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Abbas et al., 2000 - Google Patents

In vitro metabolism and interaction of cilostazol with human hepatic cytochrome P450 isoforms

Abbas et al., 2000

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Document ID
18078791335650500717
Author
Abbas R
Chow C
Browder N
Thacker D
Bramer S
Fu C
Forbes W
Odomi M
Flockhart D
Publication year
Publication venue
Human & experimental toxicology

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1 Cilostazol (OPC-13013) undergoes extensive hepatic metabolism. The hydroxylation of the quinone moiety of cilostazol to OPC-13326 was the predominant route in all the liver preparations studies. The hydroxylation of the hexane moiety to OPC-13217 was the second …
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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins

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