Nothing Special   »   [go: up one dir, main page]

Ounallah-Saad et al., 2014 - Google Patents

Genetic or pharmacological reduction of PERK enhances cortical-dependent taste learning

Ounallah-Saad et al., 2014

View PDF @Free from Publisher
Document ID
16592463997544601109
Author
Ounallah-Saad H
Sharma V
Edry E
Rosenblum K
Publication year
Publication venue
Journal of Neuroscience

External Links

Snippet

Protein translation initiation is controlled by levels of eIF2α phosphorylation (p-eIF2α) on Ser51. In addition, increased p-eIF2α levels impair long-term synaptic plasticity and memory consolidation, whereas decreased levels enhance them. Levels of p-eIF2α are determined …
Continue reading at www.jneurosci.org (PDF) (other versions)

Classifications

    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G01N33/502Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics for testing non-proliferative effects
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/185Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic, hydroximic acids
    • A61K31/19Carboxylic acids, e.g. valproic acid
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology

Similar Documents

Publication Publication Date Title
Ounallah-Saad et al. Genetic or pharmacological reduction of PERK enhances cortical-dependent taste learning
Panicker et al. Neuronal NLRP3 is a parkin substrate that drives neurodegeneration in Parkinson’s disease
Jais et al. PNOCARC neurons promote hyperphagia and obesity upon high-fat-diet feeding
Park et al. Microglial MERTK eliminates phosphatidylserine‐displaying inhibitory post‐synapses
Pryor et al. Huntingtin promotes mTORC1 signaling in the pathogenesis of Huntington’s disease
Kawai et al. Area-specific regulation of quiescent neural stem cells by Notch3 in the adult mouse subependymal zone
Toyo-Oka et al. 14-3-3ε and ζ regulate neurogenesis and differentiation of neuronal progenitor cells in the developing brain
Su et al. Atg5-and Atg7-dependent autophagy in dopaminergic neurons regulates cellular and behavioral responses to morphine
Su et al. Lithium, a common drug for bipolar disorder treatment, regulates amyloid-β precursor protein processing
Zheng et al. A novel dephosphorylation targeting chimera selectively promoting tau removal in tauopathies
Cheng et al. SUMO-specific protease 1 is essential for stabilization of HIF1α during hypoxia
Kaneko et al. Casein kinase 1 suppresses activation of REST in insulted hippocampal neurons and halts ischemia-induced neuronal death
Lee et al. Regulator of G-protein signaling-10 negatively regulates NF-κB in microglia and neuroprotects dopaminergic neurons in hemiparkinsonian rats
Hsiao et al. Deltex1 antagonizes HIF-1α and sustains the stability of regulatory T cells in vivo
Segarra‐Mondejar et al. Synaptic activity‐induced glycolysis facilitates membrane lipid provision and neurite outgrowth
Bouhamdani et al. A Compendium of Information on the Lysosome
Mabb et al. Topoisomerase 1 regulates gene expression in neurons through cleavage complex-dependent and-independent mechanisms
Chen et al. CREB SUMOylation by the E3 ligase PIAS1 enhances spatial memory
Sałaciak et al. The calcium/calmodulin-dependent kinases II and IV as therapeutic targets in neurodegenerative and neuropsychiatric disorders
Huang et al. CRL4DCAF2 negatively regulates IL-23 production in dendritic cells and limits the development of psoriasis
Ha et al. A novel histone deacetylase 6 inhibitor improves myelination of Schwann cells in a model of Charcot–Marie–Tooth disease type 1A
López-Murcia et al. Acute complexin knockout abates spontaneous and evoked transmitter release
Khlghatyan et al. Fxr1 regulates sleep and synaptic homeostasis
Yang et al. Protein phosphatase-1 inhibitor-2 is a novel memory suppressor
Linares et al. SYF2 suppression mitigates neurodegeneration in models of diverse forms of ALS