Forró et al., 2013 - Google Patents
Enzymatic preparation of (S)-3-amino-3-(o-tolyl) propanoic acid, a key intermediate for the construction of Cathepsin inhibitorsForró et al., 2013
- Document ID
- 3224359671837601708
- Author
- Forró E
- Tasnádi G
- Fülöp F
- Publication year
- Publication venue
- Journal of Molecular Catalysis B: Enzymatic
External Links
Snippet
Enantiomerically pure (S)-3-amino-3-(o-tolyl) propanoic acid [(S)-6], identified as the preferred enantiomeric form for the construction of novel β-amino acid derivatives as inhibitors of Cathepsin, was prepared through both indirect and direct enzymatic strategies …
- 230000002255 enzymatic 0 title abstract description 21
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- C12P41/00—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture
- C12P41/003—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/004—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of alcohol- or thiol groups in the enantiomers or the inverse reaction
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- C12P41/003—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
- C12P41/005—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
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- C12P41/006—Processes using enzymes or micro-organisms to separate optical isomers from a racemic mixture by reactions involving C-N bonds, e.g. nitriles, amides, hydantoins, carbamates, lactames, transamination reactions, or keto group formation from racemic mixtures
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- C12N9/14—Hydrolases (3)
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