Nothing Special   »   [go: up one dir, main page]

Cleveland et al., 2014 - Google Patents

LMO2 induces T-cell leukemia with epigenetic deregulation of CD4

Cleveland et al., 2014

View HTML
Document ID
16980181100058035535
Author
Cleveland S
Goodings C
Tripathi R
Elliott N
Thompson M
Guo Y
Shyr Y
Davé U
Publication year
Publication venue
Experimental hematology

External Links

Snippet

In this study, we present a remarkable clonal cell line, 32080, derived from a CD2-Lmo2- transgenic T-cell leukemia with differentiation arrest at the transition from the intermediate single positive to double positive stages of T-cell development. We observed that 32080 …
Continue reading at www.sciencedirect.com (HTML) (other versions)

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues ; Not used, see subgroups
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0647—Haematopoietic stem cells; Uncommitted or multipotent progenitors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology

Similar Documents

Publication Publication Date Title
Kashi et al. Probing for a deeper understanding of rhabdomyosarcoma: insights from complementary model systems
Gu et al. Silencing of LINE-1 retrotransposons is a selective dependency of myeloid leukemia
Giambra et al. Leukemia stem cells in T-ALL require active Hif1α and Wnt signaling
Telfer et al. Localization of the domains in Runx transcription factors required for the repression of CD4 in thymocytes
Tanaka et al. Dual function of histone H3 lysine 36 methyltransferase ASH1 in regulation of Hox gene expression
Choe et al. Wnt signaling regulates intermediate precursor production in the postnatal dentate gyrus by regulating CXCR4 expression
Gerby et al. High-throughput screening in niche-based assay identifies compounds to target preleukemic stem cells
Baeten et al. Genetic models of leukemia in zebrafish
Chiang et al. High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia
Yang et al. The stem cell factor SALL4 is an essential transcriptional regulator in mixed lineage leukemia-rearranged leukemogenesis
Lacombe et al. Genetic interaction between Kit and Scl
Cleveland et al. LMO2 induces T-cell leukemia with epigenetic deregulation of CD4
Liu et al. Notch-induced endoplasmic reticulum-associated degradation governs mouse thymocyte β− selection
Fisher et al. The impact of the cellular origin in acute myeloid leukemia: learning from mouse models
Dong et al. Genome-wide analysis identifies Rag1 and Rag2 as novel Notch1 transcriptional targets in thymocytes
Konrad et al. The BTG/TOB family protein TIS21 regulates stage‐specific proliferation of developing thymocytes
Hartung et al. LSD1 inhibition modulates transcription factor networks in myeloid malignancies
Mantha et al. Activating Notch1 mutations are an early event in T-cell malignancy of Ikaros point mutant Plastic/+ mice
Sugawara et al. FET family proto-oncogene Fus contributes to self-renewal of hematopoietic stem cells
Grönroos Transcriptional regulation and cell signaling in acute lymphoblastic leukemia and hematopoiesis
ES2446215B1 (en) THERAPEUTIC APPLICATION OF CD44 INHIBITING AGENTS AGAINST HUMAN LYMPHOBLASTIC LEUKEMIA (ALL).
Gramann The Role of BMP Signaling in the Melanocyte Lineage and as a Therapeutic Target in Melanoma
Woodcroft Towards a B-Lymphoid Model of E2A-PBX1-Mediated Leukemogenesis: Evaluating the Impact of Hematopoietic Cell of Origin on the Transformation Properties of a Leukemogenic Transcription Factor
Vasic Role Of The Rna Modification N6-Methyladenosine In Normal Hematopoiesis & Disease
Shanmuganathan et al. The Biology and Pathogenesis of Chronic Myeloid Leukaemia