Amara et al., 1997 - Google Patents
A versatile synthetic dimerizer for the regulation of protein–protein interactionsAmara et al., 1997
View HTML- Document ID
- 16912543096204021109
- Author
- Amara J
- Clackson T
- Rivera V
- Guo T
- Keenan T
- Natesan S
- Pollock R
- Yang W
- Courage N
- Holt D
- Gilman M
- Publication year
- Publication venue
- Proceedings of the national academy of sciences
External Links
Snippet
The use of low molecular weight organic compounds to induce dimerization or oligomerization of engineered proteins has wide-ranging utility in biological research as well as in gene and cell therapies. Chemically induced dimerization can be used to activate …
- 230000033228 biological regulation 0 title abstract description 7
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
- C07K14/721—Steroid/thyroid hormone superfamily, e.g. GR, EcR, androgen receptor, oestrogen receptor
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