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Grignaschi et al., 1999 - Google Patents

Studies on the role of serotonin receptor subtypes in the effect of sibutramine in various feeding paradigms in rats

Grignaschi et al., 1999

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Document ID
17152790095541793159
Author
Grignaschi G
Fanelli E
Scagnol I
Samanin R
Publication year
Publication venue
British journal of pharmacology

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Snippet

The effect of the 5‐hydroxytryptamine (5‐HT) and noradrenaline (NA) reuptake inhibitor sibutramine was studied in food deprived, neuropeptide Y (NPY)‐or muscimol‐injected rats. Sibutramine dose‐dependently reduced feeding caused by food‐deprivation (ED50 …
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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