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Nakahira et al., 2008 - Google Patents

Pretreatment with S-1, an oral derivative of 5-fluorouracil, enhances gemcitabine effects in pancreatic cancer xenografts

Nakahira et al., 2008

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Document ID
17701945315768268315
Author
Nakahira S
Nakamori S
Tsujie M
Takeda S
Sugimoto K
Takahashi Y
Okami J
Marubashi S
Miyamoto A
Takeda Y
Nagano H
Dono K
Umeshita K
Sakon M
Monden M
Publication year
Publication venue
Anticancer research

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Background: The systemic administration of gemcitabine (GEM) has been accepted as a standard treatment for patients with advanced pancreatic cancer. The major mediator of cellular uptake of GEM is the human equilibrative nucleoside transporter 1 (hENT1) whose …
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    • A61K31/7072—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid having two oxo groups directly attached to the pyrimidine ring, e.g. uridine, uridylic acid, thymidine, zidovudine
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