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Dong et al., 2014 - Google Patents

Isomeric folate-conjugated polymeric micelles bind to folate receptors and display anticancer effects

Dong et al., 2014

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Document ID
2062387451047636396
Author
Dong Q
Xie Z
Xie C
Lu W
Zhang Q
Li X
Liu M
Publication year
Publication venue
Asian Pacific Journal of Cancer Prevention

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Snippet

The present study aimed to prepare and evaluate polymeric micelles conjugated with folic acid through ${\alpha} $-or ${\gamma} $-carboxyl groups for antitumor efficacy. The isomeric block copolymers, ${\alpha} $-and ${\gamma} $-folate-polyethyleneglycol-distearoyl …
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    • A61K9/51—Nanocapsules; Nanoparticles
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    • A61K9/5153—Polyesters, e.g. poly(lactide-co-glycolide)
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    • A61K47/48876—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the conjugate being characterized by a special physical or galenical form the form being a particulate, powder, adsorbate, bead, sphere the form being a solid micro- or nanoparticle having no hollow or gas-filled core
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