d] pyrimidine series
Davoodnia et al. Synthesis of novel benzimidazo [1, 2-c][1, 2, 4] triazolo [4, 3-a] quinazoline derivatives
Khattab et al. Ring closure reaction of 5‐hydroxy‐pyrido [2, 3‐d] pyrimidine‐2, 4, 7‐triones to benzo [b] pyrimido [4, 5‐h] 1, 6‐naphthyridine‐1, 3, 6‐triones
Bakhite et al. Fused thieno [2, 3-b] pyridines: synthesis and characterization of new condensed pyridothienopyrimidines
Wang et al. Synthesis and properties of novel pyrazolopyrimidine derivatives containing sulfur atom
US3335141A (en) 4-substituted-1-alkyl-6-(5-nitro-2-furyl)-1h-pyrazolo[3, 4-d]pyrimidines
Abu‐Zied et al. Synthesis and Reactions of Some Novel Triazolo‐, Azolo‐, Tetrazolo‐Pyridopyrimidine and Their Nucleoside Derivatives
Kheder et al. A convenient access to new pyrido [4, 3-d] pyrimidine, thiazolo [3, 4-c] pyrimidine and pyrimido [4, 5-d] pyridazine derivatives
Sheradsky et al. 6, 7-Dihydro-5H-pyrrolo [3, 4-d] pyrimidines. Syntheses Based on 3-Amino-and 3-Methoxy-1-acyl-4-cyano-3-pyrrolines1
Abdallah et al. Synthesis of Tetra-and Pentaheterocyclic Compounds incorporated Isoquinoline Moiety
Tsuji et al. Temperature‐dependent reaction of 1, 4, 6‐triaminopyrimidine‐2 (1H)‐thiones with vilsmeier reagent. formation of [1, 2, 4] triazolo [1, 5‐c] pyrimidin‐5 (6H)‐ones