Nothing Special   »   [go: up one dir, main page]

Welter et al., 1990 - Google Patents

The cellular myb oncogene is amplified, rearranged and activated in human glioblastoma cell lines

Welter et al., 1990

Document ID
18177156682730592338
Author
Welter C
Henn W
Theisinger B
Fischer H
Zang K
Blin N
Publication year
Publication venue
Cancer letters

External Links

Snippet

The human c-myb gene which encodes a DNA binding protein and which is rarely amplified in neoplastic cells was found to be altered in four human glioblastoma cell lines. It exists in multiple copies in 2 out of 4 cases studied. The degree of amplification as determined by …
Continue reading at www.sciencedirect.com (other versions)

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Hybridisation probes
    • C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
    • C12Q1/6886—Hybridisation probes for diseases caused by alterations of genetic material for cancer
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6813—Hybridisation assays
    • C12Q1/6841—"In-situ" hybridisation
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4736—Retinoblastoma protein
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/82—Translation products from oncogenes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00—Oligonucleotides characterized by their use

Similar Documents

Publication Publication Date Title
Nakai et al. Frequent p53 gene mutations in blast crisis of chronic myelogenous leukemia, especially in myeloid crisis harboring loss of a chromosome 17p
Adesina et al. p53 gene mutation and mdm2 gene amplification are uncommon in medulloblastoma
Kallioniemi et al. ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.
Okamoto et al. Loss of constitutional heterozygosity in colon carcinoma from patients with familial polyposis coli
Carroll et al. p53 oncogene mutations in three human prostate cancer cell lines
Kozbor et al. Amplification of the c-myc oncogene in one of five human breast carcinoma cell lines
Welter et al. The cellular myb oncogene is amplified, rearranged and activated in human glioblastoma cell lines
Popescu et al. Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12–21.32
Saito et al. Amplification of the E2F1 transcription factor gene in the HEL erythroleukemia cell line
Sugita et al. Molecular definition of a small amplification domain within 3q26 in tumors of cervix, ovary, and lung
CA2323525A1 (en) Therapeutic and diagnostic applications based on the role of the cxcr-4 gene in tumorigenesis
EP0539366A1 (en) Methods for detecting human leukemias
Kim et al. Identification of two distinct tumor-suppressor loci on the long arm of chromosome 10 in small cell lung cancer
Latil et al. Oncogene amplifications in early‐stage human prostate carcinomas
Sanchez et al. Fractionated ionizing radiation accelerates loss of amplified MDR1 genes harbored by extrachromosomal DNA in tumor cells
Cannizzaro et al. Chromosome localization of human ARH genes, a ras-related gene family
Kennaugh et al. The chromosome breakpoint at 14q32 in an ataxia telangiectasia t (14; 14) T cell clone is different from the 14q32 breakpoint in Burkitts and an inv (14) T cell lymphoma
Wang et al. Analysis of EGF receptor amplicons reveals amplification of multiple expressed sequences
US5049662A (en) Kit for diagnosing cancer metastatic potential
Ferrari et al. Expression of growth-regulated genes in human acute leukemias
Diaz et al. Trisomy 8 in human hematologic neoplasia and the c-myc and c-mos oncogenes
MIYAKI et al. Amplification and enhanced expression of cellular oncogene c-Ki-ras-2 in a human epidermoid carcinoma of the lung
Karasawa et al. Detection of c-myc oncogene amplification in a CML blastic phase patient with double minute chromosomes
Su et al. Genetics of cutaneous malignant melanoma
Crossen et al. Characterization of the C-MYC amplicon in a case of acute myeloid leukemia with double minute chromosomes