Verhoeyen et al., 1993 - Google Patents
Construction of a reshaped HMFG1 antibody and comparison of its fine specificity with that of the parent mouse antibody.Verhoeyen et al., 1993
View PDF- Document ID
- 1738454667038415512
- Author
- Verhoeyen M
- Saunders J
- Price M
- Marugg J
- Briggs S
- Broderick E
- Eida S
- Mooren A
- Badley R
- Publication year
- Publication venue
- Immunology
External Links
Snippet
A human antibody with milk mucin specificity was obtained by transferring the complementarity determining regions (CDR) of the mouse antibody HMFG1 onto carefully selected human framework regions. The resulting reshaped human antibody, HuHMFG1 …
- 102000004965 antibodies 0 title abstract description 84
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses, e.g. hepatitis E virus
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
- C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/44—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material not provided for elsewhere, e.g. haptens, metals, DNA, RNA, amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/46—Hybrid immunoglobulins
- C07K16/468—Immunoglobulins having two or more different antigen binding sites, e.g. multifunctional antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody
- A61K51/1003—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody or an immunoglobulin, or a fragment thereof, e.g. a camelised human single domain antibody, or the Fc fragment of an antibody not used, see subgroups
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP0348442B1 (en) | Altered antibody | |
| US6174691B1 (en) | Minimum recognition unit of a PEM mucin tandem repeat specific monoclonal antibody | |
| Verhoeyen et al. | Construction of a reshaped HMFG1 antibody and comparison of its fine specificity with that of the parent mouse antibody. | |
| US6518415B1 (en) | Recombinant human anti-Lewis Y antibodies | |
| JP3105898B2 (en) | Method for producing recombinant DNA protein | |
| FI108777B (en) | Method for producing an antibody molecule processed by CDR graft | |
| DE69431602T2 (en) | MONOCLONAL ANTIBODIES FOR THE DIAGNOSIS AND TREATMENT OF COLORECTAL CANCER | |
| CA2035899C (en) | Chimeric anti-cea antibody | |
| EP0856054B1 (en) | Monoclonal antibody br110 and uses thereof | |
| EP0388151A1 (en) | Modified antibodies | |
| FI114611B (en) | Shaped human antibody or formulated human antibody fragment | |
| JPH1070991A (en) | Chimeric immunogloblin gene for tumor-relating antigen | |
| KR970007783B1 (en) | Specific binding agents | |
| US5645817A (en) | Granulocyte-binding antibody constructs, their preparation and use | |
| Williams | Novel antibody reagents: production and potential | |
| KOGA et al. | Mouse-human chimeric monoclonal antibody to carcinoembryonic antigen (CEA): in vitro and in vivo activities | |
| Vola et al. | Recombinant anti-human melanoma antibodies are versatile molecules | |
| CA2080260C (en) | Monoclonal antibodies against tumor-associated antigens, processes for the preparation thereof and the use thereof | |
| RU2102479C1 (en) | CHIMERIC MONOCLONAL ANTIBODY INTERACTING WITH HUMAN PLACENTAL ALKALINE PHOSPHATASE, VARIABLE REGION OF HEAVY γ-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY, VARIABLE REGION OF LIGHT K-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY, FRAGMENT OF CDNA ENCODING VARIABLE REGION OF HEAVY γ-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY AND FRAGMENT OF CDNA ENCODING VARIABLE REGION OF LIGHT K-CHAIN OF CHIMERIC MONOCLONAL ANTIBODY | |
| LEFRANC | INHIBITION OF T CELL ACTIVATION WITH A HUMANIZED ANTI-/31 INTEGRIN CHAIN mAb |