Nothing Special   »   [go: up one dir, main page]

Nene, 2015 - Google Patents

Identification and Characterization of the Cdc73 Transcription Factor as a Suppressor of Genome Instability

Nene, 2015

View PDF
Document ID
2752011844268602104
Author
Nene R
Publication year

External Links

Snippet

Genome instability is an increasingly well-appreciated aspect of tumorigenesis, and genome rearrangements, such as translocations, copy number changes, and aneuploidy, are seen in many cancers. The Kolodner Laboratory has developed a variety of assays to study the …
Continue reading at escholarship.org (PDF) (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1034—Isolating an individual clone by screening libraries
    • C12N15/1079—Screening libraries by altering the phenotype or phenotypic trait of the host
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
    • C12N15/80—Vectors or expression systems specially adapted for eukaryotic hosts for fungi
    • C12N15/81—Vectors or expression systems specially adapted for eukaryotic hosts for fungi for yeasts
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Hybridisation probes
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving viable micro-organisms
    • C12Q1/025—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving viable micro-organisms for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/01—Preparation of mutants without inserting foreign genetic material therein; Screening processes therefor

Similar Documents

Publication Publication Date Title
Ii et al. Mus81 functions in the quality control of replication forks at the rDNA and is involved in the maintenance of rDNA repeat number in Saccharomyces cerevisiae
Pâques et al. Multiple pathways of recombination induced by double-strand breaks in Saccharomyces cerevisiae
Batté et al. Recombination at subtelomeres is regulated by physical distance, double‐strand break resection and chromatin status
Wang et al. Chromosome fusions following telomere loss are mediated by single-strand annealing
Rog et al. Sumoylation of RecQ helicase controls the fate of dysfunctional telomeres
Hofstatter et al. Comparative genomics supports sex and meiosis in diverse Amoebozoa
Nene et al. Cdc73 suppresses genome instability by mediating telomere homeostasis
Liang et al. SUMO E3 ligase Mms21 prevents spontaneous DNA damage induced genome rearrangements
Xu et al. TEN1 is essential for CDC13-mediated telomere capping
US20060105361A1 (en) Donor yeast strain for transfer of genetic material
Crawford et al. Separable roles of the DNA damage response kinase Mec1ATR and its activator Rad24RAD17 within the regulation of meiotic recombination
Nene Identification and Characterization of the Cdc73 Transcription Factor as a Suppressor of Genome Instability
Moertl et al. Regulation of double-stranded DNA gap repair by the RAD6 pathway
Mansisidor Mechanisms of Ribosomal DNA Copy-number Regulation
Stantial Stabilization of Topoisomerase 2 Mutants Initiates the Formation of Duplications in DNA
Mukherjee Non-canonical function of the spindle checkpoint protein Mad3 in meiosis
Dolce Investigating the roles of Ctf4 in DNA damage tolerance
Li Construction and analysis of a genome-wide insertion library in Schizosaccharomyces pombe reveals novel aspects of DNA repair
Kimble Homology-Directed Repair of One-and Two-Ended DNA Double-Strand Breaks
Wilson Biochemical and Functional Characterization of Rpa2 N-Terminal Phosphorylation During DNA Repair and Checkpoint Adaptation in Saccharomyces cerevisiae
MacKenzie Understanding Mechanisms by which Cells Escape the Spindle Checkpoint in Budding Yeast Mitosis and Meiosis
Che The roles of histone H3 lysine 56 acetylation in DNA repair
Rodriguez Role of Large Genome Rearrangements on Genome Organization and Gene Expression in Neurospora Crassa
Reilly Bypassable essential genes affecting regulation of heterochromatin silencing in S. pombe
Paek Formation of dicentric and acentric chromosomes, by a template switch mechanism, in budding yeast