Nothing Special   »   [go: up one dir, main page]

Wheaton et al., 2016 - Google Patents

The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis

Wheaton et al., 2016

View HTML
Document ID
16398671238791285289
Author
Wheaton A
Velikoff M
Agarwal M
Loo T
Horowitz J
Sisson T
Kim K
Publication year
Publication venue
American Journal of Physiology-Lung Cellular and Molecular Physiology

External Links

Snippet

Transforming growth factor-β (TGF-β) is a critical driver of acute lung injury and fibrosis. Injury leads to activation of TGF-β, which regulates changes in the cellular and matrix makeup of the lung during the repair and fibrosis phase. TGF-β can also initiate alveolar …
Continue reading at journals.physiology.org (HTML) (other versions)

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
    • G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by the preceding groups
    • G01N33/48—Investigating or analysing materials by specific methods not covered by the preceding groups biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/55—Protease inhibitors
    • A61K38/57—Protease inhibitors from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans

Similar Documents

Publication Publication Date Title
Wheaton et al. The vitronectin RGD motif regulates TGF-β-induced alveolar epithelial cell apoptosis
Lagares et al. ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis
Rubel et al. Collagen receptors integrin alpha2beta1 and discoidin domain receptor 1 regulate maturation of the glomerular basement membrane and loss of integrin alpha2beta1 delays kidney fibrosis in COL4A3 knockout mice
Kim et al. Epithelial cell α3β1 integrin links β-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis
Kubota et al. M-CSF inhibition selectively targets pathological angiogenesis and lymphangiogenesis
Cipolla et al. IL-17A deficiency mitigates bleomycin-induced complement activation during lung fibrosis
Mori et al. Expression and regulation of intracellular SMAD signaling in scleroderma skin fibroblasts
Owen et al. Regulation of lamellipodial persistence, adhesion turnover, and motility in macrophages by focal adhesion kinase
Yasar Yildiz et al. Functional stability of plasminogen activator inhibitor‐1
Besschetnova et al. Regulatory mechanisms of anthrax toxin receptor 1-dependent vascular and connective tissue homeostasis
Rayego-Mateos et al. Interplay between extracellular matrix components and cellular and molecular mechanisms in kidney fibrosis
Connolly et al. Selective abrogation of the uPA-uPAR interaction in vivo reveals a novel role in suppression of fibrin-associated inflammation
Wypasek et al. Mast cells in human stenotic aortic valves are associated with the severity of stenosis
Larsson et al. Antiangiogenic effects of latent antithrombin through perturbed cell-matrix interactions and apoptosis of endothelial cells
Kalucka et al. Loss of epithelial hypoxia-inducible factor prolyl hydroxylase 2 accelerates skin wound healing in mice
Trujillo et al. Neutrophil recruitment to the lung in both C5a-and CXCL1-induced alveolitis is impaired in vitamin D–binding protein–deficient mice
Znoyko et al. Expression of oncostatin M and its receptors in normal and cirrhotic human liver
Kanno et al. Alpha2‐antiplasmin regulates the development of dermal fibrosis in mice by prostaglandin F2α synthesis through adipose triglyceride lipase/calcium‐independent phospholipase A2
Wheaton et al. Lung epithelial cell focal adhesion kinase signaling inhibits lung injury and fibrosis
Horowitz et al. Urokinase plasminogen activator overexpression reverses established lung fibrosis
Kanno et al. The antifibrotic effect of α2AP neutralization in systemic sclerosis dermal fibroblasts and mouse models of systemic sclerosis
Tang et al. Latent transforming growth factor-β1 protects against bleomycin-induced lung injury in mice
Leask Suppl 1: Getting Out of a Sticky Situation: Targeting the Myofibroblast in Scleroderma
Ai et al. Methyl-CpG-binding domain protein 2 contributes to renal fibrosis through promoting polarized M1 macrophages
Balsara et al. A deficiency of uPAR alters endothelial angiogenic function and cell morphology