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Cao et al., 2005 - Google Patents

DNA constructs designed to produce short hairpin, interfering RNAs in transgenic mice sometimes show early lethality and an interferon response

Cao et al., 2005

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Document ID
16481199980074390320
Author
Cao W
Hunter R
Strnatka D
McQueen C
Erickson R
Publication year
Publication venue
J Appl Genet

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Snippet

Arylamine N-acetyltransferase (NAT) genes were targeted for inhibition using short hairpin RNA (shRNA) using two different RNA polymerase III promoters. Constructs were developed for NAT1 and NAT2, the endogenous mouse genes, and for human NAT1. There were fetal …
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