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Shen et al., 2012 - Google Patents

Efficient synthesis of a chiral precursor for angiotensin-converting enzyme (ACE) inhibitors in high space-time yield by a new reductase without external cofactors

Shen et al., 2012

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Document ID
18429847459057070478
Author
Shen N
Ni Y
Ma H
Wang L
Li C
Zheng G
Zhang J
Xu J
Publication year
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Organic letters

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A new reductase, CgKR2, with the ability to reduce ethyl 2-oxo-4-phenylbutyrate (OPBE) to ethyl (R)-2-hydroxy-4-phenylbutyrate ((R)-HPBE), an important chiral precursor for angiotensin-converting enzyme (ACE) inhibitors, was discovered. For the first time,(R)-HPBE …
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