Nothing Special   »   [go: up one dir, main page]

Mahajan et al., 2010 - Google Patents

Shepherding AKT and androgen receptor by Ack1 tyrosine kinase

Mahajan et al., 2010

View HTML
Document ID
16929894574819706340
Author
Mahajan K
Mahajan N
Publication year
Publication venue
Journal of cellular physiology

External Links

Snippet

Ack1 (also known as ACK, TNK2, or activated Cdc42 kinase) is a structurally unique non‐ receptor tyrosine kinase that is expressed in diverse cell types. It integrates signals from plethora of ligand‐activated receptor tyrosine kinases (RTKs), for example, MERTK, EGFR …
Continue reading at www.ncbi.nlm.nih.gov (HTML) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
    • A61K31/404—Indoles, e.g. pindolol
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876—Hybridisation probes
    • C12Q1/6883—Hybridisation probes for diseases caused by alterations of genetic material
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/48—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving transferase
    • C12Q1/485—Measuring or testing processes involving enzymes, nucleic acids or micro-organisms; Compositions therefor; Processes of preparing such compositions involving transferase involving kinase
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca

Similar Documents

Publication Publication Date Title
Mahajan et al. Shepherding AKT and androgen receptor by Ack1 tyrosine kinase
Yamamoto et al. Activation of Wnt signaling promotes olaparib resistant ovarian cancer
Huang et al. The many substrates and functions of NEDD4-1
Wang et al. The diverse roles of SPOP in prostate cancer and kidney cancer
Majumder et al. Akt-regulated pathways in prostate cancer
Koryakina et al. Androgen receptor phosphorylation: biological context and functional consequences
Jančík et al. Clinical relevance of KRAS in human cancers
Vinet et al. Protein arginine methyltransferase 5: A novel therapeutic target for triple‐negative breast cancers
Cheung et al. Naturally occurring neomorphic PIK3R1 mutations activate the MAPK pathway, dictating therapeutic response to MAPK pathway inhibitors
Yang et al. Novel membrane-associated androgen receptor splice variant potentiates proliferative and survival responses in prostate cancer cells
Li et al. KDM5B is essential for the hyperactivation of PI3K/AKT signaling in prostate tumorigenesis
Luo et al. NQO1 is regulated by PTEN in glioblastoma, mediating cell proliferation and oxidative stress
Ritter et al. Molecular insight into the regulation and function of MCAK
Asano et al. Frequent amplification of receptor tyrosine kinase genes in well-differentiated/dedifferentiated liposarcoma
Boissan et al. Learning about the functions of NME/NM23: lessons from knockout mice to silencing strategies
Huang et al. TTK regulates proliferation and apoptosis of gastric cancer cells through the Akt‐mTOR pathway
Lu et al. Targeting carcinogenesis: a role for the prolyl isomerase Pin1?
US9493813B2 (en) Modulation of phosphatidylinositol-5-phosphate-4-kinase activity
Kashiwagi et al. Downregulation of phosphodiesterase 4B (PDE4B) activates protein kinase A and contributes to the progression of prostate cancer
Grasso et al. Fitter mitochondria are associated with radioresistance in human head and neck SQD9 cancer cells
Huo et al. Lung cancer driven by BRAFG469V mutation is targetable by EGFR kinase inhibitors
Liao et al. Clinical and biological significance of PIM1 kinase in osteosarcoma
Gilic et al. Targeting protein tyrosine kinase 6 in cancer
Min et al. Targeting epidermal growth factor receptor in paclitaxel-resistant human breast and lung cancer cells with upregulated glucose-6-phosphate dehydrogenase
Jung et al. ABCC4/MRP4 contributes to the aggressiveness of Myc‐associated epithelial ovarian cancer