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Polyak et al., 1994 - Google Patents

Cloning of p27Kip1, a cyclin-dependent kinase inhibitor and a potential mediator of extracellular antimitogenic signals

Polyak et al., 1994

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Document ID
17209919266724464342
Author
Polyak K
Lee M
Erdjument-Bromage H
Koff A
Roberts J
Tempst P
Massagué J
Publication year
Publication venue
Cell

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Snippet

Summary We cloned~ 27~'p', a cyclin-dependent kinase inhibitor implicated in Gl phase arrest by TGFp and cell-cell contact.~ 27~'P'associates with cyclin E-Cdk2 complexes in vivo and in vitro, prevents their activation, and inhibits previously activated complexes, and …
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
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    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
    • C07K14/4702—Regulators; Modulating activity
    • C07K14/4703—Inhibitors; Suppressors
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    • C07K14/4738—Cell cycle regulated proteins, e.g. cyclin, CDC, INK-CCR
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