Yue et al., 2015 - Google Patents
Synthesis of bifunctional molecules containing [12] aneN 3 and coumarin moieties as effective DNA condensation agents and new non-viral gene vectorsYue et al., 2015
View PDF- Document ID
- 16641346371026658636
- Author
- Yue P
- Zhang Y
- Guo Z
- Cao A
- Lu Z
- Zhai Y
- Publication year
- Publication venue
- Organic & Biomolecular Chemistry
External Links
Snippet
A series of bifunctional molecules with different combinations of macrocyclic polyamine [12] aneN3 and coumarin moieties, 4a/b and 5a/b, were synthesized by a two-step copper (I)- mediated alkyne–azide click reactions between 1, 3, 5-tris (azidomethyl) benzene and Boc …
- 229920003013 deoxyribonucleic acid 0 title abstract description 114
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
- A61K47/48—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
- A61K47/48007—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the pharmacologically- or therapeutically-active agent being covalently bound or complexed to a modifying agent
- A61K47/48023—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the pharmacologically- or therapeutically-active agent being covalently bound or complexed to a modifying agent the modifying agent being an organic compound
- A61K47/48061—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates the pharmacologically- or therapeutically-active agent being covalently bound or complexed to a modifying agent the modifying agent being an organic compound the modifying agent being a heterocyclic compound
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
Similar Documents
Publication | Publication Date | Title |
---|---|---|
Zhu et al. | Intracellularly disintegratable polysulfoniums for efficient gene delivery | |
Sansone et al. | DNA condensation and cell transfection properties of guanidinium calixarenes: dependence on macrocycle lipophilicity, size, and conformation | |
Zhang et al. | Linear polycations by ring-opening polymerization as non-viral gene delivery vectors | |
Yue et al. | Synthesis of bifunctional molecules containing [12] aneN 3 and coumarin moieties as effective DNA condensation agents and new non-viral gene vectors | |
Li et al. | Engineering the aromaticity of cationic helical polypeptides toward “self-activated” DNA/siRNA delivery | |
Ding et al. | Gemini-type tetraphenylethylene amphiphiles containing [12] aneN3 and long hydrocarbon chains as nonviral gene vectors and gene delivery monitors | |
Yin et al. | The effect of a nuclear localization sequence on transfection efficacy of genes delivered by cobalt (II)–polybenzimidazole complexes | |
Ma et al. | [12] aneN3-based gemini-type amphiphiles with two-photon absorption properties for enhanced nonviral gene delivery and bioimaging | |
Sheng et al. | ‘Click’synthesized sterol-based cationic lipids as gene carriers, and the effect of skeletons and headgroups on gene delivery | |
Yan et al. | Effective and reversible DNA condensation induced by bifunctional molecules containing macrocyclic polyamines and naphthyl moieties | |
Gao et al. | [12] aneN3-based lipid with naphthalimide moiety for enhanced gene transfection efficiency | |
Avitabile et al. | Incorporation of naked peptide nucleic acids into liposomes leads to fast and efficient delivery | |
Kumar et al. | Enhanced gene transfection efficiency by polyamidoamine (PAMAM) dendrimers modified with ornithine residues | |
Mével et al. | Important role of phosphoramido linkage in imidazole‐based dioleyl helper lipids for liposome stability and primary cell transfection | |
Lee et al. | A photo-degradable gene delivery system for enhanced nuclear gene transcription | |
Zheng et al. | A novel gemini-like cationic lipid for the efficient delivery of siRNA | |
Gao et al. | Functional lipids based on [12] aneN 3 and naphthalimide as efficient non-viral gene vectors | |
Yang et al. | A Fluorescent Self-Reporting Vector with GSH Reduction Responsiveness for Nucleic Acid Delivery | |
Muripiti et al. | α-Tocopherol-based cationic amphiphiles with a novel pH sensitive hybrid linker for gene delivery | |
Tschiche et al. | Crosslinked Redox‐Responsive Micelles Based on Lipoic Acid‐Derived Amphiphiles for Enhanced siRNA Delivery | |
Illescas et al. | Multivalent cationic dendrofullerenes for gene transfer: Synthesis and DNA complexation | |
Yan et al. | Syntheses of bifunctional molecules containing [12] aneN 3 and carbazol moieties as effective DNA condensation agents | |
Hu et al. | Cytoplasmic reactive cationic amphiphiles for efficient intracellular delivery and self-reporting smart release | |
Le et al. | Direct Cytosolic Delivery of Proteins and CRISPR-Cas9 Genome Editing by Gemini Amphiphiles via Non-Endocytic Translocation Pathways | |
Chaltin et al. | Delivery of antisense oligonucleotides using cholesterol-modified sense dendrimers and cationic lipids |